Egf

Summary

Gene Symbol: Egf
Description: epidermal growth factor
Alias: AI790464, pro-epidermal growth factor, Pro-epidermal growth factor precursor (EGF)
Species: mouse
Products:     Egf

Top Publications

  1. Pascall J, Brown K. Structural analysis of the 5'-flanking sequence of the mouse epidermal growth factor gene. J Mol Endocrinol. 1988;1:5-11 pubmed
    ..Computer-aided sequence comparisons have indicated regions of the gene which may be involved in hormonal regulation. ..
  2. Bryant P, Schmid J, Fenton S, Buckalew A, Abbott B. Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha. Toxicol Sci. 2001;62:103-14 pubmed
    ..These responses are correlated with disruption of expression of epidermal growth factor (EGF) receptor ligands, primarily EGF and transforming growth factor-alpha (TGF-alpha), and altered epithelial cell ..
  3. Gonzalez L, Díaz M, Miquet J, Sotelo A, Fernandez D, Dominici F, et al. GH modulates hepatic epidermal growth factor signaling in the mouse. J Endocrinol. 2010;204:299-309 pubmed publisher
    Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis and progression of different types of cancer...
  4. Harvey M, Leco K, Arcellana Panlilio M, Zhang X, Edwards D, Schultz G. Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor. Development. 1995;121:1005-14 pubmed
    ..and cytokines in other tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated...
  5. Chepenik K, Diaz A, Jimenez S. Epidermal growth factor coordinately regulates the expression of prostaglandin G/H synthase and cytosolic phospholipase A2 genes in embryonic mouse cells. J Biol Chem. 1994;269:21786-92 pubmed
    ..However, treatment of these cultures with epidermal growth factor (EGF) permits the cells to activate PLA2 in response to A23187...
  6. Huotari M, Miettinen P, Palgi J, Koivisto T, Ustinov J, Harari D, et al. ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology. 2002;143:4437-46 pubmed
    The neuregulin (NRG)/epidermal growth factor (EGF) family of growth factors consists of several ligands that specifically activate four erbB receptor-tyrosine kinases, namely erbB-1 (EGF-R), erbB-2 (neu), erbB-3, and erbB-4...
  7. Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Gotz M, et al. Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny. Stem Cells. 2010;28:775-87 pubmed publisher
    ..in neural stem/progenitor cells was diminished after ChABC treatment, but unaltered after epidermal growth factor (EGF) stimulation...
  8. Wang L, Wu X, Shi T, Lu L. Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor ?B subtype-regulated CCCTC binding factor (CTCF) activation. J Biol Chem. 2013;288:24363-71 pubmed publisher
    Epidermal growth factor (EGF) plays an important role in corneal epithelial migration and proliferation to improve the wound healing process...
  9. Lakshmanan J, Fisher D. An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease. Biochem Biophys Res Commun. 1993;196:892-901 pubmed
    The C57BL/6J CPK heterozygous breeders secrete in urine a variant EGF-prohormone with a molecular mass of 154 kDa in addition to the normal 165 kDa EGF-prohormone...
  10. Lemmens K, Doggen K, De Keulenaer G. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am J Physiol Heart Circ Physiol. 2011;300:H931-42 pubmed publisher
    ..Inhibiting this system during physiological overload may cause LV dysfunction in the absence of myocardial cell death. ..

Detail Information

Publications114 found, 100 shown here

  1. Pascall J, Brown K. Structural analysis of the 5'-flanking sequence of the mouse epidermal growth factor gene. J Mol Endocrinol. 1988;1:5-11 pubmed
    ..Computer-aided sequence comparisons have indicated regions of the gene which may be involved in hormonal regulation. ..
  2. Bryant P, Schmid J, Fenton S, Buckalew A, Abbott B. Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the expression of EGF and/or TGF-alpha. Toxicol Sci. 2001;62:103-14 pubmed
    ..These responses are correlated with disruption of expression of epidermal growth factor (EGF) receptor ligands, primarily EGF and transforming growth factor-alpha (TGF-alpha), and altered epithelial cell ..
  3. Gonzalez L, Díaz M, Miquet J, Sotelo A, Fernandez D, Dominici F, et al. GH modulates hepatic epidermal growth factor signaling in the mouse. J Endocrinol. 2010;204:299-309 pubmed publisher
    Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis and progression of different types of cancer...
