Dyrk1a

Summary

Gene Symbol: Dyrk1a
Description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
Alias: 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, Gm10783, Mnbh, Mp86, mmb, dual specificity tyrosine-phosphorylation-regulated kinase 1A, dual specificity YAK1-related kinase, protein kinase minibrain homolog
Species: mouse
Products:     Dyrk1a

Top Publications

  1. Mao J, Maye P, Kogerman P, Tejedor F, Toftgard R, Xie W, et al. Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1. J Biol Chem. 2002;277:35156-61 pubmed
    To investigate the cellular role of dual specificity Yak1-related kinase (Dyrk) 1, a nuclear localized dual specificity protein kinase, we examined its effect on transcriptional regulation using reporter gene assays...
  2. Ortiz Abalia J, Sahún I, Altafaj X, Andreu N, Estivill X, Dierssen M, et al. Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome. Am J Hum Genet. 2008;83:479-88 pubmed publisher
    Genetic-dissection studies carried out with Down syndrome (DS) murine models point to the critical contribution of Dyrk1A overexpression to the motor abnormalities and cognitive deficits displayed in DS individuals...
  3. Martinez de Lagran M, Altafaj X, Gallego X, Marti E, Estivill X, Sahún I, et al. Motor phenotypic alterations in TgDyrk1a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiol Dis. 2004;15:132-42 pubmed
    ..Here we investigate the motor profile of transgenic mice overexpressing Dyrk1a, Tg(Dyrk1a)1Cff (hereafter TgDyrk1a), a candidate gene hypothesized to cause some of the neurological defects ..
  4. Fotaki V, Martinez de Lagran M, Estivill X, Arbones M, Dierssen M. Haploinsufficiency of Dyrk1A in mice leads to specific alterations in the development and regulation of motor activity. Behav Neurosci. 2004;118:815-21 pubmed
    b>DYRK1A is a protein kinase proposed to be involved in neurogenesis. Gene-targeting disruption of Dyrk1A in mice leads to decreased body and brain size, with no severe disturbance of behavior...
  5. Fotaki V, Dierssen M, Alcantara S, Martinez S, Marti E, Casas C, et al. Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice. Mol Cell Biol. 2002;22:6636-47 pubmed
    b>DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved in postembryonic neurogenesis in flies...
  6. Laguna A, Aranda S, Barallobre M, Barhoum R, Fernandez E, Fotaki V, et al. The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell. 2008;15:841-53 pubmed publisher
    ..We show here that DYRK1A (minibrain), a protein kinase essential for normal growth, is a negative regulator of the intrinsic apoptotic ..
  7. Hämmerle B, Elizalde C, Tejedor F. The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. Eur J Neurosci. 2008;27:1061-74 pubmed publisher
    ..MNB/DYRK1A is one of the genes on human chromosome 21 that has raised most interest, due to its relationship with the brain ..
  8. Ahn K, Jeong H, Choi H, Ryoo S, Kim Y, Goo J, et al. DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects. Neurobiol Dis. 2006;22:463-72 pubmed
    ..The DYRK1A gene on human chromosome 21q22...
  9. Marti E, Altafaj X, Dierssen M, De La Luna S, Fotaki V, Alvarez M, et al. Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system. Brain Res. 2003;964:250-63 pubmed
    b>Dyrk1A and its Drosophila orthologue, the protein minibrain (mnb), belong to a family of serine/threonine kinases involved in the development of the central nervous system (CNS)...

More Information

Publications77

  1. Tejedor F, Zhu X, Kaltenbach E, Ackermann A, Baumann A, Canal I, et al. minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila. Neuron. 1995;14:287-301 pubmed
    ..The mnb kinases share extensive sequence similarities with kinases involved in the regulation of cell division. ..
  2. Hamelet J, Noll C, Ripoll C, Paul J, Janel N, Delabar J. Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice. Biochem Biophys Res Commun. 2009;378:673-7 pubmed publisher
    ..As DYRK1A, a serine/threonine kinase, has been described as a candidate antiapoptotic factor, we have analyzed the ..
  3. Souchet B, Guedj F, Sahún I, Duchon A, Daubigney F, Badel A, et al. Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage. Neurobiol Dis. 2014;69:65-75 pubmed publisher
    ..Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine kinase DYRK1A, as a candidate for inducing cognitive dysfunction...
