Ednra

Summary

Gene Symbol: Ednra
Description: endothelin receptor type A
Alias: AEA001, ET-AR, ETa, Gpcr10, Mhdaaea1, endothelin-1 receptor, ET-A, G-protein coupled receptor 10, endothelin A receptor
Species: mouse

Top Publications

  1. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
  2. pmc Deletion of the endothelin-A receptor gene within the developing mandible
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY, 40292, USA
    Cell Tissue Res 319:447-53. 2005
  3. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
  4. pmc Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol
    Rafal M Kedzierski
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell Biol 23:8226-32. 2003
  5. ncbi Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
  6. ncbi Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
    H Yanagisawa
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    Development 125:825-36. 1998
  7. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
  8. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
  9. pmc Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
    Amir Rattner
    Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:E3830-9. 2013
  10. pmc Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation
    Sibylle Sabrautzki
    Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstr 1, 85764, Neuherberg, Germany
    Mamm Genome 27:587-598. 2016

Scientific Experts

  • Tomoyuki Kuwaki
  • Charles S Wingo
  • Shaifali Bhalla
  • A P Davenport
  • Hironori Yuyama
  • VESA M KAARTINEN
  • Kazuhiro Kawamura
  • Lazaros Kochilas
  • R M Fryer
  • Tiffany L Thai
  • William B Mathews
  • Christopher T Gordon
  • Yaz Y Kisanuki
  • Bo Yang
  • Yukiko Kurihara
  • Hiroki Kurihara
  • Rieko Asai
  • Masashi Yanagisawa
  • Takahiro Sato
  • Donald E Kohan
  • Taro Kitazawa
  • Louis Bruno Ruest
  • Yasunobu Uchijima
  • Yuqiang Ge
  • Giovanni Levi
  • David E Clouthier
  • Kazuhiro Maeda
  • Sachiko Miyagawa-Tomita
  • Deborah Stuart
  • Koichi Nishiyama
  • Takako Makita
  • Yuichiro Arima
  • Laura Rosanò
  • Yumiko Kawamura
  • Javier Adur
  • D E Clouthier
  • Sibylle Sabrautzki
  • H Yanagisawa
  • Jie Niu
  • Peter K Stricklett
  • Eleana Manousiouthakis
  • Simona Buelli
  • Lorenz H Lehmann
  • Anthony J Donato
  • Jian Guo
  • Ki Sung Kim
  • Amir Rattner
  • Yingmei Zhang
  • Lenyta Oliveira Gomes
  • Nelida Olave
  • Ye Sun
  • Vladislav Bugaj
  • M Yanagisawa
  • Kyung Jin Jung
  • Yong Ri Jin
  • Ryan Boyd
  • Anna Bagnato
  • Martin Smollich
  • Sebastian Stösser
  • MyoungKun Jeoung
  • Panayiota Papadopoulos
  • - Bo Yang
  • David Marchant
  • Hong Qiang Feng
  • Ben Fogelgren
  • Tao Liu
  • Kazuo Tonami
  • Kathryn N Ivey
  • Qingjie Xia
  • Jin Liu
  • Yuri Kotelevtsev
  • J A Richardson
  • S B Bender
  • Yan Luo
  • S C Williams
  • Makoto Abe
  • Ana Cristina Scarparo
  • Alan Bagnall
  • Ardavan Akhavan
  • Naoko Kanzaki-Kato
  • Shigetomo Fukuhara
  • Aaron D Gitler
  • Katherine E Wiley
  • Jana Ortmann
  • Tsuyoshi Uchide
  • Kaname Saida
  • Jiexia Quan
  • Satoshi Takizawa
  • Christoph Lengger
  • Ingrid L Vargas Panesso

Detail Information

Publications84

  1. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  2. pmc Deletion of the endothelin-A receptor gene within the developing mandible
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY, 40292, USA
    Cell Tissue Res 319:447-53. 2005
    Signaling from the endothelin-A (Ednra) receptor is responsible for initiating multiple signaling pathways within neural crest cells (NCCs)...
  3. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
  4. pmc Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol
    Rafal M Kedzierski
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell Biol 23:8226-32. 2003
    ..Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac ..
  5. ncbi Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Development 125:813-24. 1998
    ..Here we demonstrate that mice deficient for one type of endothelin receptor, ETA, mimic the human conditions collectively termed CATCH 22 or velocardiofacial syndrome, which include severe ..
