Egr1

Summary

Gene Symbol: Egr1
Description: early growth response 1
Alias: A530045N19Rik, ETR103, Egr-1, Krox-1, Krox-24, Krox24, NGF1-A, NGFI-A, NGFIA, TIS8, Zenk, Zfp-6, Zif268, egr, early growth response protein 1, Krox-24 nuclear protein, nerve growth factor-induced protein A, transcription factor Zif268, zinc finger protein Krox-24
Species: mouse
Products:     Egr1

Top Publications

  1. Tsai Morris C, Cao X, Sukhatme V. 5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 1988;16:8835-46 pubmed
    b>Egr-1 is a murine zinc finger encoding cDNA whose expression is modulated by a variety of ligand-receptor interactions and is often coregulated with c-fos (1)...
  2. Yan S, Fujita T, Lu J, Okada K, Shan Zou Y, Mackman N, et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med. 2000;6:1355-61 pubmed
    Activation of the zinc-finger transcription factor early growth response (Egr)-1, initially linked to developmental processes, is shown here to function as a master switch activated by ischemia to trigger expression of pivotal regulators ..
  3. Boyle K, Hadaschik D, Virtue S, Cawthorn W, Ridley S, O Rahilly S, et al. The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ. 2009;16:782-9 pubmed publisher
    The zinc finger-containing transcription factors Egr1 (Krox24) and Egr2 (Krox20) have been implicated in the proliferation and differentiation of many cell types...
  4. Langmann T, Ebert S, Walczak Y, Weigelt K, Ehrengruber M, Stiewe T, et al. Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo. Neuromolecular Med. 2009;11:87-96 pubmed publisher
    We have previously identified activation of microglia and induction of the early growth response gene 1 (Egr1) in the retina of retinoschisin-deficient (Rs1h(-/Y)) mice...
  5. Dinkel A, Aicher W, Haas C, Zipfel P, Peter H, Eibel H. Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells. J Immunol. 1997;159:2678-84 pubmed
    Activation of mature B cells via Ag receptor cross-linking induces transient expression of the transcription factor Egr-1...
  6. Srivastava S, Weitzmann M, Kimble R, Rizzo M, Zahner M, Milbrandt J, et al. Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp-1. J Clin Invest. 1998;102:1850-9 pubmed
    ..cells from ovariectomized mice exhibit increased casein kinase II-dependent phosphorylation of the nuclear protein Egr-1...
  7. Maltzman J, Carman J, Monroe J. Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes. Mol Cell Biol. 1996;16:2283-94 pubmed
    The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes...
  8. Lee S, Tourtellotte L, Wesselschmidt R, Milbrandt J. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J Biol Chem. 1995;270:9971-7 pubmed
    NGFI-A (also known as EGR-1, zif/268, and Krox-24) is a zinc finger transcription factor induced in many cell types by a variety of growth and differentiation stimuli...
  9. Okada M, Wang C, Hwang D, Sakaguchi T, Olson K, Yoshikawa Y, et al. Transcriptional control of cardiac allograft vasculopathy by early growth response gene-1 (Egr-1). Circ Res. 2002;91:135-42 pubmed
    Expression of the zinc finger transcription factor early growth response gene-1 (Egr-1) is triggered rapidly after mechanical vascular injury or after a precipitous drop in ambient oxygen, whereupon it induces the expression of diverse ..

More Information

Publications70

  1. Jones M, Errington M, French P, Fine A, Bliss T, Garel S, et al. A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci. 2001;4:289-96 pubmed
    ..dentate gyrus of the hippocampus is associated with a rapid and robust transcription of the immediate early gene Zif268. We used a mutant mouse with a targeted disruption of Zif268 to ask whether this gene, which encodes a zinc finger ..
  2. Krones Herzig A, Mittal S, Yule K, Liang H, English C, Urcis R, et al. Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53. Cancer Res. 2005;65:5133-43 pubmed
    The early growth response 1 (Egr1) gene is a transcription factor that acts as both a tumor suppressor and a tumor promoter...
