Gene Symbol: Ehd2
Description: EH-domain containing 2
Alias: BC027084, C130052H20Rik, EH domain-containing protein 2
Species: mouse
Products:     Ehd2

Top Publications

  1. Braun A, Pinyol R, Dahlhaus R, Koch D, Fonarev P, Grant B, et al. EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. Mol Biol Cell. 2005;16:3642-58 pubmed
    ..Our data thus reveal that, in addition to a crucial role in endocytic internalization, syndapin protein complexes play an important role in endocytic receptor recycling. ..
  2. Posey A, Pytel P, Gardikiotes K, Demonbreun A, Rainey M, George M, et al. Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. J Biol Chem. 2011;286:7379-88 pubmed publisher
    ..We also found that Fer1L5 protein binds directly to the endocytic recycling proteins EHD1 and EHD2 and that the second C2 domain in Fer1L5 mediates this interaction...
  3. Guilherme A, Soriano N, Bose S, Holik J, Bose A, Pomerleau D, et al. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. J Biol Chem. 2004;279:10593-605 pubmed
    Here we identified two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton...
  4. Doherty K, Demonbreun A, Wallace G, Cave A, Posey A, Heretis K, et al. The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion. J Biol Chem. 2008;283:20252-60 pubmed publisher
    ..We found that myoferlin binds directly to the eps15 homology domain protein, EHD2. Members of the EHD family have been previously implicated in endocytosis as well as endocytic recycling, a process ..
  5. Morén B, Shah C, Howes M, Schieber N, McMahon H, Parton R, et al. EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol Biol Cell. 2012;23:1316-29 pubmed publisher
    Eps15 homology domain-containing 2 (EHD2) belongs to the EHD-containing protein family of dynamin-related ATPases involved in membrane remodeling in the endosomal system...
  6. Hong H, Chakravarti A, Takahashi J. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Proc Natl Acad Sci U S A. 2004;101:1748-53 pubmed
    ..The hyh mutant provides a valuable in vivo model to study vesicle/membrane trafficking and provides insight into the potential roles of alpha-SNAP in embryogenesis and brain development. ..
  7. Ludwig A, Howard G, Mendoza Topaz C, Deerinck T, Mackey M, Sandin S, et al. Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 2013;11:e1001640 pubmed publisher
    ..Caveolin and cavin proteins, as well as EHD2 and pacsin 2, are all present in caveolae...
  8. Daumke O, Lundmark R, Vallis Y, Martens S, Butler P, McMahon H. Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature. 2007;449:923-7 pubmed
  9. Arya P, Rainey M, Bhattacharyya S, Mohapatra B, George M, Kuracha M, et al. The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol. 2015;408:41-55 pubmed publisher

More Information


  1. Guilherme A, Soriano N, Furcinitti P, Czech M. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. J Biol Chem. 2004;279:40062-75 pubmed
    ..EHD1 is a member of a family of four closely related proteins (EHD1, EHD2, EHD3, and EHD4), which also contain a P-loop near the N terminus and a central coiled-coil domain...
  2. Naslavsky N, Caplan S. C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH?. J Cell Sci. 2005;118:4093-101 pubmed
    ..EHD1, EHD2 and EHD4 have also been implicated in the internalization of receptors and their transport to early endosomes.
  3. Shah C, Hegde B, Morén B, Behrmann E, Mielke T, Moenke G, et al. Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure. 2014;22:409-420 pubmed publisher
    The dynamin-related Eps15-homology domain-containing protein 2 (EHD2) is a membrane-remodeling ATPase that regulates the dynamics of caveolae...
  4. Chae T, Allen K, Davisson M, Sweet H, Walsh C. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Mamm Genome. 2002;13:239-44 pubmed
    ..Our physical map and transcript map may be useful for positional cloning of genes in this unusually gene-rich region of the genome. ..
  5. Gudmundsson H, Hund T, Wright P, Kline C, Snyder J, Qian L, et al. EH domain proteins regulate cardiac membrane protein targeting. Circ Res. 2010;107:84-95 pubmed publisher
    ..proteins and identified 4 members of a unique Eps15 homology (EH) domain-containing protein family (EHD1, EHD2, EHD3, EHD4) that serve critical roles in endosome-based membrane protein targeting in other cell types...