Gene Symbol: Dynll2
Description: dynein light chain LC8-type 2
Alias: 1700064A15Rik, 6720463E02Rik, C87222, DLC8, DLC8b, Dlc2, dynein light chain 2, cytoplasmic, 8 kDa dynein light chain b
Species: mouse
Products:     Dynll2

Top Publications

  1. Wagner W, Fodor E, Ginsburg A, Hammer J. The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain. Biochemistry. 2006;45:11564-77 pubmed
    The myosin Va light chain DYNLL2 has been proposed to function as an adaptor to link the myosin to certain cargo. Here, we mapped the binding site for DYNLL2 within the myosin Va heavy chain...
  2. Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T. Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. Biochem Biophys Res Commun. 2004;314:396-402 pubmed
    ..The interaction was validated by the results of a pull-down assay and indirect immunofluorescence analysis. The significance of Hsp105alpha and Hsp105alpha-binding proteins in cells was discussed. ..
  3. Lin Y, Chen N, Shih Y, Liao Y, Xue L, Lo S. DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene. 2010;29:3010-6 pubmed publisher
    ..Although DLC2 shares a similar domain structure with that of DLC1, the function of DLC2 is not well characterized...
  4. Puthalakath H, Villunger A, O Reilly L, Beaumont J, Coultas L, Cheney R, et al. Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science. 2001;293:1829-32 pubmed
    ..Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures. ..
  5. Wei L, Imanaka Yoshida K, Wang L, Zhan S, Schneider M, DeMayo F, et al. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002;129:1705-14 pubmed
    ..These results reveal new biological functions for Rho family proteins as essential determinants of cell proliferation signals at looping and chamber maturation stages in mammalian cardiac development. ..
  6. Day C, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian L, et al. Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. Biochem J. 2004;377:597-605 pubmed
    ..In vivo DLC2 is found exclusively as a component of the myosin V motor complex and Bmf binds DLC2 selectively...
  7. Goggolidou P, Hadjirin N, Bak A, Papakrivopoulou E, Hilton H, Norris D, et al. Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014;23:5303-16 pubmed publisher
    ..The identification of a novel modulator of Wnt signaling has important implications for understanding the pathobiology of renal disease. ..
  8. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..
  9. Chen Y, Gerwin C, Sheng Z. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. J Neurosci. 2009;29:9429-38 pubmed publisher
    ..Thus, our study provides new mechanistic insights into controlling mitochondrial mobility through a dynamic interaction between the mitochondrial docking receptor and axonal cytoskeleton. ..

More Information


  1. Banks G, Haas M, Line S, Shepherd H, AlQatari M, Stewart S, et al. Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci. 2011;31:5483-94 pubmed publisher
    ..These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system. ..
  2. Moutin E, Raynaud F, Fagni L, Perroy J. GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity. J Cell Sci. 2012;125:2030-40 pubmed publisher
    ..complex, guanylate-kinase-associated protein (GKAP) interacts with dynein light chain 2 (DLC2, also known as DYNLL2), a protein associated with molecular motors...
  3. Goggolidou P, Stevens J, Agueci F, Keynton J, Wheway G, Grimes D, et al. ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014;141:3966-77 pubmed publisher
    ..DYNLL1 in cultured cells recapitulated the in vivo ciliogenesis phenotypes and expression of DYNLL1 or the related DYNLL2 rescued the effects of loss of ATMIN, demonstrating that ATMIN primarily promotes ciliogenesis by regulating ..