Elavl1

Summary

Gene Symbol: Elavl1
Description: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
Alias: 2410055N02Rik, HUR, Hua, W91709, ELAV-like protein 1, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), HU-antigen A, elav-like generic protein, hu-antigen R, melG
Species: mouse
Products:     Elavl1

Top Publications

  1. Di Marco S, Mazroui R, Dallaire P, Chittur S, Tenenbaum S, Radzioch D, et al. NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol. 2005;25:6533-45 pubmed
    ..relies on both transcriptional activation via NF-kappaB and increased mRNA stability via the RNA-binding protein HuR. Moreover, we show that HuR regulates iNOS expression in an AMP-activated protein kinase (AMPK)-dependent manner...
  2. Gantt K, Cherry J, Richardson M, Karschner V, Atasoy U, Pekala P. The regulation of glucose transporter (GLUT1) expression by the RNA binding protein HuR. J Cell Biochem. 2006;99:565-74 pubmed
    b>HuR is a ligand for nuclear mRNAs containing adenylate-uridylate-rich (ARE) elements in the 3'-untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins that then facilitate nuclear export of the complex...
  3. Atasoy U, Watson J, Patel D, Keene J. ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J Cell Sci. 1998;111 ( Pt 21):3145-56 pubmed
    ..Therefore, much like the primarily cytoplasmic HuB, HuA becomes temporally localized in the cytoplasm where it can potentially regulate the stability or translation of ..
  4. Sgantzis N, Yiakouvaki A, Remboutsika E, Kontoyiannis D. HuR controls lung branching morphogenesis and mesenchymal FGF networks. Dev Biol. 2011;354:267-79 pubmed publisher
    ..Here we demonstrate that the RNA-binding protein (RBP) HuR is an essential regulator of mesenchymal responses during lung branching...
  5. van der Giessen K, Di Marco S, Clair E, Gallouzi I. RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation. J Biol Chem. 2003;278:47119-28 pubmed
    ..b>HuR, an RNA-binding protein that regulates both the stability and cellular movement of ARE-containing mRNAs, interacts ..
  6. Nguyen Chi M, Chalmel F, Agius E, Vanzo N, Khabar K, Jégou B, et al. Temporally regulated traffic of HuR and its associated ARE-containing mRNAs from the chromatoid body to polysomes during mouse spermatogenesis. PLoS ONE. 2009;4:e4900 pubmed publisher
    ..Here, we describe a new component of the CB, the RNA binding protein HuR, known in somatic cells to control the stability/translation of AU-rich containing mRNAs (ARE-mRNAs).
  7. Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, et al. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009;29:2762-76 pubmed publisher
    b>HuR is an RNA-binding protein implicated in a diverse array of pathophysiological processes due to its effects on the posttranscriptional regulation of AU- and U-rich mRNAs...
  8. Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, et al. Macrophage ?2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. Am J Pathol. 2012;180:1751-60 pubmed publisher
    b>HuR is a member of the Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated degradation...
  9. Yiakouvaki A, Dimitriou M, Karakasiliotis I, Eftychi C, Theocharis S, Kontoyiannis D. Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest. 2012;122:48-61 pubmed publisher
    ..The RNA-binding protein HuR binds to and regulates such mRNAs, but its exact role in inflammation remains unclear...

More Information

Publications85

  1. Chi M, Auriol J, Jégou B, Kontoyiannis D, Turner J, de Rooij D, et al. The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Mol Biol Cell. 2011;22:2875-85 pubmed publisher
    ..Here, we focused on the RNA binding protein Embryonic Lethal Abnormal Vision (ELAV) L1/Human antigen R (HuR) known to be a key regulator of posttranscriptional regulation in somatic cells but the function of which during ..
  2. Yu T, Wang P, Rao J, Zou T, Liu L, Xiao L, et al. Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function. Nucleic Acids Res. 2011;39:8472-87 pubmed publisher
    ..The RNA-binding protein HuR modulates the stability and translation of many target mRNAs...
