Gene Symbol: Ebf1
Description: early B cell factor 1
Alias: Ebf, OE-1, Olf-1, Olf1, transcription factor COE1, early B-cell factor
Species: mouse
Products:     Ebf1

Top Publications

  1. Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, et al. CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism. J Biol Chem. 2004;279:1777-86 pubmed
    ..The transcription factors Pax5a or BSAP (B cell lineage-specific activator protein) and EBF (early B cell factor) are constitutively expressed in spleen B cells and CD40 cross-linking induces increases in Pax5a and EBF ..
  2. Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M. Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006;133:3993-4004 pubmed
    ..These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions. ..
  3. Thal M, Carvalho T, He T, Kim H, Gao H, Hagman J, et al. Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci U S A. 2009;106:552-7 pubmed publisher
    ..have suggested a hierarchical model of early B cell commitment wherein E2A proteins (E47 and E12) activate early B cell factor (Ebf1), which in turn activates expression of the B cell commitment factor, Pax5...
  4. Jin K, Xiang M. Ebf1 deficiency causes increase of Müller cells in the retina and abnormal topographic projection at the optic chiasm. Biochem Biophys Res Commun. 2011;414:539-44 pubmed publisher
    ..Here we describe the changes in cell differentiation and retinal ganglion cell (RGC) projection in Ebf1 knockout mice...
  5. Horowitz M, Lorenzo J. B lymphocytes and the skeleton. Ann N Y Acad Sci. 2007;1117:82-93 pubmed
    ..O/E-1-deficient mice are runted, have increased bone formation parameters, and have a striking increase in osteoblasts. Remarkably, these mice also exhibit a dramatic expansion of adipocytes in the medullary canal of long bones. ..
  6. Smith E, Gisler R, Sigvardsson M. Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression. J Immunol. 2002;169:261-70 pubmed
    The early B cell factor (EBF) is a transcription factor shown crucial for the development of B lymphocytes...
  7. Croci L, Chung S, Masserdotti G, Gianola S, Bizzoca A, Gennarini G, et al. A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Development. 2006;133:2719-29 pubmed
  8. Garel S, Garcia Dominguez M, Charnay P. Control of the migratory pathway of facial branchiomotor neurones. Development. 2000;127:5297-307 pubmed
    ..In embryos deficient for Ebf1, a gene normally expressed in fbm neurones, part of the fbm neurones migrate dorsally within r5...
  9. Colombo E, Collombat P, Colasante G, Bianchi M, Long J, Mansouri A, et al. Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci. 2007;27:4786-98 pubmed
    ..Altogether, these results highlight the critical functions of Arx in promoting neural migration and regulating basal ganglia differentiation in mice, consistent with the phenotype of XLAG patients...

More Information


  1. Treiber T, Mandel E, Pott S, Gyory I, Firner S, Liu E, et al. Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. Immunity. 2010;32:714-25 pubmed publisher
    The transcription factor early B cell factor-1 (Ebf1) is a key determinant of B lineage specification and differentiation...
  2. Garel S, Marin F, Grosschedl R, Charnay P. Ebf1 controls early cell differentiation in the embryonic striatum. Development. 1999;126:5285-94 pubmed
    b>Ebf1/Olf-1 belongs to a small multigene family encoding closely related helix-loop-helix transcription factors, which have been proposed to play a role in neuronal differentiation...
  3. O RIORDAN M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 1999;11:21-31 pubmed
    The transcription factors EBF and E2A are required at a similar step in early B cell differentiation. EBF and E2A synergistically upregulate transcription of endogenous B cell-specific genes in a non-B cell line...
  4. Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 1995;376:263-7 pubmed
    Early B-cell factor (EBF) is a cell type-specific transcription factor that is expressed at all antigen-independent stages of B-lymphocyte differentiation and participates in the regulation of the mb-1 gene...
  5. Hesslein D, Fretz J, Xi Y, Nelson T, Zhou S, Lorenzo J, et al. Ebf1-dependent control of the osteoblast and adipocyte lineages. Bone. 2009;44:537-46 pubmed publisher
    b>Ebf1 is a transcription factor essential for B cell fate specification and function and important for the development of olfactory sensory neurons...