  4. Arqué G, de Lagrán M, Arbones M, Dierssen M. Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Neurobiol Dis. 2009;36:312-9 pubmed publisher
    Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease...
  5. Guo X, Williams J, Schug T, Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem. 2010;285:13223-32 pubmed publisher
    b>DYRK1A (the dual specificity tyrosine phosphorylation-regulated kinase 1A) plays an important role in body growth and brain physiology...
  6. Park J, Oh Y, Yoo L, Jung M, Song W, Lee S, et al. Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010;285:31895-906 pubmed publisher
    ..and, more specifically, a regulatory role for dual-specificity tyrosine-(Y) phosphorylation-regulated kinase 1A (Dyrk1A), a DSCR gene product, in embryonic neuronal cell proliferation...
  7. Song W, Sternberg L, Kasten Sportes C, Keuren M, Chung S, Slack A, et al. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region". Genomics. 1996;38:331-9 pubmed
    ..To study genes potentially responsible for some of these phenotypes, we cloned a human candidate gene (DYRK) from 21q22...
  8. Branchi I, Bichler Z, Minghetti L, Delabar J, Malchiodi Albedi F, Gonzalez M, et al. Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration. J Neuropathol Exp Neurol. 2004;63:429-40 pubmed
    ..The 152F7 fragment, in addition to genes also located on the other DCR-1 fragments, bears the DYRK1A gene, encoding for a serine-threonine kinase...
  9. Hämmerle B, Vera Samper E, Speicher S, Arencibia R, Martinez S, Tejedor F. Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions. Dev Biol. 2002;246:259-73 pubmed
    ..We propose that Mnb defines a transition step between proliferating and neurogenic divisions of NEP cells. ..
  10. Rahmani Z, Lopes C, Rachidi M, Delabar J. Expression of the mnb (dyrk) protein in adult and embryonic mouse tissues. Biochem Biophys Res Commun. 1998;253:514-8 pubmed
    ..The high degree of homology of the human gene to the murine gene (dyrk) allowed us to use a human polyclonal anti-mnb antibody to study the expression pattern of the protein in adult and ..
  11. Benavides Piccione R, Dierssen M, Ballesteros Yanez I, Martinez de Lagran M, Arbones M, Fotaki V, et al. Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse. Neurobiol Dis. 2005;20:115-22 pubmed
    The gene encoding the dual-specificity tyrosine-regulated kinase DYRK1A maps to the chromosomal segment HSA21q22.2, which lies within the Down syndrome critical region...
  12. Thomazeau A, Lassalle O, Iafrati J, Souchet B, Guedj F, Janel N, et al. Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a. J Neurosci. 2014;34:1138-47 pubmed publisher
    The gene Dyrk1a is the mammalian ortholog of Drosophila minibrain. Dyrk1a localizes in the Down syndrome (DS) critical region of chromosome 21q22.2 and is a major candidate for the behavioral and neuronal abnormalities associated with DS...
  13. Altafaj X, Dierssen M, Baamonde C, Marti E, Visa J, Guimera J, et al. Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet. 2001;10:1915-23 pubmed
    ..The specific genes responsible for these phenotypic alterations have not yet been defined. DYRK1A, the human homolog of the Drosophila minibrain gene, maps to the DS critical region of human chromosome 21 and is ..
  14. Altafaj X, Martin E, Ortiz Abalia J, Valderrama A, Lao Peregrín C, Dierssen M, et al. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2013;52:117-27 pubmed publisher
    ..In the present study, we evaluated whether the normalization of the expression levels of Dyrk1A (Dual specificity tyrosine-phosphorylation-regulated kinase 1A), a candidate gene for DS, might correct ..
  15. Guedj F, Pereira P, Najas S, Barallobre M, Chabert C, Souchet B, et al. DYRK1A: a master regulatory protein controlling brain growth. Neurobiol Dis. 2012;46:190-203 pubmed publisher
    Copy number variation in a small region of chromosome 21 containing DYRK1A produces morphological and cognitive alterations in human...
  16. Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X, et al. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006;441:595-600 pubmed
    ..Here we report that two genes, DSCR1 and DYRK1A , lie within the critical region of human chromosome 21 and act synergistically to prevent nuclear occupancy of ..
