Gene Symbol: Egflam
Description: EGF-like, fibronectin type III and laminin G domains
Alias: 5930412K08, AU040377, pikachurin, EGF-like, fibronectin type-III and laminin G-like domain-containing protein, nectican
Hu H, Li J, Zhang Z, Yu M. Pikachurin interaction with dystroglycan is diminished by defective O-mannosyl glycosylation in congenital muscular dystrophy models and rescued by LARGE overexpression. Neurosci Lett. 2011;489:10-5 pubmed publisher
..Mouse knockouts of dystroglycan and its extracellular matrix binding partner pikachurin recapitulate this phenotype...
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, et al
. Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 2008;11:923-31 pubmed publisher
..We identified pikachurin, an extracellular matrix-like retinal protein, and observed that it localized to the synaptic cleft in the ..
Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe Suzuki Y, Takeda S, et al
. Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. J Biol Chem. 2010;285:31208-16 pubmed publisher
b>Pikachurin, the most recently identified ligand of dystroglycan, plays a crucial role in the formation of the photoreceptor ribbon synapse...
Omori Y, Araki F, Chaya T, Kajimura N, Irie S, Terada K, et al
. Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells. J Neurosci. 2012;32:6126-37 pubmed publisher
..In the DG CKO retina, pikachurin, a DG ligand in the retina, is markedly decreased at photoreceptor synapses...
Han J, Townes Anderson E. Cell specific post-translational processing of pikachurin, a protein involved in retinal synaptogenesis. PLoS ONE. 2012;7:e50552 pubmed publisher
b>Pikachurin is a recently identified, highly conserved, extracellular matrix-like protein...
Nagaya M, Ueno S, Kominami T, Nakanishi A, Koyasu T, Kondo M, et al
. Pikachurin Protein Required for Increase of Cone Electroretinogram B-Wave during Light Adaptation. PLoS ONE. 2015;10:e0128921 pubmed publisher
..To accomplish this, we examined the ERGs during light adaptation in Pikachurin null-mutant (Pika -/-) mice, which have a misalignment of the bipolar cell dendritic tips to the photoreceptor ..
Sugita Y, Araki F, Chaya T, Kawano K, Furukawa T, Miura K. Role of the mouse retinal photoreceptor ribbon synapse in visual motion processing for optokinetic responses. PLoS ONE. 2015;10:e0124132 pubmed publisher
..In order to understand its role in visual processing, the present study utilized Pikachurin-null mutant mice that show improper formation of the photoreceptor ribbon synapse...
Kominami T, Ueno S, Nakanishi A, Kominami A, Kondo M, Furukawa T, et al
. Temporal Properties of Cone ERGs of Pikachurin Null Mutant Mouse. Invest Ophthalmol Vis Sci. 2016;57:1264-9 pubmed publisher
b>Pikachurin is an extracellular matrix-like protein located in the synaptic cleft of photoreceptors. Pikachurin null mutant (Pika-/-) mice have abnormal ON bipolar cell function...