  3. Nowotarski S, Shantz L. Cytoplasmic accumulation of the RNA-binding protein HuR stabilizes the ornithine decarboxylase transcript in a murine nonmelanoma skin cancer model. J Biol Chem. 2010;285:31885-94 pubmed publisher
    ..Thus, we sought to investigate whether the ODC transcript interacts with the RNA-binding protein HuR, which is known to bind to and stabilize its target mRNAs...
  4. Beauchamp P, Nassif C, Hillock S, van der Giessen K, von Roretz C, Jasmin B, et al. The cleavage of HuR interferes with its transportin-2-mediated nuclear import and promotes muscle fiber formation. Cell Death Differ. 2010;17:1588-99 pubmed publisher
    ..such a mechanism and show that during myogenesis, a fraction of the posttranscriptional regulator human antigen R (HuR) is cleaved in a caspase-dependent manner in both cell culture and animal models...
  5. Ghosh M, Aguila H, Michaud J, Ai Y, Wu M, Hemmes A, et al. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. 2009;119:3530-43 pubmed publisher
    ..Here, we report that murine HuR is essential for life; postnatal global deletion of Elavl1 induced atrophy of hematopoietic organs, extensive loss of intestinal villi, obstructive enterocolitis, and ..
  6. Papadaki O, Milatos S, Grammenoudi S, Mukherjee N, Keene J, Kontoyiannis D. Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. J Immunol. 2009;182:6779-88 pubmed publisher
    b>HuR emerged as a posttranscriptional regulator of mRNAs involved in cellular control, stress, and immunity but its role in governing such responses remains elusive...
  7. Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim H, Kuwano Y, et al. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J. 2009;28:1271-82 pubmed publisher
    The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins...
  8. Cho S, Jung Y, Zhang J, Chen X. The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation. J Biol Chem. 2012;287:14535-44 pubmed publisher
    The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu protein family, plays a critical role in many cellular processes, including cell proliferation, angiogenesis, and inflammatory response...
  9. Li H, Park S, Kilburn B, Jelinek M, Henschen Edman A, Aswad D, et al. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002;277:44623-30 pubmed
    The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light...
  10. Figueroa A, Cuadrado A, Fan J, Atasoy U, Muscat G, Munoz Canoves P, et al. Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol. 2003;23:4991-5004 pubmed
    In this report, we investigate the role of the RNA-binding protein HuR during skeletal myogenesis...
  11. Katsanou V, Papadaki O, Milatos S, Blackshear P, Anderson P, Kollias G, et al. HuR as a negative posttranscriptional modulator in inflammation. Mol Cell. 2005;19:777-89 pubmed
    b>HuR is an RNA binding protein with an alleged role in the posttranscriptional activation of inflammatory mRNAs bearing AU-rich elements (AREs)...
  12. van der Giessen K, Gallouzi I. Involvement of transportin 2-mediated HuR import in muscle cell differentiation. Mol Biol Cell. 2007;18:2619-29 pubmed
    ..two proteins are regulated posttranscriptionally through their ability to associate with the RNA-binding protein HuR. HuR localizes first to the nucleus and then to the cytoplasm during muscle differentiation...
  13. Qin W, Li X, Xie L, Li S, Liu J, Jia L, et al. A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice. Nucleic Acids Res. 2016;44:6423-33 pubmed publisher
    ..Mechanistically, APOA4-AS directly interacts with mRNA stabilizing protein HuR and stabilizes APOA4 mRNA. Deletion of HuR dramatically reduces both APOA4-AS and APOA4 transcripts...
  14. Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K, et al. High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS ONE. 2013;8:e59095 pubmed publisher
    Human antigen R (HuR) regulates the stability of mRNA and is associated with cell proliferation, angiogenesis, and lymphangiogenesis. However, the clinical significance and pathological role of HuR in bladder cancer remains unclear...
  15. Joassard O, Bélanger G, Karmouch J, Lunde J, Shukla A, Chopard A, et al. HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation. J Neurosci. 2015;35:10949-62 pubmed publisher
    ..We also observed that denervation increased expression of the RNA-binding protein human antigen R (HuR) and induced its translocation to the cytoplasm...
