Ebi3

Summary

Gene Symbol: Ebi3
Description: Epstein-Barr virus induced gene 3
Alias: EBI-3, IL-27, IL-27 subunit beta, IL-27B, epstein-Barr virus-induced gene 3 protein homolog, interleukin-27 subunit beta
Species: mouse

Top Publications

  1. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
  2. pmc Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    Edward E S Nieuwenhuis
    Gastroenterology Division and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16951-6. 2002
  3. ncbi EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005
  4. ncbi IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    Wanda Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:3021-9. 2007
  5. doi Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines
    Dustin Cobb
    Department of Microbiology and Immunology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23298, USA
    J Immunol 188:3766-73. 2012
  6. doi Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis
    Yuhui Ouyang
    Key Laboratory of Otolaryngology, Head and Neck Surgery Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
    ORL J Otorhinolaryngol Relat Spec 73:313-20. 2011
  7. pmc Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation
    Joshua J Obar
    Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 187:4967-78. 2011
  8. pmc The plasticity of regulatory T cell function
    Meenu R Pillai
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 187:4987-97. 2011
  9. doi IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn
    Eiichi Hasegawa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Leukoc Biol 91:267-73. 2012
  10. pmc Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis
    Jin Qing Liu
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Immunol 188:3099-106. 2012

Scientific Experts

  • Kiyoshi Hirahara
  • Jurgen Siebler
  • Elif Dokmeci
  • Lauren W Collison
  • Richard S Blumberg
  • Dario A A Vignali
  • Mark Birkenbach
  • Stefan Wirtz
  • Markus F Neurath
  • Brian R Rosborough
  • Zhenzhen Liu
  • Benjamin M Matta
  • Jin Qing Liu
  • Jason S Stumhofer
  • Vandana Chaturvedi
  • Hiroki Yoshida
  • Meenu R Pillai
  • Peter R Galle
  • Emanuele Tirotta
  • Angus W Thomson
  • Xue Feng Bai
  • Fatemeh Talebian
  • Dustin Cobb
  • Eiichi Hasegawa
  • Lindsay L Jones
  • Aisling O Hara Hall
  • Yuhui Ouyang
  • Christopher A Hunter
  • Jie Sun
  • Joshua J Obar
  • Jerold E Rehg
  • Atsunobu Takeda
  • David Finkelstein
  • Honglian Tong
  • Michael L Jones
  • Francois Rousseau
  • Kelli Boyd
  • Takashi Igawa
  • Creg J Workman
  • Kerstin A Sauer
  • Jin jin Yan
  • Jianfei Yang
  • Susetta Finotto
  • Hans A Lehr
  • Petra Scholtes
  • Roman Karwot
  • Wanda Niedbala
  • Michael Hausding
  • Joanne Trgovcich
  • Ingrid Tubbe
  • Sabine Zahn
  • J H Zhang
  • Sophie Lucas
  • Edward E S Nieuwenhuis
  • Stefan Pflanz
  • Keunwook Lee
  • Shulin Li
  • Boyi Gan
  • Lai Chu Wu
  • Thomas E Lane
  • Holger Hackstein
  • Jean Oak
  • Mark Boothby
  • Dàlia Raïch-Regué
  • Lanny Gov
  • Suzi Klaus
  • Ronald A Depinho
  • Michelle R Tsukamoto
  • Patrick Duncker
  • Heth R Turnquist
  • Beena John
  • Daniel P Beiting
  • Yuji Oshima
  • Xuejun Zhang
  • Koh Hei Sonoda
  • Cristina Tato
  • Kazuko Saeki
  • Giorgio Raimondi
  • Steven L Reiner
  • John Grainger
  • Sara Cherry
  • Gretchen Harms Pritchard
  • Elia D Tait Wojno
  • Laurence A Turka
  • Nicolas Bouladoux
  • Tajie H Harris
  • Sagie Wagage
  • Fu Dong Shi
  • Guillaume Oldenhove
  • M Merle Elloso