  3. Liao Y, Shikapwashya O, Shteyer E, Dieckgraefe B, Hruz P, Rudnick D. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004;279:43107-16 pubmed
    The early growth response-1 transcription factor (Egr-1) is induced as part of the immediate-early gene expression response during early liver regeneration...
  4. Lemaire P, Revelant O, Bravo R, Charnay P. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci U S A. 1988;85:4691-5 pubmed
    ..These properties suggest that Krox-20 and Krox-24 may encode transcription factors with identical DNA target sequences and that these factors may be involved in the modulation of cell proliferation and differentiation. ..
  5. Sukhatme V, Cao X, Chang L, Tsai Morris C, Stamenkovich D, Ferreira P, et al. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell. 1988;53:37-43 pubmed
    ..Sequence analysis of murine Egr-1 cDNA predicts a protein with three DNA binding zinc fingers. The human EGR1 gene maps to chromosome 5 (bands 5q23-31)...
  6. Gururajan M, Simmons A, Dasu T, Spear B, Calulot C, Robertson D, et al. Early growth response genes regulate B cell development, proliferation, and immune response. J Immunol. 2008;181:4590-602 pubmed
    b>Egr-1 (early growth response gene-1) is an immediate early gene encoding a zinc finger motif-containing transcription factor. Upon cross-linking of BCR, mature B cells undergo proliferation with an increase in Egr-1 message...
  7. Lazarevic V, Zullo A, Schweitzer M, Staton T, Gallo E, Crabtree G, et al. The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells. Nat Immunol. 2009;10:306-13 pubmed publisher
    ..NKT cells developed normally in the absence of Egr1 or Egr3, which suggests that Egr2 is a specific regulator of NKT cell differentiation...
  8. Shin S, Kim J, Baker A, Lim Y, Lee Y. Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor alpha. Mol Cancer Res. 2010;8:507-19 pubmed publisher
    ..b>Egr-1 is a member of the zinc-finger transcription factor family induced by diverse stimuli, including TNFalpha...
  9. Sukhatme V, Kartha S, Toback F, Taub R, Hoover R, Tsai Morris C. A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res. 1987;1:343-55 pubmed
    ..We report on the molecular cloning of a novel early growth response (egr) gene which also satisfies these conditions. In response to serum, its 3...
  10. Gashler A, Swaminathan S, Sukhatme V. A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1. Mol Cell Biol. 1993;13:4556-71 pubmed
    b>Egr-1 is an immediate-early response gene induced transiently and ubiquitously by mitogenic stimuli and also regulated in response to signals that initiate differentiation...
  11. Reumann M, Strachna O, Lukashova L, Verdelis K, Donnelly E, Boskey A, et al. Early growth response gene 1 regulates bone properties in mice. Calcif Tissue Int. 2011;89:1-9 pubmed publisher
    ..Here, we determined the consequence of loss of early growth response gene 1 (EGR-1) on bone properties...
  12. McMahon A, Champion J, McMahon J, Sukhatme V. Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues. Development. 1990;108:281-7 pubmed
    We have investigated developmental expression of the gene Egr-1, which encodes a protein containing three zinc fingers...
  13. Christy B, Lau L, Nathans D. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc Natl Acad Sci U S A. 1988;85:7857-61 pubmed
    ..The SRE-like sequences could be responsible for the coordinate activation of zif/268 and fos after serum stimulation of 3T3 cells. ..
  14. Wu M, Melichian D, de la Garza M, Gruner K, Bhattacharyya S, Barr L, et al. Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing. Am J Pathol. 2009;175:1041-55 pubmed publisher
    The early growth response gene (Egr-1) codes for a zinc finger transcription factor that has important roles in the regulation of cell growth, differentiation, and survival...
  15. Svaren J, Sevetson B, Apel E, Zimonjic D, Popescu N, Milbrandt J. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol Cell Biol. 1996;16:3545-53 pubmed
    ..corepressor, NAB1, which represses transcriptional activation mediated by NGFI-A (also known as Egr-1, zif268, and Krox24) and Krox20...
