E2f2

Summary

Gene Symbol: E2f2
Description: E2F transcription factor 2
Alias: E2F-2, transcription factor E2F2
Species: mouse
Products:     E2f2

Top Publications

  1. Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, et al. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest. 2004;113:1398-407 pubmed
    ..Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo...
  2. Li F, Zhu J, Hogan C, DeGregori J. Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice. Mol Cell Biol. 2003;23:3607-22 pubmed
    ..We show that the combined loss of E2F1 and E2F2 in mice leads to profound cell-autonomous defects in the hematopoietic development of multiple cell lineages...
  3. Bueno M, Gómez de Cedrón M, Laresgoiti U, Fernandez Piqueras J, Zubiaga A, Malumbres M. Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol. 2010;30:2983-95 pubmed publisher
    ..Given the known function of E2F of inducing other oncogenic miRNAs, control of miRNAs by E2F is likely to play multiple roles in cell proliferation and in proliferative diseases such as cancer. ..
  4. Murga M, Fernandez Capetillo O, Field S, Moreno B, Borlado L, Fujiwara Y, et al. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. Immunity. 2001;15:959-70 pubmed
    ..Here we characterize the phenotype of mice deficient in E2F2. We show that E2F2 is required for immunologic self-tolerance...
  5. Enos M, Bancos S, Bushnell T, Crispe I. E2F4 modulates differentiation and gene expression in hematopoietic progenitor cells during commitment to the lymphoid lineage. J Immunol. 2008;180:3699-707 pubmed
    ..However, we did not detect effects on cell proliferation. These findings emphasize the significance of E2F4 in controlling gene expression and cell fate. ..
  6. Dagnino L, Fry C, Bartley S, Farnham P, Gallie B, Phillips R. Expression patterns of the E2F family of transcription factors during murine epithelial development. Cell Growth Differ. 1997;8:553-63 pubmed
    ..Thus, selective regulation of E2F forms occurs during murine epithelial development, irrespective of the ectodermal or endodermal origin of such epithelia. ..
  7. Sharma N, Timmers C, Trikha P, Saavedra H, Obery A, Leone G. Control of the p53-p21CIP1 Axis by E2f1, E2f2, and E2f3 is essential for G1/S progression and cellular transformation. J Biol Chem. 2006;281:36124-31 pubmed
    ..Previous work has demonstrated that the targeted inactivation of E2f1, E2f2, and E2f3 results in elevated p21(CIP1) protein levels, loss of E2F target gene expression, and cell cycle arrest ..
  8. Tsai S, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, et al. Mouse development with a single E2F activator. Nature. 2008;454:1137-41 pubmed publisher
    ..begin to evaluate this genetic complexity, we targeted the inactivation of the entire subset of activators, E2f1, E2f2, E2f3a and E2f3b, singly or in combination in mice...
  9. Iglesias Ara A, Zenarruzabeitia O, Fernandez Rueda J, Sánchez Tilló E, Field S, Celada A, et al. Accelerated DNA replication in E2F1- and E2F2-deficient macrophages leads to induction of the DNA damage response and p21(CIP1)-dependent senescence. Oncogene. 2010;29:5579-90 pubmed publisher
    ..Using compound E2F1/E2F2-deficient mice, we have examined the effects of E2F1 and E2F2 loss on the differentiation and simultaneous ..

More Information

Publications78

  1. Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez J, et al. E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. Nucleic Acids Res. 2013;41:10185-98 pubmed publisher
    b>E2F2 is essential for the maintenance of T lymphocyte quiescence...
  2. Zhou J, Zhu Y, Cheng M, Dinesh D, Thorne T, Poh K, et al. Regulation of vascular contractility and blood pressure by the E2F2 transcription factor. Circulation. 2009;120:1213-21 pubmed publisher
    ..Here, we investigated the potential role of E2F2 in blood pressure regulation...