  16. Zhang W, Vreeland A, Noy N. RNA-binding protein HuR regulates nuclear import of protein. J Cell Sci. 2016;129:4025-4033 pubmed
    The RNA-binding protein HuR binds to elements rich in adenylate and uridylate (AU-rich elements) in target mRNAs and stabilizes them against degradation...
  17. Deschenes Furry J, Belanger G, Mwanjewe J, Lunde J, Parks R, Perrone Bizzozero N, et al. The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells. J Biol Chem. 2005;280:25361-8 pubmed
    ..assays, and immunoprecipitation followed by reverse transcription-PCR, we found that the mRNA-stabilizing protein HuR interacts directly with AChE transcripts...
  18. Degese M, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, et al. An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation. Biochem J. 2015;467:77-90 pubmed publisher
    ..Several AU-rich binding proteins (AUBPs), including HuR (Hu-antigen R, Elav-like protein 1, ELAVL1) and KSRP (far upstream element-binding protein 2, KHSRP) bind to a fos AU-rich element (ARE) present in the 3'-..
  19. Mahboubi H, Koromilas A, Stochaj U. AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization. Mol Pharmacol. 2016;90:460-8 pubmed publisher
    ..Taken together, we provide mechanistic insights into the regulation of SG formation. We propose that AMPK activation stimulates oxidant-induced SG formation but limits their fusion into larger granules. ..
  20. Nagaoka K, Suzuki T, Kawano T, Imakawa K, Sakai S. Stability of casein mRNA is ensured by structural interactions between the 3'-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex. Biochim Biophys Acta. 2006;1759:132-40 pubmed
    ..In the immunoprecipitation analysis, the poly(A)-binding protein (PABP) and the RNA-binding protein HuR were pulled down by 3'-UTR cRNA, and the absence of the ARE site reduced the binding of these proteins...
  21. Embade N, Fernandez Ramos D, Varela Rey M, Beraza N, Sini M, Gutiérrez de Juan V, et al. Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. Hepatology. 2012;55:1237-48 pubmed publisher
    b>Hu antigen R (HuR) is a central RNA-binding protein regulating cell dedifferentiation, proliferation, and survival, which are well-established hallmarks of cancer...
  22. Seko Y, Azmi H, Fariss R, Ragheb J. Selective cytoplasmic translocation of HuR and site-specific binding to the interleukin-2 mRNA are not sufficient for CD28-mediated stabilization of the mRNA. J Biol Chem. 2004;279:33359-67 pubmed
    ..For a number of proto-oncogenes and cytokines, the HuR protein has been shown to avidly bind the AU-rich elements that confer instability upon their mRNAs...
  23. Mufti J, Hajarnis S, Shepardson K, Gummadi L, Taylor L, Curthoys N. Role of AUF1 and HuR in the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in LLC-PK?-F? cells. Am J Physiol Renal Physiol. 2011;301:F1066-77 pubmed publisher
    ..Electrophoretic mobility shift assays established that purified recombinant HuR, another AU element binding protein, also binds with high affinity and specificity to multiple sites within the ..
  24. Lu L, Wang S, Zheng L, Li X, Suswam E, Zhang X, et al. Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem. 2009;284:33989-98 pubmed publisher
    ..Here, we show that the major RNA stabilizer, Hu Antigen R (HuR), and TIA-1-related protein (TIAR) colocalize with mutant SOD1 in mouse spinal cord extracts and cultured ..
  25. Ziegeler G, Ming J, Koseki J, Sevinc S, Chen T, Ergun S, et al. Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem. 2010;285:15408-19 pubmed publisher
    ..The embryonic lethal abnormal vision (ELAV)-like RNA-binding protein HuR is thought be important for the translation of p27(Kip1), however, different reports attributed diametrically ..
  26. Ramgolam V, Degregorio S, Rao G, Collinge M, Subaran S, Markovic Plese S, et al. T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade. PLoS ONE. 2010;5:e14450 pubmed publisher
    ..AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing protein, HuR. However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism...
  27. McDermott B, Ellis S, Bou Gharios G, Clegg P, Tew S. RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis Cartilage. 2016;24:1263-73 pubmed publisher
    ..Immunohistochemical localisation of MMP13 and the RNABP human antigen R (HuR) was performed in E13.5 and E16.5 mouse embryo sections...
