Gene Symbol: Ednrb
Description: endothelin receptor type B
Alias: ET-B, ET-BR, ETR-b, ETb, Sox10m1, endothelin receptor type B, endothelin B receptor, endothelin receptor non-selective type, piebald
Species: mouse
Products:     Ednrb

Top Publications

  1. Kumagai T, Wada A, Tsudzuki M, Nishimura M, Kunieda T. Nucleotide sequence of endothelin-B receptor gene reveals origin of piebald mutation in laboratory mouse. Exp Anim. 1998;47:265-9 pubmed
    b>Piebald (Ednrbs) is a coat color mutation of laboratory mice caused by a decreased expression of endothelin-B receptor gene (Ednrb)...
  2. Koide T, Moriwaki K, Uchida K, Mita A, Sagai T, Yonekawa H, et al. A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele. Mamm Genome. 1998;9:15-9 pubmed
    ..Characterization of the causative gene for piebald, endothelin receptor type B (ednrb), demonstrated that the allele in JF1 is same as that of classic piebald allele, suggesting an ..
  3. Adameyko I, Lallemend F, Furlan A, Zinin N, Aranda S, Kitambi S, et al. Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development. 2012;139:397-410 pubmed publisher
    ..of both neural crest- and SCP-derived progenitors into melanocytes, and an initial small pool of nerve-associated melanoblasts expands in number and disperses under the control of endothelin receptor B (Ednrb) and Wnt5a signaling.
  4. Makita T, Sucov H, Gariepy C, Yanagisawa M, Ginty D. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008;452:759-63 pubmed publisher
    ..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs. ..
  5. Rattner A, Yu H, Williams J, Smallwood P, Nathans J. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013;110:E3830-9 pubmed publisher
    ..The response to Edn2 is sufficiently potent that it overrides the activities of other homeostatic regulators of angiogenesis, such as Vegf. ..
  6. Reid K, Turnley A, Maxwell G, Kurihara Y, Kurihara H, Bartlett P, et al. Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development. 1996;122:3911-9 pubmed
    ..These findings indicate two key roles for endothelin in melanocyte development: regulation of expansion of the progenitor pool and differentiation of progenitors into mature melanocytes. ..
  7. Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M. Reduced expression of the endothelin receptor type B gene in piebald mice caused by insertion of a retroposon-like element in intron 1. J Biol Chem. 2006;281:10799-807 pubmed
    Mice carrying the piebald mutation exhibit white coat spotting due to the regional absence of neural crest-derived melanocytes...
  8. Barlow A, de Graaff E, Pachnis V. Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron. 2003;40:905-16 pubmed
    ..Two signaling systems mediated by RET and EDNRB have been identified as critical players in enteric neurogenesis...
  9. McCallion A, Stames E, Conlon R, Chakravarti A. Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb. Proc Natl Acad Sci U S A. 2003;100:1826-31 pubmed
    ..that interactions between mutations in the genes encoding the RET receptor tyrosine kinase and the endothelin receptor type B (EDNRB) are central to the genesis of HSCR...

More Information


  1. Lane P. Association of megacolon with two recessive spotting genes in the mouse. J Hered. 1966;57:29-31 pubmed
  2. Southard Smith E, Kos L, Pavan W. Sox10 mutation disrupts neural crest development in Dom Hirschsprung mouse model. Nat Genet. 1998;18:60-4 pubmed
    ..These include mice with deficiencies of endothelin B receptor (Ednrb(s-l); refs 1,2) endothelin 3 (Edn3(ls): refs 1,3) the tyrosine kinase receptor cRet and glial-..
  3. Shin M, Levorse J, Ingram R, Tilghman S. The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature. 1999;402:496-501 pubmed
    Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons...
  4. Owens S, Broman K, Wiltshire T, Elmore J, Bradley K, Smith J, et al. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum Mol Genet. 2005;14:1549-58 pubmed
  5. Carrasquillo M, McCallion A, Puffenberger E, Kashuk C, Nouri N, Chakravarti A. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat Genet. 2002;32:237-44 pubmed
    ..and non-complementation of aganglionosis in mouse intercrosses between Ret null and the Ednrb hypomorphic piebald allele are suggestive of epistasis between EDNRB and RET...