  6. ncbi Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
    H Yanagisawa
    Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    Development 125:825-36. 1998
    ..exhibited craniofacial and cardiac abnormalities virtually identical to the defects seen in ET-1 and endothelin A receptor (ETA)-deficient embryos...
  7. pmc Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons
    Takako Makita
    The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 452:759-63. 2008
    ..1), acting through the endothelin receptor EdnrA (refs 2, 3), directs extension of axons of a subset of sympathetic neurons from the superior cervical ganglion to ..
  8. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
    ..The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation...
  9. pmc Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
    Amir Rattner
    Departments of Molecular Biology and Genetics, Neuroscience, and Ophthalmology and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:E3830-9. 2013
    ..The response to Edn2 is sufficiently potent that it overrides the activities of other homeostatic regulators of angiogenesis, such as Vegf. ..
  10. pmc Viable Ednra Y129F mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation
    Sibylle Sabrautzki
    Institute of Experimental Genetics and German Mouse Clinic, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstr 1, 85764, Neuherberg, Germany
    Mamm Genome 27:587-598. 2016
    ..dominant mouse model carrying a non-synonymous sequence variation within the endothelin receptor type A gene (Ednra c.386A>T, p.Tyr129Phe) derived by an ENU mutagenesis program...
  11. doi Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice
    Shaifali Bhalla
    Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA
    Fundam Clin Pharmacol 27:498-509. 2013
    ..Imidazoline receptors and α₂-adrenoceptors are involved in agmatine-induced reversal of oxycodone hypothermia. Our findings also suggest that ET(A) receptors may be involved in blockade of oxycodone hypothermia by agmatine...
  12. doi Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms
    Ki Sung Kim
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 130:553-66. 2013
    ..In craniofacial development, Edn1 binds to Endothelin type-A receptor (Ednra) to induce homeobox genes Dlx5/Dlx6 and determines the mandibular identity in the first pharyngeal arch...
  13. pmc β-arrestin-1 drives endothelin-1-mediated podocyte activation and sustains renal injury
    Simona Buelli
    IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Centro Anna Maria Astori, Bergamo, Italy
    J Am Soc Nephrol 25:523-33. 2014
    ....
  14. pmc Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development
    Anthony J Donato
    George E Wahlen Department of Veterans Affairs Medical Center, Geriatric Research Education and Clinical Center, 500 Foothill Drive, Salt Lake City, UT 84148, USA Department of Internal Medicine, University of Utah School of Medicine, University of Utah, 30 N 1900 E AB193 SOM, Salt Lake City, UT 84132 0001, USA
    Life Sci 118:238-43. 2014
    The role of vascular smooth muscle endothelin A receptors (ETA) in development and normal physiology remains incompletely understood. To address this, mice were generated with smooth muscle-specific knockout (KO) of ETA.
  15. pmc Targeting endothelin receptors A and B attenuates the inflammatory response and improves locomotor function following spinal cord injury in mice
    Jian Guo
    Department of Orthopaedic Surgery, Ningbo Beilun People Hospital, Ningbo, Zhejiang 315800, P R China
    Int J Mol Med 34:74-82. 2014
    ..The findings of the present study therefore suggested an association between ETAR and ETBR in regulating early pathogenesis of SCI and determining the outcomes of long‑term neurological recovery...
  16. pmc Venous endothelin guides sympathetic innervation of the developing mouse heart
    Eleana Manousiouthakis
    1 Developmental Neuroscience Program, The Saban Research Institute, Children s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, California 90027, USA 2
    Nat Commun 5:3918. 2014
    ..of these routes is determined by venous endothelium-derived endothelin-1, acting through its specific receptor Ednra expressed within a subpopulation of STG neurons...
  17. pmc Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling
    Lorenz H Lehmann
    Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, D 69120 Heidelberg, Germany DZHK German Centre for Cardiovascular Research, partner site Heidelberg Mannheim, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 111:13499-504. 2014
    In preclinical studies, endothelin receptor A (ETA) antagonists (ETAi) attenuated the progression of heart failure (HF). However, clinical HF trials failed to demonstrate beneficial effects of ETAi...
