Gene Symbol: Dync1i2
Description: dynein cytoplasmic 1 intermediate chain 2
Alias: 3110079H08Rik, AW554389, Dncic2, cytoplasmic dynein 1 intermediate chain 2, DH IC-2, cytoplasmic dynein intermediate chain 2 isoform 2.1, cytoplasmic dynein intermediate chain 2 isoform 2.2, cytoplasmic dynein intermediate chain 2 isoform 2.5, dynein intermediate chain 2, cytosolic, dynein, cytoplasmic, intermediate chain 2
Species: mouse
Products:     Dync1i2

Top Publications

  1. Sasaki S, Shionoya A, Ishida M, Gambello M, Yingling J, Wynshaw Boris A, et al. A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system. Neuron. 2000;28:681-96 pubmed
    ..These results suggest that LIS1 and NUDEL regulate CDHC activity during neuronal migration and axonal retrograde transport in a Cdk5/p35-dependent fashion. ..
  2. Crackower M, Sinasac D, Xia J, Motoyama J, Prochazka M, Rommens J, et al. Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human. Genomics. 1999;55:257-67 pubmed
    ..A dynamic expression profile was also found for Dnci2 in the developing mouse limb bud. The data presented here provide a framework for the further analysis of the functional role of Dnci1 and Dnci2 in mouse and DNCI1 in human. ..
  3. Pfister K, Fisher E, Gibbons I, Hays T, Holzbaur E, McIntosh J, et al. Cytoplasmic dynein nomenclature. J Cell Biol. 2005;171:411-3 pubmed
    ..This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms. ..
  4. Suzuki K, Mansson J. Animal models of lysosomal disease: an overview. J Inherit Metab Dis. 1998;21:540-7 pubmed
    ..After all, the mouse is not human. ..
  5. Liu Y, Hogan B. Differential gene expression in the distal tip endoderm of the embryonic mouse lung. Gene Expr Patterns. 2002;2:229-33 pubmed
    ..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization. ..
  6. Shah M, Baterina O, Taupin V, Farquhar M. ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression. J Cell Biol. 2013;202:113-27 pubmed publisher
    ..These results identify a novel mechanism for sorting receptors for trafficking to the ERC and link ERC trafficking to regulated intramembrane proteolysis (RIP) and expression of megalin. ..
  7. Shibata M, Hattori H, Sasaki T, Gotoh J, Hamada J, Fukuuchi Y. Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab. 2002;22:810-20 pubmed
    ..During MCAO, Bad did not show any change in phosphorylation state or subcellular localization. ..
  8. Pyr dit Ruys S, Delaive E, Demazy C, Dieu M, Raes M, Michiels C. Identification of DH IC-2 as a HIF-1 independent protein involved in the adaptive response to hypoxia in tumor cells: A putative role in metastasis. Biochim Biophys Acta. 2009;1793:1676-90 pubmed publisher
    ..These results are important to better understand cancer development since they highlight a HIF-1 independent mechanism, which may be involved in metastasis. ..
  9. Banks G, Haas M, Line S, Shepherd H, AlQatari M, Stewart S, et al. Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. J Neurosci. 2011;31:5483-94 pubmed publisher
    ..These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system. ..

More Information


  1. Inaba Y, Shinohara K, Botilde Y, Nabeshima R, Takaoka K, Ajima R, et al. Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Genes Cells. 2016;21:728-39 pubmed publisher
    ..The IC2-IC1 interaction, which is the first step of ODA assembly, was normal in Lrrc6(-/-) mice testes. Our results suggest that ODA proteins may be transported from the cytoplasm to the cilia by an Lrrc6-dependent mechanism. ..
  2. Kuta A, Deng W, Morsi El Kadi A, Banks G, Hafezparast M, Pfister K, et al. Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. PLoS ONE. 2010;5:e11682 pubmed publisher
    ..this multiprotein complex includes dynein intermediate chains 1 and 2 which are encoded by two genes, Dync1i1 and Dync1i2. These proteins are involved in dynein cargo binding and dynein complexes with different intermediate chains bind ..
  3. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
  4. Calderilla Barbosa L, Seibenhener M, Du Y, Diaz Meco M, Moscat J, Yan J, et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci. 2014;127:4052-63 pubmed publisher
    ..In this model, SQSTM1 would not only affect the association of polyubiquitylated protein aggregates and endosomes with dynein, but would also be required for normal dynein function. ..