Genomes and Genes
Gene Symbol: Edn1
Description: endothelin 1
Alias: ET-1, PPET1, preproET, endothelin-1, preproendothelin-1
Publications139 found, 100 shown here
- Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitudeAmie K Lund
College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, USA
Hypertension 51:803-9. 2008..Our studies establish the AHR KO mouse as a model in which modest decreases in PIO(2) lead to hypoxemia, increased plasma ET-1, and systemic hypertension without increased pulmonary prepro-ET-1 mRNA expression...
- Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusionJustin W C Leung
Department of Anatomy, The University of Hong Kong, HKSAR, China
Brain Res 1266:121-9. 2009....
- Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathwaysAmie K Lund
Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
Arterioscler Thromb Vasc Biol 29:511-7. 2009....
- A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchymeT Thomas
Department of Pediatrics, Division of Cardiology and Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9148, USA edu
Development 125:3005-14. 1998..Mice harboring a null mutation of the endothelin-1 gene (Edn1), which is expressed in the epithelial layer of the branchial arches and encodes for the endothelin-1 (ET-1) ..
- Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient miceKazuo Yamashiro
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Charterhouse Square, London, UK
J Cereb Blood Flow Metab 30:1494-503. 2010..Taken together, our data suggest that the endothelial dysfunction observed in MCA associated with hypercholesterolemia is prevented by cilostazol, an effect likely due to the increase in eNOS phosphorylation and, therefore, activity...
- High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxideK L Sweazea
College of Nursing and Health Innovation, Arizona State University, Tempe, AZ 85287 4501, USA
Horm Metab Res 43:470-6. 2011..Therefore, oxidative stress and iNOS are involved in the attenuation of endothelin-1 mediated vasoconstriction observed in isolated mesenteric arteries from high fat fed rats...
- Selective over-expression of endothelin-1 in endothelial cells exacerbates inner retinal edema and neuronal death in ischemic retinaSimon S F Cheung
Department of Anatomy, The University of Hong Kong, Hong Kong, China
PLoS ONE 6:e26184. 2011..Thus, over-expression of endothelial ET-1 in TET-1 mice may contribute to increased glutamate-induced neurotoxicity on neuronal cells and water accumulation in inner retina leading to edema...
- Mast cells promote homeostasis by limiting endothelin-1-induced toxicityMarcus Maurer
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 432:512-6. 2004..These findings identify a new biological function for mast cells: promotion of homeostasis by limiting the toxicity associated with an endogenous mediator...
- Role of endothelin 1 in the pathogenesis of chronic chagasic heart diseaseHerbert B Tanowitz
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
Infect Immun 73:2496-503. 2005On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy...
- BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertensionM Talati
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 27232 2650, USA
Am J Physiol Lung Cell Mol Physiol 299:L363-73. 2010..This is the first description of protein expression that distinguishes HPAH from IPAH in patients...
- Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosisK Laghmani
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9003, USA
J Clin Invest 107:1563-9. 2001..In C57BL/6 mice, excess acid ingestion increased renal cortical preproET-1 mRNA expression 2.4-fold and decreased preproET-3 mRNA expression by 37%...
- Endogenous aldosterone contributes to acute angiotensin II-stimulated plasminogen activator inhibitor-1 and preproendothelin-1 expression in heart but not aortaJames M Luther
Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6602, USA
Endocrinology 150:2229-36. 2009..Endogenous aldosterone contributes to the acute stimulatory effect of Ang II on PAI-1 and ppET-1 mRNA expression in the heart; renin activity correlates with basal profibrotic gene expression in the kidney...
- Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birthNicole S Olgun
College of Pharmacy and Allied Health Professions, St John s University, Jamaica, New York 11439, USA
Am J Pathol 177:1929-35. 2010..These findings may be of clinical significance, as there is currently no FDA-approved therapy for women presenting with threatened preterm delivery...
- Increased gene expression of endothelin-1 and vasoactive intestinal contractor/endothelin-2 in the mammary gland of lactating miceTakaharu Kozakai
Laboratory of Gene Function Analysis, Institute of Molecular and Cell Biology, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, 305 8566, Ibaraki, Japan
Biochem Biophys Res Commun 297:1339-43. 2002..The observed increase in ET-1 expression in differentiated epithelial cells suggests physiological roles for ET-1, including milk production and secretion in the mammary gland of lactating mice...
- Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchymeKathryn Ivey
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
Dev Biol 255:230-7. 2003..We conclude that the Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of ET-1 signaling in the pharyngeal arch mesenchyme...
- Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cellsFrancesca Spinella
Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, Rome 00158, Italy
J Biol Chem 278:41294-301. 2003....
- Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblastsH Tokuda
Department of Internal Medicine, Chubu National Hospital, National Institute for Longevity Sciences, Obu, Aichi 474 8511, Japan
Eur J Endocrinol 149:239-45. 2003..In the present study, we have investigated the involvement of SAPK/JNK in ET-1-induced HSP27 in MC3T3-E1 cells...
- Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatmentPierre Sonveaux
University of Louvain Medical School, Unit of Pharmacology and Therapeutics FATH 5349, Brussels, Belgium
Cancer Res 64:3209-14. 2004..Thus, blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led us to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy...
- Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanismDeepa Bedi
Boshell Diabetes and Metabolic Diseases Research Program, Department of Anatomy, Physiology and Pharmacology, Auburn University, USA
Biochem Biophys Res Commun 345:332-9. 2006..In conclusion, we demonstrate that ET-1 inhibits basal and insulin-stimulated adiponectin secretion through PIP(2) modulation of the actin cytoskeleton...
- Endothelin-1 induces connective tissue growth factor expression in cardiomyocytesAnna Grazia Recchia
Department of Pharmaco Biology, Cell Biology, University of Calabria, 87036 Rende CS, Italy
J Mol Cell Cardiol 46:352-9. 2009..CTGF inhibitors should be considered in setting a comprehensive pharmacological approach towards ET-1 induced cardiovascular diseases...
- Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cellsLisa R Stow
Department of Medicine, University of Florida, Gainesville, FL 32610, United States
Steroids 77:360-6. 2012Aldosterone stimulates the endothelin-1 gene (Edn1) in renal collecting duct (CD) cells by a mechanism involving the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR)...
- The inhibitory effect of miRNA-1 on ET-1 gene expressionDong Li
Department of Physiology, Second Military Medical University, Shanghai 200433, China
FEBS Lett 586:1014-21. 2012..We further confirmed that miRNA-1 could inhibit endogenous ET-1 gene expression at the post-transcriptional level. Our study provides a new perspective on the regulatory mechanism of ET-1 gene...
- Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injectionVictor K L Hung
Department of Anaesthesiology, The University of Hong Kong, HKSAR, China
Life Sci 91:618-22. 2012..Therefore, the aim of this study is to determine the role of cell-type specific ET-1 induction in the modulation of inflammatory pain processing...
- Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cellsA Yogi
Kidney Research Centre, University of Ottawa Ottawa Health Research Institute, 451 Smyth Rd, Ottawa, ON, KIH 8M5
Arterioscler Thromb Vasc Biol 27:1960-7. 2007..Here we sought to determine whether upstream regulators of mitogen-activated protein kinases (MAPKs) are differentially regulated by ET-1 and Ang II focusing on the role of c-Src and the small GTPase Ras...
- Lack of iNOS impairs endothelial function in endothelin-1 transgenic miceThomas Quaschning
Department of Nephrology, University Hospital of Freiburg, Freiburg, Germany
Kidney Blood Press Res 31:127-34. 2008....
- Mouse preproendothelin-1 gene. cDNA cloning, sequence analysis and determination of sites of expression during embryonic developmentT S Chan
Institute of Molecular Biology, University of Hong Kong
Eur J Biochem 234:819-26. 1995..These data will be useful for analyzing the function of ET-1 in these organs...
- Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1T Kuwaki
Department of Physiology, Faculty of Medicine, University of Tokyo, Japan
Am J Physiol 270:R1279-86. 1996..Our results demonstrate that ventilatory responses to hypoxia and hypercapnia are impaired in ET-1-deficient mice and suggest that endogenous ET-1 participates in the physiological control of ventilation...
- Identification of an endothelial cell-specific regulatory region in the murine endothelin-1 geneX Bu
Department of Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
J Biol Chem 272:32613-22. 1997..The combination of all three elements promotes binding of a protein complex that is endothelial cell-specific. This is the first evidence for an endothelial cell-specific DNA regulatory element and cognate binding proteins...
