Gene Symbol: Eda
Description: ectodysplasin-A
Alias: EDA1, Ed1, Eda-A1, Eda-A2, HED, Tnlg7c, XLHED, tabby, ectodysplasin-A, EDA protein homolog, tumor necrosis factor ligand 7c
Species: mouse
Products:     Eda

Top Publications

  1. Lyon M. Order of loci on the X-chromosome of the mouse. Genet Res. 1966;7:130-3 pubmed
  2. Pispa J, Mikkola M, Mustonen T, Thesleff I. Ectodysplasin, Edar and TNFRSF19 are expressed in complementary and overlapping patterns during mouse embryogenesis. Gene Expr Patterns. 2003;3:675-9 pubmed
    Ectodysplasin (Eda), a member of the tumor necrosis factor (TNF) superfamily, and its receptor Edar are necessary components of ectodermal organ development...
  3. Kumar A, Eby M, Sinha S, Jasmin A, Chaudhary P. The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem. 2001;276:2668-77 pubmed
    ..Collectively, the above results suggest that EDAR utilizes a novel signal transduction pathway. Finally, ectodysplasin A can physically interact with the extracellular domain of EDAR and thus represents its biological ligand.
  4. GRUNEBERG H. The molars of the tabby mouse, and a test of the 'single-active X-chromosome' hypothesis. J Embryol Exp Morphol. 1966;15:223-44 pubmed
  5. Laurikkala J, Mikkola M, Mustonen T, Aberg T, Koppinen P, Pispa J, et al. TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol. 2001;229:443-55 pubmed
    ..Our in situ hybridization analysis of the expression of ectodysplasin (encoded by the Tabby gene) and edar (encoded by the downless gene) during mouse tooth morphogenesis showed that they are expressed in ..
  6. Sofaer J. Aspects of the tabby-crinkled-downless syndrome. II. Observations on the reaction to changes of genetic background. J Embryol Exp Morphol. 1969;22:207-27 pubmed
  7. Pispa J, Jung H, Jernvall J, Kettunen P, Mustonen T, Tabata M, et al. Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF. Dev Biol. 1999;216:521-34 pubmed
    b>Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands...
  8. Peterkova R, Lesot H, Viriot L, Peterka M. The supernumerary cheek tooth in tabby/EDA mice-a reminiscence of the premolar in mouse ancestors. Arch Oral Biol. 2005;50:219-25 pubmed
    A supernumerary cheek tooth occurs mesially to the first molar in tabby/EDA (Ta) mice affected by hypohidrotic ectodermal dysplasia...
  9. Charles C, Pantalacci S, Peterkova R, Tafforeau P, Laudet V, Viriot L. Effect of eda loss of function on upper jugal tooth morphology. Anat Rec (Hoboken). 2009;292:299-308 pubmed publisher
    The Tabby/eda mice, which bear a loss of function mutation for the eda (ectodysplasinA) gene, are known to display developmental anomalies in organs with an ectodermal origin...

More Information


  1. Kristenová P, Peterka M, Lisi S, Gendrault J, Lesot H, Peterkova R. Different morphotypes of functional dentition in the lower molar region of tabby (EDA) mice. Orthod Craniofac Res. 2002;5:205-14 pubmed
    To sort and classify the highly variable lower molar dentition in tabby (Ta) mice postnatally...
  2. Newton K, French D, Yan M, Frantz G, Dixit V. Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency. Mol Cell Biol. 2004;24:1608-13 pubmed
    b>EDA-A1 and EDA-A2 are members of the tumor necrosis factor family of ligands...
  3. Drew C, Lin C, Jiang T, Blunt G, Mou C, Chuong C, et al. The Edar subfamily in feather placode formation. Dev Biol. 2007;305:232-45 pubmed
    ..Our findings illustrate the roles of these three receptors during avian skin morphogenesis and also suggest that activators of feather placode fate undergo mutual regulation to reach a decision on skin appendage location and size. ..
  4. Mustonen T, Pispa J, Mikkola M, Pummila M, Kangas A, Pakkasjärvi L, et al. Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev Biol. 2003;259:123-36 pubmed
    ..We have overexpressed two splice forms of ectodysplasin, Eda-A1 and Eda-A2, binding to Edar and another TNF receptor, Xedar, respectively, under the keratin 14 (K14) promoter ..