  3. Wu L, Timmers C, Maiti B, Saavedra H, Sang L, Chong G, et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001;414:457-62 pubmed
    ..E2F1, E2F2 and E2F3 belong to a subclass of E2F factors thought to act as transcriptional activators important for progression ..
  4. Chong J, Wenzel P, Sáenz Robles M, Nair V, Ferrey A, Hagan J, et al. E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature. 2009;462:930-4 pubmed publisher
    ..protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells ..
  5. Saavedra H, Wu L, de Bruin A, Timmers C, Rosol T, Weinstein M, et al. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ. 2002;13:215-25 pubmed
    The Rb/E2F pathway plays a critical role in the control ofcellular proliferation. Here, we report that E2F1, E2F2, and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency...
  6. Timmers C, Sharma N, Opavsky R, Maiti B, Wu L, Wu J, et al. E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop. Mol Cell Biol. 2007;27:65-78 pubmed
    ..approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts leads to the activation of p53 and the induction of p53 target genes, ..
  7. Dirlam A, Spike B, Macleod K. Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007;27:8713-28 pubmed
    ..The identification of a tissue-restricted role for E2f-2 in erythropoiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and differentiation...
  8. Sáenz Robles M, Markovics J, Chong J, Opavsky R, Whitehead R, Leone G, et al. Intestinal hyperplasia induced by simian virus 40 large tumor antigen requires E2F2. J Virol. 2007;81:13191-9 pubmed
    ..Furthermore, unlike their normal counterparts, enterocytes expressing T antigen contain abundant levels of E2F2 and E2F3a...
  9. Chong J, Tsai S, Sharma N, Opavsky R, Price R, Wu L, et al. E2f3a and E2f3b contribute to the control of cell proliferation and mouse development. Mol Cell Biol. 2009;29:414-24 pubmed publisher
    ..to support E2F target gene expression and cell proliferation in the absence of other E2F activators, E2f1 and E2f2, suggesting that these isoforms have redundant functions...
  10. Zhu J, Field S, Gore L, Thompson M, Yang H, Fujiwara Y, et al. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol. 2001;21:8547-64 pubmed
    ..We show that the combined loss of E2F1 and E2F2 results in profound effects on hematopoietic cell proliferation and differentiation, as well as increased ..
  11. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998;12:2245-62 pubmed
  12. Infante A, Laresgoiti U, Fernández Rueda J, Fullaondo A, Galan J, Diaz Uriarte R, et al. E2F2 represses cell cycle regulators to maintain quiescence. Cell Cycle. 2008;7:3915-27 pubmed
    ..We have investigated the role of E2F2 in regulating cellular proliferation...
  13. Opavsky R, Tsai S, Guimond M, Arora A, Opavska J, Becknell B, et al. Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis. Proc Natl Acad Sci U S A. 2007;104:15400-5 pubmed
    ..mouse model of Myc-induced T cell lymphomagenesis and analyzed tumor progression in mice deficient for E2f1, E2f2, or E2f3...
  14. Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park C, et al. Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001;8:105-13 pubmed
    Previous work has shown that the Myc transcription factor induces transcription of the E2F1, E2F2, and E2F3 genes...
  15. Karlseder J, Rotheneder H, Wintersberger E. Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996;16:1659-67 pubmed
    ..For this interaction, the C-terminal part of Sp1 and the N terminus of E2F1, a domain also present in E2F2 and E2F3 but absent in E2F4 and E2F5, were essential...
  16. Wenzel P, Chong J, Sáenz Robles M, Ferrey A, Hagan J, Gomez Y, et al. Cell proliferation in the absence of E2F1-3. Dev Biol. 2011;351:35-45 pubmed publisher
    ..mouse embryonic fibroblasts that concomitant loss of three E2F activators with overlapping functions (E2F1, E2F2, and E2F3) triggered the p53-p21(Cip1) response and caused cell cycle arrest...