  4. Harvey M, Leco K, Arcellana Panlilio M, Zhang X, Edwards D, Schultz G. Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor. Development. 1995;121:1005-14 pubmed
    ..and cytokines in other tissues, the effect of leukaemia inhibitory factor (LIF) and epidermal growth factor (EGF) on their activity was investigated...
  5. Chepenik K, Diaz A, Jimenez S. Epidermal growth factor coordinately regulates the expression of prostaglandin G/H synthase and cytosolic phospholipase A2 genes in embryonic mouse cells. J Biol Chem. 1994;269:21786-92 pubmed
    ..However, treatment of these cultures with epidermal growth factor (EGF) permits the cells to activate PLA2 in response to A23187...
  6. Huotari M, Miettinen P, Palgi J, Koivisto T, Ustinov J, Harari D, et al. ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology. 2002;143:4437-46 pubmed
    The neuregulin (NRG)/epidermal growth factor (EGF) family of growth factors consists of several ligands that specifically activate four erbB receptor-tyrosine kinases, namely erbB-1 (EGF-R), erbB-2 (neu), erbB-3, and erbB-4...
  7. Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Gotz M, et al. Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny. Stem Cells. 2010;28:775-87 pubmed publisher
    ..in neural stem/progenitor cells was diminished after ChABC treatment, but unaltered after epidermal growth factor (EGF) stimulation...
  8. Wang L, Wu X, Shi T, Lu L. Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor ?B subtype-regulated CCCTC binding factor (CTCF) activation. J Biol Chem. 2013;288:24363-71 pubmed publisher
    Epidermal growth factor (EGF) plays an important role in corneal epithelial migration and proliferation to improve the wound healing process...
  9. Lakshmanan J, Fisher D. An inborn error in epidermal growth factor prohormone metabolism in a mouse model of autosomal recessive polycystic kidney disease. Biochem Biophys Res Commun. 1993;196:892-901 pubmed
    The C57BL/6J CPK heterozygous breeders secrete in urine a variant EGF-prohormone with a molecular mass of 154 kDa in addition to the normal 165 kDa EGF-prohormone...
  10. Lemmens K, Doggen K, De Keulenaer G. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am J Physiol Heart Circ Physiol. 2011;300:H931-42 pubmed publisher
    ..Inhibiting this system during physiological overload may cause LV dysfunction in the absence of myocardial cell death. ..
  11. Tagaya Y, Miura A, Okada S, Ohshima K, Mori M. Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation. Endocrinology. 2012;153:3308-19 pubmed publisher
    ..knocked down by short hairpin RNA in cultured CHO cells expressing the human insulin and epidermal growth factor (EGF) receptors (CHO/IE) and in 3T3-L1 cells...
  12. Kera H, Yuki S, Nogawa H. FGF7 signals are relayed to autocrine EGF family growth factors to induce branching morphogenesis of mouse salivary epithelium. Dev Dyn. 2014;243:552-9 pubmed publisher
    ..Because LPA is a well-known activator of epidermal growth factor (EGF) signaling, we hypothesized the involvement of autocrine EGF family growth factors in the branching morphogenesis...
  13. Hung K, Huang H, Cho C, Chang S, Yu C. Nuclear magnetic resonance structure of the cytoplasmic tail of heparin binding EGF-like growth factor (proHB-EGF-CT) complexed with the ubiquitin homology domain of Bcl-2-associated athanogene 1 from Mus musculus (mBAG-1-UBH). Biochemistry. 2014;53:1935-46 pubmed publisher
    The membrane form of heparin binding EGF-like growth factor (proHB-EGF) yields secreted HB-EGF and a membrane-anchored cytoplasmic tail (proHB-EGF-CT), which may be targeted to the nuclear membrane after a shedding stimulus...
  14. Riese D, Kim E, Elenius K, Buckley S, Klagsbrun M, Plowman G, et al. The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. J Biol Chem. 1996;271:20047-52 pubmed
    The epidermal growth factor (EGF) family hormones amphiregulin (AR), transforming growth factor-alpha (TGF-alpha), and heparin-binding EGF-like growth factor (HB-EGF) are thought to play significant roles in the genesis or progression of ..