  5. Pummila M, Fliniaux I, Jaatinen R, James M, Laurikkala J, Schneider P, et al. Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development. 2007;134:117-25 pubmed
    ..Ectodysplasin-A (Eda), a tumour necrosis factor-like signalling molecule, and its receptor Edar are required for the development of a ..
  6. Sofaer J. Aspects of the tabby-crinkled-downless syndrome. I. The development of tabby teeth. J Embryol Exp Morphol. 1969;22:181-205 pubmed
  7. Tucker A, Headon D, Schneider P, Ferguson B, Overbeek P, Tschopp J, et al. Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development. 2000;127:4691-700 pubmed
    b>tabby and downless mutant mice have apparently identical defects in teeth, hair and sweat glands. Recently, genes responsible for these spontaneous mutations have been identified...
  8. Liu F, Chu E, WATT B, Zhang Y, Gallant N, Andl T, et al. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008;313:210-24 pubmed
  9. Mou C, Jackson B, Schneider P, Overbeek P, Headon D. Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A. 2006;103:9075-80 pubmed
    ..This Edar-BMP activation-inhibition mechanism appears to operate alongside a labile prepattern, suggesting that Edar-mediated stabilization of beta-catenin active foci is a key event in determining definitive follicle locations. ..
  10. Cui C, Durmowicz M, Ottolenghi C, Hashimoto T, Griggs B, Srivastava A, et al. Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet. 2003;12:2931-40 pubmed
    ..their action further, we conditionally expressed the isoforms as tetracycline ('Tet')-regulated transgenes in Tabby (EDA-negative) and wild-type mice...
  11. Charles C, Pantalacci S, Peterkova R, Peterka M, Laudet V, Viriot L. Disruption of the palatal rugae pattern in Tabby (eda) mutant mice. Eur J Oral Sci. 2007;115:441-8 pubmed
    ..Therefore, we searched for and compared palatal rugae anomalies of Tabby mice bearing a mutation in the eda gene with their wild-type counterparts...
  12. Jaskoll T, Zhou Y, Trump G, Melnick M. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003;271:322-31 pubmed
    ..Abnormal phenotypes similar to HED are seen in Tabby (Eda(Ta)) and downless (Edar(dl)) mutant mice...
  13. Amar L, Dandolo L, Hanauer A, Cook A, Arnaud D, Mandel J, et al. Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics. 1988;2:220-30 pubmed
  14. Srivastava A, Pispa J, Hartung A, Du Y, Ezer S, Jenks T, et al. The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains. Proc Natl Acad Sci U S A. 1997;94:13069-74 pubmed
    Mouse Tabby (Ta) and X chromosome-linked human EDA share the features of hypoplastic hair, teeth, and eccrine sweat glands. We have cloned the Ta gene and find it to be homologous to the EDA gene...
  15. Isaacs K, Brown G, Moore G. Interactions between epidermal growth factor and the Tabby mutation in skin. Exp Dermatol. 1998;7:273-80 pubmed
    Mutations of the X-linked genes Tabby (Ta) in mice and EDA in humans result in developmental and functional abnormalities, primarily in the skin and hair follicles...
  16. Hill N, Laib A, Duncan M. Mutation of the ectodysplasin-A gene results in bone defects in mice. J Comp Pathol. 2002;126:220-5 pubmed
    ..An animal model of EDA, the Tabby mouse, also has mutations in the ectodysplasin-A gene and defects similar to those of human beings with EDA...
  17. Zhang M, Brancaccio A, Weiner L, Missero C, Brissette J. Ectodysplasin regulates pattern formation in the mammalian hair coat. Genesis. 2003;37:30-7 pubmed
    ..Here we present evidence of follicular patterning by ectodysplasin-A1 (Eda-A1), a signaling protein necessary for the proper development of hair and other appendages...
  18. Keer J, Hamvas R, Brockdorff N, Page D, Rastan S, Brown S. Genetic mapping in the region of the mouse X-inactivation center. Genomics. 1990;7:566-72 pubmed
    ..We report the assignment of two new loci, EM13 and DXSmh44, to the Ccg-1/Pgk-1 interval. ..
