Egfr

Summary

Gene Symbol: Egfr
Description: epidermal growth factor receptor
Alias: 9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2, epidermal growth factor receptor, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, waved 2
Species: mouse
Products:     Egfr

Top Publications

  1. Henriksen L, Grandal M, Knudsen S, van Deurs B, Grøvdal L. Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. PLoS ONE. 2013;8:e58148 pubmed publisher
    The epidermal growth factor receptor (EGFR) regulates normal growth and differentiation, but dysregulation of the receptor or one of the EGFR ligands is involved in the pathogenesis of many cancers...
  2. Yamaoka T, Yan F, Cao H, Hobbs S, Dise R, Tong W, et al. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008;105:11772-7 pubmed publisher
    ..Activation of ErbB family members, including EGF receptor (EGFR/ErbB1), promotes cell survival and regulates several signals that overlap with those stimulated by TNF...
  3. Yi T, Lee H, Cha J, Ko S, Kim H, Shin H, et al. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. J Cell Physiol. 2008;217:409-22 pubmed publisher
    The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility...
  4. Cheng X, Jin J, Hu L, Shen D, Dong X, Samie M, et al. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010;141:331-43 pubmed publisher
    ..hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-alpha and EGFR. Conversely, excessive activities of TGF-alpha/EGFR result in hairless phenotypes and skin cancers...
  5. Hofman E, Bader A, Voortman J, van den Heuvel D, Sigismund S, Verkleij A, et al. Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization. J Biol Chem. 2010;285:39481-9 pubmed publisher
    The current activation model of the EGF receptor (EGFR) predicts that binding of EGF results in dimerization and oligomerization of the EGFR, leading to the allosteric activation of the intracellular tyrosine kinase...
  6. Cavet M, Pang J, Yin G, Berk B. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 2008;22:3607-16 pubmed publisher
    ..GPCR) kinase-2 interacting protein 1 (GIT1) is a multifunctional scaffolding protein that regulates epidermal growth factor receptor (EGFR) signaling pathways...
  7. Lee T, Threadgill D. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis. 2009;47:85-92 pubmed publisher
    The epidermal growth factor receptor (EGFR) is important for normal homeostasis in a variety of tissues and, when abnormally expressed or mutated, contributes to the development of many diseases...
  8. Gao Y, Hubbert C, Yao T. The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010;285:11219-26 pubmed publisher
    ..Here, we show that HDAC6 associates with the endosomal compartments and controls epidermal growth factor receptor (EGFR) trafficking and degradation. We found that loss of HDAC6 promoted EGFR degradation...
  9. Li H, Chou S, Hamasaki T, Perez Garcia C, O Leary D. Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations. Neural Dev. 2012;7:10 pubmed publisher
    ..Our results show that NRGs act as repellents for migrating ErbB4-expressing, MGE-derived GABAergic INs and that the patterned expression of NRGs funnels INs as they migrate from the MGE to their cortical destinations. ..
  10. Schneider M, Mayer Roenne B, Dahlhoff M, Proell V, Weber K, Wolf E, et al. High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent. J Bone Miner Res. 2009;24:455-67 pubmed publisher
    Signaling through the epidermal growth factor receptor (EGFR) by ligands such as epidermal growth factor (EGF), transforming growth factor alpha (TGFA), and amphiregulin (AREG) has been reported to have effects on skeletal growth...

Detail Information

Publications62

  1. Henriksen L, Grandal M, Knudsen S, van Deurs B, Grøvdal L. Internalization mechanisms of the epidermal growth factor receptor after activation with different ligands. PLoS ONE. 2013;8:e58148 pubmed publisher
    The epidermal growth factor receptor (EGFR) regulates normal growth and differentiation, but dysregulation of the receptor or one of the EGFR ligands is involved in the pathogenesis of many cancers...
  2. Yamaoka T, Yan F, Cao H, Hobbs S, Dise R, Tong W, et al. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008;105:11772-7 pubmed publisher
    ..Activation of ErbB family members, including EGF receptor (EGFR/ErbB1), promotes cell survival and regulates several signals that overlap with those stimulated by TNF...
  3. Yi T, Lee H, Cha J, Ko S, Kim H, Shin H, et al. Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling. J Cell Physiol. 2008;217:409-22 pubmed publisher
    The epidermal growth factor receptor (EGFR) functions in various cellular physiological processes such as proliferation, differentiation, and motility...