  28. Miyashita H, Watanabe T, Hayashi H, Suzuki Y, Nakamura T, Ito S, et al. Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS ONE. 2012;7:e46459 pubmed publisher
    ..The synthesis of VASH1 was regulated by HuR-mediated post-transcriptional regulation. We sought to define the underlying mechanism...
  29. Sun S, Zhang X, Lyu L, Li X, Yao S, Zhang J. Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1. J Biol Chem. 2016;291:25823-25836 pubmed
    ..The RNA-binding proteins HuR and AUF1 directly bound to the ATX mRNA 3'UTR and had antagonistic functions in ATX expression...
  30. von Roretz C, Gallouzi I. Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem. 2010;285:16806-13 pubmed publisher
    The RNA-binding protein human antigen R (HuR) has been implicated in apoptosis in multiple ways...
  31. Chang S, Elemento O, Zhang J, Zhuang Z, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. 2014;111:18309-14 pubmed publisher
    ..We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also know as HuR) regulates the alternative splicing of eukaryotic translation initiation factor 4E nuclear ..
  32. Gubin M, Techasintana P, Magee J, Dahm G, Calaluce R, Martindale J, et al. Conditional knockout of the RNA-binding protein HuR in CD4? T cells reveals a gene dosage effect on cytokine production. Mol Med. 2014;20:93-108 pubmed publisher
    ..The RBP HuR binds to labile mRNAs, usually leading to increases in mRNA stability and/or translation...
  33. Chung H, Rao J, Zou T, Liu L, Xiao L, Gu H, et al. Jnk2 deletion disrupts intestinal mucosal homeostasis and maturation by differentially modulating RNA-binding proteins HuR and CUGBP1. Am J Physiol Cell Physiol. 2014;306:C1167-75 pubmed publisher
    ..JNK2-deficient intestinal epithelium was associated with an increase in the level of the RNA-binding protein HuR and with a decrease in the abundance of CUG-binding protein 1 (CUGBP1)...
  34. Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman D, et al. HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases. Glia. 2017;65:945-963 pubmed publisher
    ..Here, we investigated the role of HuR, an RNA-binding protein that regulates gene expression through posttranscriptional pathways, on the molecular and ..
  35. Gouble A, Morello D. Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, throughout murine development. Oncogene. 2000;19:5377-84 pubmed
    The AUF1 (hnRNPD) and HuR (ELAV-like) proteins, potential trans-acting factors for regulated mRNA decay, bind in vitro to A+U-rich elements (AREs) found in the 3' untranslated region (3' UTR) of many labile transcripts...
  36. Liu L, Christodoulou Vafeiadou E, Rao J, Zou T, Xiao L, Chung H, et al. RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway. Mol Biol Cell. 2014;25:3308-18 pubmed publisher
    ..The RNA-binding protein HuR is highly expressed in the gut mucosa and modulates the stability and translation of target mRNAs, but its exact ..
  37. Cherry J, Jones H, Karschner V, Pekala P. Post-transcriptional control of CCAAT/enhancer-binding protein beta (C/EBPbeta) expression: formation of a nuclear HuR-C/EBPbeta mRNA complex determines the amount of message reaching the cytosol. J Biol Chem. 2008;283:30812-20 pubmed publisher
    In 3T3-L1 cells, HuR is constitutively expressed and prior to induction of differentiation localized predominantly to the nucleus...
  38. de Frutos S, Nitta C, Caldwell E, Friedman J, Gonzalez Bosc L. Regulation of soluble guanylyl cyclase-alpha1 expression in chronic hypoxia-induced pulmonary hypertension: role of NFATc3 and HuR. Am J Physiol Lung Cell Mol Physiol. 2009;297:L475-86 pubmed publisher
    ..was independent of NFATc3 but mediated by nuclear accumulation of the mRNA-stabilizing protein human antigen R (HuR)...