  6. Dang R, Sasaki N, Torigoe D, Agui T. Anatomic modifications in the enteric nervous system of JF1 mice with the classic piebald mutation. J Vet Med Sci. 2012;74:391-4 pubmed
    ..The mutation in JF1 and the classic piebald was previously thought to be the same recessive allele in the endothelin B receptor gene (Ednrb) according to the haplotype pattern, which is insufficient for this conclusion...
  7. Pavan W, Tilghman S. Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. Proc Natl Acad Sci U S A. 1994;91:7159-63 pubmed
    Mice homozygous for the piebald lethal (sl) mutation have a predominantly white coat due to the absence of neural crest-derived melanocytes in the hair follicles...
  8. Yanagisawa H, Yanagisawa M, Kapur R, Richardson J, Williams S, Clouthier D, et al. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 1998;125:825-36 pubmed
    ..gut were also absent in ECE-1-/- embryos, reproducing the developmental phenotype seen in ET-3-/- and endothelin B receptor (ETB)-/- mice...
  9. Hosoda K, Hammer R, Richardson J, Baynash A, Cheung J, Giaid A, et al. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 1994;79:1267-76 pubmed
    ..b>Piebald-lethal (sl) mice exhibit a recessive phenotype identical to that of the EDNRB knockout mice...
  10. Van Raamsdonk C, Fitch K, Fuchs H, de Angelis M, Barsh G. Effects of G-protein mutations on skin color. Nat Genet. 2004;36:961-8 pubmed
    ..and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb. Interactions between Gq and Kit receptor tyrosine kinase signaling can mediate coordinate or independent control ..
  11. Gosain A, Barlow Anacker A, Erickson C, Pierre J, Heneghan A, Epstein M, et al. Impaired Cellular Immunity in the Murine Neural Crest Conditional Deletion of Endothelin Receptor-B Model of Hirschsprung's Disease. PLoS ONE. 2015;10:e0128822 pubmed publisher
    ..b>EdnrB was deleted from the neural crest (EdnrBNCC-/-) resulting in mutants with defective NCC migration, distal colonic ..
  12. Thorn S, Giesy S, Myers M, Boisclair Y. Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling. Endocrinology. 2010;151:3985-95 pubmed publisher
    ..These data imply the existence of an unknown mechanism whereby leptin-dependent STAT3 signaling and obesity alter mammary ductal development. ..
  13. Liu Y, Chen X, Xu C, Cao L, Lin J, Chen G, et al. Tail vein injection of mmLDL upregulates mouse mesenteric artery ETB receptors via activation of the ERK1/2 pathway. Vascul Pharmacol. 2017;96-98:33-39 pubmed publisher
    ..Understanding the effect of mmLDL on ETB receptors and its mechanism can provide ideas for cardiovascular disease prevention and treatment. ..
  14. Watabe H, Soma Y, Kawa Y, Ito M, Ooka S, Ohsumi K, et al. Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression. J Invest Dermatol. 2002;119:583-9 pubmed
    ..Moreover, immunostaining and reverse transcription-polymerase chain reaction analysis revealed that endothelin B receptor expression was induced in NCC-/melb4 cells following treatment with 1,25-dihydroxyvitamin D3...
  15. Bockamp E, McLaughlin F, Murrell A, Gottgens B, Robb L, Begley C, et al. Lineage-restricted regulation of the murine SCL/TAL-1 promoter. Blood. 1995;86:1502-14 pubmed
    ..These results suggest that inactivity of SCL promoter 1a in T cells reflected the absence of GATA-1 rather than the presence of trans-dominant negative regulators. ..
  16. Iribarne M, Ogawa L, Torbidoni V, Dodds C, Dodds R, Suburo A. Blockade of endothelinergic receptors prevents development of proliferative vitreoretinopathy in mice. Am J Pathol. 2008;172:1030-42 pubmed publisher
    ..In addition, the presence of ET-1 and ETR-B in human fibrous membranes suggests that similar treatments could be helpful after PVR has been established. ..
  17. Ida Eto M, Ohgami N, Iida M, Yajima I, Kumasaka M, Takaiwa K, et al. Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing. J Biol Chem. 2011;286:29621-6 pubmed publisher
    Impairments of endothelin receptor B (Ednrb/EDNRB) cause the development of Waardenburg-Shah syndrome with congenital hearing loss, hypopigmentation, and megacolon disease in mice and humans...