  6. Gao H, Lukin K, Ramírez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009;106:11258-63 pubmed publisher
    ..Early B-cell factor (EBF), which is crucial for B-cell lineage specification, reprograms mb-1 (Ig-alpha) promoters by increasing chromatin ..
  7. Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 2010;11:171-9 pubmed publisher
    ..Expression of the genes encoding the B cell-specification factor EBF1 and the B cell-commitment protein Pax5 as well as V(H) gene recombination were normal in STAT5- or IL-7 receptor ..
  8. Garel S, Yun K, Grosschedl R, Rubenstein J. The early topography of thalamocortical projections is shifted in Ebf1 and Dlx1/2 mutant mice. Development. 2002;129:5621-34 pubmed
    ..To address this issue, we examined Ebf1(-/-) embryos in which a subset of thalamic axons does not reach the neocortex...
  9. Sigvardsson M, Clark D, Fitzsimmons D, Doyle M, Akerblad P, Breslin T, et al. Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter. Mol Cell Biol. 2002;22:8539-51 pubmed
    Previous studies have suggested that the early-B-cell-specific mb-1(Igalpha) promoter is regulated by EBF and Pax-5...
  10. Zandi S, Mansson R, Tsapogas P, Zetterblad J, Bryder D, Sigvardsson M. EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors. J Immunol. 2008;181:3364-72 pubmed
    ..network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development...
  11. Lobo M, Karsten S, Gray M, Geschwind D, Yang X. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nat Neurosci. 2006;9:443-52 pubmed
    ..We further demonstrate that Ebf1 is a lineage-specific transcription factor essential to the differentiation of striatonigral neurons...
  12. Wang S, Lewcock J, Feinstein P, Mombaerts P, Reed R. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development. 2004;131:1377-88 pubmed
    The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH) transcription factors has been implicated in olfactory system gene regulation, nervous system development and B-cell differentiation...
  13. Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, et al. Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling. Cell. 2011;146:761-71 pubmed publisher
    ..These data highlight adipogenic cells as skin niche cells that positively regulate skin stem cell activity, and suggest that adipocyte lineage cells may alter epithelial stem cell function clinically. ..
  14. Jimenez M, Akerblad P, Sigvardsson M, Rosen E. Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol Cell Biol. 2007;27:743-57 pubmed
    ..The three primary members of this family, Ebf1, 2, and 3, are all expressed in adipocytes, and Ebf1 promotes adipogenesis when overexpressed in NIH 3T3 ..
  15. Garel S, Marin F, Mattei M, Vesque C, Vincent A, Charnay P. Family of Ebf/Olf-1-related genes potentially involved in neuronal differentiation and regional specification in the central nervous system. Dev Dyn. 1997;210:191-205 pubmed
    Two novel mouse genes, Ebf2 and Ebf3, have been identified which show high similarity to the rodent Ebf/Olf-1 and the Drosophila collier genes...
  16. Maier H, Ostraat R, Gao H, Fields S, Shinton S, Medina K, et al. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004;5:1069-77 pubmed
    ..In this context, early B cell factor (EBF), a transcription factor required for B lymphopoiesis, potentiated activation of mb-1 by Pax5...
  17. Kikuchi K, Kasai H, Watanabe A, Lai A, Kondo M. IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. J Immunol. 2008;181:383-92 pubmed
    IL-7 plays a critical role in B cell fate decision by regulating early B cell factor (EBF) expression. However, it was not clear when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice...
  18. Travis A, Hagman J, Hwang L, Grosschedl R. Purification of early-B-cell factor and characterization of its DNA-binding specificity. Mol Cell Biol. 1993;13:3392-400 pubmed
    Early-B-cell factor (EBF) is a nuclear protein that recognizes a functionally important sequence in the promoter of the mb-1 gene...
  19. Lobo M, Yeh C, Yang X. Pivotal role of early B-cell factor 1 in development of striatonigral medium spiny neurons in the matrix compartment. J Neurosci Res. 2008;86:2134-46 pubmed publisher
    ..Early B-cell factor 1 (Ebf1) is a critical transcription factor implicated in striatal MSN development...
