Gene Symbol: Eif6
Description: eukaryotic translation initiation factor 6
Alias: 1110004P11, AA408895, CAB, Itgb4bp, eIF-6, imc-415, p27(BBP), p27BBP, eukaryotic translation initiation factor 6, B4 integrin interactor, integrin beta 4 binding protein
Species: mouse
Products:     Eif6

Top Publications

  1. Gandin V, Miluzio A, Barbieri A, Beugnet A, Kiyokawa H, Marchisio P, et al. Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature. 2008;455:684-8 pubmed publisher
    ..No eIFs have been found to link extracellular stimuli to the activity of the large 60S ribosomal subunit. eIF6 binds 60S ribosomes precluding ribosome joining in vitro...
  2. Cho S, Cho J, Kim I, Vliagoftis H, Metcalfe D, Oh C. Identification and characterization of the inducible murine mast cell gene, imc-415. Biochem Biophys Res Commun. 1998;252:123-7 pubmed
    ..homology to both a human beta4 integrin-binding protein (p27(BBP)) and a human translation initiation factor 6 (eIF6), which in turn are identical. In vitro translation of the imc-415 gene yielded a band of an approximately 26 kDa...
  3. Wood L, Ashby M, Grunfeld C, Feingold K. Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. J Biol Chem. 1999;274:11653-9 pubmed
    ..to the human sequence for eukaryotic translation initiation factor (eIF) 6, thus identifying the gene as murine eIF6. Functional studies of the yeast eIF6 homolog, YPR016c, were initiated in Saccharomyces cerevisiae to determine the ..
  4. Ceci M, Offenhauser N, Marchisio P, Biffo S. Formation of nuclear matrix filaments by p27(BBP)/eIF6. Biochem Biophys Res Commun. 2002;295:295-9 pubmed
    p27(BBP)/eIF6 is an evolutionarily conserved protein necessary for ribosome biogenesis which was cloned in mammals for its ability to bind the cytodomain of beta 4 integrin...
  5. Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, et al. Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Cancer Cell. 2011;19:765-75 pubmed publisher
    Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit formation. eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation delays tumorigenesis and reduces tumor growth in vivo...
  6. Brina D, Miluzio A, Ricciardi S, Biffo S. eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression. Biochim Biophys Acta. 2015;1849:830-5 pubmed publisher
    Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast). eIF6 binds 60S ribosomal subunits and blocks their joining to 40S...
  7. Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen P, Viero G, et al. eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nat Commun. 2015;6:8261 pubmed publisher
    ..Cells with reduced eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The role of insulin-regulated translation is unknown...
  8. Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, et al. Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation. J Thromb Haemost. 2015;13:2108-18 pubmed publisher
    ..b>Eukaryotic translation initiation factor 6 (eIF6) is a critical translation factor that rescues the quasilethal effect of the loss of the ..
  9. Yang S, Tan J, Liu D, Loreni F, Peng X, Yang Q, et al. Eukaryotic initiation factor 6 modulates myofibroblast differentiation at transforming growth factor-β1 transcription level via H2A.Z occupancy and Sp1 recruitment. J Cell Sci. 2015;128:3977-89 pubmed publisher
    Eukaryotic initiation factor 6 (eIF6) is a pivotal regulator of ribosomal function, participating in translational control...

Scientific Experts

More Information


  1. Bai Y, Feng J, Zhang Q, Wu H, Du Y, Wei W. Effects of the eukaryotic initiation factor 6 gene on expression levels of inflammatory mediators in M2 macrophages during scar repair. Mol Med Rep. 2016;14:819-24 pubmed publisher
    The aim of the present study was to evaluate the effects of the eukaryotic initiation factor 6 (eIF6) gene on the secretion of M2 macrophage fibrosis?associated factors and the expression levels of key proteases during scar repair...
  2. Shu Q, Tan J, Ulrike V, Zhang X, Yang J, Yang S, et al. Involvement of eIF6 in external mechanical stretch-mediated murine dermal fibroblast function via TGF-β1 pathway. Sci Rep. 2016;6:36075 pubmed publisher
    ..Our previous experiments suggested that eukaryotic initiation factor 6 (eIF6) acted as a regulator of TGF-β1 expression, and negatively impact on collagen synthesis...
  3. Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, et al. High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans. Dev Comp Immunol. 2017;77:69-76 pubmed publisher
    Eukaryotic Initiation Factor 6 (eIF6) is required for 60S ribosomal subunit biogenesis and efficient initiation of translation...
  4. Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen P, Bonomo M, et al. The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks. Cell Rep. 2017;21:1507-1520 pubmed publisher
    ..We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS ..
  5. Biffo S, Sanvito F, Costa S, Preve L, Pignatelli R, Spinardi L, et al. Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. J Biol Chem. 1997;272:30314-21 pubmed
    ..These results suggest that the p27(BBP) is an in vivo interactor of beta4, possibly linking beta4 to the intermediate filament cytoskeleton. ..