Gene Symbol: Ednra
Description: endothelin receptor type A
Alias: AEA001, ET-AR, ETa, Gpcr10, Mhdaaea1, endothelin-1 receptor, ET-A, G-protein coupled receptor 10, endothelin A receptor
Species: mouse
Products:     Ednra

Top Publications

  1. Gitler A, Lu M, Epstein J. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004;7:107-16 pubmed
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis. ..
  2. Yanagisawa H, Yanagisawa M, Kapur R, Richardson J, Williams S, Clouthier D, et al. Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 1998;125:825-36 pubmed
    ..exhibited craniofacial and cardiac abnormalities virtually identical to the defects seen in ET-1 and endothelin A receptor (ETA)-deficient embryos...
  3. Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, et al. An endothelin-1 switch specifies maxillomandibular identity. Proc Natl Acad Sci U S A. 2008;105:18806-11 pubmed publisher
    ..The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation...
  4. Makita T, Sucov H, Gariepy C, Yanagisawa M, Ginty D. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008;452:759-63 pubmed publisher
    ..1), acting through the endothelin receptor EdnrA (refs 2, 3), directs extension of axons of a subset of sympathetic neurons from the superior cervical ganglion to ..
  5. Clouthier D, Hosoda K, Richardson J, Williams S, Yanagisawa H, Kuwaki T, et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development. 1998;125:813-24 pubmed
    ..Here we demonstrate that mice deficient for one type of endothelin receptor, ETA, mimic the human conditions collectively termed CATCH 22 or velocardiofacial syndrome, which include severe ..
  6. Ruest L, Kedzierski R, Yanagisawa M, Clouthier D. Deletion of the endothelin-A receptor gene within the developing mandible. Cell Tissue Res. 2005;319:447-53 pubmed
    Signaling from the endothelin-A (Ednra) receptor is responsible for initiating multiple signaling pathways within neural crest cells (NCCs)...
  7. Rattner A, Yu H, Williams J, Smallwood P, Nathans J. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013;110:E3830-9 pubmed publisher
    ..The response to Edn2 is sufficiently potent that it overrides the activities of other homeostatic regulators of angiogenesis, such as Vegf. ..
  8. Jin Y, Turcotte T, Crocker A, Han X, Yoon J. The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Dev Biol. 2011;352:1-13 pubmed publisher
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate. ..
  9. Kedzierski R, Grayburn P, Kisanuki Y, Williams C, Hammer R, Richardson J, et al. Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol. 2003;23:8226-32 pubmed
    ..Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac ..

More Information


  1. Winnier G, Kume T, Deng K, Rogers R, Bundy J, Raines C, et al. Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999;213:418-31 pubmed
    ..Implications for the development of human congenital heart defects are discussed. ..
  2. Sabrautzki S, Sandholzer M, Lorenz Depiereux B, Brommage R, Przemeck G, Vargas Panesso I, et al. Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation. Mamm Genome. 2016;27:587-598 pubmed
    ..dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program...
  3. Adur J, Uchide T, Takizawa S, Quan J, Saida K. Real-time polymerase chain reaction quantification of gene expression levels of murine endothelin-A and endothelin-B receptors: gene expression profiles by the standard curve method. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S321-8 pubmed
    A rapid analysis method for murine endothelin-A (ETA) and endothelin-B (ETB) receptor gene expression levels was established using real-time quantitative reverse transcriptase-polymerase chain reaction...
  4. Mathews W, Murugesan N, Xia J, Scheffel U, Hilton J, Ravert H, et al. Synthesis and in vivo evaluation of novel PET radioligands for imaging the endothelin-A receptor. J Nucl Med. 2008;49:1529-36 pubmed publisher
    The endothelin subtype-A (ETA) receptor is a member of a family of G-protein-coupled receptors that plays a central role in vasoconstriction, cell proliferation, and hormone production...