  15. Borm M, He J, Kelsall B, Pena A, Strober W, Bouma G. A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models. Gastroenterology. 2005;128:74-85 pubmed
    ..Identification of this gene(s) may contribute to further understanding of the mechanisms underlying human inflammatory bowel disease. ..
  16. Nicholson S, Metcalf D, Sprigg N, Columbus R, Walker F, Silva A, et al. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Proc Natl Acad Sci U S A. 2005;102:2328-33 pubmed
    ..the ability of SOCS-5 to negatively regulate signaling cascades downstream of the epidermal growth factor receptor (EGF-R) has been examined by using an EGF-responsive cell line engineered to constitutively express the EGF-R and SOCS-5 ..
  17. Shintani Y, Maeda M, Chaika N, Johnson K, Wheelock M. Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am J Respir Cell Mol Biol. 2008;38:95-104 pubmed
    ..Thus, our data are consistent with the hypothesis that collagen I induces EMT in lung cancer cells by activating autocrine TGF-beta3 signaling. Epidermal growth factor also seems to initiate EMT via a TGF-dependent mechanism. ..
  18. Eritja N, Mirantes C, Llobet D, Yeramian A, Bergada L, Dosil M, et al. Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth. Am J Pathol. 2013;183:277-87 pubmed publisher
    ..between loss of PTEN, growth factors [eg, insulin/insulin-like growth factor (IGF)-1], epidermal growth factor (EGF), and hyperestrogenism in the development of endometrial carcinoma is still controversial...
  19. Yang C, Lowther K, Lalioti M, Seli E. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice. Endocrinology. 2016;157:405-16 pubmed publisher
    ..OOXs were cocultured with WT oocytes, cumulus expansion failed to occur in response to epidermal growth factor (EGF)...
  20. Hinton D, Evans S, Shur B. Altering the expression of cell surface beta 1,4-galactosyltransferase modulates cell growth. Exp Cell Res. 1995;219:640-9 pubmed
    ..Evidence is presented suggesting that surface GalTase interacts with the epidermal growth factor (EGF) receptor, as suggested by others...
  21. Kashimata M, Sayeed S, Ka A, Onetti Muda A, Sakagami H, Faraggiana T, et al. The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF. Dev Biol. 2000;220:183-96 pubmed
    We have previously reported that epidermal growth factor (EGF) stimulates branching morphogenesis of the fetal mouse submandibular gland (SMG) (M. Kashimata and E. W. Gresik, 1997, Dev. Dyn...
  22. Ozaki K, Miyazaki S, Tanimura S, Kohno M. Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci. 2005;118:5861-71 pubmed
    ..The cooperative interactions observed among Sprouty isoforms could represent an advanced system that functions to regulate strictly the activation state of the RTK/ERK pathway in mammalian cells...
  23. Freeman J, Feng Y, Demehri F, Dempsey P, Teitelbaum D. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015;29:2943-58 pubmed publisher
    Recent studies suggest a close interaction between epidermal growth factor (EGF) and TLR signaling in the modulation of intestinal epithelial cell (IEC) proliferation; however, how these signaling pathways adjust IEC proliferation is ..
  24. Dinchuk J, Focht R, Kelley J, Henderson N, Zolotarjova N, Wynn R, et al. Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J Biol Chem. 2002;277:12970-7 pubmed
    ..beta-hydroxylase activity in liver preparations, and exhibit no hydroxylation of the epidermal growth factor (EGF) domain of clotting Factor X...
  25. Mak K, Chan S. Epidermal growth factor as a biologic switch in hair growth cycle. J Biol Chem. 2003;278:26120-6 pubmed
    ..We propose that epidermal growth factor functions as a biologic switch that is turned on and off in hair follicles at the beginning and end of the anagen phase of the hair cycle, guarding the entry to and exit from the anagen phase. ..
  26. Clark J, Gan H, Samocha A, Fox A, Buchman T, Coopersmith C. Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol. 2009;297:G471-9 pubmed publisher
    Systemic administration of epidermal growth factor (EGF) decreases mortality in a murine model of septic peritonitis...