  18. Fryer R, Rakestraw P, Banfor P, Cox B, Opgenorth T, Reinhart G. Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade. Am J Physiol Heart Circ Physiol. 2006;290:H2554-9 pubmed
  19. Fogelgren B, Yang S, Sharp I, Huckstep O, Ma W, Somponpun S, et al. Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. Am J Physiol Renal Physiol. 2009;296:F1166-78 pubmed publisher
    ..Defects are associated with embryological deficiencies of Six2, suggesting that proper levels of this protein during nephrogenesis are critical for normal glomerular development and adult renal function. ..
  20. Ong A. Surprising new roles for endothelins. BMJ. 1996;312:195-6 pubmed
  21. Catar R, Muller G, Brandt A, Langbein H, Brunssen C, Goettsch C, et al. Increased gene expression of the cardiac endothelin system in obese mice. Horm Metab Res. 2015;47:509-15 pubmed publisher
    ..In conclusion, an increased expression of genes of the endothelin system was observed in the hearts of 18-week-old mice after high-fat diet, possibly contributing to later cardiovascular complications of obesity. ..
  22. Eng S, Dykes I, Lanier J, Fedtsova N, Turner E. POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia. Neural Dev. 2007;2:3 pubmed
  23. Ulbrich M, Schmidt V, Ronsiek M, Mussmann A, Bartsch J, Augustin M, et al. Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse. Neuroreport. 2002;13:535-9 pubmed
    ..Our analysis provides access to genes that modify neurodegeneration, the human counterparts of which may be responsible for the variable expression of hereditary spinal muscular atrophies. ..
  24. Kuc R, Maguire J, Davenport A. Quantification of endothelin receptor subtypes in peripheral tissues reveals downregulation of ET(A) receptors in ET(B)-deficient mice. Exp Biol Med (Maywood). 2006;231:741-5 pubmed
  25. Asher J, Friedman T. Mouse and hamster mutants as models for Waardenburg syndromes in humans. J Med Genet. 1990;27:618-26 pubmed
    ..One or more of the mouse mutant alleles, Ph (patch), s (piebald), Sp (splotch), and Mior (microphthalmia-Oak Ridge) and the hamster mutation Wh (anophthalmic white) may be ..
  26. Adur J, Takizawa S, Quan J, Uchide T, Saida K. Increased gene expression and production of murine endothelin receptors after birth. Biochem Biophys Res Commun. 2003;305:700-6 pubmed
    ..These findings were corroborated through observation of the correlation between the gene expression and (poly)peptide production of the ET system in normal skin before and after parturition. ..
  27. Kelland N, Kuc R, McLean D, Azfer A, Bagnall A, Gray G, et al. Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1. Can J Physiol Pharmacol. 2010;88:644-51 pubmed publisher
    Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of ..
  28. Laghmani K, Preisig P, Moe O, Yanagisawa M, Alpern R. Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. J Clin Invest. 2001;107:1563-9 pubmed
    ..In conclusion, metabolic acidosis increases ET-1 expression, which increases NHE3 activity via the ET(B) receptor. ..
  29. Loftus S, Baxter L, Buac K, Watkins Chow D, Larson D, Pavan W. Comparison of melanoblast expression patterns identifies distinct classes of genes. Pigment Cell Melanoma Res. 2009;22:611-22 pubmed publisher
  30. Lamoreux M. Strain-specific white-spotting patterns in laboratory mice. Pigment Cell Res. 1999;12:383-90 pubmed
    ..Patterns of white spotting were examined on mice mutant at the piebald (s), patch (Ph), dominant spotting (W(J2)) rumpwhite (Rw) or belted (bt) loci...
  31. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo A, et al. Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab. 2008;28:468-81 pubmed
    ..b>Endothelin B receptor (ET(B)R) immunoreactivity was strong on cultured astrocytes and reactive astrocytes around infarct in WT ..
  32. Mayer T. Pigment cell migration in piebald mice. Dev Biol. 1967;15:521-35 pubmed
  33. Yamasaki R, Fujii T, Wang B, Masaki K, Kido M, Yoshida M, et al. Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation. J Neurosci. 2016;36:11929-11945 pubmed
    ..Among the cell surface protein genes, endothelin receptor type B (EDNRB) was most upregulated...