  5. Abe M, Ruest L, Clouthier D. Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice. Int J Dev Biol. 2007;51:97-105 pubmed
    ..Multiple factors direct the patterning of these NCCs, including endothelin-1-mediated endothelin A receptor (Edn1/Ednra) signaling...
  6. Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, et al. Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development. 2010;137:3823-33 pubmed publisher
    ..identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A (Ednra) gene expression, which contributes to chamber myocardium through a unique type of cell behavior...
  7. Metz M, Schäfer B, Tsai M, Maurer M, Galli S. Evidence that the endothelin A receptor can enhance IgE-dependent anaphylaxis in mice. J Allergy Clin Immunol. 2011;128:424-6.e1 pubmed publisher
  8. Luo Y, Tang Y, Xia Q, Liu J. The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea. Cell Mol Biol Lett. 2007;12:595-603 pubmed
  9. Olave N, Nicola T, Zhang W, Bulger A, James M, Oparil S, et al. Transforming growth factor-? regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure. Am J Physiol Lung Cell Mol Physiol. 2012;302:L857-65 pubmed publisher
    ..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-? signaling indicates that TGF-? is upstream of ET-1 during hypoxia-induced signaling in the newborn lung. ..
  10. Ruest L, Xiang X, Lim K, Levi G, Clouthier D. Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development. 2004;131:4413-23 pubmed
    ..Endothelin-A receptor (Ednra) signaling in crest cells is crucial for their development, as Ednra(-/-) mice are born with severe craniofacial ..
  11. Tavares A, Cox T, Maxson R, Ford H, Clouthier D. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017;144:2021-2031 pubmed publisher
    ..of pharyngeal arch 1 is patterned dorsally by Jagged-Notch signaling and ventrally by endothelin receptor A (EDNRA) signaling...
  12. Zhang Y, Li L, Hua Y, Nunn J, Dong F, Yanagisawa M, et al. Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Biol. 2012;4:97-107 pubmed publisher
    ..These data suggest that ETAKO protects against cold exposure-induced cardiac remodeling and dysfunction mediated through TRPV1 and mitochondrial function. ..
  13. Guo J, Li Y, He Z, Zhang B, Li Y, Hu J, et al. Targeting endothelin receptors A and B attenuates the inflammatory response and improves locomotor function following spinal cord injury in mice. Int J Mol Med. 2014;34:74-82 pubmed publisher
    ..The findings of the present study therefore suggested an association between ETAR and ETBR in regulating early pathogenesis of SCI and determining the outcomes of long?term neurological recovery. ..
  14. Bugaj V, Mironova E, Kohan D, Stockand J. Collecting duct-specific endothelin B receptor knockout increases ENaC activity. Am J Physiol Cell Physiol. 2012;302:C188-94 pubmed publisher
    ..ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice...
  15. Reid K, Turnley A, Maxwell G, Kurihara Y, Kurihara H, Bartlett P, et al. Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development. 1996;122:3911-9 pubmed
    ..These findings indicate two key roles for endothelin in melanocyte development: regulation of expansion of the progenitor pool and differentiation of progenitors into mature melanocytes. ..
  16. Papadopoulos P, Ongali B, Hamel E. Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease. Can J Physiol Pharmacol. 2010;88:652-60 pubmed publisher
    ..Here we studied the effects of chronic treatments with selective ETA (ABT-627) or ETB (A-192621) receptor antagonist on cerebrovascular reactivity, cerebral perfusion, or memory ..
  17. Lynch I, Welch A, Kohan D, Cain B, Wingo C. Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct. Am J Physiol Renal Physiol. 2013;305:F568-73 pubmed publisher
    ..In the presence of ET-1, ENaC-mediated JNa is significantly inhibited. Blockade of either ETA or ETB receptor restored JNa to control rates; however, only ETA receptor blockade restored a benzamil-sensitive ..