  17. Martinez de Lagran M, Bortolozzi A, Millan O, Gispert J, Gonzalez J, Arbones M, et al. Dopaminergic deficiency in mice with reduced levels of the dual-specificity tyrosine-phosphorylated and regulated kinase 1A, Dyrk1A(+/-). Genes Brain Behav. 2007;6:569-78 pubmed
    The dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) gene encodes a protein kinase known to play a critical role in neurodevelopment...
  18. Laguna A, Barallobre M, Marchena M, Mateus C, Ramírez E, Martinez Cue C, et al. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet. 2013;22:2775-84 pubmed publisher
    ..Moreover, we show that mice bearing only one additional copy of Dyrk1a have the same retinal phenotype as Ts65Dn mice and normalization of Dyrk1a gene copy number in Ts65Dn mice ..
  19. Kurabayashi N, Sanada K. Increased dosage of DYRK1A and DSCR1 delays neuronal differentiation in neocortical progenitor cells. Genes Dev. 2013;27:2708-21 pubmed publisher
    ..Here we show that DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A) and DSCR1 (DS critical region 1), two genes ..
  20. Kadri F, Pacifici M, Wilk A, Parker Struckhoff A, Del Valle L, Hauser K, et al. HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase. J Biol Chem. 2015;290:30931-46 pubmed publisher
    ..This mechanism involved Tat-mediated increased expression of DYRK1A and was prevented by DYRK1A silencing...
  21. Patil N, Cox D, Bhat D, Faham M, Myers R, Peterson A. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat Genet. 1995;11:126-9 pubmed
    ..The mutation alters the putative ion-permeable, pore-forming domain of the protein, suggesting that granule cell differentiation is regulated by changes in membrane permeability. ..
  22. McElyea S, Starbuck J, Tumbleson Brink D, Harrington E, Blazek J, Ghoneima A, et al. Influence of prenatal EGCG treatment and Dyrk1a dosage reduction on craniofacial features associated with Down syndrome. Hum Mol Genet. 2016;25:4856-4869 pubmed publisher
    ..Hypothetically, three copies of Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A), a trisomic gene found in most humans with DS ..
  23. Song W, Chung S, Kurnit D. The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers. Biochem Biophys Res Commun. 1997;231:640-4 pubmed
    We mapped the murine copy of the Dyrk gene and examined its subcellular localization and self-interaction...
  24. Lee Y, Ha J, Kim H, Kim Y, Chang E, Song W, et al. Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis. J Biol Chem. 2009;284:33343-51 pubmed publisher
    b>DYRK1A is a serine/threonine kinase that has been linked to mental retardation associated with Down syndrome. In the present report, we describe a previously unknown role for DYRK1A in bone homeostasis...
  25. Hille S, Dierck F, Kühl C, Sosna J, Adam Klages S, Adam D, et al. Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling. Cardiovasc Res. 2016;110:381-94 pubmed publisher
    Down syndrome-associated dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (DYRK1A) is a ubiquitously expressed protein kinase...
  26. Ruiz Mejias M, Martínez de Lagrán M, Mattia M, Castano Prat P, Perez Mendez L, Ciria Suarez L, et al. Overexpression of Dyrk1A, a Down Syndrome Candidate, Decreases Excitability and Impairs Gamma Oscillations in the Prefrontal Cortex. J Neurosci. 2016;36:3648-59 pubmed publisher
    The dual-specificity tyrosine phosphorylation-regulated kinase DYRK1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a major candidate of Down syndrome brain alterations and cognitive ..
  27. Becker W, Weber Y, Wetzel K, Eirmbter K, Tejedor F, Joost H. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J Biol Chem. 1998;273:25893-902 pubmed
    ..we show that the kinase belongs to a new family of protein kinases comprising at least seven mammalian isoforms (DYRK1A, DYRK1B, DYRK1C, DYRK2, DYRK3, DYRK4A, and DYRK4B), the yeast homolog Yak1p, and the Drosophila kinase minibrain (..
  28. Thompson B, Bhansali R, Diebold L, Cook D, Stolzenburg L, Casagrande A, et al. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015;212:953-70 pubmed publisher
    ..Here, we show that the dual specificity tyrosine-regulated kinase 1A (DYRK1A) restrains Cyclin D3 protein levels by phosphorylating T283 to induce its degradation...