  20. Decker T, Pasca di Magliano M, McManus S, Sun Q, Bonifer C, Tagoh H, et al. Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. Immunity. 2009;30:508-20 pubmed publisher
    ..only at the onset of pro-B cell development through induction of chromatin remodeling by the transcription factor EBF1. These experiments demonstrate a stepwise activation of Pax5 in early lymphopoiesis and provide mechanistic ..
  21. Wang S, Tsai R, Reed R. The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. J Neurosci. 1997;17:4149-58 pubmed
    The Olf-1/EBF helix-loop-helix (HLH) transcription factor has been implicated in olfactory gene regulation and in B-cell development...
  22. Roessler S, Gyory I, Imhof S, Spivakov M, Williams R, Busslinger M, et al. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol. 2007;27:579-94 pubmed
    ..important insight into the transcriptional control of B lymphopoiesis, whereby E2A was suggested to act upstream of EBF1 and Pax5 downstream of EBF1...
  23. Akerblad P, Lind U, Liberg D, Bamberg K, Sigvardsson M. Early B-cell factor (O/E-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation. Mol Cell Biol. 2002;22:8015-25 pubmed
    ..Thus, our data point to the importance of O/E target genes for adipocyte differentiation and suggest a novel role for O/E-1 as an initiator and stimulator of adipogenesis. ..
  24. Seet C, Brumbaugh R, Kee B. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med. 2004;199:1689-700 pubmed
    ..factors encoded by the E2A gene function at the apex of a transcriptional hierarchy involving E2A, early B cell factor (EBF), and Pax5, which is essential for B lymphopoiesis...
  25. Medina K, Pongubala J, Reddy K, Lancki D, Dekoter R, Kieslinger M, et al. Assembling a gene regulatory network for specification of the B cell fate. Dev Cell. 2004;7:607-17 pubmed
    ..1, Ikaros, E2A, EBF, and Pax-5. Loss of PU...
  26. Pongubala J, Northrup D, Lancki D, Medina K, Treiber T, Bertolino E, et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol. 2008;9:203-15 pubmed publisher
    ..lineage restriction and B cell fate commitment require the transcription factor Pax5, but the function of early B cell factor (EBF) in these processes remains mostly unexplored...
  27. Hagman J, Belanger C, Travis A, Turck C, Grosschedl R. Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev. 1993;7:760-73 pubmed
    Early B-cell factor (EBF) was identified previously as a tissue-specific and differentiation stage-specific DNA-binding protein that participates in the regulation of the pre-B and B lymphocyte-specific mb-1 gene...
  28. Nery S, Fishell G, Corbin J. The caudal ganglionic eminence is a source of distinct cortical and subcortical cell populations. Nat Neurosci. 2002;5:1279-87 pubmed
    ..Moreover, we report that the migratory fate of cells from the CGE is intrinsically determined by embryonic day 13.5 (E13.5). Together, these results provide the first insights into the development and fate of the CGE. ..
  29. Lu K, Evans S, Hirano S, Liu F. Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014;111:E168-77 pubmed publisher
    ..The dual action of developmental control by Isl1 in promoting appropriate striatonigral but repressing inappropriate striatopallidal genetic profiles may ensure sharpening of the striatonigral identity during development. ..
  30. Banerjee A, Northrup D, Boukarabila H, Jacobsen S, Allman D. Transcriptional repression of Gata3 is essential for early B cell commitment. Immunity. 2013;38:930-42 pubmed publisher
    ..engineered to prevent transcription factor binding to a defined cis element, we show that the transcription factor EBF1 promotes B cell lineage commitment by directly repressing expression of the T-cell-lineage-requisite Gata3 gene...
  31. Martín Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion Poll L, et al. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Development. 2017;144:1566-1577 pubmed publisher
    ..These findings demonstrate that He is involved in the correct development of a subset of striatopallidal MSNs and reveal new cellular mechanisms for neuronal development. ..