  18. Kawamura K, Ye Y, Liang C, Kawamura N, Gelpke M, Rauch R, et al. Paracrine regulation of the resumption of oocyte meiosis by endothelin-1. Dev Biol. 2009;327:62-70 pubmed publisher
    ..hormone-receptor pairs, we found increases in ovarian transcripts for endothelin-1 and endothelin receptor type A (EDNRA) in response to the preovulatory luteinizing hormone (LH)/human chorionic gonadotropin (hCG) stimulation...
  19. Yuyama H, Koakutsu A, Fujiyasu N, Fujimori A, Sato S, Shibasaki K, et al. Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S479-82 pubmed
    ..These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer). ..
  20. Feng H, Weymouth N, Rockey D. Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease. Am J Physiol Gastrointest Liver Physiol. 2009;297:G27-33 pubmed publisher
    ..The data imply a relationship between hepatic fibrogenesis or fibrosis and vasomotor responses. ..
  21. Akhavan A, McHugh K, Guruli G, Bies R, Zamboni W, Strychor S, et al. Endothelin receptor A blockade enhances taxane effects in prostate cancer. Neoplasia. 2006;8:725-32 pubmed
    ..This study demonstrates ABT-627 to have additive antitumor effects when used in combination with taxane drugs both in vitro and in vivo. ..
  22. Davenport A, Kuc R. Down-regulation of ETA receptors in ETB receptor-deficient mice. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S276-8 pubmed
    Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney...
  23. Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell L, et al. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. J Biol Chem. 2001;276:43663-7 pubmed
    The insulin and the endothelin type A (ETA) receptor both can couple into the heterotrimeric G protein alpha(q/11) (Galpha(q/11)), leading to Galpha(q/11) tyrosine phosphorylation, phosphatidylinositol 3-kinase activation, and subsequent ..
  24. Ivey K, Sutcliffe D, Richardson J, Clyman R, Garcia J, Srivastava D. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008;103:388-95 pubmed publisher
  25. Stösser S, Agarwal N, Tappe Theodor A, Yanagisawa M, Kuner R. Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion. Pain. 2010;148:206-14 pubmed publisher
    ..These results help understand the role of ET(A) receptors in complex biological processes and peripheral cell-cell interactions involved in inflammatory and tumor-associated pain. ..
  26. Gomes L, Hara D, Rae G. Endothelin-1 induces itch and pain in the mouse cheek model. Life Sci. 2012;91:628-33 pubmed publisher
    ..This study reexamines these sensory effects of ET-1 in the new mouse cheek model, in which pruritogens and algogens evoke distinct behavioral responses...
  27. Niu J, Wu J, Li X, Zhang F. Association between endothelin-1/endothelin receptor A and inflammation in mouse kidneys following acute ischemia/reperfusion. Mol Med Rep. 2015;11:3981-7 pubmed publisher
    ..Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease...
  28. Kisanuki Y, Emoto N, Ohuchi T, Widyantoro B, Yagi K, Nakayama K, et al. Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension. 2010;56:121-8 pubmed publisher
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor. ..
  29. Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y. Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S17-21 pubmed
    ..Neither compensation by redundant expression of other ET isoforms nor upregulation of ET receptors could explain the elevated blood pressure in Edn1+/- heterozygous mice. ..
  30. Boyd R, Rätsep M, Ding L, Wang H. ETA and ETB receptors are expressed in vascular adventitial fibroblasts. Am J Physiol Heart Circ Physiol. 2011;301:H2271-8 pubmed publisher
    ..The ET(A) receptor subtype mediates collagen I expression, whereas the ET(B) receptor subtype may play a protective role through increasing the clearance of the ET-1 peptide. ..
  31. Kitazawa T, Fujisawa K, Narboux Nême N, Arima Y, Kawamura Y, Inoue T, et al. Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015;402:162-74 pubmed publisher
    ..The present findings suggest context-dependent function of Hoxa2 in CNCC regional specification and morphogenesis, and provide novel insights into the evolution of taxa-specific patterning of PA-derived structures. ..