  19. Lyon M. Genetic activity of sex chromosomes in somatic cells of mammals. Philos Trans R Soc Lond B Biol Sci. 1970;259:41-52 pubmed
  20. Cui C, Kunisada M, Esibizione D, Douglass E, Schlessinger D. Analysis of the temporal requirement for eda in hair and sweat gland development. J Invest Dermatol. 2009;129:984-93 pubmed publisher
    ..We find that Eda-A1 restores sweat glands and all hair subtypes in Tabby, but each requires its action at an idiosyncratic time of development: by E17 for guard, by E19 for awl, and ..
  21. Kangas A, Evans A, Thesleff I, Jernvall J. Nonindependence of mammalian dental characters. Nature. 2004;432:211-4 pubmed
    ..We investigated how three different levels of the cell signalling protein ectodysplasin (Eda) changed dental characters in mouse...
  22. Sofaer J, MacLean C. Dominance in threshold characters. A comparison of two tabby alleles in the mouse. Genetics. 1970;64:273-80 pubmed
  23. Falconer D. Linkage in the mouse: the sex-linked genes and Rough. Z Indukt Abstamm Vererbungsl. 1954;86:263-8 pubmed
  24. GRUNEBERG H. The tabby syndrome in the mouse. Proc R Soc Lond B Biol Sci. 1971;179:139-56 pubmed
  25. Nielsen J, Chapman V. Electrophoretic variation for x-chromosome-linked phosphoglycerate kinase (pgk-1) in the mouse. Genetics. 1977;87:319-25 pubmed
    ..Pgk-1 showed 29/122 recombinations with Hq, 5/185 with Ta and 0/108 recombinants with Mo. Based on these recombination data, a gene order of Hq-Ta-Pgk-1-Mo is suggested. ..
  26. Vandenput L, Swinnen J, Boonen S, van Herck E, Erben R, Bouillon R, et al. Role of the androgen receptor in skeletal homeostasis: the androgen-resistant testicular feminized male mouse model. J Bone Miner Res. 2004;19:1462-70 pubmed
    ..whereas cortical thickness as well as trabecular BMD and structure were fully maintained by T in the corresponding Tabby control mice...
  27. Blecher S, Kapalanga J, Lalonde D. Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Nature. 1990;345:542-4 pubmed
    b>Tabby (Ta), a murine X-linked mutant gene, produces a syndrome of ectodermal dysplasia including anhidrosis (absence of sweat glands)...
  28. Koppinen P, Pispa J, Laurikkala J, Thesleff I, Mikkola M. Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res. 2001;269:180-92 pubmed
    b>Tabby and downless mutant mice have identical phenotypes characterized by deficient development of several ectodermally derived organs such as teeth, hair, and sweat glands...
  29. Drogemuller C, Distl O, Leeb T. Partial deletion of the bovine ED1 gene causes anhidrotic ectodermal dysplasia in cattle. Genome Res. 2001;11:1699-705 pubmed
    Anhidrotic ectodermal dysplasia (ED1) is characterized by hypotrichosis, reduced number of sweat glands, and incisior anodontia in human, mouse, and cattle...
  30. Srivastava A, Durmowicz M, Hartung A, Hudson J, Ouzts L, Donovan D, et al. Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby mice. Hum Mol Genet. 2001;10:2973-81 pubmed
    ..for the most common form of the ectodermal dysplasia and the defective orthologous gene in mice produces the tabby phenotype, suggesting its vital role in the development of hair, sweat glands and teeth...
  31. Brockdorff N, Kay G, Smith S, Keer J, Hamvas R, Brown S, et al. High-density molecular map of the central span of the mouse X chromosome. Genomics. 1991;10:17-22 pubmed
    ..been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb...
  32. Jamieson R, Zhou S, Wheatley S, Koopman P, Tam P. Sertoli cell differentiation and Y-chromosome activity: a developmental study of X-linked transgene activity in sex-reversed X/XSxra mouse embryos. Dev Biol. 1998;199:235-44 pubmed
  33. Vielkind U, Hardy M. Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy. Acta Anat (Basel). 1996;157:183-94 pubmed
    Wild-type mice have three main types of hair in their pelage: tylotrichs, awls and zigzags. Tabby mice have a yellowish coat consisting of awls only, whereas downy mice have a sparse grayish coat consisting of unusually fine hairs...
  34. Garcin C, Huttner K, Kirby N, Schneider P, Hardman M. Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair. J Invest Dermatol. 2016;136:1022-1030 pubmed publisher
    The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages...