- Renal sympathetic nerve activity in mice: comparison between mice and rats and between normal and endothelin-1 deficient miceG Y Ling
Department of Physiology, School of Medicine, Chiba University, Chiba 260 8670, Japan
Brain Res 808:238-49. 1998..Baroreceptor resetting and normally preserved hypoxia-induced chemoreflex may explain a part of the elevation of AP in ET-1 deficient mice...
- Disruption of ET-1 gene enhances pulmonary responses to methacholine via functional mechanism in knockout miceT Nagase
Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Appl Physiol (1985) 87:2020-4. 1999..Recently, it has been reported that ET-1 and a gene encoding ET-1 (Edn1) might be involved in airway hyperresponsiveness, which is a major feature of bronchial asthma...
- Endothelin-mediated induction of heme oxygenase-1 in the spinal cord is attenuated in transgenic mice overexpressing superoxide dismutaseMartin Weinzierl
Department of Neurological Surgery, RWTH Aachen, Germany
Brain Res 1030:125-32. 2004..Together, these findings suggest that ET-1 mediates oxidative stress in the spinal cord through the modulation of spinal cord blood flow...
- Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in miceHironori Yuyama
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
J Cardiovasc Pharmacol 44:S479-82. 2004..These results suggest that selective endothelin-A receptor antagonists relieve pain in patients with various diseases in which ET-1 production increases (e.g. prostate cancer)...
- Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetesS B Bender
Department of Biomedical Sciences, Ohio University College of Osteopathic Medicine, Athens, Ohio 45701, USA
Am J Physiol Heart Circ Physiol 293:H2281-8. 2007..Therefore, in this model, enhanced coronary ET-1 responsiveness is mediated primarily through smooth muscle ET(B) receptors, whereas the interaction with alpha(1)-ARs is mediated solely through the ET(A) receptor subtype...
- Vascular inflammation in absence of blood pressure elevation in transgenic murine model overexpressing endothelin-1 in endothelial cellsFarhad Amiri
Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
J Hypertens 26:1102-9. 2008..To further characterize this model, the role of vascular inflammation was investigated in young male transgenic and wild-type littermate mice...
- Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1Fernando de Paiva Conte
Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
J Leukoc Biol 84:652-60. 2008..These findings suggest that endogenous ETs contribute to knee-joint inflammation, acting through ET(A) and ET(B) receptors and modulating edema formation, neutrophil recruitment, and production of inflammatory mediators...
- Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complicationsJane Chiu
Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
Can J Physiol Pharmacol 86:365-72. 2008..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications...
- Role of endogenous endothelin in endothelial dysfunction in murine model of systemic sclerosis: tight skin mice 1Vincent Richard
Inserm U644 and Rouen University Hospital, Institute for Biomedical Research and IFRMP 23, University of Rouen, Rouen, France
Fundam Clin Pharmacol 22:649-55. 2008..The ET antagonist bosentan prevents endothelial alterations, suggesting a major role of ET in the adverse vascular effects of SSc...
- Paracrine regulation of the resumption of oocyte meiosis by endothelin-1Kazuhiro Kawamura
Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
Dev Biol 327:62-70. 2009....
- Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsiaCissy Chenyi Zhou
Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
J Immunol 186:6024-34. 2011..In this study, we found that IgG from women with PE, in contrast to IgG from normotensive pregnant women, induced preproET-1 mRNA expression via angiotensin II type 1 receptor activation in kidneys and placentas in pregnant mice...
- Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1Y Kurihara
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
J Clin Invest 96:293-300. 1995..To clarify the physiological and pathophysiological role of ET-1, we disrupted the mouse Edn1 locus encoding ET-1 by gene targeting and demonstrated that ET-1 is essential to the normal development of ..
- Cranial and cardiac neural crest defects in endothelin-A receptor-deficient miceD E Clouthier
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Development 125:813-24. 1998..These observations define a novel genetic pathway for inductive communication between cephalic neural crest cells and their environmental counterparts...
- Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial archA Trumpp
G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
Genes Dev 13:3136-48. 1999..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
- Endothelin-1 protects astrocytes from hypoxic/ischemic injuryM C Ho
Institute of Molecular Biology, The University of Hong Kong, Pokfulam
FASEB J 15:618-26. 2001..The present study suggests that astrocytes without ET-1 are more vulnerable to H and H/I injuries and that the up-regulation of astrocytic ET-1 is essential for the survival of astrocytes...
- Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophyRalph V Shohet
Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 101:2088-93. 2004b>Endothelin 1 (ET-1), a potent vasoconstrictor peptide expressed by endothelium, is also produced in the heart in response to a variety of stresses...
- Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expressionMasaki Ieda
Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
J Clin Invest 113:876-84. 2004..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
- Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolalityYuqiang Ge
Division of Nephrology, University of Utah Health Sciences Center, 30 North 1900 East, Salt Lake City, Utah 84132, USA
Am J Physiol Renal Physiol 288:F912-20. 2005..These data indicate that CD ET-1 KO increases renal sensitivity to the urinary concentrating effects of AVP and suggest that ET-1 functions as a physiological autocrine regulator of AVP action in the CD...
- Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusionJustin W C Leung
Institute of Molecular Biology, The University of Hong Kong, Hong Kong SAR, China
J Cardiovasc Pharmacol 44:S293-300. 2004..Our present TET model will serve as an ideal model for studying the role of endothelial ET- 1 in the pathogenesis of ischemic stroke...
- Endogenous endothelin-1 is required for cardiomyocyte survival in vivoXiao Song Zhao
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Circulation 114:830-7. 2006..To investigate the role of ET-1 in the heart, we created mice with cardiomyocyte deletion of ET-1...
- Klf2 is an essential regulator of vascular hemodynamic forces in vivoJohn S Lee
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Dev Cell 11:845-57. 2006..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
- Endothelins are vascular-derived axonal guidance cues for developing sympathetic neuronsTakako Makita
The Solomon H Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 452:759-63. 2008..Moreover, they suggest a model in which newborn sympathetic neurons distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs...
- An endothelin-1 switch specifies maxillomandibular identityTakahiro Sato
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 105:18806-11. 2008..The endothelin-1 (Edn1)/endothelin receptor type-A (Ednra)-->Dlx5/6-->Hand2 signaling pathway is necessary for lower jaw formation...
- Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transitionBambang Widyantoro
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Circulation 121:2407-18. 2010..The underlying mechanism, however, remains elusive. Here, we hypothesize that ET-1 might contribute to the accumulation of cardiac fibroblasts through an endothelial-to-mesenchymal transition in diabetic hearts...
- Low blood pressure in endothelial cell-specific endothelin 1 knockout miceYaz Y Kisanuki
Departments of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Tex75390 8584, USA
Hypertension 56:121-8. 2010..Taken in conjunction with other lines of genetically altered mice, our results provide evidence for a paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 acting on the vascular smooth muscle ET(A) receptor...
- The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interactionYong Ri Jin
Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
Dev Biol 352:1-13. 2011..Dlx5, Dlx6, and Hand2 genes in mesenchymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1), within ectodermal cells...
- Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposureNelida Olave
Department of Pediatrics, Univ of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Physiol Lung Cell Mol Physiol 302:L857-65. 2012..ETAR blockade improves function but not development of the hypoxic newborn lung. Reduction of ET-1 via inhibition of TGF-β signaling indicates that TGF-β is upstream of ET-1 during hypoxia-induced signaling in the newborn lung...
- ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophySuko Adiarto
Kobe University Graduate School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine, Japan
Life Sci 91:651-7. 2012..The exact feature of these pathways and the intercellular communications involved remain unclear. In this study, we explored the role of endothelial cell-derived ET-1 in the development of AngII-induced cardiac fibrosis and hypertrophy...
- Coronary veins determine the pattern of sympathetic innervation in the developing heartJoseph Nam
Laboratory of Stem Cell and Neuro Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10 6C103, 10 Center Drive, Bethesda, MD 20892, USA
Development 140:1475-85. 2013..The proposed mechanism underlies a distinct, stereotypical pattern of autonomic innervation that is adapted to the complex tissue structure and physiology of the heart...
- Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1Y Kurihara
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Nature 368:703-10. 1994..These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis...
- Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retentionDowhan Ahn
Division of Nephrology, University of Utah Health Sciences Center, 1900 East 30 North, Salt Lake City, UT 84132, USA
J Clin Invest 114:504-11. 2004..These studies indicate that CD-derived ET-1 is an important physiologic regulator of renal Na excretion and systemic BP...
- Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessationDyah W Anggrahini
Division of Cardiovascular Medicine, Department of Internal Medicine, 7 5 1 Kusunoki, Chuo, Kobe 650 0017, Japan
Cardiovasc Res 82:143-51. 2009..In this study, we determined the role of vascular endothelial ET-1 on vascular inflammation and neointima formation using vascular endothelial ET-1-knockout [ET-1(f/f); Tie2-Cre (+)] mice...