  16. Xie L, Korkmaz K, Braun K, Bock J. Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampus. J Neurochem. 2013;125:457-64 pubmed publisher
    ..and two immediate early genes underlying experience-induced synaptic plasticity, Arc and early growth response 1 (Egr1) were analyzed. We show here that repeated ELS induces a rapid increase of Arc and Egr1 in the mouse hippocampus...
  17. Carter J, Lefebvre J, Wiest D, Tourtellotte W. Redundant role for early growth response transcriptional regulators in thymocyte differentiation and survival. J Immunol. 2007;178:6796-805 pubmed
    ..Three Egr proteins, Egr1, Egr2, and Egr3, are induced during thymocyte differentiation in response to pre-TCR signaling, suggesting they may ..
  18. Min I, Pietramaggiori G, Kim F, Passegue E, Stevenson K, Wagers A. The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells. Cell Stem Cell. 2008;2:380-91 pubmed publisher
    b>EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues...
  19. Yu J, Zhang S, Saito K, Williams S, Arimura Y, Ma Y, et al. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009;28:21-33 pubmed publisher
    The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes...
  20. Nose K, Ohba M. Functional activation of the egr-1 (early growth response-1) gene by hydrogen peroxide. Biochem J. 1996;316 ( Pt 2):381-3 pubmed
    ..Hydrogen peroxide at non-toxic doses induced the accumulation of mRNA for the early growth response-1 (egr-1) gene in mouse osteoblastic cells...
  21. Lejard V, Blais F, Guerquin M, Bonnet A, Bonnin M, Havis E, et al. EGR1 and EGR2 involvement in vertebrate tendon differentiation. J Biol Chem. 2011;286:5855-67 pubmed publisher
    ..We investigated the involvement of the early growth response transcription factors Egr1 and Egr2 in vertebrate tendon formation...
  22. Baumgärtel K, Genoux D, Welzl H, Tweedie Cullen R, Koshibu K, Livingstone Zatchej M, et al. Control of the establishment of aversive memory by calcineurin and Zif268. Nat Neurosci. 2008;11:572-8 pubmed publisher
    ..critically regulates the establishment of emotional memory through mechanisms involving the immediate early gene Zif268 (also known as Egr1)...
  23. Topilko P, Levi G, Merlo G, Mantero S, Desmarquet C, Mancardi G, et al. Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells. J Neurosci Res. 1997;50:702-12 pubmed
    Krox-20 and Krox-24 (Egr-1) encode closely related zinc finger transcription factors, which interact with the same DNA target sequences. Krox-20 is required for myelination in the peripheral nervous system...
  24. Lee S, Wang Y, Milbrandt J. Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1). Mol Cell Biol. 1996;16:4566-72 pubmed
    The zinc finger protein NGFI-A (also called EGR1, Krox24, or zif268) is a candidate regulator of myeloid cell differentiation. Evidence supporting this hypothesis is twofold...
  25. McMahon S, Monroe J. The role of early growth response gene 1 (egr-1) in regulation of the immune response. J Leukoc Biol. 1996;60:159-66 pubmed
    ..Evidence from several systems indicates that the immediate early gene, egr-1 may be of particular importance in the immune system...
  26. Huang R, Adamson E. A biological role for Egr-1 in cell survival following ultra-violet irradiation. Oncogene. 1995;10:467-75 pubmed
    ..The specific roles of this increased expression are largely unknown. We show here that in mouse NIH3T3 cells, Egr-1 expression is increased two-fold 10 min after u.v...
  27. Schippert R, Schaeffel F, Feldkaemper M. Microarray analysis of retinal gene expression in Egr-1 knockout mice. Mol Vis. 2009;15:2720-39 pubmed
    We found earlier that 42 day-old Egr-1 knockout mice had longer eyes and a more myopic refractive error compared to their wild-types...
