Gene Symbol: Eif4g2
Description: eukaryotic translation initiation factor 4, gamma 2
Alias: DAP-5, E130105L11Rik, Nat1, Natm1, p97, eukaryotic translation initiation factor 4 gamma 2, eIF-4-gamma 2, eIF-4G 2, eIF4G 2, eif4g2, novel APOBEC-1 target 1, translation repressor Nat1
Species: mouse
Products:     Eif4g2

Top Publications

  1. Yang H, Jansen A, Komar A, Zheng X, Merrick W, Costes S, et al. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol. 2003;23:26-37 pubmed
    ..Pdcd4 binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4-eIF4A binding and consequent inhibition of translation are required for Pdcd4 transrepression of AP-1. ..
  2. Waskiewicz A, Johnson J, Penn B, Mahalingam M, Kimball S, Cooper J. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol. 1999;19:1871-80 pubmed
    ..This suggests that phosphorylation of eIF4E is catalyzed by Mnk1 or a very similar kinase in cells and is independent of other mitogenic signals that release eIF4E from 4EBP1. ..
  3. Shaughnessy J, Largaespada D, Tian E, Fletcher C, Cho B, Vyas P, et al. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. Oncogene. 1999;18:2069-84 pubmed
    ..Experiments are in progress to test whether Mrvi1 is a tumor suppressor gene. ..
  4. Imataka H, Olsen H, Sonenberg N. A new translational regulator with homology to eukaryotic translation initiation factor 4G. EMBO J. 1997;16:817-25 pubmed
    ..Here, we describe a new eukaryotic translational regulator (hereafter called p97) which exhibits 28% identity to the C-terminal two-thirds of eIF4G...
  5. Yamanaka S, Zhang X, Maeda M, Miura K, Wang S, Farese R, et al. Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 2000;19:5533-41 pubmed
    b>NAT1/p97/DAP5 is a newly identified protein that shares homology with the translation initiation factor eIF4G...
  6. Kimball S, Horetsky R, Ron D, Jefferson L, Harding H. Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes. Am J Physiol Cell Physiol. 2003;284:C273-84 pubmed
    ..Finally, we also show that stress granules contain many, if not all, of the components of the 48S preinitiation complex, but not 60S ribosomal subunits, suggesting that they represent stalled translation initiation complexes. ..
  7. Guenther U, Handoko L, Laggerbauer B, Jablonka S, Chari A, Alzheimer M, et al. IGHMBP2 is a ribosome-associated helicase inactive in the neuromuscular disorder distal SMA type 1 (DSMA1). Hum Mol Genet. 2009;18:1288-300 pubmed publisher
    ..We propose that IGHMBP2 is functionally linked to translation, and that mutations in its helicase domain interfere with this function in DSMA1 patients. ..
  8. Waters L, Strong S, Ferlemann E, Oka O, Muskett F, Veverka V, et al. Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor. J Biol Chem. 2011;286:17270-80 pubmed publisher
    ..Pdcd4 has also been reported to interact directly with the middle region of eIF4G, however, we were unable to obtain any evidence for even a weak, transient direct interaction. ..
  9. Plaks V, Gershon E, Zeisel A, Jacob Hirsch J, Neeman M, Winterhager E, et al. Blastocyst implantation failure relates to impaired translational machinery gene expression. Reproduction. 2014;148:87-98 pubmed publisher
    ..revealed a low expression of Egr1, Rpl21 and Eif4a1 in Cx43(del/del) oocytes and downregulation of Rpl15 and Eif4g2 in the resulting blastocysts...

More Information


  1. Shaughnessy J, Jenkins N, Copeland N. cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G. Genomics. 1997;39:192-7 pubmed
    A novel mammalian gene, Eif4g2, with a high degree of homology to the p82 subunit of the wheat germ eukaryotic translation initiation factor eIF-(iso)4F and mammalian eIF-4G has been isolated...
  2. Yamanaka S, Poksay K, Arnold K, Innerarity T. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme. Genes Dev. 1997;11:321-33 pubmed
    ..Using a modified differential display technique, we identified a novel mRNA (NAT1 for novel APOBEC-1 target no. 1) that is extensively edited at multiple sites in these livers...
  3. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-42 pubmed
    ..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells. ..
  4. Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi Miyagawa S, Nakano T, et al. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009;284:6507-19 pubmed publisher
    ..These observations indicate that MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal. ..
  5. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..
  6. Zambrano A, García Carpizo V, Villamuera R, Aranda A. Thyroid hormone increases bulk histones expression by enhancing translational efficiency. Mol Endocrinol. 2015;29:68-75 pubmed publisher
    ..translation was associated with augmented transcription of the eukaryotic translation initiation factor 4 γ2 (EIF4G2)...
  7. Levy Strumpf N, Kimchi A. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene. 1998;17:3331-40 pubmed