  4. Cheng X, Jin J, Hu L, Shen D, Dong X, Samie M, et al. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010;141:331-43 pubmed publisher
    ..hair phenotypes in mice result from naturally occurring loss-of-function mutations in the genes for TGF-alpha and EGFR. Conversely, excessive activities of TGF-alpha/EGFR result in hairless phenotypes and skin cancers...
  5. Hofman E, Bader A, Voortman J, van den Heuvel D, Sigismund S, Verkleij A, et al. Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization. J Biol Chem. 2010;285:39481-9 pubmed publisher
    The current activation model of the EGF receptor (EGFR) predicts that binding of EGF results in dimerization and oligomerization of the EGFR, leading to the allosteric activation of the intracellular tyrosine kinase...
  6. Cavet M, Pang J, Yin G, Berk B. An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor. FASEB J. 2008;22:3607-16 pubmed publisher
    ..GPCR) kinase-2 interacting protein 1 (GIT1) is a multifunctional scaffolding protein that regulates epidermal growth factor receptor (EGFR) signaling pathways...
  7. Lee T, Threadgill D. Generation and validation of mice carrying a conditional allele of the epidermal growth factor receptor. Genesis. 2009;47:85-92 pubmed publisher
    The epidermal growth factor receptor (EGFR) is important for normal homeostasis in a variety of tissues and, when abnormally expressed or mutated, contributes to the development of many diseases...
  8. Gao Y, Hubbert C, Yao T. The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation. J Biol Chem. 2010;285:11219-26 pubmed publisher
    ..Here, we show that HDAC6 associates with the endosomal compartments and controls epidermal growth factor receptor (EGFR) trafficking and degradation. We found that loss of HDAC6 promoted EGFR degradation...
  9. Li H, Chou S, Hamasaki T, Perez Garcia C, O Leary D. Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations. Neural Dev. 2012;7:10 pubmed publisher
    ..Our results show that NRGs act as repellents for migrating ErbB4-expressing, MGE-derived GABAergic INs and that the patterned expression of NRGs funnels INs as they migrate from the MGE to their cortical destinations. ..
  10. Schneider M, Mayer Roenne B, Dahlhoff M, Proell V, Weber K, Wolf E, et al. High cortical bone mass phenotype in betacellulin transgenic mice is EGFR dependent. J Bone Miner Res. 2009;24:455-67 pubmed publisher
    Signaling through the epidermal growth factor receptor (EGFR) by ligands such as epidermal growth factor (EGF), transforming growth factor alpha (TGFA), and amphiregulin (AREG) has been reported to have effects on skeletal growth...
  11. Murthy A, Defamie V, Smookler D, Di Grappa M, Horiuchi K, Federici M, et al. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. J Clin Invest. 2010;120:2731-44 pubmed publisher
    ..Loss of Timp3 enhanced metalloproteinase-dependent EGFR signaling due to increased release of the EGFR ligands TGF-alpha, amphiregulin, and HB-EGF, while depletion of shed ..
  12. Tsai N, Tsui Y, Pintar J, Loh H, Wei L. Kappa opioid receptor contributes to EGF-stimulated neurite extension in development. Proc Natl Acad Sci U S A. 2010;107:3216-21 pubmed publisher
    ..EGF and activated EGF receptor (EGFR) levels are elevated in embryonic spinal cords during late gestation stages, with concurrent rise in protein levels ..
  13. Aguirre A, Dupree J, Mangin J, Gallo V. A functional role for EGFR signaling in myelination and remyelination. Nat Neurosci. 2007;10:990-1002 pubmed
    ..Using both gain- and loss-of-function approaches, we explored the role of epidermal growth factor receptor (EGFR) signaling in adult myelin repair and in oligodendrogenesis...
  14. Schreier B, Döhler M, Rabe S, Schneider B, Schwerdt G, Ruhs S, et al. Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. Arterioscler Thromb Vasc Biol. 2011;31:1643-52 pubmed publisher
    Pathophysiological effects of the epidermal growth factor receptor (EGFR or ErbB1) include vascular remodeling...
  15. Macdonald J, Pike L. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. Proc Natl Acad Sci U S A. 2008;105:112-7 pubmed publisher
    ....
  16. Hakonen E, Ustinov J, Mathijs I, Palgi J, Bouwens L, Miettinen P, et al. Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation. Diabetologia. 2011;54:1735-43 pubmed publisher
    b>Epidermal growth factor receptor (EGFR) signalling is essential for the proper fetal development of pancreatic islets and in the postnatal formation of an adequate beta cell mass...