  32. Kitazawa T, Takechi M, Hirasawa T, Adachi N, Narboux Nême N, Kume H, et al. Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids. Nat Commun. 2015;6:6853 pubmed publisher
    ..We propose that differences in connection and release by various pharyngeal skeletal elements resulted in structural diversity, leading to the acquisition of the tympanic membrane in two distinct manners during amniote evolution. ..
  33. Feiner L, Webber A, Brown C, Lu M, Jia L, Feinstein P, et al. Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption. Development. 2001;128:3061-70 pubmed
    ..Their entry is disrupted in semaphorin 3C mutant mice. These data suggest that semaphorin 3C promotes crest cell migration into the proximal cardiac outflow tract. ..
  34. Jeoung M, Lee S, Hawng H, Cheon Y, Jeong Y, Gye M, et al. Identification of a novel role for endothelins within the oviduct. Endocrinology. 2010;151:2858-67 pubmed publisher
    ..Overall, these results suggest a novel and requisite role for endothelins within the oviduct during fertilization and/or early embryo development. ..
  35. Jung K, Kim D, Lee H, Lee Y, Lee S, Che J, et al. The role of endothelin receptor A during myelination of developing oligodendrocytes. J Korean Med Sci. 2011;26:92-9 pubmed publisher
    Endothelin (ET)-1 and its receptors (ETA and ETB receptor) are present in the central nervous system. ET exerts biological effects on gliogenesis and glial cell functions...
  36. Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff Swiercz D, et al. Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008;135:755-65 pubmed publisher
    The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3) and their G-protein-coupled type A (Ednra) and type B (Ednrb) receptors...
  37. Zhang Y, Knutsen G, Brown M, Ruest L. Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2. Mol Endocrinol. 2013;27:892-908 pubmed publisher
    The endothelin-A receptor (Ednra) is involved in several physiological, pathological, and developmental pathways...
  38. Smollich M, Götte M, Fischgräbe J, Macedo L, Brodie A, Chen S, et al. ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole. Breast Cancer Res Treat. 2010;123:345-57 pubmed publisher
    Endothelin-1 (ET-1) and endothelin A receptor (ETAR) contribute to the development and progression of breast carcinomas by modulating cell proliferation, angiogenesis, and anti-apoptosis...
  39. Bo Yang -, Chen Y, Li T, Feng Q. Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation. J Renin Angiotensin Aldosterone Syst. 2010;11:119-23 pubmed publisher
    ..103+/-3 mmHg, p<0.001). We conclude that RAAS components are upregulated under endothelin blockade. Dual blockade of the RAAS and endothelin system is beneficial for blood pressure control. ..
  40. Kanzaki Kato N, Tamakoshi T, Fu Y, Chandra A, Itakura T, Uezato T, et al. Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc Res. 2005;65:711-8 pubmed
    ..Endothelin receptor type-A (ETA) is one of the two known endothelin receptors that belong to the G-protein-coupled receptor family...
  41. Bhalla S, Andurkar S, Gulati A. Involvement of ??-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice. Fundam Clin Pharmacol. 2013;27:498-509 pubmed publisher
    ..Imidazoline receptors and ??-adrenoceptors are involved in agmatine-induced reversal of oxycodone hypothermia. Our findings also suggest that ET(A) receptors may be involved in blockade of oxycodone hypothermia by agmatine. ..
  42. Thai T, Arendshorst W. ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo. Am J Physiol Renal Physiol. 2008;295:F360-8 pubmed publisher
    ..We hypothesized that this signaling pathway is activated by ETA and ETB receptors in the renal vasculature to mediate vasoconstriction in vivo...
  43. Dibra D, Xia X, Mitra A, Cutrera J, Lozano G, Li S. Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice. Hepatology. 2016;63:1000-12 pubmed publisher
    ..Mechanistically, endothelin A receptor (ETAR)-positive macrophages are highly accumulated in the inflamed liver, and chemical inhibition of ETAR ..
