Efnb1

Summary

Gene Symbol: Efnb1
Description: ephrin B1
Alias: Cek5-L, EFL-3, Elk-L, Epl2, Eplg2, LERK-2, Lerk2, Stra1, ephrin-B1, CEK5 receptor ligand, Cek ligand, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, stimulated by retinoic acid gene 1 protein
Species: mouse
Products:     Efnb1

Top Publications

  1. Yu G, Mao J, Wu Y, Luo H, Wu J. Ephrin-B1 is critical in T-cell development. J Biol Chem. 2006;281:10222-9 pubmed
    ..In this study, we investigated the role of EFNB1 and the Ephs it interacts with (collectively called EFNB1 receptors) in mouse T-cell development...
  2. Contractor A, Rogers C, Maron C, Henkemeyer M, Swanson G, Heinemann S. Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science. 2002;296:1864-9 pubmed
    ..These findings suggest that PDZ interactions in the postsynaptic neuron and trans-synaptic interactions between postsynaptic EphB receptors and presynaptic B-ephrins are necessary for the induction of mossy fiber LTP. ..
  3. Mendes S, Henkemeyer M, Liebl D. Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006;26:882-92 pubmed
    ..Our results support a significant role for ephrins and Eph receptors in CC development and may provide insight to possible mechanisms involved in axon midline crossing and human disorder. ..
  4. Catchpole T, Henkemeyer M. EphB2 tyrosine kinase-dependent forward signaling in migration of neuronal progenitors that populate and form a distinct region of the dentate niche. J Neurosci. 2011;31:11472-83 pubmed publisher
  5. Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg P, Klein R. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999;22:511-24 pubmed
    ..Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands. ..
  6. Wang Y, Nakayama M, Pitulescu M, Schmidt T, Bochenek M, Sakakibara A, et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 2010;465:483-6 pubmed publisher
    ..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth. ..
  7. Twigg S, Kan R, Babbs C, Bochukova E, Robertson S, Wall S, et al. Mutations of ephrin-B1 (EFNB1), a marker of tissue boundary formation, cause craniofrontonasal syndrome. Proc Natl Acad Sci U S A. 2004;101:8652-7 pubmed
    ..Here, we show that the classical female CFNS phenotype is caused by heterozygous loss-of-function mutations in EFNB1, which encodes a member of the ephrin family of transmembrane ligands for Eph receptor tyrosine kinases...
  8. Arvanitis D, Jungas T, Behar A, Davy A. Ephrin-B1 reverse signaling controls a posttranscriptional feedback mechanism via miR-124. Mol Cell Biol. 2010;30:2508-17 pubmed publisher
    ..We observed that the EfnB1 3' untranslated region (3'-UTR) confers instability to mRNA transcripts, and we identified miR-124 as a ..
  9. Palmer A, Zimmer M, Erdmann K, Eulenburg V, Porthin A, Heumann R, et al. EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell. 2002;9:725-37 pubmed
    ..Our data suggest the presence of a switch mechanism that allows a shift from phosphotyrosine/SFK-dependent signaling to PDZ-dependent signaling. ..

More Information

Publications83

  1. Cheng S, Zhao S, Nelson B, Kesavan C, Qin X, Wergedal J, et al. Targeted disruption of ephrin B1 in cells of myeloid lineage increases osteoclast differentiation and bone resorption in mice. PLoS ONE. 2012;7:e32887 pubmed publisher
    Disruption of ephrin B1 in collagen I producing cells in mice results in severe skull defects and reduced bone formation...
  2. Adams R, Wilkinson G, Weiss C, Diella F, Gale N, Deutsch U, et al. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 1999;13:295-306 pubmed
  3. Wang H, Chen Z, Anderson D. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell. 1998;93:741-53 pubmed
    ..These results provide evidence that differences between arteries and veins are in part genetically determined and suggest that reciprocal signaling between these two types of vessels is crucial for morphogenesis of the capillary beds. ..
  4. Henkemeyer M, Orioli D, Henderson J, Saxton T, Roder J, Pawson T, et al. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996;86:35-46 pubmed
    ..These results indicate that Nuk, a receptor that binds transmembrane ligands, plays a critical and unique role in the pathfinding of specific axons in the mammalian central nervous system. ..