  17. Chen J, Chen J, Nagai K, Plieth D, Tan M, Lee T, et al. EGFR signaling promotes TGFβ-dependent renal fibrosis. J Am Soc Nephrol. 2012;23:215-24 pubmed publisher
    ..Ang II both stimulates TGFβ signaling and activates the EGF receptor (EGFR), but the relative contribution of these pathways to renal fibrogenesis is unknown...
  18. Ferron S, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, et al. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010;7:367-79 pubmed publisher
    ..dual-specificity kinase Dyrk1A is part of a molecular pathway involved in the regulation of biased epidermal growth factor receptor (EGFR) signaling in the progeny of dividing neural stem cells (NSC) of the adult subependymal zone (..
  19. Aguirre A, Rubio M, Gallo V. Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature. 2010;467:323-7 pubmed publisher
    ..EGFR (epidermal growth factor receptor) and Notch signalling pathways have fundamental roles during development of multicellular organisms...
  20. Lichtenberger B, Tan P, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell. 2010;140:268-79 pubmed publisher
    ..Surprisingly, complete tumor inhibition occurs in the absence of VEGF in EGFR mutant mice, demonstrating that VEGFR and EGFR synergize in neoplastic cells to promote tumor growth...
  21. Sanchis A, Bayo P, Sevilla L, Perez P. Glucocorticoid receptor antagonizes EGFR function to regulate eyelid development. Int J Dev Biol. 2010;54:1473-80 pubmed publisher
    ..These defects are due, at least in part, to the lack of antagonism between GR and epidermal growth factor receptor (EGFR) signaling, causing sustained activation of the MAPK/AP-1 pathway and the upregulation of ..
  22. Griol Charhbili V, Fassot C, Messaoudi S, Perret C, Agrapart V, Jaisser F. Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt. Hypertension. 2011;57:238-44 pubmed publisher
    ..Activation of the epidermal growth factor receptor (EGFR) is thought to mediate the vascular effects of aldo, but this has yet to be demonstrated in ..
  23. Samarakoon R, Dobberfuhl A, Cooley C, Overstreet J, Patel S, Goldschmeding R, et al. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal. 2013;25:2198-209 pubmed publisher
    ..TGF-β1/SMAD3 pathway activation in renal fibrosis (induced by ureteral ligation) correlated with epidermal growth factor receptor(Y845) (EGFR(Y845)) and p53(Ser15) phosphorylation and induction of disease causative target genes ..
  24. Ishibe S, Karihaloo A, Ma H, Zhang J, Marlier A, Mitobe M, et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development. 2009;136:337-45 pubmed publisher
    ..Met(fl/fl);HoxB7-Cre;wa-2/wa-2 mice, which lack normal Egfr and Met signaling, exhibit small kidneys with a marked decrease in UB branching at E14...
  25. Schreier B, Rabe S, Schneider B, Bretschneider M, Rupp S, Ruhs S, et al. Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension. 2013;61:333-40 pubmed publisher
    The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, contributes to parainflammatory dysregulation, possibly causing cardiovascular dysfunction and remodeling...
  26. Evangelopoulos M, Weis J, Kruttgen A. Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. J Neurosci Res. 2009;87:2138-44 pubmed publisher
    ..Interestingly, we found that mevastatin triggered phosphorylation of the key kinases epidermal growth factor receptor (EGFR), ERK1/2, and Akt/protein kinase B...
  27. Chen J, Chen J, Harris R. Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury. Kidney Int. 2012;82:45-52 pubmed publisher
    To determine the role of epidermal growth factor receptor (EGFR) activation in renal functional and structural recovery from acute kidney injury (AKI), we generated mice with a specific EGFR deletion in the renal proximal tubule (EGFR(..
  28. Hsieh M, Thao K, Conti M. Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation. PLoS ONE. 2011;6:e21574 pubmed publisher
    ..that luteinizing hormone (LH) stimulation of ovulatory follicles causes transactivation of the epidermal growth factor receptor (EGFR) has provided insights into the mechanisms of ovulation...
  29. Schneider M, Werner S, Paus R, Wolf E. Beyond wavy hairs: the epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol. 2008;173:14-24 pubmed publisher
    The epidermal growth factor receptor (EGFR) network, including its seven ligands and four related receptors, represents one of the most complex signaling systems in biology...
  30. Lee Hoeflich S, Crocker L, Yao E, Pham T, Munroe X, Hoeflich K, et al. A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy. Cancer Res. 2008;68:5878-87 pubmed publisher
    b>Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified breast cancer...
  31. Barrick C, Yu M, Chao H, Threadgill D. Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice. Toxicol Appl Pharmacol. 2008;228:315-25 pubmed publisher
    Molecule-targeted therapies like those against the epidermal growth factor receptor (EGFR) are becoming widely used in the oncology clinic...