  18. doi Association between endothelin-1/endothelin receptor A and inflammation in mouse kidneys following acute ischemia/reperfusion
    Jie Niu
    Morphology Laboratory of Xinxiang Medical University, Xinxiang, Henan 453003, P R China
    Mol Med Rep 11:3981-7. 2015
    ..Expression of endothelin‑1 (ET‑1) and its receptor ETA were also reported to be involved in the development of acute and chronic renal disease...
  19. pmc Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia
    Christopher T Gordon
    INSERM UMR 1163, Institut Imagine, Paris 75015, France Université Paris Descartes Sorbonne Paris Cité, Institut Imagine, Paris 75015, France Electronic address
    Am J Hum Genet 96:519-31. 2015
    The endothelin receptor type A (EDNRA) signaling pathway is essential for the establishment of mandibular identity during development of the first pharyngeal arch...
  20. pmc Developmental genetic bases behind the independent origin of the tympanic membrane in mammals and diapsids
    Taro Kitazawa
    1 Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan 2 Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, Chiyoda ku, Tokyo 102 0076, Japan
    Nat Commun 6:6853. 2015
    ..We propose that differences in connection and release by various pharyngeal skeletal elements resulted in structural diversity, leading to the acquisition of the tympanic membrane in two distinct manners during amniote evolution. ..
  21. doi Postotic and preotic cranial neural crest cells differently contribute to thyroid development
    Kazuhiro Maeda
    Department of Pediatric Cardiology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Dev Biol 409:72-83. 2016
    ..Therefore, not only the postotic CNC, but also the preotic CNC plays an important role in thyroid morphogenesis. ..
  22. doi ETA and ETB receptors are expressed in vascular adventitial fibroblasts
    Ryan Boyd
    Department of Community Health Sciences, Faculty of Applied Health Sciences, Brock University, St Catharines, Ontario, Canada
    Am J Physiol Heart Circ Physiol 301:H2271-8. 2011
    ..The ET(A) receptor subtype mediates collagen I expression, whereas the ET(B) receptor subtype may play a protective role through increasing the clearance of the ET-1 peptide...
  23. pmc Collecting duct-specific endothelin B receptor knockout increases ENaC activity
    Vladislav Bugaj
    Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
    Am J Physiol Cell Physiol 302:C188-94. 2012
    ..ET-1 significantly decreased ENaC open probability in CD isolated from wild-type (WT) and CD ETA KO mice but not CD ETB KO and CD ETA/B KO mice...
  24. pmc Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure
    Nelida Olave
    Department of Pediatrics, Univ of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Physiol Lung Cell Mol Physiol 302:L857-65. 2012
    ..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-β signaling indicates that TGF-β is upstream of ET-1 during hypoxia-induced signaling in the newborn lung...
  25. pmc Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development
    Ye Sun
    Department of Urology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Dev Dyn 241:663-74. 2012
    ..In this study, we report an unexpected stage- and tissue-specific function of β-catenin during mammalian jaw development...
  26. pmc Disruption of the endothelin A receptor in the nephron causes mild fluid volume expansion
    Deborah Stuart
    Division of Nephrology, University of Utah Health Sciences Center, 1900 East 30 North, Salt Lake City, UT 84132, USA
    BMC Nephrol 13:166. 2012
    Endothelin, via endothelin A receptors (ETA), exerts multiple pathologic effects that contribute to disease pathogenesis throughout the body...
  27. pmc Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction
    Yingmei Zhang
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    J Mol Cell Biol 4:97-107. 2012
    ..These data suggest that ETAKO protects against cold exposure-induced cardiac remodeling and dysfunction mediated through TRPV1 and mitochondrial function...
  28. doi Endothelin-1 induces itch and pain in the mouse cheek model
    Lenyta Oliveira Gomes
    Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Life Sci 91:628-33. 2012
    ..This study reexamines these sensory effects of ET-1 in the new mouse cheek model, in which pruritogens and algogens evoke distinct behavioral responses...
  29. pmc Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention
    Yuqiang Ge
    Division of Nephrology, Univ of Utah Health Sciences Center, 1900 East, 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 295:F1635-40. 2008
    ..CD-specific knockout (KO) of ET-1 causes hypertension, CD-specific KO of the ETA receptor does not alter BP, while CD-specific KO of the ETB receptor increases BP to a lesser extent than CD ET-1 ..
  30. pmc ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo
    Tiffany L Thai
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7545, USA
    Am J Physiol Renal Physiol 295:F360-8. 2008
    ..We hypothesized that this signaling pathway is activated by ETA and ETB receptors in the renal vasculature to mediate vasoconstriction in vivo...