  32. Lakhina V, Falnikar A, Bhatnagar L, Tole S. Early thalamocortical tract guidance and topographic sorting of thalamic projections requires LIM-homeodomain gene Lhx2. Dev Biol. 2007;306:703-13 pubmed
    ..Furthermore, the absence of Lhx2 in the ventral telencephalon selectively disrupts a subset of thalamic axon topography, indicating a specific rather than a general perturbation of cues in this structure. ..
  33. Rajaii F, Bitzer Z, Xu Q, Sockanathan S. Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol. 2008;316:371-82 pubmed publisher
  34. Akerblad P, Rosberg M, Leanderson T, Sigvardsson M. The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor. Mol Cell Biol. 1999;19:392-401 pubmed
    Early B-cell factor (EBF) is a transcription factor suggested as essential for early B-lymphocyte development by findings in mice where the coding gene has been inactivated by homologous disruption...
  35. Pattyn A, Hirsch M, Goridis C, Brunet J. Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b. Development. 2000;127:1349-58 pubmed
    ..Thus, the loss of function of Phox2b in hindbrain motor neurons exemplifies a novel control point in the generation of CNS neurons. ..
  36. Lau M, Schwartz M, Kundu S, Savol A, Wang P, Marr S, et al. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017;355:1081-1084 pubmed publisher
    ..We propose that CBX2-driven nucleosome compaction is a key mechanism by which PcG proteins maintain gene silencing during mouse development. ..
  37. Yang C, Ramamoorthy S, Boller S, Rosenbaum M, Rodriguez Gil A, Mittler G, et al. Interaction of CCR4-NOT with EBF1 regulates gene-specific transcription and mRNA stability in B lymphopoiesis. Genes Dev. 2016;30:2310-2324 pubmed
    Transcription factor EBF1 (early B-cell factor 1) regulates early B-cell differentiation by poising or activating lineage-specific genes and repressing genes associated with alternative cell fates...
  38. Griffin M, Zhou Y, Kang S, Zhang X, Mikkelsen T, Rosen E. Early B-cell factor-1 (EBF1) is a key regulator of metabolic and inflammatory signaling pathways in mature adipocytes. J Biol Chem. 2013;288:35925-39 pubmed publisher
    b>EBF1 plays a crucial role in early adipogenesis; however, despite high expression in mature adipocytes, its function in these cells is currently unknown...
  39. Müller M, Jabs N, Lorke D, Fritzsch B, Sander M. Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. Development. 2003;130:5815-26 pubmed
    ..Taken together, our findings demonstrate a requirement for Nkx6.1 in the development of postmitotic motoneurons, and suggest a cell-autonomous function in the control of branchio-motoneuron migration. ..
  40. MacLaren E, Bennett B, Johnson T, Sikela J. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. Mamm Genome. 2006;17:147-56 pubmed
    ..These genes represent novel candidates for the LORR phenotype and provide new targets for future studies into the neuronal processes underlying ethanol sensitivity. ..
  41. Gyory I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, et al. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012;26:668-82 pubmed publisher
    The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1...
  42. Sakhinia E, Byers R, Bashein A, Hoyland J, Buckle A, Brady G. Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis. Br J Haematol. 2006;135:105-16 pubmed
    ..To overcome this, the expression profile of lymphoid and myeloid-associated genes (LEF1, EBF, CD19, Sox-4, B29, CD45, C-fms, lysozyme, PU...
  43. Ikawa T, Masuda K, Lu M, Minato N, Katsura Y, Kawamoto H. Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood. 2004;103:530-7 pubmed
    ..We propose that the wave of p-Ts in fetal blood disclosed by this study represents the ontogenically earliest thymic immigrants. ..
  44. Ehrman L, Mu X, Waclaw R, Yoshida Y, Vorhees C, Klein W, et al. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013;110:E4026-35 pubmed publisher
  45. Gao H, Mejhert N, Fretz J, Arner E, Lorente Cebrián S, Ehrlund A, et al. Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab. 2014;19:981-92 pubmed publisher
    ..However, the causal relationships and the mechanisms controlling WAT morphology are unclear. Herein, we identified EBF1 as an adipocyte-expressed transcription factor with decreased expression/activity in WAT hypertrophy...