  39. Zhou H, Hinman M, Barron V, Geng C, Zhou G, Luo G, et al. Hu proteins regulate alternative splicing by inducing localized histone hyperacetylation in an RNA-dependent manner. Proc Natl Acad Sci U S A. 2011;108:E627-35 pubmed publisher
    ..This "reaching back" interaction with chromatin provides a means to ensure accurate and efficient regulation of alternative splicing. ..
  40. Lin N, Lin C, Chang C. Modulation of immediate early gene expression by tristetraprolin in the differentiation of 3T3-L1 cells. Biochem Biophys Res Commun. 2008;365:69-74 pubmed
    ..Biotinylated MKP-1 AREs also could bring down TTP and the other ARE-binding protein HuR. RNA EMSA and competition assays showed that each of three AREs located in 3'UTR of MKP-1 mRNA has differential ..
  41. Shi J, He Y, Hewett S, Hewett J. Interleukin 1β Regulation of the System xc- Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR. J Biol Chem. 2016;291:1643-51 pubmed publisher
    ..Additionally, IL-1β induces HuR translocation from the nucleus to the cytoplasm...
  42. Nishino T, Matsunaga R, Jikihara H, Uchida M, Maeda A, Qi G, et al. Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse. Biochim Biophys Acta. 2016;1861:1816-1827 pubmed publisher
    ..of mRNA involving an AU-rich element (ARE) in its 3'UTR dependence on the RNA stabilizer, human antigen R (HuR), which is one of the CLPABP-binding proteins...
  43. King P, Fuller J, Nabors L, Detloff P. Analysis of the 5' end of the mouse Elavl1 (mHuA) gene reveals a transcriptional regulatory element and evidence for conserved genomic organization. Gene. 2000;242:125-31 pubmed
    mHuA (Elavl1) belongs to a highly conserved family of genes encoding RNA-binding proteins and has been linked to cell growth and proliferation through its regulation of mRNA stability...
  44. Guo J, Li M, Meng X, Sui J, Dou L, Tang W, et al. MiR-291b-3p induces apoptosis in liver cell line NCTC1469 by reducing the level of RNA-binding protein HuR. Cell Physiol Biochem. 2014;33:810-22 pubmed publisher
    ..Using computational miRNA target prediction databases, HuR was predicted as a target of miR-291b-3p...
  45. Good P. A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A. 1995;92:4557-61 pubmed
    ..Surprisingly, elrA is expressed in all adult tissues tested and at all times during development. Thus, the widely expressed elrA is expected to have a related function in all cells. ..
  46. Giammanco A, Blanc V, Montenegro G, Klos C, Xie Y, Kennedy S, et al. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res. 2014;74:5322-35 pubmed publisher
    b>HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis...
  47. Vreeland A, Levi L, Zhang W, Berry D, Noy N. Cellular retinoic acid-binding protein 2 inhibits tumor growth by two distinct mechanisms. J Biol Chem. 2014;289:34065-73 pubmed publisher
    ..function of the protein is exerted in the absence of RA and mediated by the RNA-binding and stabilizing protein HuR. CRABP2 directly binds to HuR, markedly strengthens its interactions with target mRNAs, and thus increases their ..
  48. Liu L, Zhuang R, Xiao L, Chung H, Luo J, Turner D, et al. HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation. Mol Cell Biol. 2017;37: pubmed publisher
    ..The RNA-binding protein HuR regulates the stability and translation of target mRNAs and is involved in many aspects of gut epithelium ..
  49. Tsai N, Ho P, Wei L. Regulation of stress granule dynamics by Grb7 and FAK signalling pathway. EMBO J. 2008;27:715-26 pubmed publisher
    ..Grb7), an RNA-binding, translational regulator, as an integral component of SGs, which directly interacts with Hu antigen R (HuR) and is required for cells to form SGs...
  50. Kuwano Y, Rabinovic A, Srikantan S, Gorospe M, Demple B. Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation. Mol Cell Biol. 2009;29:2622-35 pubmed publisher
    ..All seven mRNAs showed at least one hit of a signature motif for the stabilizing RNA-binding protein (RBP) HuR; accordingly, ribonucleoprotein immunoprecipitation analysis revealed that all seven mRNAs associated with HuR...