  31. doi Paracrine regulation of the resumption of oocyte meiosis by endothelin-1
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 327:62-70. 2009
    ..hormone-receptor pairs, we found increases in ovarian transcripts for endothelin-1 and endothelin receptor type A (EDNRA) in response to the preovulatory luteinizing hormone (LH)/human chorionic gonadotropin (hCG) stimulation...
  32. pmc Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism
    Louis Bruno Ruest
    Department of Craniofacial Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Dev Biol 328:94-108. 2009
    ..signaling cascades participate in patterning cranial NCCs, some of which are regulated by endothelin-A receptor (Ednra) signaling...
  33. pmc Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice
    Ben Fogelgren
    Deptartment of Anatomy, Biochemistry, and Physiology, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
    Am J Physiol Renal Physiol 296:F1166-78. 2009
    ..Defects are associated with embryological deficiencies of Six2, suggesting that proper levels of this protein during nephrogenesis are critical for normal glomerular development and adult renal function...
  34. doi Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis
    David Marchant
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Pathology and Laboratory Medicine, University of British Columbia, Providence Heart and Lung Institute, St Paul s Hospital, Vancouver, BC V6Z1Y6, Canada
    Circ Res 104:813-21. 2009
    ..Caution must be exercised during treatment of suspected infectious myocarditis with supportive vasoactive remedies...
  35. pmc Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease
    Hong Qiang Feng
    Division of Digestive and Liver Diseases, The University of Texas, Southwestern Medical Center, Dallas, TX 75390 8887, USA
    Am J Physiol Gastrointest Liver Physiol 297:G27-33. 2009
    ..The data imply a relationship between hepatic fibrogenesis or fibrosis and vasomotor responses...
  36. doi Expression and localization of endothelin-1 and its receptors in the spiral ganglion neurons of mouse
    Tao Liu
    Department of Otorhinolaryngology, West China Hospital of Sichuan University, No 37 Guo Xue Xiang, 610041, Chengdu, Sichuan, People s Republic of China
    Cell Mol Neurobiol 29:739-45. 2009
    ..The present results suggest that ET-1 may play physiological roles in the spiral ganglion cells via ETAR and ETBR...
  37. doi Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion
    Sebastian Stösser
    Institute for Pharmacology, University of Heidelberg, Heidelberg, Germany
    Pain 148:206-14. 2010
    ..These results help understand the role of ET(A) receptors in complex biological processes and peripheral cell-cell interactions involved in inflammatory and tumor-associated pain...
  38. doi ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole
    Martin Smollich
    Department of Obstetrics and Gynecology, University Hospital of Munster, Albert Schweitzer Str 33, 48129, Munster, Germany
    Breast Cancer Res Treat 123:345-57. 2010
    Endothelin-1 (ET-1) and endothelin A receptor (ETAR) contribute to the development and progression of breast carcinomas by modulating cell proliferation, angiogenesis, and anti-apoptosis...
  39. doi Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation
    - Bo Yang
    Department of Cardiology, Chinese PLA People s Liberation Army General Hospital, No 28, Fu xing Road, Beijing 100853, China
    J Renin Angiotensin Aldosterone Syst 11:119-23. 2010
    ..To compare the level of expression of the renin-angiotensin-aldosterone system (RAAS) in mice with or without the endothelin-1 receptor antagonist bosentan and to examine the potential value in blood pressure regulation...
  40. pmc Identification of a novel role for endothelins within the oviduct
    MyoungKun Jeoung
    Division of Clinical and Reproductive Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Endocrinology 151:2858-67. 2010
    ..Overall, these results suggest a novel and requisite role for endothelins within the oviduct during fertilization and/or early embryo development...
  41. doi Low blood pressure in endothelial cell-specific endothelin 1 knockout mice
    Yaz Y Kisanuki
    Departments of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Tex75390 8584, USA
    Hypertension 56:121-8. 2010
    ..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor...
  42. doi Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease
    Panayiota Papadopoulos
    Laboratory of Cerebrovascular Research, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
    Can J Physiol Pharmacol 88:652-60. 2010
    ..Here we studied the effects of chronic treatments with selective ETA (ABT-627) or ETB (A-192621) receptor antagonist on cerebrovascular reactivity, cerebral perfusion, or memory ..