  27. Jin N, Cho S, Raso M, Wistuba I, Smith Y, Yang Y, et al. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009;136:3347-56 pubmed publisher
    ..adaptor protein containing CRIB, SH3 and 14-3-3 interacting domains and has been shown to negatively regulate EGF signaling...
  28. van Berlo J, Elrod J, van den Hoogenhof M, York A, Aronow B, Duncan S, et al. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res. 2010;107:1032-40 pubmed publisher
    ..These results indicate that GATA-6 is both necessary and sufficient for regulating the cardiac hypertrophic response and differentiated gene expression, both alone and in coordination with GATA-4. ..
  29. Ruff Jamison S, Chen K, Cohen S. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science. 1993;261:1733-6 pubmed
    Intraperitoneal injection of epidermal growth factor (EGF) into mice resulted in the appearance in liver nuclei of three tyrosine phosphorylated proteins (84, 91, and 92 kilodaltons) within minutes after administration of EGF...
  30. Chen B, Bronson R, Klaman L, Hampton T, Wang J, Green P, et al. Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. Nat Genet. 2000;24:296-9 pubmed
  31. Goldshmit Y, Greenhalgh C, Turnley A. Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons. Eur J Neurosci. 2004;20:2260-6 pubmed
    ..regulator of cytokine signalling, suppressor of cytokine signalling-2 (SOCS2) and epidermal growth factor (EGF), both of which are expressed in the cortical plate during neural development, promote neurite outgrowth of ..
  32. Leung Hagesteijn C, Hu M, Mahendra A, Hartwig S, Klamut H, Rosenblum N, et al. Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis. Mol Cell Biol. 2005;25:3648-57 pubmed
    ..We conclude that ILK functions in a BMP7/p38(MAPK)/ATF-2 signaling pathway and stimulates epithelial cell morphogenesis. ..
  33. Kashimata M, Gresik E. Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit. Dev Dyn. 1997;208:149-61 pubmed
    Epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-alpha) regulate branching morphogenesis of fetal mouse submandibular gland (SMG) rudiments in vitro...
  34. Jaskoll T, Melnick M. Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999;256:252-68 pubmed
    ..We report here the protein expression in embryonic SMGs of four signal transduction pathways: TGF-alpha/EGF/EGF-R; IGF-II/IGF-IR/IGF-IIR; TGF-betas and cognate receptors; TNF, IL-6, and cognate receptors...
  35. Abbott B, Lin T, Rasmussen N, Albrecht R, Schmid J, Peterson R. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD. Toxicol Sci. 2003;76:427-36 pubmed
    ..Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha), both of which bind the EGF receptor (EGFR), are expressed in ..
  36. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol. 2004;6:547-54 pubmed
    ..These results suggest that direct protein-protein interactions coordinate cross-talk between the Notch-Hes and JAK-STAT pathways. ..
  37. Pennock S, Rheaume M, Mukai S, Kazlauskas A. A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol. 2011;179:2931-40 pubmed publisher
    ..We conclude that combination therapy encompassing a subset of vitreal growth factors and cytokines is a potential approach to prevent PVR...
  38. Appleton I, Tomlinson A, Colville Nash P, Willoughby D. Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes. Lab Invest. 1993;69:405-14 pubmed
    ..of transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1) and IL-..
  39. Tschumperlin D, Dai G, Maly I, Kikuchi T, Laiho L, McVittie A, et al. Mechanotransduction through growth-factor shedding into the extracellular space. Nature. 2004;429:83-6 pubmed
  40. Flinder L, Timofeeva O, Rosseland C, Wierød L, Huitfeldt H, Skarpen E. EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase. J Cell Physiol. 2011;226:2267-78 pubmed publisher
    ..This site regulates FAK's ability to act as a scaffold for EGF-mediated signaling, including activation of ERK...
  41. Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, et al. Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. FASEB J. 2013;27:3132-43 pubmed publisher
    ..in the recruitment of macrophages and a 70-80% attenuation in hepatic expression of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1)...
  42. Zhang H, Nan W, Wang S, Zhang T, Si H, Wang D, et al. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway. Biochimie. 2016;127:10-8 pubmed publisher
    The effect of epidermal growth factor (EGF) on the development and growth of hair follicle is controversial...