  34. Cattanach B. A chemically-induced variegated-type position effect in the mouse. Z Vererbungsl. 1961;92:165-82 pubmed
  35. Jeoung M, Lee S, Hawng H, Cheon Y, Jeong Y, Gye M, et al. Identification of a novel role for endothelins within the oviduct. Endocrinology. 2010;151:2858-67 pubmed publisher
    ..Overall, these results suggest a novel and requisite role for endothelins within the oviduct during fertilization and/or early embryo development. ..
  36. Favor J. Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test. Mutat Res. 1999;428:227-36 pubmed
    ..e) With the cloning of all 7 marker loci mutation analysis at the molecular level will allow a more direct assessment of the mutation process in future studies. ..
  37. Vickerman L, Neufeld S, Cobb J. Shox2 function couples neural, muscular and skeletal development in the proximal forelimb. Dev Biol. 2011;350:323-36 pubmed publisher
    ..These data demonstrate that Shox2 is required for normal skeletal, neural and muscular development in the forelimb at a similar early developmental stage in each tissue. ..
  38. Erickson C, Zaitoun I, Haberman K, Gosain A, Druckenbrod N, Epstein M. Sacral neural crest-derived cells enter the aganglionic colon of Ednrb-/- mice along extrinsic nerve fibers. J Comp Neurol. 2012;520:620-32 pubmed publisher
    ..Extrinsic nerve fibers serve as a route of entry for both rodent and avian sacral crest into the hindgut. ..
  39. Womack J, Davisson M, Eicher E, Kendall D. Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Biochem Genet. 1977;15:347-55 pubmed
    ..Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9 +/- 4.0 cM)-[Np-1, Wc]-(10.2 +/- 1.9 cM)-Es-10-(15.5 +/- 3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked. ..
  40. Okamura T, Imai Y, Kon Y, Goto M, Yamamoto M, Watanabe T. Molecular cloning and characterization of mouse testis poly(A) binding protein II encoded by the Pabp3 gene, which transcomplements meiotic mutant sme2 of S. pombe. Biochem Genet. 2000;38:1-11 pubmed
    ..Genetic mapping showed the Pabp3 gene encoding mPABII to be located near position 19.5 on mouse chromosome 14. These results suggest that mPABII might be involved in specific spermatogenetic cell differentiation. ..
  41. Okamura Y, Saga Y. Notch signaling is required for the maintenance of enteric neural crest progenitors. Development. 2008;135:3555-65 pubmed publisher
  42. Pavan W, Mac S, Cheng M, Tilghman S. Quantitative trait loci that modify the severity of spotting in piebald mice. Genome Res. 1995;5:29-41 pubmed
    Mice homozygous for the recessive mutation piebald (s) exhibit a white-spotted coat caused by the defective development of neural crest-derived melanocytes...
  43. Adur J, Uchide T, Takizawa S, Quan J, Saida K. Real-time polymerase chain reaction quantification of gene expression levels of murine endothelin-A and endothelin-B receptors: gene expression profiles by the standard curve method. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S321-8 pubmed
    A rapid analysis method for murine endothelin-A (ETA) and endothelin-B (ETB) receptor gene expression levels was established using real-time quantitative reverse transcriptase-polymerase chain reaction...
  44. Russell L, Hunsicker P, Shelby M. Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids. Mutat Res. 1992;282:151-8 pubmed
    ..However, in the case of CHL, a somewhat higher proportion of the mutations is induced in early spermatids than in the case of MLP. ..
  45. Kalinichenko V, Lim L, Stolz D, Shin B, Rausa F, Clark J, et al. Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor. Dev Biol. 2001;235:489-506 pubmed
    ..Reduction in the level of Foxf1 caused neonatal pulmonary hemorrhage and abnormalities in alveologenesis, implicating this transcription factor in the regulation of mesenchyme-epithelial interaction critical for lung morphogenesis. ..
  46. Feng H, Weymouth N, Rockey D. Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease. Am J Physiol Gastrointest Liver Physiol. 2009;297:G27-33 pubmed publisher
    ..The data imply a relationship between hepatic fibrogenesis or fibrosis and vasomotor responses. ..
  47. Viet C, Ye Y, Dang D, Lam D, Achdjian S, Zhang J, et al. Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain. Pain. 2011;152:2323-32 pubmed publisher
    ..b>EDNRB, the gene encoding the ET(B) receptor, has been shown to be hypermethylated and transcriptionally silenced in many ..