- A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activityK Saida
Fermentation Research Institute, Agency of Industrial Science and Technology, Ibaraki, Japan
J Biol Chem 264:14613-6. 1989..Furthermore, the peptide evoked a strong contractile response in the guinea pig ileum. This peptide may thus be reasonably classified as a gastrointestinal peptide, vasoactive intestinal contractor...
- Endothelin-1 mRNA in glomerular and epithelial cells of kidneyM Chen
Department of Physiology, University of Michigan, Ann Arbor 48104
Am J Physiol 265:F542-50. 1993..Our results are consistent with the proposal that ET-1 modifies tubular function in an autocrine or paracrine fashion...
- Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridizationY Kitano
Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
J Bone Miner Res 13:237-44. 1998..We conclude that ET-1 may regulate proliferation and migration of osteogenic cells in the maxillofacial region, rather than modulating the expression level of ON and OP mRNAs...
- Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in miceH Yanagisawa
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 9050, USA
J Clin Invest 102:22-33. 1998..This study demonstrates that ET-1/ETA-mediated signaling plays an essential role in a complex process of aortic arch patterning by affecting the postmigratory cardiac neural crest cell development...
- Genetic control of ventilation: what are we learning from murine models?C G Tankersley
Division of Physiology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
Curr Opin Pulm Med 5:344-8. 1999..At the conclusion of this review, the author emphasizes the relatively small number of studies that have incorporated the use of genomics to link differential ventilatory function to molecular structure...
- Role of endothelin-1 in stress response in the central nervous systemY Kurihara
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
Am J Physiol Regul Integr Comp Physiol 279:R515-21. 2000..Our findings suggest that ET-1 modulates central coordination of stress responses in close association with catecholamine metabolism...
- Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135T Kojima
Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
Biochem Biophys Res Commun 284:1039-47. 2001..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
- beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transportT Imamura
Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0673, USA
J Biol Chem 276:43663-7. 2001....
- Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidenceHuan Huang
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park, Bronx, New York, NY 10461, U S A
Clin Sci (Lond) 103:263S-266S. 2002..These data provide further support for a role for ET-1 in the pathogenesis of chronic chagasic heart disease, and indicate that cardiac myocytes are an important source of ET-1 in this disease...
- PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular developmentAaron D Gitler
Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Dev Cell 7:107-16. 2004..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
- Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotypeJohan Lundkvist
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
Genesis 41:13-22. 2005..We discuss possible reasons for the different outcomes of the same germline CADASIL mutation in mice and humans...
- Increased sensitivity to acute and persistent pain in neuron-specific endothelin-1 knockout miceF Hasue
Department of Autonomic Physiology, 1 8 1, Nohana, Chuo Ku, Chiba shi, Chiba 260 8670, Japan
Neuroscience 130:349-58. 2005..The results of the present study suggest that neuronal ET-1 is involved in endogenous pain inhibitory control likely via pathways through the hypothalamus...
- Endothelin-1 expression in vascular adventitial fibroblastsSheng Jun An
Dept of Community Health Sciences, Faculty of Applied Health Sciences, Brock Univ, St Catharines, ON, Canada L2S 3Y6
Am J Physiol Heart Circ Physiol 290:H700-8. 2006..mRNA levels of preproET-1 and type I procollagen were detected with relative RT-PCR...
- Ets-1 is a critical transcriptional regulator of reactive oxygen species and p47(phox) gene expression in response to angiotensin IIWeihua Ni
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Circ Res 101:985-94. 2007..In summary, Ets-1 functions as a critical downstream transcriptional mediator of Ang II ROS generation by regulating the expression of NAD(P)H oxidase subunits such as p47(phox)...
- Role of prostaglandins in collecting duct-derived endothelin-1 regulation of blood pressure and water excretionYuqiang Ge
Division of Nephrology, Univ of Utah Health Sciences Center, 900 East 30 North, Salt Lake City, UT 84132, USA
Am J Physiol Renal Physiol 293:F1805-10. 2007..Furthermore, the increased PGE(2) in CD ET-1 KO mice partly compensates for loss of ET-1 with respect to maintaining urinary water excretion, but not in blood pressure control...
- Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytesE Miles Whitman
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
- Connexin43 is involved in the effect of endothelin-1 on astrocyte proliferation and glucose uptakeSandra Herrero-González
Departamento de Bioquimica y Biologia Molecular, INCYL, Universidad de Salamanca, Spain
Glia 57:222-33. 2009..Interestingly, although the rate of growth in connexin43 KO astrocytes has been reported to be reduced, we observed that an acute reduction in connexin43 by siRNA increased proliferation and glucose uptake...
- Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortalityPatrick Ka Kit Yeung
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR 852, Hong Kong, China
J Cereb Blood Flow Metab 29:1891-902. 2009..The V(2) receptor antagonist, OPC-31260, may be one of the effective drugs for the early treatment of ET-1-induced cytotoxic edema and brain injury...
- Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1N F Kelland
Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh EH16 4TJ, UK
Can J Physiol Pharmacol 88:644-51. 2010..These studies suggest that EC-ETB are largely responsible for the clearance of ET-1 from the circulation...
- Endothelin-1 contributes to increased NFATc3 activation by chronic hypoxia in pulmonary arteriesSergio de Frutos
Department of Cell Biology and Physiology, School of Medicine, University of New Mexico, Albuquerque, NM, 87131, USA
Am J Physiol Cell Physiol 301:C441-50. 2011..Here, we demonstrate that ROK increases actin polymerization, thus providing structural support for NFATc3 nuclear transport...
- Collecting duct-specific endothelin B receptor knockout increases ENaC activityVladislav Bugaj
Department of Physiology, University of Texas Health Sciences Center, San Antonio, Texas 78229, USA
Am J Physiol Cell Physiol 302:C188-94. 2012....
- APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in miceYi Wang
Department of Medicine, Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
Diabetes 60:3044-54. 2011..This study aimed to investigate the roles of the multidomain adaptor protein APPL1 in modulating vascular actions of insulin in mice and in endothelial cells...
- Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic ratsQiaoling Zhou
Department of Nephropathy, Xiangya Hospital, Central South University, Changsha City, Hunan Province, People s Republic of China
PLoS ONE 7:e47360. 2012..Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes...
- Suppression of osteoblast Toll-like receptor 2 signaling by endothelin-1Ai Suzaki
Department of General Medicine, Surugadai Nihon University Hospital, Tokyo, Japan Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
J Orthop Res 32:910-4. 2014..As TLR2 represents an important mechanism by which osteoblasts recognize bacterial pathogens, a continuously elevated ET-1 status may impair pathogenic recognition by osteoblasts and consequently affect bone metabolism during infections...
- Direct action of endothelin-1 on podocytes promotes diabetic glomerulosclerosisOlivia Lenoir
Paris Cardiovascular Research Centre, Institut National de la Sante et de la Recherche Medicale, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
J Am Soc Nephrol 25:1050-62. 2014..Furthermore, these results indicate that activation of the endothelin-1 pathways selectively in podocytes mediates pathophysiologic crosstalk that influences mesangial architecture and sclerosis...
- Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infectionCristina S Rigazio
Servicio de Parasitología Chagas, Hospital de Niños Dr Ricardo Gutierrez, Gallo 1330, 1425EFD Ciudad de Buenos Aires, Argentina
Microb Pathog 73:47-52. 2014..Our findings support a role for the GATA4 signaling pathway in the myocardial production of pathogenic mediators associated with Chagas heart disease, and may help define novel therapeutic targets. ..
- A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosisOscar Busnadiego
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
J Am Soc Nephrol 26:173-82. 2015..These results strongly support a role for an ET-1/TGF-β1 axis as an inducer of MMT and subsequent peritoneal damage and fibrosis, and they highlight ET-1 as a potential therapeutic target in the treatment of PD-associated dysfunction. ..
- Endothelin-1 upregulation mediates aging-related cardiac fibrosisXianwei Wang
Central Arkansas Veterans Healthcare System, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA Key Laboratory of Henan province for Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, Henan, China Electronic address
J Mol Cell Cardiol 80:101-9. 2015..These observations in mice and human hearts suggest that aging-related cardiac fibrosis is, at least partially, dependent on the upregulation of ET-1...
- Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disordersAndré L P Tavares
Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80108, United States
Dev Biol 400:191-201. 2015Endothelin-1 (EDN1) influences both craniofacial and cardiovascular development and a number of adult physiological conditions by binding to one or both of the known endothelin receptors, thus initiating multiple signaling cascades...
- SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1Rokhsana Mortuza
Department of Pathology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
J Cell Mol Med 19:1857-67. 2015In diabetes, hyperglycaemia causes up-regulation of endothelin 1 (ET-1) and transforming growth factor beta 1 (TGF-β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase...
- Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like BehaviorsLin lin Bi
Department of Pathophysiology and Key Laboratory of Neurological Diseases of Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Mol Neurobiol 53:2054-64. 2016..Altogether, our findings establish a previously unknown anxiogenic action of ET1 in the IL cortex. AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A)R signaling pathway in the regulation of anxiety...
- Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic MacrophagesSarah McKenna
Section of Neonatology, Department of Pediatrics, Children s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045
J Immunol 195:3866-79. 2015..Together, these results mechanistically link the innate immune response mediated by IκBβ/NF-κB to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock. ..
- Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegenerationJihae Shin
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Sci Rep 6:29395. 2016..Our study reveals a possible molecular convergence between a neurodevelopmental defect and neurodegeneration mediated by LCDs. ..
- Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoterD Harats
Syntex Discovery Research, Palo Alto, California 94303
J Clin Invest 95:1335-44. 1995..Hence, this new system can be used to direct expression of molecules to the vascular wall for the purpose of examining the biological significance of either overexpression or inhibition of select proteins...
- Increased endothelin and endothelin receptor mRNA expression in polycystic kidneys of cpk miceT Nakamura
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan
J Am Soc Nephrol 4:1064-72. 1993..1-fold at 1 wk, 4.2-fold at 2 wk, and 6.2-fold at 3 wk; TNF-alpha, 2.2-fold at 1 wk, 3.8-fold at 2 wk, and 5.4-fold at 3 wk).(ABSTRACT TRUNCATED AT 250 WORDS)..
- Gene expression of endothelin isoforms and receptors in endothelin-1 knockout miceK Maemura
Third Department of Internal Medicine, University of Tokyo, Japan
J Cardiovasc Pharmacol 26:S17-21. 1995..ET-1 mRNA and peptide levels were in parallel with the number of Edn1 authentic alleles...
- Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient miceM Barton
Cardiology, University Hospital Zürich and Cardiovascular Research Laboratory, Institute of Physiology, University of Zurich, CH 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 95:14367-72. 1998..ETA receptor blockade may have therapeutic potential in patients with atherosclerosis...
- Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout miceH Morita
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
Hypertens Res 22:11-6. 1999..Mice heterozygous for the null mutation of the endothelin-1 (ET-1) gene, Edn1, may be a potential tool for studying this mechanism, because they have elevated blood pressure and disturbances in ..
- Development of the vertebrate ear: insights from knockouts and mutantsD M Fekete
Dept of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Trends Neurosci 22:263-9. 1999..Genes that are regionally expressed in the inner ear can, when absent or mutated, yield selective ablation of specific inner-ear structures or cell types...
- Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null allelesG E Winnier
Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee, 37232 2175, USA
Dev Biol 213:418-31. 1999..Implications for the development of human congenital heart defects are discussed...
- Analysis of the desmoplakin gene reveals striking conservation with other members of the plakin family of cytolinkersK J Green
Department of Pathology, R H Lurie Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
Exp Dermatol 8:462-70. 1999..Detailed characterization and mapping of these genes will facilitate their further evaluation as targets of genetic disorders and provide insights into the evolutionary relationships among molecules in this emerging gene family...
- REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENESJoyce Lloyd; Fiscal Year: 2003..These results will predict the proteins involved in early beta-globin gene suppression. ..
- Role of KLF2 in erythropoiesis and globin expressionJoyce A Lloyd; Fiscal Year: 2010..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..
- Trypanosoma cruzi and AIDS: Role of the AdipocyteHerbert Tanowitz; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- C-Reactive Protein in Extremely Low Birth Weight NeonatesNamasivayam Ambalavanan; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MMP-2 in Neonatal Hypoxic Pulmonary Vascular RemodelingNamasivayam Ambalavanan; Fiscal Year: 2008..unreadable] [unreadable]..
- Differentiation in T.cruzi:an emerging AIDS pathogenHuan Huang; Fiscal Year: 2009..To further delineate the components of this pathway, we will identify the TcPKA downstream interacting molecules, using both yeast two-hybrid assays and proteomic approaches. ..