  44. Clouthier D, Williams S, Yanagisawa H, Wieduwilt M, Richardson J, Yanagisawa M. Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice. Dev Biol. 2000;217:10-24 pubmed
    ..In particular, this developmental pathway appears distinct from the pathway that includes UFD1L, implicated as a causative gene in CATCH 22 patients, and suggests parallel complementary pathways mediating craniofacial development. ..
  45. Maeda K, Asai R, Maruyama K, Kurihara Y, Nakanishi T, Kurihara H, et al. Postotic and preotic cranial neural crest cells differently contribute to thyroid development. Dev Biol. 2016;409:72-83 pubmed publisher
    ..Therefore, not only the postotic CNC, but also the preotic CNC plays an important role in thyroid morphogenesis. ..
  46. Catar R, Muller G, Brandt A, Langbein H, Brunssen C, Goettsch C, et al. Increased gene expression of the cardiac endothelin system in obese mice. Horm Metab Res. 2015;47:509-15 pubmed publisher
    ..In conclusion, an increased expression of genes of the endothelin system was observed in the hearts of 18-week-old mice after high-fat diet, possibly contributing to later cardiovascular complications of obesity. ..
  47. Kochilas L, Merscher Gomez S, Lu M, Potluri V, Liao J, Kucherlapati R, et al. The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. Dev Biol. 2002;251:157-66 pubmed
    ..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation. ..
  48. Lenoir O, Milon M, Virsolvy A, Henique C, Schmitt A, Masse J, et al. Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosis. J Am Soc Nephrol. 2014;25:1050-62 pubmed publisher
    ..We then generated mice with a podocyte-specific double deletion of ETAR and ETBR (NPHS2-Cre×Ednra(lox/lox)×Ednrb(lox/lox) [Pod-ETRKO])...
  49. Hua L, Vedantham V, Barnes R, Hu J, Robinson A, Bressan M, et al. Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014;393:245-254 pubmed publisher
    ..We found that mouse embryos that were homozygous null for both ednra and ednrb, the genes encoding the two Endothelin receptors in mice, were born at predicted Mendelian frequency and ..
  50. Donato A, Lesniewski L, Stuart D, Walker A, Henson G, Sorensen L, et al. Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci. 2014;118:238-43 pubmed publisher
    ..Mice were homozygous for loxP-flanked exons 6-8 of the EDNRA gene (floxed) or were also hemizygous for a transgene expressing Cre recombinase under control of the smooth ..
  51. Fryer R, Rakestraw P, Banfor P, Cox B, Opgenorth T, Reinhart G. Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade. Am J Physiol Heart Circ Physiol. 2006;290:H2554-9 pubmed
  52. Wang J, Lu S, Zheng Q, Hu N, Yu W, Li N, et al. Cardiac-Specific Knockout of ETA Receptor Mitigates Paraquat-Induced Cardiac Contractile Dysfunction. Cardiovasc Toxicol. 2016;16:235-43 pubmed publisher
    ..This study was designed to examine the role of endothelin receptor A (ETA) in paraquat-induced cardiac contractile and mitochondrial injury...
  53. Scarparo A, Isoldi M, de Lima L, Visconti M, Castrucci A. Expression of endothelin receptors in frog, chicken, mouse and human pigment cells. Comp Biochem Physiol A Mol Integr Physiol. 2007;147:640-6 pubmed
    ..RT-PCR was performed with specific primers for ETC, ETA(X) or ETA in Xenopus laevis melanophores, ETA or ETB(2) in chicken melanocytes, ETA or ETB in murine (B-16, S-91 or ..
  54. Gordon C, Weaver K, Zechi Ceide R, Madsen E, Tavares A, Oufadem M, et al. Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015;96:519-31 pubmed publisher
    The endothelin receptor type A (EDNRA) signaling pathway is essential for the establishment of mandibular identity during development of the first pharyngeal arch...
