Gene Symbol: Eif2s2
Description: eukaryotic translation initiation factor 2, subunit 2 (beta)
Alias: 2810026E11Rik, 38kDa, AA408636, AA571381, AA986487, AW822225, D2Ertd303e, EIF2, EIF2B, eukaryotic translation initiation factor 2 subunit 2, eIF-2-beta, eukaryotic translation initiation factor 2 subunit beta, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)
Cinelli P, Casanova E, Uhlig S, Lochmatter P, Matsuda T, Yokota T, et al
. Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. BMC Dev Biol. 2008;8:57 pubmed publisher
..Two of them, Pem/Rhox5 and Pramel7, when overexpressed in ES cells are able to maintain the embryonic stem cells in a pluripotent state in a LIF independent manner as STAT3 or Nanog. ..
Charles C, Abler A, Lau L. cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992;7:187-90 pubmed
..Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life. ..
Tanaka K, Tamura H, Tanaka H, Katoh M, Futamata Y, Seki N, et al
. Spermatogonia-dependent expression of testicular genes in mice. Dev Biol. 2002;246:466-79 pubmed
..As the mRNAs of these jsd/jsd-derived genes were barely detectable in the W/W(v) testis, we propose that early spermatogonial germ cells regulate the expression of a group of testicular genes. ..
Heaney J, Michelson M, Youngren K, Lam M, Nadeau J. Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet. 2009;18:1395-404 pubmed publisher
..The A(y) mutation deletes Raly and Eif2s2, and induces the ectopic expression of agouti, all of which are potential TGCT-modifying mutations...
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy G, et al
. Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2?-ATF4 pathway in the commitment of myoblastic into osteoblastic cells. Calcif Tissue Int. 2014;94:454-64 pubmed publisher
..In the present study, we examined the relationship among BMP-2, Tmem119, and the PERK-eIF2?-ATF4 endoplasmic reticulum (ER) stress response pathway in the differentiation of C2C12 myoblasts into ..
Silva R, Sattlegger E, Castilho B. Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response. J Cell Sci. 2016;129:4521-4533 pubmed
..Regulation of the activity of the translation initiation factor 2 (eIF2) is a paramount mechanism for cells to rapidly adjust the rate of protein synthesis and to trigger reprogramming of ..
Raini G, Sharet R, Herrero M, Atzmon A, Shenoy A, Geiger T, et al
. Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease. J Neurochem. 2017;141:694-707 pubmed publisher
Eukaryotic translation initiation factor 2B (eIF2B) is a master regulator of protein synthesis under normal and stress conditions...
Kebache S, Zuo D, Chevet E, Larose L. Modulation of protein translation by Nck-1. Proc Natl Acad Sci U S A. 2002;99:5406-11 pubmed
..SH3 domains of Nck-1 interact with the C-terminal region of the beta subunit of the eukaryotic initiation factor 2 (eIF2 beta)...
Cambiaghi T, Pereira C, Shanmugam R, Bolech M, Wek R, Sattlegger E, et al
. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014;443:592-7 pubmed publisher
..to a range of environmental stresses, phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2?) represses general protein synthesis coincident with increased translation of specific mRNAs, such as those ..