  35. Rawlins E, Hogan B. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn. 2005;233:1378-85 pubmed
    ..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...
  36. Toda I, Sullivan B, Wickham L, Sullivan D. Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol. 1999;71:49-61 pubmed
    ..e. Tabby)...
  37. Zhang Y, Tomann P, Andl T, Gallant N, Huelsken J, Jerchow B, et al. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009;17:49-61 pubmed publisher
    ..Wnt/beta-catenin signaling is initially activated independently of EDA/EDAR/NF-kappaB activity in primary hair follicle primordia...
  38. Hamvas R, Zinn A, Keer J, Fisher E, Beer Romero P, Brown S, et al. Rps4 maps near the inactivation center on the mouse X chromosome. Genomics. 1992;12:363-7 pubmed
    ..The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human. ..
  39. Cui C, Kunisada M, Esibizione D, Grivennikov S, Piao Y, Nedospasov S, et al. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet. 2007;16:2583-90 pubmed
    ..As expected, Tabby mice, which lack the EDA gene, the putative upstream regulator of LTbeta in skin, showed similar though milder ..
  40. Sofaer J. Additive effects of the genes tabby and crinkled on tooth size in the mouse. Genet Res. 1979;33:169-74 pubmed
  41. Wells K, Mou C, Headon D, Tucker A. Recombinant EDA or Sonic Hedgehog rescue the branching defect in Ectodysplasin A pathway mutant salivary glands in vitro. Dev Dyn. 2010;239:2674-84 pubmed publisher
    ..In humans and mice, HED is caused by mutations in Ectodysplasin A (Eda) pathway genes...
  42. Knapp P, Adjan V, Hauser K. Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse. Neurosci Lett. 2009;451:114-8 pubmed publisher
    ..Mechanism(s) leading to deficient KOP expression in jimpy mice remain unclear. We speculate that loss of KOP may be related to increased [Ca(2+)](i) and premature death of jimpy oligodendrocytes. ..
  43. Boran T, Lesot H, Peterka M, Peterkova R. Increased apoptosis during morphogenesis of the lower cheek teeth in tabby/EDA mice. J Dent Res. 2005;84:228-33 pubmed
    ..could also be involved in the reduction of tooth number and the determination of anomalous tooth boundaries in tabby (Ta)/EDA mice...
  44. Cui C, Yin M, Sima J, Childress V, Michel M, Piao Y, et al. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014;141:3752-60 pubmed publisher
    ..Wnt signaling was blocked in skin epithelium, and was accompanied by sharp downregulation of downstream Wnt, Eda and Shh pathway genes...
  45. Berning A, Eicher E, Paul W, Scher I. Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. J Immunol. 1980;124:1875-7 pubmed
    ..We have determined that xid is situated on the X-chromosome between the genes Ta (tabby) and Hyp (hypophosphatemia), genetic distances being Ta-6.6 +/- 1.8-xid-12.2 +/- 2.3-Hyp.
  46. Avner P, Amar L, Arnaud D, Hanauer A, Cambrou J. Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987;84:1629-33 pubmed
    ..X chromosome using an interspecific cross involving Mus spretus to a contiguous region lying proximally to the Tabby (Ta) locus. Pedigree and recombinational analysis establish the marker order as being Hprt-FIX-c11-G6PD-St14-1...
  47. Kunisada M, Cui C, Piao Y, Ko M, Schlessinger D. Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet. 2009;18:1769-78 pubmed publisher
    ..To initiate analyses, we compared the model of Eda mutant Tabby mice, in which sweat glands were not formed, with wild-type (WT) mice...
  48. Cui C, Kunisada M, Piao Y, Childress V, Ko M, Schlessinger D. Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS ONE. 2010;5:e10009 pubmed publisher
    ..Primary hair formation is ectodysplasin (Eda) dependent, but it has been puzzling that Tabby (Eda(-/y)) mice still make secondary hair...
  49. Cattanach B, Wolfe H, Lyon M. A comparative study of the coats of chimaeric mice and those of heterozygotes for X-linked genes. Genet Res. 1972;19:213-28 pubmed
  50. Cui C, Kunisada M, Childress V, Michel M, Schlessinger D. Shh is required for Tabby hair follicle development. Cell Cycle. 2011;10:3379-86 pubmed publisher
    In embryonic Eda mutant ("Tabby") mice, the development of one of the two major types of hair, "primary" hair fails, but other "secondary" hairs develop in normal numbers, though shorter and slightly ..