  5. Xing W, Kim J, Wergedal J, Chen S, Mohan S. Ephrin B1 regulates bone marrow stromal cell differentiation and bone formation by influencing TAZ transactivation via complex formation with NHERF1. Mol Cell Biol. 2010;30:711-21 pubmed publisher
    Mutations of ephrin B1 in humans result in craniofrontonasal syndrome...
  6. North H, Zhao X, Kolk S, Clifford M, Ziskind D, Donoghue M. Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling. Development. 2009;136:2467-76 pubmed publisher
    ..Although most ephrins were undetectable in cortical progenitors, ephrin B1 was highly expressed...
  7. Arvanitis D, Behar A, Tryoen Toth P, Bush J, Jungas T, Vitale N, et al. Ephrin B1 maintains apical adhesion of neural progenitors. Development. 2013;140:2082-92 pubmed publisher
    ..Here, we show that ephrin B1, a cell surface protein that engages in cell signaling upon binding cognate Eph receptors, controls normal ..
  8. Davy A, Bush J, Soriano P. Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies craniofrontonasal syndrome. PLoS Biol. 2006;4:e315 pubmed
    ..Our results uncover a novel role for Eph/ephrins in regulating GJC in vivo and suggest that the pleiotropic defects seen in CFNS patients are due to improper regulation of GJC in affected tissues. ..
  9. Birgbauer E, Cowan C, Sretavan D, Henkemeyer M. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development. 2000;127:1231-41 pubmed
    ..Thus, while Eph kinase function is involved in RGC axon mapping in the brain, RGC axon pathfinding within the retina is partially mediated by EphB receptors acting in a kinase-independent manner. ..
  10. Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J. 1996;15:6035-49 pubmed
    ..These results demonstrate essential and cooperative functions for Sek4 and Nuk in establishing axon pathways in the developing brain, and during the development of facial structures. ..
  11. Holland S, Gale N, Mbamalu G, Yancopoulos G, Henkemeyer M, Pawson T. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature. 1996;383:722-5 pubmed
    ..Furthermore, we show that TM ligands, as well as Nuk, are phosphorylated on tyrosine in mouse embryos, indicating that this is a physiological process. EPH receptors and their TM ligands therefore mediate bidirectional cell signalling. ..
  12. Luo H, Charpentier T, Wang X, Qi S, Han B, Wu T, et al. Efnb1 and Efnb2 proteins regulate thymocyte development, peripheral T cell differentiation, and antiviral immune responses and are essential for interleukin-6 (IL-6) signaling. J Biol Chem. 2011;286:41135-52 pubmed publisher
    ..In this study, both Efnb1 and Efnb2 were null-mutated in the T cell compartment of mice through loxP-mediated gene deletion...
  13. Luria V, Krawchuk D, Jessell T, Laufer E, Kania A. Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. Neuron. 2008;60:1039-53 pubmed publisher
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program. ..
  14. Wang Y, Ying G, Liu X, Wang W, Dong J, Ni Z, et al. Induction of ephrin-B1 and EphB receptors during denervation-induced plasticity in the adult mouse hippocampus. Eur J Neurosci. 2005;21:2336-46 pubmed
    ..These results suggest that the ephrin-B1/EphB system may participate in the lesion-induced plasticity processes in the adult mouse hippocampus. ..
  15. Williams S, Mann F, Erskine L, Sakurai T, Wei S, Rossi D, et al. Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron. 2003;39:919-35 pubmed
    ..EphB1 null mice exhibit a dramatically reduced ipsilateral projection, suggesting that this receptor contributes to the formation of the ipsilateral retinal projection, most likely through its repulsive interaction with ephrin-B2. ..
  16. Compagni A, Logan M, Klein R, Adams R. Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell. 2003;5:217-30 pubmed
    ..Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males. ..
  17. Lu Q, Sun E, Klein R, Flanagan J. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 2001;105:69-79 pubmed
    ..This study reveals a pathway that links reverse signaling to cellular guidance, uncovers a novel mode of control for G proteins, and demonstrates a mechanism for selective regulation of responsiveness to neuronal guidance cues. ..
  18. Davy A, Aubin J, Soriano P. Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev. 2004;18:572-83 pubmed
    ..reverse signaling during embryonic development, we have generated mouse lines carrying mutations in the efnb1 gene...