  17. Bernards R. E2F: a nodal point in cell cycle regulation. Biochim Biophys Acta. 1997;1333:M33-40 pubmed
  18. Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, et al. Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol. 2015;17:1036-48 pubmed publisher
  19. Zhang J, Bahi N, Zubiaga A, Comella J, Llovera M, Sanchis D. Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues. FEBS Lett. 2007;581:5781-6 pubmed
    ..Therefore, the genes regulating caspase-dependent cell death are expressed in embryonic organs in an E2F-independent manner and a developmental-related silencing event represses these genes in postmitotic adult tissues. ..
  20. Caretti G, Salsi V, Vecchi C, Imbriano C, Mantovani R. Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters. J Biol Chem. 2003;278:30435-40 pubmed
    ..These data indicate that following the release of E2Fs/HDACs, a hierarchy of PCAF-NF-Y-p300 interactions and H3-H4 acetylations are required for activation of cell-cycle promoters. ..
  21. Klutho P, Pennington S, Scott J, Wilson K, Gu S, Doddapattar P, et al. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arterioscler Thromb Vasc Biol. 2015;35:2594-604 pubmed publisher
  22. Chen D, Pacal M, Wenzel P, Knoepfler P, Leone G, Bremner R. Division and apoptosis of E2f-deficient retinal progenitors. Nature. 2009;462:925-9 pubmed publisher
    The activating E2f transcription factors (E2f1, E2f2 and E2f3) induce transcription and are widely viewed as essential positive cell cycle regulators...
  23. Delgado I, Fresnedo O, Iglesias A, Rueda Y, Syn W, Zubiaga A, et al. A role for transcription factor E2F2 in hepatocyte proliferation and timely liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2011;301:G20-31 pubmed publisher
    ..Present evidence suggests that E2F2 may act both as a suppressor and promoter of proliferation, depending on the cellular context...
  24. Kusek J, Greene R, Nugent P, Pisano M. Expression of the E2F family of transcription factors during murine development. Int J Dev Biol. 2000;44:267-77 pubmed
  25. Chen D, Chen Y, Forrest D, Bremner R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ. 2013;20:931-40 pubmed publisher
    ..Indeed, mouse retinoblastoma (Rb)-null retinal neuron death requires E2f1, but not E2f2 or E2f3. However, we report an entirely distinct mechanism in dying cone photoreceptors...
  26. Vohra B, Planer W, Armon J, Fu M, Jain S, Heuckeroth R. Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Dev Dyn. 2007;236:106-17 pubmed
    ..5 male RetDN heterozygous mouse gut explants in organ culture significantly increased the rate of ENS precursor migration through the bowel. ..
  27. Pusapati R, Weaks R, Rounbehler R, McArthur M, Johnson D. E2F2 suppresses Myc-induced proliferation and tumorigenesis. Mol Carcinog. 2010;49:152-6 pubmed publisher
    ..Studies in mice and humans suggest that E2F2 functions as a tumor suppressor...
  28. Rempel R, Mori S, Gasparetto M, Glozak M, Andrechek E, Adler S, et al. A role for E2F activities in determining the fate of Myc-induced lymphomagenesis. PLoS Genet. 2009;5:e1000640 pubmed publisher
    ..Whereas the absence of E2F1 and E2F3 function has no impact on Myc-mediated tumor development, the absence of E2F2 substantially accelerates the time of tumor onset. Conversely, tumor development is delayed by the absence of E2F4...
  29. Pilon A, Arcasoy M, Dressman H, Vayda S, Maksimova Y, Sangerman J, et al. Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. Mol Cell Biol. 2008;28:7394-401 pubmed publisher
    ..of a network of genes involved in cell cycle regulation, with the critical regulator of the cell cycle, E2f2, at a hub...
  30. Sáenz Robles M, Case A, Chong J, Leone G, Pipas J. The retinoblastoma tumor suppressor regulates a xenobiotic detoxification pathway. PLoS ONE. 2011;6:e26019 pubmed publisher
  31. Yuwanita I, Barnes D, Monterey M, O Reilly S, Andrechek E. Increased metastasis with loss of E2F2 in Myc-driven tumors. Oncotarget. 2015;6:38210-24 pubmed publisher
    ..Surprisingly, we observed that the loss of E2F2 sharply increased the percentage of lung metastasis in MMTV-Myc transgenic mice...