  28. Davis S, Bozon B, Laroche S. How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning?. Behav Brain Res. 2003;142:17-30 pubmed
    The immediate early genes (IEGs) are activated rapidly and transiently in response to a multitude of stimuli. The zif268 belongs to a category of regulatory IEGs that activate downstream target genes and is considered to be a triggering ..
  29. Lee S, Sadovsky Y, Swirnoff A, Polish J, Goda P, Gavrilina G, et al. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996;273:1219-21 pubmed
    The immediate-early transcription factor NGFI-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression...
  30. Bhattacharyya S, Chen S, Wu M, Warner Blankenship M, Ning H, Lakos G, et al. Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma. Am J Pathol. 2008;173:1085-99 pubmed publisher
    ..The transcription factor early growth response-1 (Egr-1) mediates the stimulation of collagen transcription elicited by TGF-beta and is necessary for the development of ..
  31. Pacini L, Suffredini S, Ponti D, Coppini R, Frati G, Ragona G, et al. Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice. Can J Physiol Pharmacol. 2013;91:1135-42 pubmed publisher
    Early growth response-1 one gene (Egr-1), one of the immediate early response genes, plays an important role in the adaptive response of the myocardium to hypertrophic stimuli...
  32. Valjent E, Aubier B, Corbillé A, Brami Cherrier K, Caboche J, Topilko P, et al. Plasticity-associated gene Krox24/Zif268 is required for long-lasting behavioral effects of cocaine. J Neurosci. 2006;26:4956-60 pubmed
    ..We examined the role of Zif268, an immediate-early gene induced by drugs of abuse under the control of ERK, in behavioral responses to cocaine ..
  33. Pawlinski R, Pedersen B, Kehrle B, Aird W, Frank R, Guha M, et al. Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model. Blood. 2003;101:3940-7 pubmed
    ..In this study, the role of Egr-1 in lipopolysaccharide (LPS) induction of TF and inflammatory mediators in vivo was evaluated using Egr-1(+/+) and ..
  34. Virolle T, Krones Herzig A, Baron V, De Gregorio G, Adamson E, Mercola D. Egr1 promotes growth and survival of prostate cancer cells. Identification of novel Egr1 target genes. J Biol Chem. 2003;278:11802-10 pubmed
    In the majority of aggressive tumorigenic prostate cancer cells, the transcription factor Egr1 is overexpressed...
  35. Wu X, Cheng J, Li P, Yang M, Qiu S, Liu P, et al. Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. Arterioscler Thromb Vasc Biol. 2010;30:471-6 pubmed publisher
    ..promoter element (-270--130) contains 2 consensus sequences for binding of early growth reponse-1 (Egr-1) transcriptional factor. Mechanical stretch stimulated both Egr-1 mRNA (4.6-fold) and protein (5...
  36. Ghosh A, Bhattacharyya S, Lafyatis R, Farina G, Yu J, Thimmapaya B, et al. p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-?: epigenetic feed-forward amplification of fibrosis. J Invest Dermatol. 2013;133:1302-10 pubmed publisher
    ..Stimulation of p300 by TGF-? was independent of Smads and involved the early-immediate transcription factor Egr-1 (early growth response 1), a key regulator of profibrotic TGF-? signaling...
  37. Hu T, Gimferrer I, Simmons A, WIEST D, Alberola Ila J. The Ras/MAPK pathway is required for generation of iNKT cells. PLoS ONE. 2011;6:e19890 pubmed publisher
    ..levels of this pathway our results refute this paradigm, and demonstrate that Ras, and its downstream effectors Egr-1 and Egr-2 are required for positive selection of iNKT cells...
  38. Pardo P, Mohamed J, Lopez M, Boriek A. Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response. J Biol Chem. 2011;286:2559-66 pubmed publisher
    ..In this report, we unravel a mechanism triggered by mechanical stretch of skeletal muscle cells that leads to an EGR1-dependent transcriptional activation of the Sirt1 gene...