  43. doi Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation
    Rieko Asai
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 137:3823-33. 2010
    ..identify in the mouse a subpopulation of the first (crescent-forming) field marked by endothelin receptor type A (Ednra) gene expression, which contributes to chamber myocardium through a unique type of cell behavior...
  44. pmc The role of endothelin receptor A during myelination of developing oligodendrocytes
    Kyung Jin Jung
    Department of Anatomy, Institute for Brain Research, Chungnam National University School of Medicine, Daejeon, Korea
    J Korean Med Sci 26:92-9. 2011
    Endothelin (ET)-1 and its receptors (ETA and ETB receptor) are present in the central nervous system. ET exerts biological effects on gliogenesis and glial cell functions...
  45. doi Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney
    Taro Kitazawa
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Gene Expr Patterns 11:371-7. 2011
    ..function and various disease processes through two distinct G protein-coupled receptors, Edn receptors type-A (Ednra) and type-B (Ednrb)...
  46. ncbi Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles
    G E Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 213:418-31. 1999
    ..Implications for the development of human congenital heart defects are discussed...
  47. pmc Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY 40292, USA
    Development 131:4413-23. 2004
    ..Endothelin-A receptor (Ednra) signaling in crest cells is crucial for their development, as Ednra(-/-) mice are born with severe craniofacial ..
  48. ncbi Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells
    Vesa Kaartinen
    Developmental Biology Program, The Saban Research Institute of Childrens Hospital Los Angeles, Departments of Pathology and Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Development 131:3481-90. 2004
    ..Thus, the type I BMP receptor ALK2 plays an essential cell-autonomous role in the development of the cardiac outflow tract and aortic arch derivatives...
  49. ncbi Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha
    Veerle Compernolle
    Flanders Interuniversitary Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Res 60:569-79. 2003
    ..We attempted to further characterize the underlying mechanisms resulting in abnormal cardiogenesis and defective angiogenesis in mice deficient for HIF-1alpha (HIF-1alpha(-/-))...
  50. ncbi Increased gene expression and production of murine endothelin receptors after birth
    Javier Adur
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Biochem Biophys Res Commun 305:700-6. 2003
    ..These findings were corroborated through observation of the correlation between the gene expression and (poly)peptide production of the ET system in normal skin before and after parturition...
  51. ncbi The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome
    Lazaros Kochilas
    Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
    Dev Biol 251:157-66. 2002
    ..Based on our studies, we propose that Lgdel genes are required for the expression of soluble signals that regulate neural crest cell differentiation...
  52. ncbi Targeted disruption of semaphorin 3C leads to persistent truncus arteriosus and aortic arch interruption
    L Feiner
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Development 128:3061-70. 2001
    ..Their entry is disrupted in semaphorin 3C mutant mice. These data suggest that semaphorin 3C promotes crest cell migration into the proximal cardiac outflow tract...
  53. ncbi beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport
    T Imamura
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
    J Biol Chem 276:43663-7. 2001
    The insulin and the endothelin type A (ETA) receptor both can couple into the heterotrimeric G protein alpha(q/11) (Galpha(q/11)), leading to Galpha(q/11) tyrosine phosphorylation, phosphatidylinositol 3-kinase activation, and subsequent ..
  54. ncbi Endothelin in the central control of cardiovascular and respiratory functions
    T Kuwaki
    Department of Physiology, School of Medicine, Chiba University, Japan
    Clin Exp Pharmacol Physiol 26:989-94. 1999
    ..To address this question, we examined ABP and ventilation in mutant mice deficient in ET-1, ETA and ETB receptors and endothelin-converting enzyme-1, which were made by gene targeting. 2...
  55. ncbi Temporal requirement of signaling cascade involving endothelin-1/endothelin receptor type A in branchial arch development
    Shigetomo Fukuhara
    Department of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Mech Dev 121:1223-33. 2004
    ..epithelium and core mesenchyme, acts on cranial neural crest-derived ectomesenchymcal cells expressing endothelin A receptor (ETAR) and regulates expression of crucial genes such as Dlx6, a member of distalless homeobox gene family,..
  56. ncbi Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice
    T Ohuchi
    Department of Physiology, Faculty of Medicine, The University of Tokyo, Tokyo 113, Japan
    Am J Physiol 276:R1071-7. 1999
    Exogenously administered endothelin (ET) elicits both pressor and depressor responses through the ETA and/or the ETB receptor on vascular smooth muscle cells and ETB on endothelial cells...