  43. Jiang X, McClellan S, Barrett R, Berger E, Zhang Y, Hazlett L. VIP and growth factors in the infected cornea. Invest Ophthalmol Vis Sci. 2011;52:6154-61 pubmed publisher
    ..C57BL/6 (B6) mice were injected with VIP and mRNA and protein levels, and immunostaining for EGF, FGF, HGF, and VEGF-A were done...
  44. Seth R, Shum L, Wu F, Wuenschell C, Hall F, Slavkin H, et al. Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy. Dev Biol. 1993;158:555-9 pubmed
    Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, ..
  45. Assimacopoulos S, Grove E, Ragsdale C. Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003;23:6399-403 pubmed
    ..The cortical antihem is identified by gene expression for three epidermal growth factor (EGF) family members, Tgf(alpha), Neuregulin 1, and Neuregulin 3, as well as two other signaling molecules, Fgf7 and the ..
  46. Shimizu T, Han J, Asada Y, Okamoto H, Maeda T. Localization of am3 using EL congenic mouse strains. J Dent Res. 2005;84:315-9 pubmed
    ..These results confine the am3 locus to an approximately 4.4-cM region, and demonstrate that other unmapped genes are also involved in the absence of M3 in EL/Sea mice. ..
  47. Fong J, Nimlamool W, Falk M. EGF induces efficient Cx43 gap junction endocytosis in mouse embryonic stem cell colonies via phosphorylation of Ser262, Ser279/282, and Ser368. FEBS Lett. 2014;588:836-44 pubmed publisher
    ..stem cell colonies - endogenously expressing the GJ protein connexin43 (Cx43) - with epidermal growth factor (EGF) inhibited intercellular communication by 64% and activated both, MAPK and PKC signaling cascades to phosphorylate ..
  48. Fu N, Rios A, Pal B, Soetanto R, Lun A, Liu K, et al. EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival. Nat Cell Biol. 2015;17:365-75 pubmed publisher
    ..Interestingly, EGF was identified as one of the most highly upregulated genes on lactogenesis and inhibition of EGF or mTOR signalling ..
  49. Gattone V, Andrews G, Niu F, Chadwick L, Klein R, Calvet J. Defective epidermal growth factor gene expression in mice with polycystic kidney disease. Dev Biol. 1990;138:225-30 pubmed
    ..expression in cystic kidneys over the 3-week postnatal period, during which time renal preproEGF mRNA and proEGF/EGF protein normally reach significant levels...
  50. Kent R, Fallows D, Geissler E, Glaser T, Emanuel J, Lalley P, et al. Genes encoding alpha and beta subunits of Na,K-ATPase are located on three different chromosomes in the mouse. Proc Natl Acad Sci U S A. 1987;84:5369-73 pubmed
    ..alpha subunit mapped to three different mouse chromosomes: the alpha 1 gene (Atpa-1) cosegregated with the Egf gene on chromosome 3; alpha 2 (Atpa-2) with the cytochrome P-450PB gene family/coumarin hydroxylase locus on ..
  51. Pathak B, Gilbert D, Harrison C, Luetteke N, Chen X, Klagsbrun M, et al. Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl). Genomics. 1995;28:116-8 pubmed
    The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor...
  52. Lee D, Pearsall R, Das S, Dey S, Godfrey V, Threadgill D. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol. 2004;24:8907-16 pubmed
    ..However, Ereg null mice are highly susceptible to cancer-predisposing intestinal damage caused by oral administration of dextran sulfate sodium. ..
  53. Jin C, Samuelson L, Cui C, Sun Y, Gerber D. MAPK/ERK and Wnt/?-Catenin pathways are synergistically involved in proliferation of Sca-1 positive hepatic progenitor cells. Biochem Biophys Res Commun. 2011;409:803-7 pubmed publisher
    ..Epidermal growth factor (EGF) supplementation shows a significant increase in Sca-1(+) HPC proliferation and colony formation while stimulating ..
  54. Zhu Y, Wang M, Lin H, Huang C, Shi X, Luo J. Epidermal growth factor up-regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase- and phosphatidylinositol-3-kinase-dependent pathways. Exp Cell Res. 2002;280:97-106 pubmed
    Epidermal growth factor (EGF) induces tumorigenic transformation of mouse epidermal cells (JB6 P(+)). We cloned a full-length EGF-responsive cDNA in JB6P(+) cells; EGF up-regulated mRNA expression of this gene 5- to 6-fold...