  32. Castillo D, Campalans A, Belluscio L, Carcagno A, Radicella J, Cánepa E, et al. E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells. Cell Cycle. 2015;14:1300-14 pubmed publisher
    ..We show a novel mechanism, conserved among diverse species, in which E2F1 and E2F2, the latter specifically in neuronal cells, are transcriptionally induced after DNA damage...
  33. Ghazaryan S, Sy C, Hu T, An X, Mohandas N, Fu H, et al. Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation. Mol Cell Biol. 2014;34:2833-47 pubmed publisher
    ..Remarkably, inactivation of E2f2 rescued the erythropoietic defects resulting from Rb and E2f8 deficiencies...
  34. Tessem J, Jensen J, Pelli H, Dai X, Zong X, Stanley E, et al. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 2008;57:1605-17 pubmed publisher
    ..Mice deficient for the transcription factors E2F1 and E2F2 suffer from a chronic pancreatitis-like syndrome and become diabetic...
  35. Garrett Engele C, Tasch M, Hwang H, Fero M, Perlmutter R, Clurman B, et al. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. PLoS Genet. 2007;3:e219 pubmed
    ..Thus, we have identified and characterized transcriptional repression of p27 by Id3 as a new mechanism decreasing p27 protein in tumors...
  36. Chen D, Opavsky R, Pacal M, Tanimoto N, Wenzel P, Seeliger M, et al. Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol. 2007;5:e179 pubmed
    ..These data reveal a mechanism through which Rb regulates neural differentiation directly, and, unexpectedly, it involves inhibition of E2f3a, not potentiation of tissue-specific factors. ..
  37. Iglesias Ara A, Zenarruzabeitia O, Buelta L, Merino J, Zubiaga A. E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution. Cell Death Differ. 2015;22:1577-89 pubmed publisher
    Tissue homeostasis requires tight regulation of cellular proliferation, differentiation and apoptosis. E2F1 and E2F2 transcription factors share a critical role in tissue homeostasis, since their combined inactivation results in overall ..
  38. Wu J, Sabirzhanov B, Stoica B, Lipinski M, Zhao Z, Zhao S, et al. Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury. Cell Cycle. 2015;14:3698-712 pubmed publisher
    ..E2F1 and E2F2 are members of the activator sub-family of E2F transcription factors that play an important role in proliferating ..
  39. Maldonado E, Delgado I, Furland N, Buqué X, Iglesias A, Aveldaño M, et al. The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice. PLoS ONE. 2014;9:e112620 pubmed publisher
    ..E2Fs are master regulators of cellular proliferation. We have recently shown that E2F2 activity facilitates the completion of liver regeneration after partial hepatectomy (PH) by regulating the ..
  40. Trikha P, Sharma N, Opavsky R, Reyes A, Pena C, Ostrowski M, et al. E2f1-3 are critical for myeloid development. J Biol Chem. 2011;286:4783-95 pubmed publisher
    ..In current models of mammalian cell cycle control, E2f activators (E2f1, E2f2, and E2f3) are portrayed as the ultimate transcriptional effectors that commit cells to enter and progress through ..
  41. Zhou J, Wu M, Xu S, Cheng M, Ding C, Liu Y, et al. Contrasting roles of E2F2 and E2F3 in cardiac neovascularization. PLoS ONE. 2013;8:e65755 pubmed publisher
    ..Here we investigated the roles of E2F2 and E2F3 in EC growth, angiogenesis, and their functional impact on myocardial infarction (MI)...
  42. Dagnino L, Fry C, Bartley S, Farnham P, Gallie B, Phillips R. Expression patterns of the E2F family of transcription factors during mouse nervous system development. Mech Dev. 1997;66:13-25 pubmed
    ..We conclude that individual E2F forms are differentially regulated during the development of distinct tissues, and especially during neuronal development. ..