  55. Qi H, Casalena G, Shi S, Yu L, Ebefors K, Sun Y, et al. Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility. Diabetes. 2017;66:763-778 pubmed publisher
    ..endothelial mitochondrial dysfunction was associated with increased glomerular endothelin-1 receptor type A (Ednra) expression and increased circulating endothelin-1 (Edn1)...
  56. Dufek B, Meehan D, Delimont D, Cheung L, Gratton M, Phillips G, et al. Endothelin A receptor activation on mesangial cells initiates Alport glomerular disease. Kidney Int. 2016;90:300-310 pubmed publisher
    ..These microspikes do not form when cells are treated with the endothelin A receptor antagonist sitaxentan or under conditions of small, interfering RNA knockdown of endothelin A receptor ..
  57. Yanagisawa H, Hammer R, Richardson J, Williams S, Clouthier D, Yanagisawa M. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. J Clin Invest. 1998;102:22-33 pubmed
    ..generated from its inactive precursor by endothelin-converting enzyme-1 (ECE-1) and acts on the endothelin-A (ETA) receptor...
  58. Ruest L, Clouthier D. Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism. Dev Biol. 2009;328:94-108 pubmed publisher
    ..signaling cascades participate in patterning cranial NCCs, some of which are regulated by endothelin-A receptor (Ednra) signaling...
  59. Kuwaki T, Ling G, Onodera M, Ishii T, Nakamura A, Ju K, et al. Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol. 1999;26:989-94 pubmed
    ..To address this question, we examined ABP and ventilation in mutant mice deficient in ET-1, ETA and ETB receptors and endothelin-converting enzyme-1, which were made by gene targeting. 2...
  60. Ohuchi T, Kuwaki T, Ling G, deWit D, Ju K, Onodera M, et al. Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice. Am J Physiol. 1999;276:R1071-7 pubmed
    Exogenously administered endothelin (ET) elicits both pressor and depressor responses through the ETA and/or the ETB receptor on vascular smooth muscle cells and ETB on endothelial cells...
  61. Kitano Y, Kurihara H, Kurihara Y, Maemura K, Ryo Y, Yazaki Y, et al. Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. J Bone Miner Res. 1998;13:237-44 pubmed
    ..and whether expression of bone matrix genes are modulated by ET-1, we examined gene expression of ET-1 receptors, ETA and ETB, and that of the bone matrix proteins, osteonectin (ON) and osteopontin (OP), both in the head regions of ..
  62. Wiley K, Davenport A. Endothelin receptor pharmacology and function in the mouse: comparison with rat and man. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S4-6 pubmed
    ..The endothelin-A (ETA) selective antagonist bound to mouse heart with two affinities, yielding a KDETA of 1.1 +/- 0...
  63. Barton M, Haudenschild C, d Uscio L, Shaw S, Munter K, Luscher T. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A. 1998;95:14367-72 pubmed
    ..mice and C57BL/6 control mice were treated with a Western-type diet to accelerate atherosclerosis with or without ETA receptor antagonist LU135252 (50 mg/kg/d) for 30 wk...
  64. Buelli S, Rosanò L, Gagliardini E, Corna D, Longaretti L, Pezzotta A, et al. ?-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury. J Am Soc Nephrol. 2014;25:523-33 pubmed publisher
  65. Ge Y, Stricklett P, Hughes A, Yanagisawa M, Kohan D. Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure. Am J Physiol Renal Physiol. 2005;289:F692-8 pubmed
    ..Furthermore, the CD ET(A) receptor does not appear to be involved in modulation of systemic blood pressure or renal Na excretion under physiological conditions. ..
  66. Liu T, Long L, Tang T, Xia Q, Liu J, He G, et al. Expression and localization of endothelin-1 and its receptors in the spiral ganglion neurons of mouse. Cell Mol Neurobiol. 2009;29:739-45 pubmed publisher
    ..The present results suggest that ET-1 may play physiological roles in the spiral ganglion cells via ETAR and ETBR. ..