  51. Barra J. An X-linked recessive mutation producing cleft palate, crooked tail, and polydactyly in mice. J Hered. 1990;81:388-92 pubmed
    ..It maps proximal to Tabby. Hemizygous males and homozygous females exhibit skeletal malformations of the tail, polydactyly of the hind feet, ..
  52. De Backer O, Verheyden A, Martin B, Godelaine D, De Plaen E, Brasseur R, et al. Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes. Genomics. 1995;28:74-83 pubmed
    ..Smage1/2 transcripts were detected in several tumor and embryonal cell lines but not in normal mouse tissues with the exception of testis. Expression of Smage3 was found in embryos from Day 11 to Day 15. ..
  53. Huijing F, Eicher E, Coleman D. Location of phosphorylase kinase (Phk) in the mouse X chromosome. Biochem Genet. 1973;9:193-6 pubmed
  54. Rao M, Jaszczak E, Landis S. Innervation of footpads of normal and mutant mice lacking sweat glands. J Comp Neurol. 1994;346:613-25 pubmed
    ..Three mouse mutations, Tabby (Ta), crinkled (cr), and downless (dl), disrupt the interactions between the mesenchyme and epidermis that are ..
  55. Sima J, Piao Y, Chen Y, Schlessinger D. Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development. 2016;143:4723-4735 pubmed
    ..expression of Dkk4 arrests MG growth at early germ phase, which is similar to that observed in Eda-ablated Tabby mice...
  56. Nasir J, Fisher E, Brockdorff N, Disteche C, Lyon M, Brown S. Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome. Proc Natl Acad Sci U S A. 1990;87:399-403 pubmed
    ..First, the repeat sequence island encompasses a 1-megabase region devoid of CpG islands; second, it features a high concentration of L1 long interspersed repeat sequences. ..
  57. Esibizione D, Cui C, Schlessinger D. Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene. 2008;427:42-6 pubmed publisher
    ..earlier used expression profiling to infer genes differentially expressed at various developmental time points in Tabby (Eda-deficient) compared to wild-type mouse skin...
  58. Xiao Y, Thoresen D, Miao L, Williams J, Wang C, ATIT R, et al. A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet. 2016;12:e1006150 pubmed publisher
    ..We found dermal Wnt signaling and subsequent epidermal Eda/Edar signaling promoted Merkel cell morphogenesis by inducing Shh expression in early follicles...
  59. Kowalczyk Quintas C, Schuepbach Mallepell S, Willen L, Smith T, Huttner K, Kirby N, et al. Pharmacological stimulation of Edar signaling in the adult enhances sebaceous gland size and function. J Invest Dermatol. 2015;135:359-368 pubmed publisher
    Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands...
  60. Heilig R, Lemaire C, Mandel J, Dandolo L, Amar L, Avner P. Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome. Nature. 1987;328:168-70 pubmed
    ..Both sequences map to the region of 10 centimorgan lying between the Tabby (Ta) and St14-1 (DxPas8) loci, close to the phosphorylase b kinase locus (Phk)...
  61. Wang Y, Li S, Chen X, Ma B, He H, Liu T, et al. Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice. Am J Pathol. 2016;186:32-42 pubmed publisher
    ..tear film and ocular surface changes occurring in X-linked anhidrotic-hypohidrotic ectodermal dysplasia mice (Tabby), which lack the meibomian gland...
  62. Kapalanga J, Blecher S. Effect of the X-linked gene Tabby (Ta) on eyelid opening and incisor eruption in neonatal mice is opposite to that of epidermal growth factor. Development. 1990;108:349-55 pubmed
    Studies on eyelid opening and incisor eruption in 216 neonatal Tabby (Ta)-bearing mice and wildtype controls (35 Ta/Y, 62 + /Y, 30 Ta/Ta, 57 Ta/+ and 32 +/+) showed that in animals hemizygous and homozygous for Ta, the timing of eyelid ..