  39. Topilko P, Schneider Maunoury S, Levi G, Trembleau A, Gourdji D, Driancourt M, et al. Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice. Mol Endocrinol. 1998;12:107-22 pubmed
    The zinc finger transcription factor Krox-24 (NGFI-A, Egr-1) is encoded by an immediate-early serum response gene expressed in various physiological situations and tissues. To investigate its function, we have created a null allele...
  40. Shen N, Yu X, Pan F, Gao X, Xue B, Li C. An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. J Biol Chem. 2011;286:14508-15 pubmed publisher
    ..We have previously found that early growth responsive gene-1 (Egr-1), a zinc finger transcription factor, is highly expressed in db/db mice and in the fat tissue of individuals with ..
  41. Besnard A, Caboche J, Laroche S. Recall and reconsolidation of contextual fear memory: differential control by ERK and Zif268 expression dosage. PLoS ONE. 2013;8:e72006 pubmed publisher
    ..Conversely, hippocampal expression of the immediate early gene Zif268 is necessary for CFC reconsolidation but not consolidation...
  42. Dinkel A, Warnatz K, Ledermann B, Rolink A, Zipfel P, Burki K, et al. The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells. J Exp Med. 1998;188:2215-24 pubmed
    In mature B lymphocytes, the zinc finger transcription factor early growth response 1 (Egr-1) is one of the many immediate-early genes induced upon B cell antigen receptor engagement...
  43. McMullen M, Pritchard M, Wang Q, Millward C, Croniger C, Nagy L. Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice. Gastroenterology. 2005;128:2066-76 pubmed
    Early growth response-1 (Egr-1), an immediate early gene/zinc-finger transcription factor, is required for maximal stimulation of tumor necrosis factor alpha (TNF-alpha) transcription in response to lipopolysaccharide (LPS)...
  44. Bozon B, Davis S, Laroche S. A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retrieval. Neuron. 2003;40:695-701 pubmed
    ..Here, we explore whether zif268, an activity-dependent inducible immediate early gene (IEG) required for consolidation of new memories, is also ..
  45. Boone D, Qi Y, Li Z, Hann S. Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism. Proc Natl Acad Sci U S A. 2011;108:632-7 pubmed publisher
    ..Here we show that ARF is necessary for c-Myc to drive transcription of a unique noncanonical target gene, Egr1. In contrast, c-Myc induces another family member, Egr2, through a canonical mechanism that is inhibited by ARF...
  46. Abdulkadir S, Qu Z, Garabedian E, Song S, Peters T, Svaren J, et al. Impaired prostate tumorigenesis in Egr1-deficient mice. Nat Med. 2001;7:101-7 pubmed
    The transcription factor early growth response protein 1 (EGR1) is overexpressed in a majority of human prostate cancers and is implicated in the regulation of several genes important for prostate tumor progression...
  47. Collins S, Lutz M, Zarek P, Anders R, Kersh G, Powell J. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol. 2008;38:528-36 pubmed publisher
    ..This approach revealed roles for the early growth response (Egr) family of transcription factors and the Egr coactivator/corepressor NGFI-A-binding protein (NAB)2 in regulating T ..
  48. Li B, Power M, Lin T. De novo synthesis of early growth response factor-1 is required for the full responsiveness of mast cells to produce TNF and IL-13 by IgE and antigen stimulation. Blood. 2006;107:2814-20 pubmed
    Early growth-response factor 1 (Egr-1) is a zinc-finger transcription factor that plays a regulatory role in the expression of many genes important for inflammation...
  49. Wang B, Chen J, Santiago F, Janes M, Kavurma M, Chong B, et al. Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler Thromb Vasc Biol. 2010;30:536-45 pubmed publisher
    The transcription factor early growth response (EGR)-1 has been implicated as a key vascular phenotypic switch through its control of inducible transcription...