  55. Limesand K, Barzen K, Quissell D, Anderson S. Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF. Cell Death Differ. 2003;10:345-55 pubmed
    ..IGF1 also suppressed apoptosis induced by taxol and brefeldin A. EGF was unable to suppress apoptosis induced by etoposide, but was able to synergize with IGF1 to further suppress ..
  56. Kiley S, Thornhill B, Belyea B, Neale K, Forbes M, Luetteke N, et al. Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats. Kidney Int. 2005;68:504-14 pubmed
    Epidermal growth factor (EGF) markedly attenuates tubular apoptosis induced by unilateral ureteral obstruction (UUO) in the neonatal rat, and reduces apoptosis induced by mechanical stretch of cultured rat tubular cells...
  57. Lee D, Lee K, Song N, Seo S, Heo Y, Kang N, et al. 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J Biol Chem. 2010;285:21458-66 pubmed publisher
    ..in vivo studies have shown that isoflavones exhibit anti-proliferative activity against epidermal growth factor (EGF) receptor-positive malignancies of the breast, colon, skin, and prostate...
  58. Fenton S, Groce N, Lee D. Characterization of the mouse epidermal growth factor promoter and 5'-flanking region. Role for an atypical TATA sequence. J Biol Chem. 1996;271:30870-8 pubmed
    ..toward delineating mechanisms that regulate its activity, we have characterized the mouse epidermal growth factor (EGF) promoter...
  59. Minami S, Iwamoto R, Mekada E. HB-EGF decelerates cell proliferation synergistically with TGFalpha in perinatal distal lung development. Dev Dyn. 2008;237:247-58 pubmed
    Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family of growth factors that is suggested to be involved in distal lung development...
  60. Rousselet E, Benjannet S, Marcinkiewicz E, Asselin M, Lazure C, Seidah N. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. J Biol Chem. 2011;286:9185-95 pubmed publisher
    Although the processing profile of the membrane-bound epidermal growth factor precursor (pro-EGF) is tissue-specific, it has not been investigated at the cellular level nor have the cognate proteinases been defined...
  61. Sugimoto M, Cutler A, Shen B, Moss S, Iyengar S, Klein R, et al. Inhibition of EGF signaling protects the diabetic retina from insulin-induced vascular leakage. Am J Pathol. 2013;183:987-95 pubmed publisher
    ..in increased vascular leakage apparently mediated by betacellulin and signaling via the epidermal growth factor (EGF) receptor...
  62. Kilpatrick T, Bartlett P. Cloned multipotential precursors from the mouse cerebrum require FGF-2, whereas glial restricted precursors are stimulated with either FGF-2 or EGF. J Neurosci. 1995;15:3653-61 pubmed
    Fibroblast growth factor-2 (FGF-2) and epidermal growth factor (EGF) have both been reported to stimulate precursors in the developing CNS...
  63. Ilatovskaya D, Pavlov T, Levchenko V, Staruschenko A. ROS production as a common mechanism of ENaC regulation by EGF, insulin, and IGF-1. Am J Physiol Cell Physiol. 2013;304:C102-11 pubmed publisher
    ..ENaC activity is acutely upregulated by epidermal growth factor (EGF), insulin, and insulin-like growth factor-1 (IGF-1)...
  64. Adachi H, Kurachi H, Homma H, Adachi K, Imai T, Sakata M, et al. Involvement of epidermal growth factor in inducing adiposity of age female mice. J Endocrinol. 1995;146:381-93 pubmed
    ..Epidermal growth factor (EGF) concentration in the submandibular gland also increases with aging...
  65. Gupta C, Singh M. Stimulation of epidermal growth factor gene expression during the fetal mouse reproductive tract differentiation: role of androgen and its receptor. Endocrinology. 1996;137:705-11 pubmed
    We have shown previously that epidermal growth factor (EGF) plays a role in testosterone-dependent fetal Wolffian duct differentiation...
  66. Kumabe S. Immunohistochemical study of genesis of the mouse oral vestibule. Okajimas Folia Anat Jpn. 2003;80:93-102 pubmed
    ..The following results were obtained: 1) EGF, TGFalpha, EGFR, PCNA, FGF2, pRb, and FGFR1-4 were immunolocalized in the developing tissues...