  57. ncbi Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction ana
    T Uchide
    National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    J Mol Endocrinol 22:161-71. 1999
    ..Gene expression of ET-1, ET-3, ETA and ETB was ubiquitous in almost all tissues we examined while gene expression of VIC was localized to certain ..
  58. pmc Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
    M Barton
    Cardiology, University Hospital Zürich and Cardiovascular Research Laboratory, Institute of Physiology, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:14367-72. 1998
    ..mice and C57BL/6 control mice were treated with a Western-type diet to accelerate atherosclerosis with or without ETA receptor antagonist LU135252 (50 mg/kg/d) for 30 wk...
  59. pmc Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
    H Yanagisawa
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
    J Clin Invest 102:22-33. 1998
    ..generated from its inactive precursor by endothelin-converting enzyme-1 (ECE-1) and acts on the endothelin-A (ETA) receptor...
  60. ncbi Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization
    Y Kitano
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Bone Miner Res 13:237-44. 1998
    ..and whether expression of bone matrix genes are modulated by ET-1, we examined gene expression of ET-1 receptors, ETA and ETB, and that of the bone matrix proteins, osteonectin (ON) and osteopontin (OP), both in the head regions of ..
  61. ncbi Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation
    K Reid
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Development 122:3911-9. 1996
    ..These findings indicate two key roles for endothelin in melanocyte development: regulation of expansion of the progenitor pool and differentiation of progenitors into mature melanocytes...
  62. ncbi Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice
    K Maemura
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Cardiovasc Pharmacol 26:S17-21. 1995
    ..Neither compensation by redundant expression of other ET isoforms nor upregulation of ET receptors could explain the elevated blood pressure in Edn1+/- heterozygous mice...
  63. ncbi Regulation of retinoblastoma gene expression in a mouse mammary tumor model
    E G Hanania
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Cancer Gene Ther 2:251-61. 1995
    ..Our studies provide experimental data to confirm that loss of RB gene activity is involved in neoplastic transformation of cells and support the multistep theory of carcinogenesis...
  64. ncbi Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis
    Naoko Kanzaki-Kato
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Cardiovasc Res 65:711-8. 2005
    ..Endothelin receptor type-A (ETA) is one of the two known endothelin receptors that belong to the G-protein-coupled receptor family...
  65. pmc Transcriptional regulation during development of the ductus arteriosus
    Kathryn N Ivey
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA
    Circ Res 103:388-95. 2008
    ....
  66. ncbi Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk mice
    T Nakamura
    Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
    J Am Soc Nephrol 4:1064-72. 1993
    ..4-fold more than controls at 3 wk. ET-3 mRNA levels did not differ between cystic and control mice. Renal ETA and ETB receptor mRNA increased gradually in cystic mice with the progression of their cysts, reaching 4.2- and 6...
  67. doi Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 135:755-65. 2008
    The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3) and their G-protein-coupled type A (Ednra) and type B (Ednrb) receptors...
  68. ncbi Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes
    S B Bender
    Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
    Am J Physiol Heart Circ Physiol 293:H2281-8. 2007
    ..Therefore, in this model, enhanced coronary ET-1 responsiveness is mediated primarily through smooth muscle ET(B) receptors, whereas the interaction with alpha(1)-ARs is mediated solely through the ET(A) receptor subtype...
  69. ncbi Combined targeting of endothelin A receptor and epidermal growth factor receptor in ovarian cancer shows enhanced antitumor activity
    Laura Rosanò
    Molecular Pathology Laboratory, Regina Elena Cancer Institute, Rome, Italy
    Cancer Res 67:6351-9. 2007
    ..The cross-signaling between the EGFR/ET(A)R pathways provides a rationale to combine EGFR inhibitors with ET(A)R antagonists, identifying new effective therapeutic opportunities for ovarian cancer...
  70. ncbi The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea
    Yan Luo
    Department of Otorhinolaryngology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
    Cell Mol Biol Lett 12:595-603. 2007
    ....
  71. pmc Fate of cranial neural crest cells during craniofacial development in endothelin-A receptor-deficient mice
    Makoto Abe
    Department of Craniofacial Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Int J Dev Biol 51:97-105. 2007
    ..Multiple factors direct the patterning of these NCCs, including endothelin-1-mediated endothelin A receptor (Edn1/Ednra) signaling...