  32. Pereira A, Fink G, Sundram S. Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF receptor. J Mol Neurosci. 2009;39:185-98 pubmed publisher
    ..protein kinase extracellular signal-regulated kinase (MAPK-ERK) cascade that links G-protein-coupled receptor and ErbB growth factor signaling systems, thereby regulating synaptic plasticity and connectivity, processes impaired in ..
  33. Norris R, Freudzon M, Nikolaev V, Jaffe L. Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH. Reproduction. 2010;140:655-62 pubmed publisher
    ..b>Epidermal growth factor receptor (EGFR) activation is an essential step in triggering LH-induced meiotic resumption, but its ..
  34. Bollée G, Flamant M, Schordan S, Fligny C, Rumpel E, Milon M, et al. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011;17:1242-50 pubmed publisher
    ..HB-EGF induction increases phosphorylation of the epidermal growth factor receptor (EGFR, also known as ErbB1) in mice with RPGN...
  35. Panigone S, Hsieh M, Fu M, Persani L, Conti M. Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol. 2008;22:924-36 pubmed publisher
    ..is the induction of epidermal growth factor (EGF)-like growth factors and transactivation of EGF receptor (EGFR) signaling...
  36. Walker F, Rothacker J, Henderson C, Nice E, Catimel B, Zhang H, et al. Ligand binding induces a conformational change in epidermal growth factor receptor dimers. Growth Factors. 2012;30:394-409 pubmed publisher
    The activation of the epidermal growth factor receptor (EGFR) kinase requires ligand binding to the extracellular domain (ECD)...
  37. Zhang C, Li A, Zhang X, Xiao H. A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation. J Biol Chem. 2011;286:9373-81 pubmed publisher
    Activated epidermal growth factor receptor (EGFR) continues to signal in the early endosome, but how this signaling process is regulated is less well understood...
  38. Zhang X, Siclari V, Lan S, Zhu J, Koyama E, Dupuis H, et al. The critical role of the epidermal growth factor receptor in endochondral ossification. J Bone Miner Res. 2011;26:2622-33 pubmed publisher
    Loss of epidermal growth factor receptor (EGFR) activity in mice alters growth plate development, impairs endochondral ossification, and retards growth...
  39. Maklad A, Nicolai J, Bichsel K, Evenson J, Lee T, Threadgill D, et al. The EGFR is required for proper innervation to the skin. J Invest Dermatol. 2009;129:690-8 pubmed publisher
    b>EGFR family members are essential for proper peripheral nervous system development. A role for EGFR itself in peripheral nervous system development in vivo, however, has not been reported...
  40. Natarajan A, Wagner B, Sibilia M. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A. 2007;104:17081-6 pubmed
    Mice lacking the EGF receptor (EGFR) die between midgestation and postnatal day 20 with various defects in neural and epithelial organs. Here, we generated mice carrying a floxed EGFR allele to inactivate the EGFR in fetal and adult liver...
  41. Andric N, Thomas M, Ascoli M. Transactivation of the epidermal growth factor receptor is involved in the lutropin receptor-mediated down-regulation of ovarian aromatase expression in vivo. Mol Endocrinol. 2010;24:552-60 pubmed publisher
    ..evidence that down-regulation of Cyp19a1 by the LH surge requires efficient signaling through the epidermal growth factor receptor (EGFR)...
  42. Jin N, Cho S, Raso M, Wistuba I, Smith Y, Yang Y, et al. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009;136:3347-56 pubmed publisher
    Mitogen-inducible gene 6 [Mig-6; Errfi1 (ErbB receptor feedback inhibitor 1); RALT (receptor-associated late transducer); gene 33] is a ubiquitously expressed adaptor protein containing CRIB, SH3 and 14-3-3 interacting domains and has ..
  43. Eremina V, Jefferson J, Kowalewska J, Hochster H, Haas M, Weisstuch J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008;358:1129-36 pubmed publisher
    ..These observations provide evidence that glomerular injury in patients who are treated with bevacizumab is probably due to direct targeting of VEGF by antiangiogenic therapy. ..
  44. Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, et al. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A. 2010;107:6912-7 pubmed publisher
    ..brain cancer that is driven by aberrant signaling of growth factor receptors, particularly the epidermal growth factor receptor (EGFR)...
  45. Zhang X, Tamasi J, Lu X, Zhu J, Chen H, Tian X, et al. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. J Bone Miner Res. 2011;26:1022-34 pubmed publisher
    While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has ..