  29. Murakami N, Bolton D, Hwang Y. Dyrk1A binds to multiple endocytic proteins required for formation of clathrin-coated vesicles. Biochemistry. 2009;48:9297-305 pubmed publisher
    ..a nuclear targeting sequence, a substantial amount of dual-specificity tyrosine phosphorylation-regulated kinase (Dyrk1A) is located within the cytoplasm of neurons...
  30. Ferron S, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, et al. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010;7:367-79 pubmed publisher
    ..Here, we present evidence that the dual-specificity kinase Dyrk1A is part of a molecular pathway involved in the regulation of biased epidermal growth factor receptor (EGFR) ..
  31. Li D, Jackson R, Yusoff P, Guy G. Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions. J Biol Chem. 2010;285:35374-85 pubmed publisher
    ..Here, we describe the direct and endogenous interaction of SPRED1 and SPRED2 with the novel kinase, DYRK1A. DYRK1A has become the subject of recent research focus as it plays a central role in Caenorhabditis elegans ..
  32. Eto K, Sonoda Y, Abe S. The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes. Mol Cell Biochem. 2011;355:217-22 pubmed publisher
    ..We report that inhibition of dual-specificity tyrosine-phosphorylation regulated kinase (DYRK) IA strongly suppressed the mitogen-stimulated SAP155 phosphorylation and constitutive splicing of I?B pre-mRNA as ..
  33. Arqué G, Casanovas A, Dierssen M. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome. PLoS ONE. 2013;8:e54285 pubmed publisher
    ..b>DYRK1A, a candidate gene for DS abnormalities has been implicated in motor function due to its expression in motor nuclei ..
  34. Notwell J, Heavner W, Darbandi S, Katzman S, McKenna W, Ortiz Londono C, et al. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016;26:1013-22 pubmed publisher
    ..Our findings highlight a TBR1-regulated network of ASD genes in the developing neocortex that are relatively intolerant to LoF mutations, indicating that these genes may play critical roles in normal cortical development. ..
  35. Song W, Song E, Jung M, Choi S, Baik H, Jin B, et al. Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). J Biol Chem. 2015;290:2321-33 pubmed publisher
    ..Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) has multiple biological functions that occur as the result of phosphorylation of diverse proteins that are ..
  36. Aranda S, Alvarez M, Turró S, Laguna A, De La Luna S. Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A. Mol Cell Biol. 2008;28:5899-911 pubmed publisher
    ..However, little is known about the kinases responsible for these posttranslational modifications. We identify DYRK1A as one of the protein kinases of Sprouty2...
  37. Jung M, Park J, Ryu Y, Choi S, Yoon S, Kwen M, et al. Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. J Biol Chem. 2011;286:40401-12 pubmed publisher
    Two genes on chromosome 21, namely dual specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) and regulator of calcineurin 1 (RCAN1), have been implicated in some of the phenotypic characteristics of Down syndrome, including ..
  38. Tlili A, Jacobs F, de Koning L, Mohamed S, Bui L, Dairou J, et al. Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice. Biochim Biophys Acta. 2013;1832:718-28 pubmed publisher
    ..We recently showed that hepatic expression of DYRK1A, a serine/threonine kinase, is negatively correlated with plasma homocysteine levels in cystathionine-beta-..
  39. Kurabayashi N, Nguyen M, Sanada K. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model. EMBO Rep. 2015;16:1548-62 pubmed publisher
    ..Here, we show that differentiation of cortical progenitor cells into astrocytes is promoted by DYRK1A, a Ser/Thr kinase encoded on human chromosome 21...
  40. Sharma S, Findlay G, Bandukwala H, Oberdoerffer S, Baust B, Li Z, et al. Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A. 2011;108:11381-6 pubmed publisher
  41. Noll C, Tlili A, Ripoll C, Mallet L, Paul J, Delabar J, et al. Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism. Mol Genet Metab. 2012;105:484-8 pubmed publisher
    ..In a previous study, we have shown that DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a), a serine/threonine kinase found on human ..
  42. Grebe C, Klingebiel T, Grau S, Toischer K, Didié M, Jacobshagen C, et al. Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Cardiovasc Res. 2011;90:521-8 pubmed publisher
    ..Recently, it has been shown that dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) phosphorylates NFAT, which limits calcineurin/NFAT signal transduction in T cells and hypertrophy in cultured ..