  67. Luetteke N, Qiu T, Fenton S, Troyer K, Riedel R, Chang A, et al. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development. 1999;126:2739-50 pubmed
    Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-knockout to generate mice lacking various combinations of the three ligands...
  68. Desmots F, Rissel M, Gilot D, Lagadic Gossmann D, Morel F, Guguen Guillouzo C, et al. Pro-inflammatory cytokines tumor necrosis factor alpha and interleukin-6 and survival factor epidermal growth factor positively regulate the murine GSTA4 enzyme in hepatocytes. J Biol Chem. 2002;277:17892-900 pubmed
    ..cultured hepatocytes by tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), and epidermal growth factor (EGF), factors that play crucial roles in hepatocyte survival and proliferation during liver regeneration...
  69. Ramljak D, Coticchia C, Nishanian T, Saji M, Ringel M, Conzen S, et al. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Exp Cell Res. 2003;287:397-410 pubmed
    ..Our findings may be of importance for understanding the emerging role of Bcl-x(L) as a potential marker of poor prognosis in breast cancer. ..
  70. Guo H, Lee I, Kamar M, Pierce M. N-acetylglucosaminyltransferase V expression levels regulate cadherin-associated homotypic cell-cell adhesion and intracellular signaling pathways. J Biol Chem. 2003;278:52412-24 pubmed
    ..Aberrant N-linked beta(1,6) branching that occurs during oncogenesis can, therefore, lessen cell-cell adhesion, contributing to increased cellular motility and invasiveness. ..
  71. Gartner J, Kearns W, Rosenberg C, Pearson P, Copeland N, Gilbert D, et al. Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3. Genomics. 1993;15:412-4 pubmed
    ..The PXMP1 gene was assigned to human chromosome 1p21-p22 by in situ hybridization and its murine homologue (Pxmp-1) to chromosome 3 by interspecific backcross analysis. ..
  72. Tsujimoto H, Yura Y, Yoshioka Y, Kusaka J, Yoshida H, Sato M. Effect of epidermal growth factor administration on the development of mouse salivary gland carcinomas. J Oral Pathol Med. 1999;28:30-6 pubmed
    This study investigated whether epidermal growth factor (EGF) administration was capable of modifying salivary gland carcinogenesis...
  73. Tran D, Russell H, Sutor S, van Deursen J, Bram R. CAML is required for efficient EGF receptor recycling. Dev Cell. 2003;5:245-56 pubmed
    ..CAML-deficient cells have severely impaired proliferative responses to the epidermal growth factor (EGF)...
  74. Derouet D, Rousseau F, Alfonsi F, Froger J, Hermann J, Barbier F, et al. Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci U S A. 2004;101:4827-32 pubmed publisher
    ..Thus, NP is a new ligand for CNTFRalpha, with important implications for murine nervous system development...
  75. Zheng Y, Peng M, Wang Z, Asara J, Tyner A. Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor. Mol Cell Biol. 2010;30:4280-92 pubmed publisher
    ..Introduction of PTK6 into SYF cells sensitized these cells to physiological levels of epidermal growth factor (EGF) and increased AKT activation...
  76. Zhang Z, Xiao C, Gibson A, Bass S, Khurana Hershey G. EGFR signaling blunts allergen-induced IL-6 production and Th17 responses in the skin and attenuates development and relapse of atopic dermatitis. J Immunol. 2014;192:859-66 pubmed publisher
    Despite the important role for epidermal growth factor (EGF) in epithelial homeostasis and wound healing, it has not been investigated in atopic dermatitis (AD). We used AD animal models to explore the role of EGF in AD...
  77. Knapp P, Adams M. Epidermal growth factor promotes oligodendrocyte process formation and regrowth after injury. Exp Cell Res. 2004;296:135-44 pubmed
    ..In this study, cultured cells are used to test whether EGF can modulate process formation in OLs both before and after transection injury...
  78. Chi L, Itäranta P, Zhang S, Vainio S. Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis. Endocrinology. 2006;147:3777-88 pubmed
    ..Based on these data, we propose that the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development. ..
