Gene Symbol: Eif2s3y
Description: eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
Alias: Eif-2gy, Spy, Tfy, eukaryotic translation initiation factor 2 subunit 3, Y-linked, eIF-2-gamma Y, eukaryotic translation initiation factor 2 subunit gamma, Y-linked, spermatogenesis Y, spermatogonial proliferation factor
Species: mouse
Products:     Eif2s3y

Top Publications

  1. Mazeyrat S, Saut N, Sargent C, Grimmond S, Longepied G, Ehrmann I, et al. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum Mol Genet. 1998;7:1713-24 pubmed
    The Delta Sxrb deletion interval of the mouse Y chromosome contains Spy, a spermatogenesis factor gene(s) whose expression is essential for the postnatal development of the mitotic germ cells, spermatogonia...
  2. Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah S, Ojarikre O, Rattigan A -, et al. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001;29:49-53 pubmed
    ..4,5), Smcy, Uty, Usp9y (also known as Dffry), Eif2s3y (also known as Eif-2gammay) and Dby10; all have closely similar X-encoded homologs...
  3. Agulnik A, Harrison W, Bishop C. Smcy transgene does not rescue spermatogenesis in sex-reversed mice. Mamm Genome. 2001;12:112-6 pubmed
    ..short arm of the Y chromosome and is known to contain gene(s) required for normal spermatogenesis; in particular, Spy, which is essential for the postnatal mitotic proliferation of spermatogonia...
  4. Xu J, Burgoyne P, Arnold A. Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet. 2002;11:1409-19 pubmed
    ..Transcripts of six Y genes were expressed at one or more ages: Usp9y, Ube1y, Smcy, Eif2s3y, Uty and Dby...
  5. Yamauchi Y, Riel J, Ruthig V, Ortega E, Mitchell M, Ward M. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016;351:514-6 pubmed publisher
    ..reproduction can be achieved when the Y gene contribution is limited to only two genes, Sry and spermatogonial proliferation factor Eif2s3y...
  6. Yamauchi Y, Riel J, Stoytcheva Z, Ward M. Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science. 2014;343:69-72 pubmed publisher
    ..the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y. Sry is believed to function primarily in sex determination during fetal life...
  7. Ashley T, Lieman J, Ward D. Multicolor FISH with a telomere repeat and Sry sequences shows that Sxr (Sex reversal) in the mouse is a new type of chromosome rearrangement. Cytogenet Cell Genet. 1995;71:217-22 pubmed
    ..This suggests that the rearrangement arose from a recombination event involving the distal Y telomere sequences, i.e., within the telomere, a structure historically assumed to be incapable of participating in chromosome rearrangements. ..
  8. Ehrmann I, Ellis P, Mazeyrat S, Duthie S, Brockdorff N, Mattei M, et al. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998;7:1725-37 pubmed
    ..These results shed light on the evolution of X-Y homologous genes. ..
  9. Vernet N, Mahadevaiah S, Ellis P, de Rooij D, Burgoyne P. Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis. Reproduction. 2012;144:433-45 pubmed publisher
    ..the Yp-derived Tp(Y)1Ct(Sxr-a) sex reversal factor provides an almost complete Yp gene complement, ii) XSxr(b)O,Eif2s3y males in which Tp(Y)1Ct(Sxr-b) has a deletion completely or partially removing eight Yp genes - the Yp gene ..

More Information


  1. Matsubara Y, Kato T, Kashimada K, Tanaka H, Zhi Z, Ichinose S, et al. TALEN-Mediated Gene Disruption on Y Chromosome Reveals Critical Role of EIF2S3Y in Mouse Spermatogenesis. Stem Cells Dev. 2015;24:1164-70 pubmed publisher
    ..Here, we report the generation of a mouse model with a mutation in EIF2S3Y, a Y chromosome-linked gene, and analysis of its phenotype...
  2. Sandstedt S, Tucker P. Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome. Genome Res. 2004;14:267-72 pubmed
    ..An analysis of smaller fragments of Smcy, Smcx, Zfy, and Zfx from seven species of Mus confirmed that the strata in Mus musculus were representative of the genus Mus. ..
  3. Li N, Mu H, Zheng L, Li B, Wu C, Niu B, et al. EIF2S3Y suppresses the pluripotency state and promotes the proliferation of mouse embryonic stem cells. Oncotarget. 2016;7:11321-31 pubmed publisher
    Eukaryotic translation initiation factor 2, subunit 3, and structural gene Y-linked (EIF2S3Y) is essential for spermatogenesis in mouse models. However, its effect on embryonic stem (ES) cells remains unknown...
  4. Mather P, Holmes R. Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes. Biochem Genet. 1984;22:981-95 pubmed
    ..This study, in combination with previous investigations on mouse aldehyde dehydrogenases, provides evidence for six genetic loci for this enzyme. ..
  5. Kobayashi S, Isotani A, Mise N, Yamamoto M, Fujihara Y, Kaseda K, et al. Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Curr Biol. 2006;16:166-72 pubmed
    ..5-fold differences, four were expressed exclusively or nearly exclusively sex dependently. Two genes (Dby and Eif2s3y) were mapped to the Y chromosome and were expressed in male blastocysts...
  6. Jackson Grusby L, Kuo A, Leder P. A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin. Genes Dev. 1992;6:29-37 pubmed
    ..Moreover, the formin encoded by this transcript bears a highly acidic amino terminus, as distinguished from the basic amino terminus encoded by other ld transcripts suggesting that it may have a distinct biochemical function. ..