  51. Stellato C, Gubin M, Magee J, Fang X, Fan J, Tartar D, et al. Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol. 2011;187:441-9 pubmed publisher
    ..The RBP HuR posttranscriptionally regulates IL-4, IL-13, and other Th2 cell-restricted transcripts...
  52. Okano H, Darnell R. A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci. 1997;17:3024-37 pubmed
  53. Techasintana P, Davis J, Gubin M, Magee J, Atasoy U. Transcriptomic-Wide Discovery of Direct and Indirect HuR RNA Targets in Activated CD4+ T Cells. PLoS ONE. 2015;10:e0129321 pubmed publisher
    ..The RBP HuR (ELAVL1) and family members are major stabilizers of mRNA...
  54. Zou T, Jaladanki S, Liu L, Xiao L, Chung H, Wang J, et al. H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR. Mol Cell Biol. 2016;36:1332-41 pubmed publisher
    ..Increasing the level of the RNA-binding protein HuR in cells overexpressing H19 prevented the stimulation of miR-675 processing from H19, promoted ZO-1 and E-cadherin ..
  55. Zhou H, Jarujaron S, Gurley E, Chen L, Ding H, Studer E, et al. HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR. Atherosclerosis. 2007;195:e134-43 pubmed
    ..Furthermore, we show that the RNA-binding protein, HuR, plays an important role in HIV PI-induced expression of TNF-alpha and IL-6...
  56. Rhee W, Ni C, Zheng Z, Chang K, Jo H, Bao G. HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010;107:6858-63 pubmed publisher
    ..Here, we show that expression of HuR in human umbilical vein endothelial cells is regulated by shear stress and statin treatment; HuR, in turn, ..
  57. Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher
    ..These findings demonstrate a role for RGs in vertebrate organogenesis. ..
  58. Repetto E, Briata P, Kuziner N, Harfe B, McManus M, Gherzi R, et al. Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012;8:e1002823 pubmed publisher
    ..Our study unveils a functional crosstalk between miRNA- and AMD-dependent gene regulation during mammalian organogenesis events. ..
  59. Zago M, Sheridan J, Nair P, Rico De Souza A, Gallouzi I, Rousseau S, et al. Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding. PLoS ONE. 2013;8:e74953 pubmed publisher
    ..We further describe that the AhR destabilizes Cox-2 mRNA by sequestering HuR within the nucleus...
  60. Hashimoto M, Tsugawa T, Kawagishi H, Asai A, Sugimoto M. Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-?B. Biochim Biophys Acta. 2014;1840:3079-87 pubmed publisher
    b>HuR (human antigen R) is a ubiquitously expressed member of the Hu/ELAV family of proteins that is involved in diverse biological processes...
  61. Lin N, Lin C, Chen Y, Chang C. Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes. FEBS J. 2007;274:867-78 pubmed
    ..immunoprecipitation and gel shift experiments demonstrated that adenine- and uridine-rich element-binding proteins, HuR and tristetraprolin itself, were associated with tristetraprolin adenine- and uridine-rich elements...
  62. Hansraj N, Xiao L, Wu J, Chen G, Turner D, Wang J, et al. Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding. Physiol Rep. 2016;4: pubmed publisher
    ..Here, we report that 14-3-3? expression is tightly regulated at the posttranscription level by RNA-binding protein HuR and plays an important role in early intestinal epithelial restitution after wounding...
  63. Chen J, Cascio J, Magee J, Techasintana P, Gubin M, Dahm G, et al. Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis. J Immunol. 2013;191:5441-50 pubmed publisher
    ..The RNA-binding protein HuR positively regulates the stability of many target mRNAs via binding the AU-rich elements present in the 3' ..
  64. Skliris A, Papadaki O, Kafasla P, Karakasiliotis I, Hazapis O, Reczko M, et al. Neuroprotection requires the functions of the RNA-binding protein HuR. Cell Death Differ. 2015;22:703-18 pubmed publisher
    ..Here, we show that the ubiquitous member of the otherwise neuronal Elavl/Hu family of RNA-binding proteins, Elavl1/HuR, has a neuroprotective role...