  79. Falck L, Forsberg J. Immunohistochemical studies on the expression and estrogen dependency of EGF and its receptor and C-fos proto-oncogene in the uterus and vagina of normal and neonatally estrogen-treated mice. Anat Rec. 1996;245:459-71 pubmed
    ..g., EGF) and proto-oncogenes (e.g., c-fos)...
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    Recent years have witnessed tremendous growth in the epidermal growth factor (EGF) family of peptide growth factors and the ErbB family of tyrosine kinases, the receptors for these factors...
  81. Umeda Y, Miyazaki Y, Shiinoki H, Higashiyama S, Nakanishi Y, Hieda Y. Involvement of heparin-binding EGF-like growth factor and its processing by metalloproteinases in early epithelial morphogenesis of the submandibular gland. Dev Biol. 2001;237:202-11 pubmed
    In the present study, the role of a member of the epidermal growth factor (EGF) family, heparin-binding EGF-like growth factor (HB-EGF), in organ development was investigated by using developing mouse submandibular gland (SMG), in which ..
  82. Iwabu A, Smith K, Allen F, Lauffenburger D, Wells A. Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway. J Biol Chem. 2004;279:14551-60 pubmed
    ..However, for epidermal growth factor (EGF)-induced fibroblast migration, molecular links between EGF receptor (EGFR) activation and force generation have not ..
  83. Holmström T, Mattsson C, Fälting J, Nedergaard J. Differential signalling pathways for EGF versus PDGF activation of Erk1/2 MAP kinase and cell proliferation in brown pre-adipocytes. Exp Cell Res. 2008;314:3581-92 pubmed publisher
    ..In primary cultures of mouse brown pre-adipocytes, both EGF (epidermal growth factor) and PDGF (platelet-derived growth factor) induced Erk1/2 activation...
  84. Islam M, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, et al. Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015;244:488-96 pubmed publisher
    ..the granular convoluted tubules (GCT), with a down-regulated expression of its marker genes, such as Klk1, Ngf, and Egf. The induction of GCT is under the control of androgens, and the Cbfb mutant SMG demonstrated down-regulated ..
  85. Kohda D, Inagaki F. Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. Biochemistry. 1992;31:11928-39 pubmed
    The three-dimensional structures of epidermal growth factors (EGF) previously reported were all in acidic solutions (pH 2.0-3.2), at which pHs EGF cannot bind to the receptor. Here we studied the structure of mouse EGF at pH 6...
  86. Kumar A, Dai X, Kozak C, Mims M, Gotto A, Ballantyne C. Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form. J Immunol. 1994;153:4088-98 pubmed
    ..Thus, expression of VCAM-1 is restricted and controlled at the level of transcription and by alternative splicing. ..
  87. Hinrichsen L, Harborth J, Andrees L, Weber K, Ungewickell E. Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. J Biol Chem. 2003;278:45160-70 pubmed
    ..Since neither clathrin nor AP-2 is essential for the internalization of EGF, we conclude that it is taken up by an alternative mechanism.
  88. Yamada A, Kimura S. Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha. FEBS Lett. 2005;579:2221-5 pubmed
    ..Induction of Ugrp2 mRNA expression by epidermal growth factor (EGF) and transforming growth factor alpha was examined using mouse transformed lung Clara cell-derived mtCC cells...
  89. Yang S, Nugent M, Panchenko M. EGF antagonizes TGF-beta-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF. Am J Physiol Lung Cell Mol Physiol. 2008;295:L143-51 pubmed publisher
    ..tropoelastin mRNA levels in lung fibroblasts through transactivation of the epidermal growth factor (EGF) receptor (EGFR)/Mek/Erk pathway, which is dependent on the NE-initiated release of soluble EGFR ligands...
  90. Yoon K, Nery S, Rutlin M, Radtke F, Fishell G, Gaiano N. Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci. 2004;24:9497-506 pubmed
  91. Hayashi H, Tsuchiya Y, Nakayama K, Satoh T, Nishida E. Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling. Genes Cells. 2008;13:941-7 pubmed publisher
    ..we demonstrate that inhibition of the ERK pathway by the MEK inhibitor U0126 or PD98059 significantly potentiates EGF- and FGF-induced Akt phosphorylation at both Thr308 and Ser473...