Detail Information

Publications35

  1. ncbi IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells
    Stefan Pflanz
    DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 16:779-90. 2002
    ..We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide...
  2. pmc Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    Edward E S Nieuwenhuis
    Gastroenterology Division and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16951-6. 2002
    Epstein-Barr virus-induced gene 3 (EBI3) is a widely expressed IL-12p40-related protein that associates as a heterodimer with either IL-12p35 or an IL-12p35 homologue, p28, to create a new cytokine (IL-27)...
  3. ncbi EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation
    Stefan Wirtz
    Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
    J Immunol 174:2814-24. 2005
    The EBV-induced gene 3 (EBI3) is expressed in dendritic cells (DCs) and part of the cytokine IL-27 that controls Th cell development. However, its regulated expression in DCs is poorly understood...
  4. ncbi IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells
    Wanda Niedbala
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    Eur J Immunol 37:3021-9. 2007
    Epstein-Barr virus-induced gene 3 (EBI3) and the p35 subunit of IL-12 have been reported to form a heterodimeric hematopoietin in human and mouse...
  5. doi Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines
    Dustin Cobb
    Department of Microbiology and Immunology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23298, USA
    J Immunol 188:3766-73. 2012
    ..cruzi-specific Th17 response. Furthermore, IL-27 could not compensate or synergize with IL-12 to suppress IL-17 production ex vivo. Thus, we have established that IL-12, not IL-27, is critical for regulating Th17 responses to T. cruzi...
  6. doi Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis
    Yuhui Ouyang
    Key Laboratory of Otolaryngology, Head and Neck Surgery Ministry of Education, Beijing Institute of Otolaryngology, Beijing, China
    ORL J Otorhinolaryngol Relat Spec 73:313-20. 2011
    Epstein-Barr virus-induced gene 3 (EBI3) is a widely expressed interleukin-12-related protein that plays a critical role in the regulation of effector T cells and inflammatory responses.
  7. pmc Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation
    Joshua J Obar
    Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 187:4967-78. 2011
    ..SLEC generation was dependent on Ebi3 expression...
  8. pmc The plasticity of regulatory T cell function
    Meenu R Pillai
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 187:4987-97. 2011
    ..These data reveal that cross-regulatory pathways exist that control the utilization of suppressive mechanisms, thereby providing T(reg) functional plasticity...
  9. doi IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn
    Eiichi Hasegawa
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Leukoc Biol 91:267-73. 2012
    ..By contrast, the administration of rIL-27 reduced VEGF production and the extent of CNV. Mice deficient in the EBI3, which lack IL-27, also showed more CNV than C57BL/6 mice, and this was reduced by IL-27 supplementation...
  10. pmc Increased Th17 and regulatory T cell responses in EBV-induced gene 3-deficient mice lead to marginally enhanced development of autoimmune encephalomyelitis
    Jin Qing Liu
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Immunol 188:3099-106. 2012
    EBV-induced gene 3 (EBI3)-encoded protein can form heterodimers with IL-27P28 and IL-12P35 to form IL-27 and IL-35...
  11. pmc Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis
    Emanuele Tirotta
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92697 3900, United States
    J Neuroimmunol 254:110-6. 2013
    Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 and p35 to form the immunomodulatory cytokines IL-27 and IL-35, respectively...
  12. pmc Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family
    Lindsay L Jones
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Mol Immunol 51:234-44. 2012
    ..heterodimeric IL-12 cytokine family is characterized by the sharing of three α (p19, p28, p35) and two β (p40 and Ebi3) subunits, and includes IL-12 (p35/p40), IL-23 (p19/p40), IL-27 (p28/Ebi3) and IL-35 (p35/Ebi3)...
  13. pmc IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells
    Zhenzhen Liu
    Department of Pathology and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Eur J Immunol 43:468-79. 2013
    ..Our results have important implications for designing immunotherapy against human cancer...
  14. pmc IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
    Benjamin M Matta
    Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 188:5227-37. 2012
    ..In this study, we show that mouse liver pDCs express higher levels of IL-27p28 and EBV-induced protein 3 (Ebi3) compared with those of splenic pDCs...
  15. pmc Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1
    Kiyoshi Hirahara
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 36:1017-30. 2012
    ..Thus, these data identify a suppressive activity of IL-27, by which CD4(+) T cells can restrict differentiation of Th17 cells in trans...
  16. pmc The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology
    Aisling O Hara Hall
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 37:511-23. 2012
    ..Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation...
  17. pmc Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
    Brian R Rosborough
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Blood 121:3619-30. 2013
    ..These findings identify the first known RAPA-insensitive mTOR pathway that is not mediated solely by mTORC2 and have implications for the use of catalytic mTOR inhibitors in inflammatory disease settings...
  18. doi Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice
    Honglian Tong
