Gene Symbol: Elf1
Description: E74-like factor 1
Alias: Elf-1, Sts1, mElf-1, p70, ETS-related transcription factor Elf-1
Species: mouse
Products:     Elf1

Top Publications

  1. San Luis B, Sondgeroth B, Nassar N, Carpino N. Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways. J Biol Chem. 2011;286:15943-54 pubmed publisher
    ..Our results suggest that the phosphatase activities of both suppressor of TCR signaling homologues cooperate in a similar but independent fashion to help set the threshold for TCR-induced T cell activation. ..
  2. Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N. A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling. Mol Cell. 2007;27:486-97 pubmed
    ..These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling. ..
  3. Nowling T, Fulton J, Chike Harris K, Gilkeson G. Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. Mol Immunol. 2008;45:1-12 pubmed
    ..Ets factors Elf1, Tel and Fli1 bind in vitro to this region and increase endogenous Fli1 expression when over-expressed in a T cell ..
  4. Geng Y, Laslo P, Barton K, Wang C. Transcriptional regulation of CD1D1 by Ets family transcription factors. J Immunol. 2005;175:1022-9 pubmed
    ..1-deficient myeloid cells. These findings are the first to demonstrate that Ets proteins are involved in the transcriptional regulation of CD1D1 and that they may function uniquely in different cell types. ..
  5. Carpino N, Turner S, Mekala D, Takahashi Y, Zang H, Geiger T, et al. Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity. 2004;20:37-46 pubmed
    ..hyperactivation of signaling proteins downstream of the TCR, a marked increase in cytokine production by Sts1/2(-/-) T cells, and increased susceptibility to autoimmunity in a mouse model of multiple sclerosis is observed...
  6. Carpino N, Chen Y, Nassar N, Oh H. The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways. Mol Immunol. 2009;46:3224-31 pubmed publisher
    ..Our observations hint at a novel regulatory mechanism downstream of the T cell receptor. ..
  7. Pimanda J, Chan W, Donaldson I, Bowen M, Green A, Gottgens B. Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer. Blood. 2006;107:4737-45 pubmed
    ..This study therefore establishes the transcriptional framework within which endoglin functions during angiogenesis. ..
  8. Davis J, Roussel M. Cloning and expression of the murine Elf-1 cDNA. Gene. 1996;171:265-9 pubmed
    ..We conclude that the expression of mElf-1 is not restricted to the lymphoid lineage, and suggest that Elf-1 may regulate the transcription of a broad spectrum of genes. ..
  9. Carpino N, Kobayashi R, Zang H, Takahashi Y, Jou S, Feng J, et al. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. Mol Cell Biol. 2002;22:7491-500 pubmed
    ..The predicated sequence indicates that p70 contains an SH3 domain and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase...