  63. Cattanach B, Rasberry C, Evans E, Dandolo L, Simmler M, Avner P. Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse. Cytogenet Cell Genet. 1991;56:137-43 pubmed
    A new radiation-induced mutation in the mouse, tabby-25H (Ta25H), has proved to be a deletion which spans both the tabby and testicular feminization (Tfm) loci on the X chromosome...
  64. Ehrmann I, Ellis P, Mazeyrat S, Duthie S, Brockdorff N, Mattei M, et al. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998;7:1725-37 pubmed
    ..These results shed light on the evolution of X-Y homologous genes. ..
  65. Knapp P, Skoff R. Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro. Dev Neurosci. 1993;15:31-6 pubmed
    ..Since there is no evidence that astrocytes make myelin proteolipid protein, the results support previous studies which suggest that this gene may code for other proteins playing an important role in the development of many cell types...
  66. Pispa J, Pummila M, Barker P, Thesleff I, Mikkola M. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet. 2008;17:3380-91 pubmed publisher
    The development of ectodermal organs requires signalling by ectodysplasin (Eda), a tumor necrosis factor (TNF) family member, its receptor Edar and downstream activation of the nuclear factor kappaB (NF-kappaB) transcription factor...
  67. Sofaer J. Differences between tabby and downless mouse epidermis and dermis in culture. Genet Res. 1974;23:219-25 pubmed
  68. Cui C, Durmowicz M, Tanaka T, Hartung A, Tezuka T, Hashimoto K, et al. EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice. Hum Mol Genet. 2002;11:1763-73 pubmed
    ..profiling on 15,000-gene mouse cDNA microarrays, comparing adult mouse skin from wild-type, EDA-defective (Tabby) mice, and Tabby mice supplemented with the EDA-A1 isoform, which is sufficient to rescue multiple Tabby ..
  69. Turtzo L, Siegel C, McCullough L. X chromosome dosage and the response to cerebral ischemia. J Neurosci. 2011;31:13255-9 pubmed publisher
    ..used to investigate the role of X chromosome dosage in female XX and XO littermates of two mouse strains (Paf and Eda(Ta))...
  70. Bulfield G, Siller W, Wight P, Moore K. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984;81:1189-92 pubmed
    ..Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome. ..
  71. Borsani G, Tonlorenzi R, Simmler M, Dandolo L, Arnaud D, Capra V, et al. Characterization of a murine gene expressed from the inactive X chromosome. Nature. 1991;351:325-9 pubmed
    ..Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. ..
  72. Amar L, Arnaud D, Cambrou J, Guenet J, Avner P. Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross. EMBO J. 1985;4:3695-700 pubmed
    ..and SPE/Pas mouse strains segregating the X chromosome markers hypoxanthine phosphoribosyl transferase (Hprt) and Tabby (Ta). Three of the probes map to the region between the centromere and Hprt, and two distal to Ta...
  73. Johnston D, Russell L, Friel P, Griswold M. Murine germ cells do not require functional androgen receptors to complete spermatogenesis following spermatogonial stem cell transplantation. Endocrinology. 2001;142:2405-8 pubmed
  74. Phillips R, Kaufman M. Bare-patches, a new sex-linked gene in the mouse, associated with a high production of XO females. II. Investigations into the nature and mechanism of the XO production. Genet Res. 1974;24:27-41 pubmed
  75. Lane P, Davisson M. Patchy fur (Paf), a semidominant X-linked gene associated with a high level of X-Y nondisjunction in male mice. J Hered. 1990;81:43-50 pubmed
    ..The effect occurs only in male carriers and thus must extend into the proximal end of the XY pairing region. ..
  76. Mortaud S, Donsez Darcel E, Roubertoux P, Degrelle H. Murine steroid sulfatase (mSTS): purification, characterization and measurement by ELISA. J Steroid Biochem Mol Biol. 1995;52:91-6 pubmed
    ..Results in ELISA confirmed the polymorphism previously demonstrated for an enzymatic mSTS activity assay in two inbred mouse strains. ..
  77. Ferguson B, Brockdorff N, Formstone E, Ngyuen T, Kronmiller J, Zonana J. Cloning of Tabby, the murine homolog of the human EDA gene: evidence for a membrane-associated protein with a short collagenous domain. Hum Mol Genet. 1997;6:1589-94 pubmed
    X-Linked hypohidrotic ectodermal dysplasia (XLHED) is a human congenital disorder resulting in abnormal tooth, hair and sweat gland development...
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