    Department of Pharmacy, FuZhou Medical College of NanChang University, Fuzhou 344000, China
    Immunol Lett 128:108-15. 2010
    ....
  19. ncbi Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cells
    J H Zhang
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biol Reprod 69:404-11. 2003
    ..The four genes were induced by gd6, and uNK cells isolated from midgestation transcribed IL-23alpha and IL-27R. This study advances the understanding of uNK cell activation during normal pregnancy...
  20. pmc IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms
    Sophie Lucas
    Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 100:15047-52. 2003
    ..Therefore, although IL-27 is unable to drive IFN gamma production on its own, it plays an important role in the early steps of TH1 commitment by contributing in a paracrine manner to the control of IL-12 responsiveness...
  21. ncbi Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major
    Sabine Zahn
    Department of Dermatology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Eur J Immunol 35:1106-12. 2005
    ..of the IL-12 family, is a heterodimer composed of p28 and IL-12p40-related Epstein-Barr virus-induced gene 3 (EBI3), and was shown to be produced by DC...
  22. pmc Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
    Stefan Wirtz
    Laboratory of Immunology, I Medical Clinic, University of Mainz, 55131 Mainz, Germany
    J Exp Med 203:1875-81. 2006
    ..Furthermore, mice deficient for the EBI3 subunit of IL-27 were resistant to CLP-induced septic peritonitis as compared with wild-type controls, and this ..
  23. ncbi Lung CD11c+ cells from mice deficient in Epstein-Barr virus-induced gene 3 (EBI-3) prevent airway hyper-responsiveness in experimental asthma
    Michael Hausding
    Laboratory of Cellular and Molecular Lung Immunology, I Medical Clinic, University of Mainz, Mainz, Germany, and Institut Universitaire de Pathologie Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Eur J Immunol 37:1663-77. 2007
    ..These results indicate a novel role for EBI-3 in controlling local immune responses in the lungs in experimental asthma...
  24. ncbi The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 450:566-9. 2007
    ..Here we demonstrate that Epstein-Barr-virus-induced gene 3 (Ebi3, which encodes IL-27beta) and interleukin-12 alpha (Il12a, which encodes IL-12alpha/p35) are highly expressed by ..
  25. ncbi Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis
    Juergen Siebler
    First Department of Medicine, University of Mainz, Mainz, Germany
    J Immunol 180:30-3. 2008
    ..In this study, we identify the cytokine IL-27p28/EBI3 as a major pathogenic factor in the ConA model of T cell-mediated hepatitis...
  26. pmc Epstein-Barr virus-induced gene 3 negatively regulates IL-17, IL-22 and RORgamma t
    Jianfei Yang
    Department of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, USA
    Eur J Immunol 38:1204-14. 2008
    Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 to form IL-27 and with IL-12p35 to form IL-35. IL-27Ralpha(-/-) mice studies indicate that IL-27 negatively regulates Th17 cell differentiation...
  27. doi Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis
    Takashi Igawa
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Mod Rheumatol 19:33-41. 2009
    ..the role of IL-27 in the development of autoimmune disorders in MRL/lpr mice, we disrupted the EBV-induced gene 3 (EBI3), which is a subunit of IL-27...
  28. ncbi Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells
    Kerstin A Sauer
    Laboratory of Cellular and Molecular Immunology of the Lung, I Medical Clinic, University of Mainz, Germany
    J Immunol 181:6148-57. 2008
    ..Taken together, these data demonstrate that targeting EBI-3 leads to a T-bet-mediated antitumor CD8(+) T cell responses in the lung...
  29. ncbi [Expression of EBI3 and p28 mRNA in the brain and spinal cord of chronic model of experimental autoimmune encephalomyelitis in C57BL/6J mice]
    Jin jin Yan
    Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 33:1028-36. 2008
    To investigate the expression of EBI3 and p28 mRNA (the 2 subunits of IL-27) in the brain and spinal cord of the model of experimental autoimmune encephalomyelitis (EAE), and to explore their effect on EAE.
  30. pmc Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 182:6121-8. 2009
    ..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
  31. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
    ..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
  32. pmc EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation
    Elif Dokmeci
    Department of Pediatrics, Section of Pediatric Pulmonology, Yale University School of Medicine, New Haven, CT, USA
    Immunology 132:559-66. 2011
    ..A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed...
  33. pmc A role for IL-27p28 as an antagonist of gp130-mediated signaling
    Jason S Stumhofer
    University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Nat Immunol 11:1119-26. 2010
    ..Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique functions...
  34. pmc IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants
    Francois Rousseau
    Unité Mixte Institut National de la Santé et de la Recherche Médicale 564, Centre Hospitalier Universitaire d Angers, 49033 Angers, France
    Proc Natl Acad Sci U S A 107:19420-5. 2010
    IL-27, consisting of the subunits IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), is a heterodimeric cytokine belonging to the IL-6/IL-12 family of cytokines...
  35. pmc IL-35-mediated induction of a potent regulatory T cell population
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1093-101. 2010
    ..Thus, iT(R)35 cells constitute a key mediator of infectious tolerance and contribute to T(reg) cell-mediated tumor progression. Furthermore, iT(R)35 cells generated ex vivo might have therapeutic utility...