  48. Robertson K, Mason I, Hall S. Hirschsprung's disease: genetic mutations in mice and men. Gut. 1997;41:436-41 pubmed
    ..Moreover, certain mutant mouse strains--namely piebald lethal and lethal spotted--exhibit striking similarities to the human condition...
  49. Osada S, Mizuno K, Saido T, Suzuki K, Kuroki T, Ohno S. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle. Mol Cell Biol. 1992;12:3930-8 pubmed
    ..These results clearly demonstrate that nPKC theta should be considered a member of the PKC family of proteins that play crucial roles in the signal transduction pathway. ..
  50. Cantrell V, Owens S, Chandler R, Airey D, Bradley K, Smith J, et al. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum Mol Genet. 2004;13:2289-301 pubmed
    ..are acting as modifiers of Sox10, we tested for association between genes in the endothelin signaling pathway (EdnrB, Edn3, Ece1) and severity of aganglionosis in an extended pedigree of B6C3FeLe.Sox10Dom mice...
  51. Ge Y, Bagnall A, Stricklett P, Strait K, Webb D, Kotelevtsev Y, et al. Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol. 2006;291:F1274-80 pubmed
    ..The role of CD endothelin B (ETB) receptors in mediating these effects is unknown...
  52. Manousiouthakis E, Mendez M, Garner M, Exertier P, Makita T. Venous endothelin guides sympathetic innervation of the developing mouse heart. Nat Commun. 2014;5:3918 pubmed publisher
    ..Our findings present venous Edn1 as a sympathetic guidance cue, and show how axon guidance mechanisms are coordinated with endorgan morphogenesis. ..
  53. Bugaj V, Mironova E, Kohan D, Stockand J. Collecting duct-specific endothelin B receptor knockout increases ENaC activity. Am J Physiol Cell Physiol. 2012;302:C188-94 pubmed publisher
    Collecting duct (CD)-derived endothelin-1 (ET-1) acting via endothelin B (ETB) receptors promotes Na(+) excretion. Compromise of ET-1 signaling or ETB receptors in the CD cause sodium retention and increase blood pressure...
  54. Davenport A, Kuc R. Down-regulation of ETA receptors in ETB receptor-deficient mice. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S276-8 pubmed
    ..sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney...
  55. Matsushima Y, Shinkai Y, Kobayashi Y, Sakamoto M, Kunieda T, Tachibana M. A mouse model of Waardenburg syndrome type 4 with a new spontaneous mutation of the endothelin-B receptor gene. Mamm Genome. 2002;13:30-5 pubmed
    ..responsible for WS4 have been cloned: genes for a transcription factor SOX10, endothelin 3 (EDN3), and endothelin B receptor (EDNRB)...
  56. Shin M, Russell L, Tilghman S. Molecular characterization of four induced alleles at the Ednrb locus. Proc Natl Acad Sci U S A. 1997;94:13105-10 pubmed
    The piebald locus on mouse chromosome 14 encodes the endothelin-B receptor (EDNRB), a G protein-coupled, seven-transmembrane domain protein, which is required for neural crest-derived melanocyte and enteric neuron development...
  57. Billingham R, Silvers W. The melanocytes of mammals. Q Rev Biol. 1960;35:1-40 pubmed
  58. Murakoshi N, Miyauchi T, Kakinuma Y, Ohuchi T, Goto K, Yanagisawa M, et al. Vascular endothelin-B receptor system in vivo plays a favorable inhibitory role in vascular remodeling after injury revealed by endothelin-B receptor-knockout mice. Circulation. 2002;106:1991-8 pubmed
    ..These results suggest that the overall effect of vascular ET(B) receptors is antiproliferative in the injured artery. ..
  59. Miller E, Czopek A, Duthie K, Kirkby N, van de Putte E, Christen S, et al. Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling. Hypertension. 2017;69:275-285 pubmed publisher
    ..These ETB receptors have no effect on vascular contraction or neointimal remodeling. ..
  60. Bagnall A, Kelland N, Gulliver Sloan F, Davenport A, Gray G, Yanagisawa M, et al. Deletion of endothelial cell endothelin B receptors does not affect blood pressure or sensitivity to salt. Hypertension. 2006;48:286-93 pubmed
    ..role of endothelial cell endothelin B receptors in these processes, we generated endothelial cell-specific endothelin B receptor knockout mice using a Cre-loxP approach...