  46. Pan L, Deng M, Xie X, Gan L. ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development. 2008;135:1981-90 pubmed publisher
    ..Thus, our results uncover a novel regulatory mechanism of BRN3B and ISL1 in RGC differentiation. ..
  47. Fulp C, Cho G, Marsh E, Nasrallah I, Labosky P, Golden J. Identification of Arx transcriptional targets in the developing basal forebrain. Hum Mol Genet. 2008;17:3740-60 pubmed publisher
  48. Uemura M, Nakao S, Suzuki S, Takeichi M, Hirano S. OL-Protocadherin is essential for growth of striatal axons and thalamocortical projections. Nat Neurosci. 2007;10:1151-9 pubmed
    ..The inability of the striatum to extend axons is also observed in vitro. These results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections. ..
  49. Wang S, Betz A, Reed R. Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate oligo-based direct selection. Mol Cell Neurosci. 2002;20:404-14 pubmed
    The Olf-1/EBF (O/E) family of transcription factors plays important roles in neural development and B-cell maturation...
  50. Geng X, Acosta S, Lagutin O, Gil H, Oliver G. Six3 dosage mediates the pathogenesis of holoprosencephaly. Development. 2016;143:4462-4473 pubmed
    ..Consistent with these results, in vivo activation of the Shh signaling pathway rescued the semilobar phenotype but not the alobar phenotype. Our findings show that variations in Six3 dosage result in different forms of HPE. ..
  51. Fretz J, Nelson T, Xi Y, Adams D, Rosen C, Horowitz M. Altered metabolism and lipodystrophy in the early B-cell factor 1-deficient mouse. Endocrinology. 2010;151:1611-21 pubmed publisher
    We previously reported that mice deficient for the transcription factor early B-cell factor (Ebf1) exhibit markedly increased numbers of osteoblasts, bone formation rate, and serum osteocalcin, but the bone marrow of Ebf1(-/-) mice is ..
  52. Yang Q, Liu S, Yin M, Yin Y, Zhou G, Zhou J. Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse. Dev Neurobiol. 2015;75:1282-94 pubmed publisher
    ..Thus, Ebf2 is identified as a novel and important regulator selectively required for midbrain PAG DA neuron development. ..
  53. Fields S, Ternyak K, Gao H, Ostraat R, Akerlund J, Hagman J. The 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes. Mol Immunol. 2008;45:3786-96 pubmed publisher
    b>Early B cell factor (EBF) is a critical regulator of B lymphocyte-specific gene transcription. EBF functions, in part, by binding to regulatory sites of genes required for the pre-B- and mature B cell receptors...
  54. Mansson R, Welinder E, Åhsberg J, Lin Y, Benner C, Glass C, et al. Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate. Proc Natl Acad Sci U S A. 2012;109:21028-33 pubmed publisher
    Recent studies have identified a number of transcriptional regulators, including E2A, early B-cell factor 1 (EBF1), FOXO1, and paired box gene 5 (PAX5), that promote early B-cell development...
  55. Lukin K, Fields S, Lopez D, Cherrier M, Ternyak K, Ramírez J, et al. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A. 2010;107:7869-74 pubmed publisher
    b>Early B cell factor (EBF)1 is essential for B lineage specification. Previously, we demonstrated the synergistic activation of Cd79a (mb-1) genes by EBF1 and its functional partner, RUNX1...
  56. Corbin J, Rutlin M, Gaiano N, Fishell G. Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development. 2003;130:4895-906 pubmed
    ..1 dependent specification of oligodendrocytes. Therefore, both integrative and antagonistic interactions between homeodomain-containing transcription factors contribute to the patterning of the telencephalon. ..
  57. Schwickert T, Tagoh H, Gultekin S, Dakic A, Axelsson E, Minnich M, et al. Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol. 2014;15:283-93 pubmed publisher
    ..Notably, binding of Ikaros and expression of its target genes were dynamically regulated at distinct stages of early B lymphopoiesis. ..
  58. DeKoter R, Lee H, Singh H. PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity. 2002;16:297-309 pubmed
    ..1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene. ..
