Genomes and Genes
Gene Symbol: Dync1i2
Description: dynein cytoplasmic 1 intermediate chain 2
Alias: 3110079H08Rik, AW554389, Dncic2, cytoplasmic dynein 1 intermediate chain 2, DH IC-2, cytoplasmic dynein intermediate chain 2 isoform 2.1, cytoplasmic dynein intermediate chain 2 isoform 2.2, cytoplasmic dynein intermediate chain 2 isoform 2.5, dynein intermediate chain 2, cytosolic, dynein, cytoplasmic, intermediate chain 2
- Inaba Y, Shinohara K, Botilde Y, Nabeshima R, Takaoka K, Ajima R, et al. Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6. Genes Cells. 2016;21:728-39 pubmed publisher..The IC2-IC1 interaction, which is the first step of ODA assembly, was normal in Lrrc6(-/-) mice testes. Our results suggest that ODA proteins may be transported from the cytoplasm to the cilia by an Lrrc6-dependent mechanism. ..
- Kuta A, Deng W, Morsi El Kadi A, Banks G, Hafezparast M, Pfister K, et al. Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. PLoS ONE. 2010;5:e11682 pubmed publisher..this multiprotein complex includes dynein intermediate chains 1 and 2 which are encoded by two genes, Dync1i1 and Dync1i2. These proteins are involved in dynein cargo binding and dynein complexes with different intermediate chains bind ..
- Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
- Calderilla Barbosa L, Seibenhener M, Du Y, Diaz Meco M, Moscat J, Yan J, et al. Interaction of SQSTM1 with the motor protein dynein--SQSTM1 is required for normal dynein function and trafficking. J Cell Sci. 2014;127:4052-63 pubmed publisher..In this model, SQSTM1 would not only affect the association of polyubiquitylated protein aggregates and endosomes with dynein, but would also be required for normal dynein function. ..