  19. Cowan C, Yokoyama N, Bianchi L, Henkemeyer M, Fritzsch B. EphB2 guides axons at the midline and is necessary for normal vestibular function. Neuron. 2000;26:417-30 pubmed
    ..This suggests EphB2 may regulate ionic homeostasis and endolymph fluid production through macromolecular associations with membrane channels that transport chloride, bicarbonate, and water. ..
  20. Adams R, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration. Cell. 2001;104:57-69 pubmed
    ..Our results indicate distinct requirements of functions mediated by the ephrinB carboxyterminus for developmental processes in the vertebrate embryo. ..
  21. Stuckmann I, Weigmann A, Shevchenko A, Mann M, Huttner W. Ephrin B1 is expressed on neuroepithelial cells in correlation with neocortical neurogenesis. J Neurosci. 2001;21:2726-37 pubmed
    ..a 47 kDa integral membrane protein, from approximately 2500 mouse telencephali reveals its identity with ephrin B1. Ephrin B1 appears at the onset of neocortical neurogenesis, being first expressed in neuron-generating ..
  22. Zimmer M, Palmer A, Köhler J, Klein R. EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol. 2003;5:869-78 pubmed
    ..Here, we show a mechanism for the termination of adhesion and the promotion of cell repulsion after intercellular (trans) interaction between two transmembrane proteins. ..
  23. Yu G, Luo H, Wu Y, Wu J. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem. 2004;279:55531-9 pubmed
    ..In this study we investigated the effect of EFNB1 on mouse T-cells...
  24. Bush J, Soriano P. Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev. 2009;23:1586-99 pubmed publisher
    ..These results demonstrate the importance of PDZ-dependent reverse signaling for a subset of Ephrin-B1 developmental roles in vivo. ..
  25. Bush J, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010;24:2068-80 pubmed publisher
  26. Alfaro D, Muñoz J, García Ceca J, Cejalvo T, Jiménez E, Zapata A. Alterations in the thymocyte phenotype of EphB-deficient mice largely affect the double negative cell compartment. Immunology. 2008;125:131-43 pubmed publisher
  27. Rogers J, Ciossek T, Menzel P, Pasquale E. Eph receptors and ephrins demarcate cerebellar lobules before and during their formation. Mech Dev. 1999;87:119-28 pubmed
    ..These expression patterns define previously unknown developmental units and suggest that Eph family proteins may contribute to cerebellar morphogenesis. ..
  28. Sapin V, Bouillet P, Oulad Abdelghani M, Dastugue B, Chambon P, Dolle P. Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation. Mech Dev. 2000;92:295-9 pubmed
    ..Three other Stra genes, including the AP-2-related gene AP-2gamma, are differentially expressed in the trophoblastic cell lineage. Thus, retinoids may regulate various signaling pathways in specific placental cell-types. ..
  29. Escalante A, Murillo B, Morenilla Palao C, Klar A, Herrera E. Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. Neuron. 2013;80:1392-406 pubmed publisher
    ..Together with previous reports, our data reveal a critical role for Zic2 as a determinant of axon midline avoidance in the CNS across species and pathways. ..
  30. de Diego I, Kyriakopoulou K, Karagogeos D, Wassef M. Multiple influences on the migration of precerebellar neurons in the caudal medulla. Development. 2002;129:297-306 pubmed
    ..Our observations provide a clearer picture of the hierarchy of environmental cues that influence the morphogenesis of these precerebellar nuclei. ..
  31. Pickles J. Expression of Ephs and ephrins in developing mouse inner ear. Hear Res. 2003;178:44-51 pubmed
    ..The results suggest that the Ephs and ephrins are likely to play a part in the differentiation of the structures of the inner ear, and show which Ephs and ephrins are most likely to play important roles in the different structures. ..
  32. Cortina C, Palomo Ponce S, Iglesias M, Fernández Masip J, Vivancos A, Whissell G, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet. 2007;39:1376-83 pubmed
    ..Our results indicate that CRC cells must silence EphB expression to avoid repulsive interactions imposed by normal ephrin-B1-expressing intestinal cells at the onset of tumorigenesis. ..
  33. Dimidschstein J, Passante L, Dufour A, van den Ameele J, Tiberi L, Hrechdakian T, et al. Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron. 2013;79:1123-35 pubmed publisher
    ..Our results demonstrate that ephrin-B1 inhibits nonradial migration of pyramidal neurons, thereby controlling the pattern of cortical columns. ..