  59. Seo W, Ikawa T, Kawamoto H, Taniuchi I. Runx1-Cbf? facilitates early B lymphocyte development by regulating expression of Ebf1. J Exp Med. 2012;209:1255-62 pubmed publisher
    ..Expression of core transcription factors regulating early B cell development, such as E2A, Ebf1, and Pax5, was reduced in B cell precursors lacking Runx1...
  60. Itoh Nakadai A, Hikota R, Muto A, Kometani K, Watanabe Matsui M, Sato Y, et al. The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program. Nat Immunol. 2014;15:1171-80 pubmed publisher
    ..Overexpression of Bach2 in pre-pro-B cells deficient in the transcription factor EBF1 and single-cell analysis of CLPs revealed that Bach2 and Bach1 repressed the expression of genes important for ..
  61. Chung W, Moyle S, Tsai P. Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology. 2008;149:4997-5003 pubmed publisher
    ..Furthermore, Kallmann syndrome stemming from FGF signaling deficiency may be due primarily to defects in early GnRH neuronal development prior to their migration into the forebrain. ..
  62. Sun C, Berry W, Olson L. PDGFR? controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017;144:83-94 pubmed publisher
    ..Our data highlight the importance of balancing stromal versus adipogenic cell expansion during white adipose tissue development, with PDGFR? activity coordinating this crucial process in the embryo. ..
  63. Coppola E, D Autréaux F, Rijli F, Brunet J. Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010;137:4211-20 pubmed publisher
  64. Treiber N, Treiber T, Zocher G, Grosschedl R. Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins. Genes Dev. 2010;24:2270-5 pubmed publisher
    Early B-cell factor 1 (Ebf1) is a key transcriptional determinant of B-lymphocyte differentiation whose DNA-binding domain has no sequence similarity to other transcription factor families...
  65. Cau E, Casarosa S, Guillemot F. Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage. Development. 2002;129:1871-80 pubmed
    ..These results illustrate the versatility of neural bHLH genes which adopt either a determination or a differentiation function, depending primarily on the timing of their expression in neural progenitors. ..
  66. Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, et al. Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia. Mol Ther. 2012;20:1187-95 pubmed publisher
    ..LV integration occurred into the 8th intron of Ebf1, a major regulator of B-lymphopoiesis...
  67. Prasad M, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, et al. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency. Blood. 2015;125:4052-9 pubmed publisher
    Early B-cell factor 1 (Ebf1) is a transcription factor with documented dose-dependent functions in normal and malignant B-lymphocyte development...
  68. Nechanitzky R, Akbas D, Scherer S, Gyory I, Hoyler T, Ramamoorthy S, et al. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nat Immunol. 2013;14:867-75 pubmed publisher
    The transcription factors EBF1 and Pax5 have been linked to activation of the B cell lineage program and irreversible loss of alternative lineage potential (commitment), respectively...
  69. Lokmane L, Proville R, Narboux Nême N, Gyory I, Keita M, Mailhes C, et al. Sensory map transfer to the neocortex relies on pretarget ordering of thalamic axons. Curr Biol. 2013;23:810-6 pubmed publisher
    ..Using Ebf1 conditional inactivation that specifically perturbs the development of an intermediate target, the basal ganglia, ..
  70. Davis J, Reed R. Role of Olf-1 and Pax-6 transcription factors in neurodevelopment. J Neurosci. 1996;16:5082-94 pubmed
    ..The nonoverlapping, cellular localization patterns of Pax-6 and Olf-1 demarcate distinct cell lineages within the developing olfactory epithelium. ..
  71. Ikeda K, Kageyama R, Suzuki Y, Kawakami K. Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development. Int J Dev Biol. 2010;54:1453-64 pubmed publisher
  72. Alcaraz W, Gold D, Raponi E, Gent P, Concepcion D, Hamilton B. Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Proc Natl Acad Sci U S A. 2006;103:19424-9 pubmed
    ..Loss of Zfp423 results in diminished proliferation by granule cell precursors in the external germinal layer, especially near the midline, and abnormal differentiation and migration of ventricular zone-derived neurons and Bergmann glia. ..