  43. García Cerro S, Martínez P, Vidal V, Corrales A, Flórez J, Vidal R, et al. Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome. PLoS ONE. 2014;9:e106572 pubmed publisher
    Down syndrome (DS) phenotypes result from the overexpression of several dosage-sensitive genes. The DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene, which has been implicated in the behavioral and neuronal ..
  44. Canzonetta C, Mulligan C, Deutsch S, Ruf S, O Doherty A, Lyle R, et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Am J Hum Genet. 2008;83:388-400 pubmed publisher
    ..Using partially trisomic ES cells, we map this effect to a three-gene segment of HSA21, containing DYRK1A. We independently identify the same locus as the most significant eQTL controlling REST expression in the human ..
  45. Park J, Jung M, Kim Y, Song W, Chung S. Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11?. J Neurochem. 2012;122:1081-91 pubmed publisher
    Dual-specificity tyrosine(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is a protein kinase that might be responsible for mental retardation and early onset of Alzheimer's disease in Down's syndrome patients...
  46. Jiang X, Liu C, Yu T, Zhang L, Meng K, Xing Z, et al. Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015;24:6540-51 pubmed publisher
    ..The partial rescue by a Dyrk1a mutation in a compound mutant carrying Dp(16)1Yey and the Dyrk1a mutation confirmed the causative role of Dyrk1a, ..
  47. Sitz J, Tigges M, Baumgärtel K, Khaspekov L, Lutz B. Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol. 2004;24:5821-34 pubmed
    b>Dyrk1A, a mammalian homolog of the Drosophila minibrain gene, encodes a dual-specificity kinase, involved in neuronal development and in adult brain physiology...
  48. Sitz J, Baumgärtel K, Hämmerle B, Papadopoulos C, Hekerman P, Tejedor F, et al. The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. Neuroscience. 2008;157:596-605 pubmed publisher
    The dual-specific kinase DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) is the mammalian orthologue of the Drosophila minibrain (MNB) protein kinase and executes diverse roles in neuronal development and adult ..
  49. Malinge S, Bliss Moreau M, Kirsammer G, Diebold L, Chlon T, Gurbuxani S, et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012;122:948-62 pubmed publisher
    ..Furthermore, through a functional screening of the trisomic genes, we demonstrated that DYRK1A, which encodes dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A, was a potent megakaryoblastic ..
  50. Khor B, Gagnon J, Goel G, Roche M, Conway K, Tran K, et al. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. elife. 2015;4: pubmed publisher
    ..biology approach, we identified a novel role for the dual specificity tyrosine-phosphorylation-regulated kinase DYRK1A in regulating this balance...
  51. Noll C, Planque C, Ripoll C, Guedj F, Diez A, Ducros V, et al. DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS ONE. 2009;4:e7540 pubmed publisher
    ..We previously found a deleterious effect of hyperhomocysteinemia on expression of DYRK1A, a Down-syndrome-associated kinase...
  52. Barallobre M, Perier C, Bove J, Laguna A, Delabar J, Vila M, et al. DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson's disease. Cell Death Dis. 2014;5:e1289 pubmed publisher
    ..Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a pleiotropic kinase involved in neural proliferation and cell death, and its role during brain growth is ..
  53. Enserink M. Behavioral genetics. Fickle mice highlight test problems. Science. 1999;284:1599-600 pubmed
  54. Lepagnol Bestel A, Zvara A, Maussion G, Quignon F, Ngimbous B, Ramoz N, et al. DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum Mol Genet. 2009;18:1405-14 pubmed publisher
    ..Here we use a transgenic DS mouse model (152F7 line) to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (..
  55. Arqué G, Fotaki V, Fernandez D, Martínez de Lagrán M, Arbones M, Dierssen M. Impaired spatial learning strategies and novel object recognition in mice haploinsufficient for the dual specificity tyrosine-regulated kinase-1A (Dyrk1A). PLoS ONE. 2008;3:e2575 pubmed publisher
    ..The DYRK1A gene is localized on the human chromosome 21q22...