  34. Qiu R, Wang X, Davy A, Wu C, Murai K, Zhang H, et al. Regulation of neural progenitor cell state by ephrin-B. J Cell Biol. 2008;181:973-83 pubmed publisher
  35. Cowan C, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001;413:174-9 pubmed
    ..These data provide a biochemical pathway whereby cytoskeletal regulators are recruited to Eph-ephrin bidirectional signalling complexes. ..
  36. Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, et al. Bidirectional ephrinB3/EphA4 signaling mediates the segregation of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream. J Neurosci. 2011;31:18364-80 pubmed publisher
    ..Thus, we conclude that cell contact-mediated bidirectional ephrinB3/EphA4 signaling mediates the sorting of MGE- and POA-derived interneurons in the deep and superficial migratory stream. ..
  37. Jin W, Qi S, Luo H. The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol. 2011;12:68 pubmed publisher
    ..Ephs interact with EFNs transmitting signals in both directions, i.e., from Ephs to EFNs and from EFNs to Ephs. EFNB1 is known to be able to co-stimulate T cells in vitro and to modulate thymocyte development in a model of foetal ..
  38. Awatramani R, Soriano P, Rodriguez C, Mai J, Dymecki S. Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation. Nat Genet. 2003;35:70-5 pubmed
    ..Our data suggest that the roof plate and choroid plexus may be formed of functional units that are capable of differentially organizing the generation of distinct neuronal cell types at different axial levels. ..
  39. Wu C, Qiu R, Wang J, Zhang H, Murai K, Lu Q. ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci. 2009;29:7404-12 pubmed publisher
    ..This study identifies ZHX2 as a novel regulator of neural progenitor cell maintenance and suggests a potential nuclear mechanism of the ephrin-B function in the cortex. ..
  40. Robichaux M, Chenaux G, Ho H, Soskis M, Dravis C, Kwan K, et al. EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proc Natl Acad Sci U S A. 2014;111:2188-93 pubmed publisher
    ..As such, our findings suggest that descending cortical axons identify specific TCA subpopulations in the dorsal VTel to coordinate reciprocal cortical-thalamic connectivity in the early developing brain. ..
  41. Takano Maruyama M, Hase K, Fukamachi H, Kato Y, Koseki H, Ohno H. Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine. Am J Physiol Gastrointest Liver Physiol. 2006;291:G163-70 pubmed
    ..This interaction is essential for the normal regulation of the Wnt/beta-catenin pathway and the subsequent EphB/EphrinB expression. ..
  42. Soto H, Wang W, Strieter R, Copeland N, Gilbert D, Jenkins N, et al. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc Natl Acad Sci U S A. 1998;95:8205-10 pubmed
    ..Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent. ..
  43. Huynh Do U, Vindis C, Liu H, Cerretti D, McGrew J, Enriquez M, et al. Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J Cell Sci. 2002;115:3073-81 pubmed
    ..Thus ephrin-B1 transduces 'outside-in' signals through C-terminal protein interactions that affect integrin-mediated attachment and migration. ..
  44. Lin D, Gish G, Songyang Z, Pawson T. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem. 1999;274:3726-33 pubmed
    ..In vitro studies demonstrated that the fifth PDZ domain of FAP-1 and full-length syntenin bound ephrin B1 via the carboxyl-terminal motif...
  45. van Amerongen R, Nawijn M, Franca Koh J, Zevenhoven J, van der Gulden H, Jonkers J, et al. Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev. 2005;19:425-30 pubmed
    ..These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus. ..
  46. Genet G, Guilbeau Frugier C, Honton B, Dague E, Schneider M, Coatrieux C, et al. Ephrin-B1 is a novel specific component of the lateral membrane of the cardiomyocyte and is essential for the stability of cardiac tissue architecture cohesion. Circ Res. 2012;110:688-700 pubmed publisher
    ..Because decreased ephrin-B1 is associated with molecular/functional cardiac defects, it could represent a new actor in the transition toward heart failure. ..
  47. Lu P, Shih C, Qi H. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science. 2017;356: pubmed publisher
    ..Here we found that GC-expressed ephrin B1 (EFNB1) repulsively inhibited T cell to B cell adhesion and GC TFH retention by signaling through T<..