  65. Chen J, Martindale J, Cramer C, Gorospe M, Atasoy U, Drew P, et al. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. J Biol Chem. 2017;292:14532-14543 pubmed publisher
    ..Here, using RNA-binding protein HuR conditional knock-out (KO) and wild-type (WT) mice, we present evidence that HuR post-transcriptionally regulates ..
  66. Park D, Xiang A, Mao F, Zhang L, Di C, Liu X, et al. Nestin is required for the proper self-renewal of neural stem cells. Stem Cells. 2010;28:2162-71 pubmed publisher
    ..These data demonstrate that nestin is important for the proper survival and self-renewal of NSCs, and that this function is surprisingly uncoupled from nestin's structural involvement in the cytoskeleton...
  67. Wang Y, Li Y, Toth J, Petroski M, Zhang Z, Zhao J. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014;16:191-8 pubmed publisher
    ..The human antigen R (HuR) and microRNA pathways were linked to these effects...
  68. Vreeland A, Yu S, Levi L, de Barros Rossetto D, Noy N. Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2. Mol Cell Biol. 2014;34:2135-46 pubmed publisher
    The RNA-binding protein HuR binds at 3' untranslated regions (UTRs) of target transcripts, thereby protecting them against degradation...
  69. Herjan T, Yao P, Qian W, Li X, Liu C, Bulek K, et al. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. J Immunol. 2013;191:640-9 pubmed publisher
    ..In this study, we report a new function of RNA-binding protein HuR in IL-17-induced Act1-mediated chemokine mRNA stabilization...
  70. Kawagishi H, Hashimoto M, Nakamura H, Tsugawa T, Watanabe A, Kontoyiannis D, et al. HuR maintains a replicative life span by repressing the ARF tumor suppressor. Mol Cell Biol. 2013;33:1886-900 pubmed publisher
    ..Here, we show that an RNA-binding protein, HuR (human antigen R), represses ARF mRNA translation, thereby maintaining the replicative life span of mouse embryonic ..
  71. Papadodima O, Chatziioannou A, Patrinou Georgoula M, Kolisis F, Pletsa V, Guialis A. HuR-regulated mRNAs associated with nuclear hnRNP A1-RNP complexes. Int J Mol Sci. 2013;14:20256-81 pubmed publisher
    ..We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and having a major nuclear localization...
  72. Nakamura H, Kawagishi H, Watanabe A, Sugimoto K, Maruyama M, Sugimoto M. Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation. Mol Cell Biol. 2011;31:1997-2009 pubmed publisher
    ..We show here that Hzf regulates p53 expression in cooperation with HuR. Hzf and HuR independently interact with the 3' untranslated region (UTR) of p53 mRNA, which facilitates the ..
  73. Talwar S, House R, Sundaramurthy S, Balasubramanian S, Yu H, PALANISAMY V. Inhibition of caspases protects mice from radiation-induced oral mucositis and abolishes the cleavage of RNA-binding protein HuR. J Biol Chem. 2014;289:3487-500 pubmed publisher
    ..We herein report that the RNA-binding protein human antigen R (HuR) undergoes cleavage modification by caspase-3 following IR-induced oral mucositis and subsequently promotes the ..
  74. Krishnamurthy P, Rajasingh J, Lambers E, Qin G, Losordo D, Kishore R. IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR. Circ Res. 2009;104:e9-18 pubmed publisher
    ..of p38 mitogen-activated protein kinase activation and repression of the cytokine mRNA-stabilizing protein HuR. IL-10 treatment significantly improved LV functions, reduced infarct size, and attenuated infarct wall thinning...
  75. Raineri I, Wegmueller D, Gross B, Certa U, Moroni C. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Nucleic Acids Res. 2004;32:1279-88 pubmed
    ..Indeed, siRNAs targeting HuR or BRF1 decreased or increased fluorescence, respectively...
  76. Lu Y, Chang S, Hafner M, Li X, Tuschl T, Elemento O, et al. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. 2014;9:2330-43 pubmed publisher
    ..To examine the interplay between miRNAs and the RBP ELAVL1 (HuR), we mapped miRNA binding sites at the transcriptome-wide scale in wild-type and Elavl1 knockout murine bone-..