  43. Chang W, Bryce D, D Souza S, Dagnino L. The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. J Biol Chem. 2004;279:51343-53 pubmed
    ..We conclude that DP-1 activity is required for normal epidermal morphogenesis and ectoderm-to-epidermis transition. ..
  44. Fujiwara K, Yuwanita I, Hollern D, Andrechek E. Prediction and genetic demonstration of a role for activator E2Fs in Myc-induced tumors. Cancer Res. 2011;71:1924-32 pubmed publisher
    ..Tumor latency decreased in the E2F1 mutant background and significantly increased in both the E2F2 and E2F3 mutants...
  45. Timchenko N, Wilde M, Darlington G. C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol. 1999;19:2936-45 pubmed
    ..The disruption of E2F-p107 complexes correlates with C/EBPalpha-mediated growth arrest of hepatocytes in newborn animals. ..
  46. Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci U S A. 2009;106:21783-8 pubmed publisher
  47. Meechan D, Tucker E, Maynard T, LaMantia A. Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A. 2009;106:16434-45 pubmed publisher
    ..Such developmental disruption may alter cortical circuitry and establish vulnerability for developmental disorders, including schizophrenia and autism. ..
  48. Zhang J, Li H, Yabut O, Fitzpatrick H, D ARCANGELO G, Herrup K. Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci. 2010;30:5219-28 pubmed publisher
    ..Formation of this complex excludes the E2F1 cofactor, DP1, thus inhibiting E2F1 binding to the promoters of various cell cycle genes. This anti-cell cycle activity is most likely a neuroprotective function of Cdk5. ..
  49. Tallack M, Keys J, Humbert P, Perkins A. EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2. J Biol Chem. 2009;284:20966-74 pubmed publisher
    ..This cell cycle defect was associated with a significant reduction in the expression levels of E2f2 and E2f4, key factors necessary for the induction of S-phase gene expression and erythropoiesis...
  50. Swartz K, Wood S, Murthy T, Ramirez O, Qin G, Pillai M, et al. E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol. 2017;37: pubmed
    ..Together, our data reveal novel, lineage-specific functions for E2F-2 and suggest that some mitotic kinases have specialized roles supporting enucleation of maturing erythroblasts. ..
  51. Redmond W, Wei C, Kreuwel H, Sherman L. The apoptotic pathway contributing to the deletion of naive CD8 T cells during the induction of peripheral tolerance to a cross-presented self-antigen. J Immunol. 2008;180:5275-82 pubmed
    ..molecular mechanisms contributing to clone 4 T cell apoptosis revealed that it proceeded in a p53, E2F1, and E2F2-independent manner...
  52. Tsume M, Kimura Yoshida C, Mochida K, Shibukawa Y, Amazaki S, Wada Y, et al. Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells. Biochem Biophys Res Commun. 2012;425:762-8 pubmed publisher
    ..These findings suggest that Brd2 is required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 pathway during mouse CNS development. ..
  53. Mill P, Mo R, Hu M, Dagnino L, Rosenblum N, Hui C. Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell. 2005;9:293-303 pubmed
    ..These findings demonstrate that Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation. ..
  54. Chen Q, Hung F, Fromm L, Overbeek P. Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2. Invest Ophthalmol Vis Sci. 2000;41:4223-31 pubmed
    ..The in vivo functions of the transcription factor E2F2 have not previously been analyzed or described in transgenic mice...
  55. Xie B, Wang P, Zhao C, Qiu L. Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger shrimp (Penaeus monodon). PLoS ONE. 2017;12:e0177420 pubmed publisher
    ..After dsRNA-E2F-2 injection, gonadosomatic index of shrimp was significantly lower than those following dsRNA-GFP and phosphate-buffered solution injections. Therefore, PmE2F-2 may be involved in ovarian maturation in P. monodon. ..