  72. ncbi Expression of endothelin receptors in frog, chicken, mouse and human pigment cells
    Ana Cristina Scarparo
    Departamento de Fisiologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Comp Biochem Physiol A Mol Integr Physiol 147:640-6. 2007
    ..RT-PCR was performed with specific primers for ETC, ETA(X) or ETA in Xenopus laevis melanophores, ETA or ETB(2) in chicken melanocytes, ETA or ETB in murine (B-16, S-91 or ..
  73. ncbi Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
    Yuqiang Ge
    Division of Nephrology, University of Utah Health Sciences Center, 1900 East, 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 291:F1274-80. 2006
    ..Systolic BP in mice with CD-specific knockout of the ETB receptor, ETA receptor (CD ETA KO) and ET-1 (CD ET-1 KO), and their respective controls were compared during normal- and high-..
  74. ncbi Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade
    Ryan M Fryer
    Department of Integrative Pharmacology, R46R, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064 6119, USA
    Am J Physiol Heart Circ Physiol 290:H2554-9. 2006
    ....
  75. ncbi Collecting duct-specific knockout of the endothelin A receptor alters renal vasopressin responsiveness, but not sodium excretion or blood pressure
    Yuqiang Ge
    Division of Nephrology, Univ of Utah Health Sciences Center, 1900 East, 30 North, Salt Lake City, UT 84132, USA
    Am J Physiol Renal Physiol 289:F692-8. 2005
    ..Furthermore, the CD ET(A) receptor does not appear to be involved in modulation of systemic blood pressure or renal Na excretion under physiological conditions...
  76. ncbi Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice
    Hironori Yuyama
    Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S479-82. 2004
    ..These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer)...
  77. ncbi Endothelin receptor pharmacology and function in the mouse: comparison with rat and man
    Katherine E Wiley
    Clinical Pharmacology Unit, Addenbrooke s Hospital, Cambridge, UK
    J Cardiovasc Pharmacol 44:S4-6. 2004
    ..The endothelin-A (ETA) selective antagonist bound to mouse heart with two affinities, yielding a KDETA of 1.1 +/- 0...
  78. ncbi Real-time polymerase chain reaction quantification of gene expression levels of murine endothelin-A and endothelin-B receptors: gene expression profiles by the standard curve method
    Javier Adur
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S321-8. 2004
    A rapid analysis method for murine endothelin-A (ETA) and endothelin-B (ETB) receptor gene expression levels was established using real-time quantitative reverse transcriptase-polymerase chain reaction...
  79. ncbi Down-regulation of ETA receptors in ETB receptor-deficient mice
    Anthony P Davenport
    Clinical Pharmacology Unit, Centre for Clinical Investigation, Addenbrookes Hospital, Cambridge, UK
    J Cardiovasc Pharmacol 44:S276-8. 2004
    Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney...
  80. ncbi Upregulation of vascular ET(B) receptor gene expression after chronic ET(A) receptor blockade in prediabetic NOD mice
    Jana Ortmann
    Medical Policlinic, University Hospital Zurich, Zurich, Switzerland
    J Cardiovasc Pharmacol 44:S105-8. 2004
    ..A subgroup of 10- week-old animals was treated with the endothelin ETA receptor antagonist LU461314 (30 mg/kg per day for 6 weeks). Blood glucose levels were normal in all animals...
  81. doi Synthesis and in vivo evaluation of novel PET radioligands for imaging the endothelin-A receptor
    William B Mathews
    Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Nucl Med 49:1529-36. 2008
    The endothelin subtype-A (ETA) receptor is a member of a family of G-protein-coupled receptors that plays a central role in vasoconstriction, cell proliferation, and hormone production...
  82. ncbi Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA
    Dev Biol 217:10-24. 2000
    ..In particular, this developmental pathway appears distinct from the pathway that includes UFD1L, implicated as a causative gene in CATCH 22 patients, and suggests parallel complementary pathways mediating craniofacial development...
  83. pmc Endothelin receptor A blockade enhances taxane effects in prostate cancer
    Ardavan Akhavan
    Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neoplasia 8:725-32. 2006
    ..This study demonstrates ABT-627 to have additive antitumor effects when used in combination with taxane drugs both in vitro and in vivo...