  61. Hammond T, McEllin B, Morton P, Raymond M, Dupree J, Gallo V. Endothelin-B Receptor Activation in Astrocytes Regulates the Rate of Oligodendrocyte Regeneration during Remyelination. Cell Rep. 2015;13:2090-7 pubmed publisher
    ..approaches and cell-specific endothelin receptor (EDNR) ablation, we show that ET-1 acts selectively through EDNRB on astrocytes--and not OPCs--to indirectly inhibit remyelination...
  62. Chakder S, McHugh K, Rattan S. Inhibitory neurotransmission in lethal spotted mutant mice: a model for Hirschsprung's disease. Gastroenterology. 1997;112:1575-85 pubmed
    ..Ls/Ls mice may serve as an appropriate animal model to investigate the pathogenesis of the inhibitory neurotransmission in Hirschsprung's disease in the distal colon and IAS. ..
  63. Roix J, Hagge Greenberg A, Bissonnette D, Rodick S, Russell L, O Brien T. Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001;157:803-15 pubmed
    The piebald deletion complex is a set of overlapping chromosomal deficiencies surrounding the endothelin receptor B locus collected during the Oak Ridge specific-locus-test mutagenesis screen...
  64. Luo Y, Tang Y, Xia Q, Liu J. The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea. Cell Mol Biol Lett. 2007;12:595-603 pubmed
  65. Webster W. Embryogenesis of the enteric ganglia in normal mice and in mice that develop congenital aganglionic megacolon. J Embryol Exp Morphol. 1973;30:573-85 pubmed
  66. Opdecamp K, Kos L, Arnheiter H, Pavan W. Endothelin signalling in the development of neural crest-derived melanocytes. Biochem Cell Biol. 1998;76:1093-9 pubmed
    In both mice and humans, mutations in the genes encoding the endothelin B receptor and its ligand endothelin 3 lead to deficiencies in neural crest-derived melanocytes and enteric neurons...
  67. Lynch I, Welch A, Kohan D, Cain B, Wingo C. Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct. Am J Physiol Renal Physiol. 2013;305:F568-73 pubmed publisher
    ..In the presence of ET-1, ENaC-mediated JNa is significantly inhibited. Blockade of either ETA or ETB receptor restored JNa to control rates; however, only ETA receptor blockade restored a benzamil-sensitive component ..
  68. Liu L, Zacchia M, Tian X, Wan L, Sakamoto A, Yanagisawa M, et al. Acid regulation of NaDC-1 requires a functional endothelin B receptor. Kidney Int. 2010;78:895-904 pubmed publisher
    ..Since increased NaDC-1 and NHE3 activities constitute part of the proximal tubule adaptation to an acid load, these studies indicate that there are similarities in the signaling pathway mediating these responses. ..
  69. Yoshimoto T, Aoyama Y, Kim T, Niimi K, Takahashi E, Itakura C. Rolling Nagoya mouse strain (PROD-rol/rol) with classic piebald mutation. J Vet Med Sci. 2014;76:1093-8 pubmed
    ..However, mutation analysis of the s locus encoding the endothelin receptor type B (Ednrb) gene in PROD-rol/rol mice had not been performed...
  70. Foller M, Mahmud H, Qadri S, Gu S, Braun M, Bobbala D, et al. Endothelin B receptor stimulation inhibits suicidal erythrocyte death. FASEB J. 2010;24:3351-9 pubmed publisher
    ..The present study explored whether the ET1-receptor ETB influences suicidal erythrocyte death...
  71. Wu J, Chen J, Rothman T, Gershon M. Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development. 1999;126:1161-73 pubmed
  72. Keeler C. The Independence of Dominant Spotting and Recessive Spotting ("Piebald") in the House Mouse. Proc Natl Acad Sci U S A. 1931;17:101-2 pubmed
  73. Rhim H, Dunn K, Aronzon A, Mac S, Cheng M, Lamoreux M, et al. Spatially restricted hypopigmentation associated with an Ednrbs-modifying locus on mouse chromosome 10. Genome Res. 2000;10:17-29 pubmed
    We have used the varied expressivity of white spotting (hypopigmentation) observed in intrasubspecific crosses of Ednrb(s) mice (Mayer Ednrb(s)/Ednrb(s) and C3HeB/FeJ Ednrb(s)/Ednrb(s)) to analyze the effects of modifier loci on the ..