More Information


  1. Gottgens B, Nastos A, Kinston S, Piltz S, Delabesse E, Stanley M, et al. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J. 2002;21:3039-50 pubmed
    ..Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation. ..
  2. Garrett Sinha L, Dahl R, Rao S, Barton K, Simon M. PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1. Blood. 2001;97:2908-12 pubmed
    ..In summary, PU.1 and Spi-B regulate common target genes required for proliferation of hematopoietic progenitors or their committed descendants, whereas Ets-1 or Elf-1 do not appear to regulate shared target genes with PU.1 or Spi-B. ..
  3. Bassuk A, Barton K, Anandappa R, Lu M, Leiden J. Expression pattern of the Ets-related transcription factor Elf-1. Mol Med. 1998;4:392-401 pubmed
  4. Calero Nieto F, Wood A, Wilson N, Kinston S, Landry J, Gottgens B. Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation. Nucleic Acids Res. 2010;38:6363-74 pubmed publisher
    ..1 controls myeloid-erythroid differentiation. Our findings therefore not only represent the first report of Elf-1 regulation but also enhance our understanding of the wider regulatory networks that control haematopoiesis. ..
  5. Choi H, Geng Y, Cho H, Li S, Giri P, Felio K, et al. Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells. Blood. 2011;117:1880-7 pubmed publisher
    ..Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development...
  6. Blagosklonny M. A node between proliferation, apoptosis, and growth arrest. Bioessays. 1999;21:704-9 pubmed
  7. Brambilla -, Br amp uuml ckner -, Orioli -, Bergemann -, Flanagan -, Klein -. Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors. Mol Cell Neurosci. 1996;8:199-209 pubmed
    ..Knowledge regarding functional ligand-receptor interactions as presented in this study will be important for the design and interpretation of in vivo experiments, e.g., loss-of-function studies in transgenic mice. ..
  8. Brooke Bisschop T, Savory J, Foley T, Ringuette R, Lohnes D. Essential roles for Cdx in murine primitive hematopoiesis. Dev Biol. 2017;422:115-124 pubmed publisher
    ..These findings demonstrate critical roles for Cdx members in murine primitive hematopoiesis upstream of Scl. ..
  9. Parashar K, Kopping E, Frank D, Sampath V, Thanassi D, Carpino N. Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases. Infect Immun. 2017;85: pubmed publisher
    ..These observations suggest the Sts proteins play an important regulatory role in the host response to bacterial infection, and they underscore a role for Sts in regulating functionally relevant immune response pathways. ..
  10. Kumazoe M, Yamashita M, Nakamura Y, Takamatsu K, Bae J, Yamashita S, et al. Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. J Immunol. 2017;199:3261-3269 pubmed publisher
    ..These data support EGCG and a cGMP inducer as potential candidate suppressors of TLR4 signaling. ..
  11. Serdobova I, Pla M, Reichenbach P, Sperisen P, Ghysdael J, Wilson A, et al. Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene. J Exp Med. 1997;185:1211-21 pubmed
  12. Lim K, Chang H. O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors. Biochem Biophys Res Commun. 2009;380:569-74 pubmed publisher
    ..These findings suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor. ..
  13. Jakoncic J, Sondgeroth B, Carpino N, Nassar N. The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:643-7 pubmed publisher
    ..Each sulfate is located at the phosphate-binding site and makes similar interactions with the catalytic residues. The structure suggests an explanation for the lower Michaelis-Menten constants at acidic pH. ..
  14. Tang Y, Katuri V, Iqbal S, Narayan T, Wang Z, Lu R, et al. ELF a beta-spectrin is a neuronal precursor cell marker in developing mammalian brain; structure and organization of the elf/beta-G spectrin gene. Oncogene. 2002;21:5255-67 pubmed
    ..It remains unclear as to whether novel beta-spectrins such as elf1-4 are distinct genes or beta-G-spectrin isoforms...
  15. Gunther C, Graves B. Identification of ETS domain proteins in murine T lymphocytes that interact with the Moloney murine leukemia virus enhancer. Mol Cell Biol. 1994;14:7569-80 pubmed
    ..This strategy could be used to identify other ETS domain proteins in crude nuclear extracts. These findings suggest multiple ETS domain proteins could regulate gene expression of Mo-MuLV. ..
  16. Lettice L, Williamson I, Wiltshire J, Peluso S, Devenney P, Hill A, et al. Opposing functions of the ETS factor family define Shh spatial expression in limb buds and underlie polydactyly. Dev Cell. 2012;22:459-67 pubmed publisher
    ..Two point mutations within the ZRS change the profile of ETS binding and activate Shh expression at an ectopic site in the limb bud. These molecular changes define a pathogenetic mechanism that leads to preaxial polydactyly (PPD)...
  17. Cieniewicz B, CARPINO N, Krug L. Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2. PLoS ONE. 2014;9:e90196 pubmed publisher
  18. Abedin M, Nguyen A, Jiang N, Perry C, Shelton J, Watson D, et al. Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res. 2014;114:1690-9 pubmed publisher
    ..Once the program is activated in early embryos, Fli1 then takes over to sustain the process in the absence of Etv2. ..