  56. Lu M, Zheng L, Han B, Wang L, Wang P, Liu H, et al. REST regulates DYRK1A transcription in a negative feedback loop. J Biol Chem. 2011;286:10755-63 pubmed publisher
    b>DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) has been shown to be involved in learning and memory impairments in Alzheimer disease and Down syndrome...
  57. Kariyawasam D, Rachdi L, Carré A, Martin M, Houlier M, Janel N, et al. DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome. Endocrinology. 2015;156:1171-80 pubmed publisher
    ..Transgenic Dyrk1A mice, obtained by bacterial artificial chromosome engineering (mBACTgDyrk1A), have 3 copies of the Dyrk1A gene...
  58. Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A. 2017;114:E1224-E1233 pubmed publisher
    ..Hap1 bound Dcaf7 competitively in cytoplasm with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), a protein implicated in Down syndrome (DS)...
  59. Geiger J, Knudsen G, Panek L, Pandit A, Yoder M, Lord K, et al. mDYRK3 kinase is expressed selectively in late erythroid progenitor cells and attenuates colony-forming unit-erythroid development. Blood. 2001;97:901-10 pubmed
    ..Thus, it is proposed that mDYRK-3 kinase functions as a lineage-restricted, stage-specific suppressor of red cell development. (Blood. 2001;97:901-910) ..
  60. Rachdi L, Kariyawasam D, Guez F, Aiello V, Arbones M, Janel N, et al. Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass. Diabetologia. 2014;57:960-9 pubmed publisher
    ..b>DYRK1A (also named minibrain/MNB) is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) ..
  61. Hijazi M, Medina J, Velasco A. Restrained Phosphatidylcholine Synthesis in a Cellular Model of Down's Syndrome is Associated with the Overexpression of Dyrk1A. Mol Neurobiol. 2017;54:1092-1100 pubmed publisher
    ..The dual-specificity tyrosine (Y) phosphorylation-regulated kinase 1A (DYRK1A) gene is located on human chromosome 21...
  62. Abekhoukh S, Planque C, Ripoll C, Urbaniak P, Paul J, Delabar J, et al. Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice. Mol Neurobiol. 2013;47:105-16 pubmed publisher
    ..we previously found an activation of extracellular signal-regulated kinase (ERK) pathway and an increase of Dyrk1A, a serine/threonine kinase involved in diverse functions ranging from development and growth to apoptosis...
  63. Litovchick L, Florens L, Swanson S, Washburn M, DeCaprio J. DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly. Genes Dev. 2011;25:801-13 pubmed publisher
    ..Here we report that DYRK1A can specifically phosphorylate LIN52 on serine residue 28, and that this phosphorylation is required for DREAM ..
  64. Qian W, Liang H, Shi J, Jin N, Grundke Iqbal I, Iqbal K, et al. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Res. 2011;39:6161-71 pubmed publisher
    ..b>Dyrk1A (dual-specificity tyrosine-phosphorylated and regulated kinase 1A) phosphorylated SC35 in vitro and interacted ..
  65. da Costa Martins P, Salic K, Gladka M, Armand A, Leptidis S, el Azzouzi H, et al. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol. 2010;12:1220-7 pubmed publisher
    ..failure, and targets the nuclear NFAT kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), constituting a pathogenic feed forward mechanism that affects calcineurin-responsive gene expression...
  66. Rachdi L, Kariyawasam D, Aiello V, Herault Y, Janel N, Delabar J, et al. Dyrk1A induces pancreatic ? cell mass expansion and improves glucose tolerance. Cell Cycle. 2014;13:2221-9 pubmed publisher
    ..The signaling pathways that positively regulate functional ? cell mass have not been fully elucidated. DYRK1A (also called minibrain/MNB) is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) ..
  67. Kaczmarski W, Barua M, Mazur Kolecka B, Frackowiak J, Dowjat W, Mehta P, et al. Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). J Neurosci Res. 2014;92:162-73 pubmed publisher
    The gene encoding dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is located within the Down syndrome (DS) critical region of chromosome 21...
  68. Kurabayashi N, Hirota T, Sakai M, Sanada K, Fukada Y. DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol. 2010;30:1757-68 pubmed publisher
    ..Here we found that Ser557 in the C-terminal tail of CRY2 is phosphorylated by DYRK1A as a priming kinase for subsequent GSK-3beta (glycogen synthase kinase 3beta)-mediated phosphorylation of Ser553, ..