  56. Azkargorta M, Fullaondo A, Laresgoiti U, Aloria K, Infante A, Arizmendi J, et al. Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes. Mol Cell Proteomics. 2010;9:2184-94 pubmed publisher
    ..To gain insight into the molecular pathways regulated by E2F2, we have analyzed the proteome of antigen receptor-activated T cells lacking E2F2...
  57. Bilousova G, Marusyk A, Porter C, Cardiff R, DeGregori J. Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol. 2005;3:e401 pubmed
  58. Wikenheiser Brokamp K. Retinoblastoma family proteins: insights gained through genetic manipulation of mice. Cell Mol Life Sci. 2006;63:767-80 pubmed
    ..This review summarizes the phenotypic consequences of Rb family ablation in mice, and discusses how these findings contribute to the increasingly complex picture of Rb family function in development and tumor suppression. ..
  59. Andrechek E. HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors. Oncogene. 2015;34:217-25 pubmed publisher
    ..Loss of any E2F delayed Neu-induced tumor onset. E2F1 loss accelerated tumor growth, while E2F2 and E2F3 loss did not...
  60. Andrechek E, Mori S, Rempel R, Chang J, Nevins J. Patterns of cell signaling pathway activation that characterize mammary development. Development. 2008;135:2403-13 pubmed publisher
    ..Taken together, these results reveal a complex pattern of pathway activity in relation to the various phases of mammary gland development. ..
  61. Smith R, Walker T, Xie X, Hou S. Involvement of the transcription factor E2F1/Rb in kainic acid-induced death of murine cerebellar granule cells. Brain Res Mol Brain Res. 2003;116:70-9 pubmed
    ..Therefore activation of Rb/E2F1 pathway appears to involve novel interactions yet to be elucidated. ..
  62. Westendorp B, Major J, Nader M, Salih M, Leenen F, Tuana B. The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB J. 2012;26:2569-79 pubmed publisher
    ..The data highlight an unprecedented role for the strict regulation of the E2F pathway in normal postnatal cardiac function. ..
  63. Hollern D, Honeysett J, Cardiff R, Andrechek E. The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer. Mol Cell Biol. 2014;34:3229-43 pubmed publisher
    ..that the E2Fs function to regulate tumor development and metastasis, we interbred MMTV-PyMT mice with E2F1, E2F2, or E2F3 knockout mice...
  64. Wenzel P, Wu L, de Bruin A, Chong J, Chen W, Dureska G, et al. Rb is critical in a mammalian tissue stem cell population. Genes Dev. 2007;21:85-97 pubmed
    ..We conclude that the Rb pathway plays a critical role in the maintenance of a mammalian stem cell population. ..
  65. Palmero I, Murga M, Zubiaga A, Serrano M. Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Oncogene. 2002;21:2939-47 pubmed
    ..We have used primary mouse fibroblasts deficient for E2F1, E2F2, or both to determine the possible role of these E2F proteins as upstream regulators of ARF in response to ..
  66. Zencak D, Schouwey K, Chen D, Ekstrom P, Tanger E, Bremner R, et al. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A. 2013;110:E593-601 pubmed publisher
    ..These data reveal that Bmi1 controls the cell cycle-related death process, highlighting this pathway as a promising therapeutic target for neuroprotection in retinal dystrophies...
  67. Yanagino T, Yuasa K, Nagahama M, Matsuda Y, Tsuji A. Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation. J Cell Biochem. 2009;106:580-8 pubmed publisher
    ..The increase in promoter activity by E2F1 was completely suppressed by the coexpression of E2F4. E2F2 and E2F3 had positive effects on the promoter activity...
  68. Wells J, Boyd K, Fry C, Bartley S, Farnham P. Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol. 2000;20:5797-807 pubmed
  69. Kopecky B, Jahan I, Fritzsch B. Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability. Dev Dyn. 2013;242:132-47 pubmed publisher
    ..In addition, our data indicate that Myc is an integral component of the evolutionary transformation process that resulted in the organ of Corti development. ..