  48. Shao H, Lou L, Pandey A, Pasquale E, Dixit V. cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase. J Biol Chem. 1994;269:26606-9 pubmed
    ..The expressed Cek5 ligand is functionally active as it induces autophosphorylation of the Cek5 RPTK. ..
  49. Park S, Sanchez M. The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997;14:533-42 pubmed
    ..These findings suggest that Eek receptor can be activated by at least three different GPI-linked ligands. ..
  50. Wilkinson G, Schittny J, Reinhardt D, Klein R. Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008;237:2220-34 pubmed publisher
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function. ..
  51. Fletcher F, Renshaw B, Hollingsworth T, Baum P, Lyman S, Jenkins N, et al. Genomic organization and chromosomal localization of mouse Eplg2, a gene encoding a binding protein for the receptor tyrosine kinase elk. Genomics. 1994;24:127-32 pubmed
    The human gene EPLG2 (Eph ligand-2) encodes a potential ligand for the receptor tyrosine kinase elk...
  52. Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, et al. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006;25:1242-52 pubmed
    ..PS1 FAD and gamma-secretase dominant-negative mutants inhibited the EphB-induced cleavage of ephrinB2 and Src autophosphorylation, raising the possibility that FAD mutants interfere with the functions of Src and ephrinB2 in the CNS. ..
  53. Ogawa K, Saeki N, Igura Y, Hayashi Y. Complementary expression and repulsive signaling suggest that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction in the rodent stomach. Histochem Cell Biol. 2013;140:659-75 pubmed publisher
    ..On the basis of these findings, we propose that EphB2 and ephrin-B1 are possibly involved in epithelial boundary formation at the squamocolumnar junction. ..
  54. Imondi R, Wideman C, Kaprielian Z. Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. Development. 2000;127:1397-410 pubmed
    ..Taken together, these data support a possible role for repulsive B-class Eph receptor/ligand interactions in constraining the orientation of longitudinal axon projections at the ventral midline. ..
  55. Risley M, Garrod D, Henkemeyer M, McLean W. EphB2 and EphB3 forward signalling are required for palate development. Mech Dev. 2009;126:230-9 pubmed publisher
    ..The reduced proliferation was not the result of abnormal vascular development within the palate. In conclusion, strong evidence is provided for specific and co-operative roles of EphB2 and EphB3 in palate development. ..
  56. Jevince A, Kadison S, Pittman A, Chien C, Kaprielian Z. Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord. J Comp Neurol. 2006;497:734-50 pubmed
    ..In addition, we unexpectedly find that mesenchymal cells, which surround the spinal cord and dorsal root ganglion, express ephrin-B1. ..
  57. Chen Z, Sun C, Reuhl K, Bergemann A, Henkemeyer M, Zhou R. Abnormal hippocampal axon bundling in EphB receptor mutant mice. J Neurosci. 2004;24:2366-74 pubmed
    ..These observations indicate that the EphB receptors and their ligand regulate hippocampal axon defasciculation at the septal target, possibly through a receptor-mediated forward signaling mechanism. ..
  58. Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, et al. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 2004;23:1075-88 pubmed
    ..These results indicate that Tiam1 is required for neurite outgrowth induced by both ephrin-B1-mediated reverse signaling and EphA2-mediated forward signaling. ..
  59. Toth J, Cutforth T, Gelinas A, Bethoney K, Bard J, Harrison C. Crystal structure of an ephrin ectodomain. Dev Cell. 2001;1:83-92 pubmed
    ..The high sequence similarity among ephrin ectodomains indicates that all ephrins may be modeled upon the ephrin-B2 structure presented here. ..
  60. Campbell T, Davy A, Liu Y, Arcellana Panlilio M, Robbins S. Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1. Biochem Biophys Res Commun. 2008;375:362-6 pubmed publisher
    ..We thus demonstrate that distinct localization and compartmentalization provide insight into the subcellular basis for differential signaling observed in ephrin-A and B classes. ..
  61. Hu Y, Wang X, Wu Y, Jin W, Cheng B, Fang X, et al. Role of EFNB1 and EFNB2 in Mouse Collagen-Induced Arthritis and Human Rheumatoid Arthritis. Arthritis Rheumatol. 2015;67:1778-88 pubmed publisher
    b>EFNB1 and EFNB2 are ligands for Eph receptor tyrosine kinases...