  46. Sibilia M, Wagner E. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science. 1995;269:234-8 pubmed
    Mice and cells lacking the epidermal growth factor receptor (EGFR) were generated to examine its physiological role in vivo...
  47. Fitch K, McGowan K, Van Raamsdonk C, Fuchs H, Lee D, Puech A, et al. Genetics of dark skin in mice. Genes Dev. 2003;17:214-28 pubmed
    ..and identified mutations in Agouti (Met1Leu, Dcc4), Sox18 (Leu220ter, Dcc1), Keratin 2e (Thr500Pro, Dsk2), and Egfr (Leu863Gln, Dsk5)...
  48. Threadgill D, Dlugosz A, Hansen L, Tennenbaum T, Lichti U, Yee D, et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science. 1995;269:230-4 pubmed
    Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background...
  49. Sternlicht M, Sunnarborg S, Kouros Mehr H, Yu Y, Lee D, Werb Z. Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 2005;132:3923-33 pubmed
    ..Postnatal mammary gland development requires epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved from its transmembrane ..
  50. Iwamoto R, Yamazaki S, Asakura M, Takashima S, Hasuwa H, Miyado K, et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003;100:3221-6 pubmed
    ..HB-EGF-ErbB interactions in the heart were examined in vivo by administering HB-EGF to WT mice...
  51. Boockvar J, Kapitonov D, Kapoor G, Schouten J, Counelis G, Bogler O, et al. Constitutive EGFR signaling confers a motile phenotype to neural stem cells. Mol Cell Neurosci. 2003;24:1116-30 pubmed
    The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration...
  52. Lee D, Cross S, Strunk K, Morgan J, Bailey C, Jackson I, et al. Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome. 2004;15:525-36 pubmed
    ..for dominant, visible mutations, exhibit a wavy coat similar to mice homozygous for the recessive Tgfa wa1 or Egfr wa2 alleles...
  53. Sibilia M, Fleischmann A, Behrens A, Stingl L, Carroll J, Watt F, et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell. 2000;102:211-20 pubmed
    The EGF receptor (EGFR) is required for skin development and is implicated in epithelial tumor formation...
  54. Hansen L, Alexander N, Hogan M, Sundberg J, Dlugosz A, Threadgill D, et al. Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development. Am J Pathol. 1997;150:1959-75 pubmed
    Mice harboring a targeted disruption of the epidermal growth factor receptor (EGFR) allele exhibit a severely disorganized hair follicle phenotype, fuzzy coat, and systemic disease resulting in death before 3 weeks...
  55. Feng G, Shen R, Heng H, Tsui L, Kazlauskas A, Pawson T. Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene. 1994;9:1545-50 pubmed
    ..The mouse Syp gene has been mapped to chromosome 5F region by the fluorescence in situ hybridization. These findings suggest specific functions for Syp in signal transduction downstream of receptor tyrosine kinases. ..
  56. Miettinen P, Berger J, Meneses J, Phung Y, Pedersen R, Werb Z, et al. Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature. 1995;376:337-41 pubmed
    ..We find that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract. ..
  57. Fox I, Kornblum H. Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions. J Neurosci Res. 2005;79:584-97 pubmed
    The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, ..
  58. Miettinen P, Warburton D, Bu D, Zhao J, Berger J, Minoo P, et al. Impaired lung branching morphogenesis in the absence of functional EGF receptor. Dev Biol. 1997;186:224-36 pubmed
    ..Taken together, our data indicate that signal transduction through the EGF receptor plays a major role in lung development and that its inactivation leads to a respiratory distress-like syndrome. ..
  59. Tyner J, Kim E, Ide K, Pelletier M, Roswit W, Morton J, et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006;116:309-21 pubmed
    ..This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes ..
  60. Frey M, Dise R, Edelblum K, Polk D. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 2006;25:5683-92 pubmed
    ..inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not internalization...
  61. Caric D, Raphael H, Viti J, Feathers A, Wancio D, Lillien L. EGFRs mediate chemotactic migration in the developing telencephalon. Development. 2001;128:4203-16 pubmed
    ..Cells that express high levels of EGFR are located in migration pathways, including the tangential pathway to the olfactory bulb via the rostral migratory ..
  62. Papaiahgari S, Zhang Q, Kleeberger S, Cho H, Reddy S. Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells. Antioxid Redox Signal. 2006;8:43-52 pubmed
    ..Likewise, the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, AG1478, blocked hyperoxia-stimulated Akt and ERK1/2 phosphorylation,..