  74. Uchide T, Masuda H, Mitsui Y, Saida K. Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reactio. J Mol Endocrinol. 1999;22:161-71 pubmed
    ..Gene expression of ET-1, ET-3, ETA and ETB was ubiquitous in almost all tissues we examined while gene expression of VIC was localized to certain tissues...
  75. Thiagarajah J, Yildiz H, Carlson T, Thomas A, Steiger C, Pieretti A, et al. Altered goblet cell differentiation and surface mucus properties in Hirschsprung disease. PLoS ONE. 2014;9:e99944 pubmed publisher
    ..Endothelin receptor B (Ednrb) mutant mice showed increased goblet cell number and size and increased cell proliferation compared to wild-type ..
  76. Hagarman J, O Brien T. An essential gene mutagenesis screen across the highly conserved piebald deletion region of mouse chromosome 14. Genesis. 2009;47:392-403 pubmed publisher
    The piebald deletion complex is a set of overlapping chromosomal deficiencies on distal mouse chromosome 14...
  77. Ro S, Hwang S, Muto M, Jewett W, Spencer N. Anatomic modifications in the enteric nervous system of piebald mice and physiological consequences to colonic motor activity. Am J Physiol Gastrointest Liver Physiol. 2006;290:G710-8 pubmed
    It has been assumed that in piebald lethal mice that develop megacolon, impaired colonic motor activity is restricted to the aganglionic distal colon...
  78. Druckenbrod N, Powers P, Bartley C, Walker J, Epstein M. Targeting of endothelin receptor-B to the neural crest. Genesis. 2008;46:396-400 pubmed publisher
    Endothelin receptor B (Ednrb) plays a critical role in the development of melanocytes and neurons and glia of the enteric nervous system...
  79. Liu B, Wu D. The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. J Biol Chem. 2003;278:2384-7 pubmed
    Endothelin (EDN) receptor type B (EDNRB) activates serum response factor (SRF) via G(q/11) and G(12/13) G proteins. In this study, we investigated the involvement of intracellular loop sequences of EDNRB in coupling to these G proteins...
  80. Druckenbrod N, Epstein M. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development. 2009;136:3195-203 pubmed publisher
    ..One of the genes associated with HSCR is endothelin receptor type B (Ednrb)...
  81. He S, Minton A, Ma H, Stankowska D, Sun X, Krishnamoorthy R. Involvement of AP-1 and C/EBP? in upregulation of endothelin B (ETB) receptor expression in a rodent model of glaucoma. PLoS ONE. 2013;8:e79183 pubmed publisher
    Previous studies showed that the endothelin B receptor (ETB) expression was upregulated and played a key role in neurodegeneration in rodent models of glaucoma...
  82. Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y. Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S17-21 pubmed
    ..ET(A) and ETB receptor mRNA levels in several organs also were not different among Edn1+/+ wild-type, Edn1+/- heterozygous, and ..
  83. Kisanuki Y, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, et al. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension. 2010;56:121-8 pubmed publisher
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor. ..
  84. Peters J, Ball S. Biochemical and recessive visible specific locus responses of C3H/HeH to fractionated, acute radiation. Mutat Res. 2003;543:137-43 pubmed
    ..The number of loci scored in the electrophoretic test has been reassessed, and it is now considered that six, not four were scored, and this has implications for the calculation of the doubling dose. ..
  85. Boyd R, R├Ątsep M, Ding L, Wang H. ETA and ETB receptors are expressed in vascular adventitial fibroblasts. Am J Physiol Heart Circ Physiol. 2011;301:H2271-8 pubmed publisher
    ..The ET(A) receptor subtype mediates collagen I expression, whereas the ET(B) receptor subtype may play a protective role through increasing the clearance of the ET-1 peptide. ..
  86. Metallinos D, Oppenheimer A, Rinchik E, Russell L, Dietrich W, Tilghman S. Fine structure mapping and deletion analysis of the murine piebald locus. Genetics. 1994;136:217-23 pubmed
    b>piebald (s) is a recessive mutation that affects the development of two cell types of neural crest origin: the melanocytes, responsible for pigment synthesis in the skin, and enteric ganglia, which innervate the lower bowel...