  50. Krones Herzig A, Adamson E, Mercola D. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci U S A. 2003;100:3233-8 pubmed
    ..However, the regulation of p53 itself has not been defined. We find that deletion of the early growth response 1 (EGR1) transcription factor leads to a striking phenotype, including complete bypass of senescence and apparent immortal ..
  51. Schippert R, Burkhardt E, Feldkaemper M, Schaeffel F. Relative axial myopia in Egr-1 (ZENK) knockout mice. Invest Ophthalmol Vis Sci. 2007;48:11-7 pubmed
    Experiments in chickens have implicated the transcription factor ZENK (also known as Egr-1, NGFI-A, zif268, tis8, cef5, and Krox24) in the feedback mechanisms for visual control of axial eye growth and myopia development...
  52. Hasan R, Phukan S, Harada S. Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2003;23:988-93 pubmed
    Early growth response gene (Egr)-1 is a key transcription factor involved in vascular pathophysiology. Its role in diabetic vascular complications, however, remains unclear...
  53. Li L, Carter J, Gao X, Whitehead J, Tourtellotte W. The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol Cell Biol. 2005;25:10286-300 pubmed
    Early growth response (Egr) transcription factors (Egr1 to Egr4) are synaptic activity-inducible immediate early genes (IEGs) that regulate some aspects of synaptic plasticity-related to learning and memory, yet the target genes regulated ..
  54. Ohba M, Shibanuma M, Kuroki T, Nose K. Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J Cell Biol. 1994;126:1079-88 pubmed
    ..We then examined the expression of early growth response-1 (egr-1) gene, which is inducible by TGF-beta 1 and H2O2...
  55. Fukuda T, Kanomata K, Nojima J, Urakawa I, Suzawa T, Imada M, et al. FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1. Biochem Biophys Res Commun. 2007;353:147-51 pubmed
    ..Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney...
  56. McCaffrey T, Fu C, Du B, Eksinar S, Kent K, Bush H, et al. High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest. 2000;105:653-62 pubmed
    ..bearing 588 known genes indicated that lesions express unexpectedly high levels of the early growth response gene, Egr-1 (NGFI-A), a zinc-finger transcription factor that modulates a cluster of stress-responsive genes including PDGF ..
  57. Chen S, Ning H, Ishida W, Sodin Semrl S, Takagawa S, Mori Y, et al. The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression. J Biol Chem. 2006;281:21183-97 pubmed
    ..to detect cellular genes whose expression is regulated by Smad3, we identified early growth response factor-1 (EGR-1) as a novel Smad3-inducible gene. Previous studies implicated Egr-1 in cell growth, differentiation, and survival...
  58. Baumgärtel K, Tweedie Cullen R, Grossmann J, Gehrig P, Livingstone Zatchej M, Mansuy I. Changes in the proteome after neuronal zif268 overexpression. J Proteome Res. 2009;8:3298-316 pubmed publisher
    ..Here, we investigated the response induced by the IEG Zif268 in the adult brain in relation to long-term memory...
  59. Carter J, Tourtellotte W. Early growth response transcriptional regulators are dispensable for macrophage differentiation. J Immunol. 2007;178:3038-47 pubmed
    Early growth response (Egr) proteins comprise a family of transcriptional regulators (Egr1-4) that modulate gene expression involved in the growth and differentiation of many cell types...
  60. Reumann M, Strachna O, Yagerman S, Torrecilla D, Kim J, Doty S, et al. Loss of transcription factor early growth response gene 1 results in impaired endochondral bone repair. Bone. 2011;49:743-52 pubmed publisher
    ..Here, we assessed the consequence of loss of early growth response gene 1 (EGR-1) on endochondral bone healing because this transcription factor has been shown to modulate repair in vascularized ..
  61. Yu X, Shen N, Zhang M, Pan F, Wang C, Jia W, et al. Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J. 2011;30:3754-65 pubmed publisher
    ..Here, we show that an early response transcription factor Egr-1 could tilt the signalling balance by blocking PI3K/Akt signalling through PTEN and augmenting Erk/MAPK signalling ..