Gene Symbol: Dync1li1
Description: dynein cytoplasmic 1 light intermediate chain 1
Alias: 1110053F02Rik, Dnclic1, LIC-1, cytoplasmic dynein 1 light intermediate chain 1, DLC-A, dynein light chain A, dynein light intermediate chain 1, cytosolic, dynein, cytoplasmic, light intermediate chain 1
Species: mouse
Products:     Dync1li1

Top Publications

  1. Bielli A, Thörnqvist P, Hendrick A, Finn R, Fitzgerald K, McCaffrey M. The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. Biochem Biophys Res Commun. 2001;281:1141-53 pubmed
    ..Additionally, GFPRab4A endosomes localize to microtubules and are redistributed by nocodazole treatment. This is the first described interaction between cytoplasmic dynein, a retrograde motor protein, and a Rab protein. ..
  2. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..
  3. Banks G, Haas M, Line S, Shepherd H, AlQatari M, Stewart S, et al. Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci. 2011;31:5483-94 pubmed publisher
    ..approach in mouse (Mus musculus) to analyze the role of one subunit, the dynein light intermediate chain 1 (Dync1li1)...
  4. Hale C, Chen W, Khatau S, Daniels B, Lee J, Wirtz D. SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. J Cell Sci. 2011;124:4267-85 pubmed publisher
    ..Using various cellular geometries and conditions, we implement a systematic and reproducible approach to identify regulators of MTOC and nucleus positioning that depend on extracellular guidance cues. ..
  5. Liu Z, Zhang S, Hao J, Xie T, Kang J. Cellular model of neuronal atrophy induced by DYNC1I1 deficiency reveals protective roles of RAS-RAF-MEK signaling. Protein Cell. 2016;7:638-50 pubmed publisher
    ..These findings demonstrate protective roles of the RAS-RAF-MEK axis against neuronal atrophy, and imply a new therapeutic target for clinical intervention. ..