  67. Sun Y, Teng I, Huo R, Rosenfeld M, Olson L, Li X, et al. Asymmetric requirement of surface epithelial ?-catenin during the upper and lower jaw development. Dev Dyn. 2012;241:663-74 pubmed publisher
    ..In addition, these findings suggest that evolutionary changes of the canonical Wnt/?-catenin signaling pathway may lead to innovation of jaws. ..
  68. Nakamura T, Ebihara I, Fukui M, Osada S, Tomino Y, Masaki T, et al. Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice. J Am Soc Nephrol. 1993;4:1064-72 pubmed
    ..4-fold more than controls at 3 wk. ET-3 mRNA levels did not differ between cystic and control mice. Renal ETA and ETB receptor mRNA increased gradually in cystic mice with the progression of their cysts, reaching 4.2- and 6...
  69. Ortmann J, Traupe T, Nett P, Celeiro J, Hofmann Lehmann R, Lange M, et al. Upregulation of vascular ET(B) receptor gene expression after chronic ET(A) receptor blockade in prediabetic NOD mice. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S105-8 pubmed
    ..A subgroup of 10- week-old animals was treated with the endothelin ETA receptor antagonist LU461314 (30 mg/kg per day for 6 weeks). Blood glucose levels were normal in all animals...
  70. Marchant D, Dou Y, Luo H, Garmaroudi F, McDonough J, Si X, et al. Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. Circ Res. 2009;104:813-21 pubmed publisher
    ..Caution must be exercised during treatment of suspected infectious myocarditis with supportive vasoactive remedies. ..
  71. Fogelgren B, Yang S, Sharp I, Huckstep O, Ma W, Somponpun S, et al. Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. Am J Physiol Renal Physiol. 2009;296:F1166-78 pubmed publisher
    ..Defects are associated with embryological deficiencies of Six2, suggesting that proper levels of this protein during nephrogenesis are critical for normal glomerular development and adult renal function. ..
  72. Lehmann L, Rostosky J, Buss S, Kreusser M, Krebs J, Mier W, et al. Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling. Proc Natl Acad Sci U S A. 2014;111:13499-504 pubmed publisher
    In preclinical studies, endothelin receptor A (ETA) antagonists (ETAi) attenuated the progression of heart failure (HF). However, clinical HF trials failed to demonstrate beneficial effects of ETAi...
  73. Fukuhara S, Kurihara Y, Arima Y, Yamada N, Kurihara H. Temporal requirement of signaling cascade involving endothelin-1/endothelin receptor type A in branchial arch development. Mech Dev. 2004;121:1223-33 pubmed
    ..epithelium and core mesenchyme, acts on cranial neural crest-derived ectomesenchymcal cells expressing endothelin A receptor (ETAR) and regulates expression of crucial genes such as Dlx6, a member of distalless homeobox gene family,..
  74. Claudino R, Leite D, Bento A, Chichorro J, Calixto J, Rae G. Potential role for ET-2 acting through ETA receptors in experimental colitis in mice. Inflamm Res. 2017;66:141-155 pubmed publisher
    ..Atrasentan treatment was effective in reducing the severity of colitis in DSS- and TNBS-treated mice, suggesting that ETA receptors might be a potential target for inflammatory bowel diseases. ..
  75. Adur J, Takizawa S, Quan J, Uchide T, Saida K. Increased gene expression and production of murine endothelin receptors after birth. Biochem Biophys Res Commun. 2003;305:700-6 pubmed
    ..These findings were corroborated through observation of the correlation between the gene expression and (poly)peptide production of the ET system in normal skin before and after parturition. ..
  76. Compernolle V, Brusselmans K, Franco D, Moorman A, Dewerchin M, Collen D, et al. Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha. Cardiovasc Res. 2003;60:569-79 pubmed
    ..HIF-1alpha is essential for proper cardiac development by modulating both neural crest migration and ventricle formation. ..