  62. Piper M, Harris L, Barry G, Heng Y, Plachez C, Gronostajski R, et al. Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 2011;519:3532-48 pubmed publisher
  63. Funato N, Nakamura M, Richardson J, Srivastava D, Yanagisawa H. Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012;21:2524-37 pubmed publisher
    ..Our present study reveals new pathogenesis of incomplete and submucous cleft palate during mammalian palatogenesis. ..
  64. Sentürk A, Pfennig S, Weiss A, Burk K, Acker Palmer A. Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature. 2011;472:356-60 pubmed publisher
    ..Notably, compound mouse mutants (Reln(+/-); Efnb3(-/-) or Reln(+/-); Efnb2(-/-)) and triple ephrin B1, B2, B3 knockouts show neuronal migration defects that recapitulate the ones observed in the neocortex, ..
  65. Kamata T, Bong Y, Mood K, Park M, Nishanian T, Lee H. EphrinB1 interacts with the transcriptional co-repressor Groucho/xTLE4. BMB Rep. 2011;44:199-204 pubmed publisher
    ..Additionally, phosphorylation of EphrinB1 by a constitutively activated fibroblast growth factor receptor resulted in loss of the interaction, suggesting that the interaction is modulated by tyrosine phosphorylation of the EphrinB1 ICD...
  66. Bergemann A, Cheng H, Brambilla R, Klein R, Flanagan J. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol. 1995;15:4921-9 pubmed
    ..Comparable patterns have been described for Eph family receptors, including Sek-4 and Nuk/Sek-3, suggesting roles for ELF-2 in patterning these regions of the embryo. ..
  67. Islam S, Loizides A, Fialkovich J, Grand R, Montgomery R. Developmental expression of Eph and ephrin family genes in mammalian small intestine. Dig Dis Sci. 2010;55:2478-88 pubmed publisher
    ..Continued intestinal expression of other family members implicates a role in differentiation. ..
  68. Mori T, Maeda N, Inoue K, Sekimoto R, Tsushima Y, Matsuda K, et al. A novel role for adipose ephrin-B1 in inflammatory response. PLoS ONE. 2013;8:e76199 pubmed publisher
    Ephrin-B1 (EfnB1) was selected among genes of unknown function in adipocytes or adipose tissue and subjected to thorough analysis to understand its role in the development of obesity...
  69. Villasenor A, Marty Santos L, Dravis C, Fletcher P, Henkemeyer M, Cleaver O. EphB3 marks delaminating endocrine progenitor cells in the developing pancreas. Dev Dyn. 2012;241:1008-19 pubmed publisher
    ..Together, these data introduce EphB3 as a new biomarker to identify beta-cells at a critical step during their step-wise differentiation and define the timeframe of endocrine differentiation. ..
  70. Koo B, Lim H, Chang H, Yoon M, Choi Y, Kong M, et al. Notch signaling promotes the generation of EphrinB1-positive intestinal epithelial cells. Gastroenterology. 2009;137:145-55, 155.e1-3 pubmed publisher
    ..Notch signaling regulates formation of the EphB2-EphrinB1 boundary in the mouse intestinal epithelium. ..
  71. Noh H, Lee H, Park E, Park S. Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development. 2016;143:461-72 pubmed publisher
  72. Nguyen T, Arthur A, Paton S, Hemming S, Panagopoulos R, Codrington J, et al. Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development. Bone. 2016;93:12-21 pubmed publisher
    ..ephrinB1 during endochondral ossification using the Cre recombination system with targeted deletion of ephrinB1 (EfnB1fl/fl) in osteogenic progenitor cells, under the control of the osterix (Osx:Cre) promoter...
  73. Villasenor A, Chong D, Henkemeyer M, Cleaver O. Epithelial dynamics of pancreatic branching morphogenesis. Development. 2010;137:4295-305 pubmed publisher
    ..Overall, these results illustrate distinct, step-wise cellular mechanisms by which pancreatic epithelium shapes itself to create a functional branching organ. ..
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    ..We also report the sequence and expression pattern in mouse embryos and adult tissues of one of these novel RA-inducible genes, Stra1, and show that it corresponds to the mouse ligand for the Cek5 receptor protein-tyrosine kinase.