Dvl1

Summary

Gene Symbol: Dvl1
Description: dishevelled segment polarity protein 1
Alias: Dvl, mKIAA4029, segment polarity protein dishevelled homolog DVL-1, DSH homolog 1, dishevelled, dsh homolog 1, dishevelled-1
Species: mouse
Products:     Dvl1

Top Publications

  1. Phillips H, Murdoch J, Chaudhry B, Copp A, Henderson D. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005;96:292-9 pubmed
  2. Lee Y, Gao Y, Wang H. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal. 2008;20:443-52 pubmed
    ..In the genomes of higher organism (including mammals), three genes encoding isoforms of Dishevelled (Dvl1, Dvl2, and Dvl3) are present...
  3. Bikkavilli R, Feigin M, Malbon C. G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 2008;121:234-45 pubmed publisher
    ..These data reveal both common and unique signaling elements in WNT3a-sensitive pathways, highlighting crosstalk from WNT3a-JNK to WNT3a-beta-catenin signaling. ..
  4. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Krönig C, et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet. 2005;37:537-43 pubmed
    ..Inversin inhibits the canonical Wnt pathway by targeting cytoplasmic dishevelled (Dsh or Dvl1) for degradation; concomitantly, it is required for convergent extension movements in gastrulating Xenopus laevis ..
  5. Rosso S, Sussman D, Wynshaw Boris A, Salinas P. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci. 2005;8:34-42 pubmed
    ..Consistent with these findings, hippocampal neurons from mice lacking Dvl1 show reduced dendritic arborization...
  6. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88 pubmed
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling. ..
  7. Wang J, Hamblet N, Mark S, Dickinson M, Brinkman B, Segil N, et al. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006;133:1767-78 pubmed
    ..Here we show, using mice with null mutations in two mammalian Dishevelled homologs, Dvl1 and Dvl2, that during neurulation a homologous mammalian PCP pathway regulates concomitant lengthening and ..
  8. Torban E, Wang H, Groulx N, Gros P. Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004;279:52703-13 pubmed
    ..mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. These findings suggest a molecular mechanism for the neural tube defect seen in Lp mice...
  9. Ahmad Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj N, Rosso S, et al. Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol. 2006;174:127-39 pubmed
    ..We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a phenotype in the cerebellum...
  10. Wang J, Mark S, Zhang X, Qian D, Yoo S, Radde Gallwitz K, et al. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet. 2005;37:980-5 pubmed

Detail Information

Publications85

  1. Phillips H, Murdoch J, Chaudhry B, Copp A, Henderson D. Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res. 2005;96:292-9 pubmed
  2. Lee Y, Gao Y, Wang H. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3. Cell Signal. 2008;20:443-52 pubmed
    ..In the genomes of higher organism (including mammals), three genes encoding isoforms of Dishevelled (Dvl1, Dvl2, and Dvl3) are present...
  3. Bikkavilli R, Feigin M, Malbon C. G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells. J Cell Sci. 2008;121:234-45 pubmed publisher
    ..These data reveal both common and unique signaling elements in WNT3a-sensitive pathways, highlighting crosstalk from WNT3a-JNK to WNT3a-beta-catenin signaling. ..
  4. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Krönig C, et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet. 2005;37:537-43 pubmed
    ..Inversin inhibits the canonical Wnt pathway by targeting cytoplasmic dishevelled (Dsh or Dvl1) for degradation; concomitantly, it is required for convergent extension movements in gastrulating Xenopus laevis ..
  5. Rosso S, Sussman D, Wynshaw Boris A, Salinas P. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Nat Neurosci. 2005;8:34-42 pubmed
    ..Consistent with these findings, hippocampal neurons from mice lacking Dvl1 show reduced dendritic arborization...
  6. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88 pubmed
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling. ..
  7. Wang J, Hamblet N, Mark S, Dickinson M, Brinkman B, Segil N, et al. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006;133:1767-78 pubmed
    ..Here we show, using mice with null mutations in two mammalian Dishevelled homologs, Dvl1 and Dvl2, that during neurulation a homologous mammalian PCP pathway regulates concomitant lengthening and ..
  8. Torban E, Wang H, Groulx N, Gros P. Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem. 2004;279:52703-13 pubmed
    ..mutations identified in two independent Lp alleles associated with neural tube defects impair binding to Dvl1, Dvl2, and Dvl3. These findings suggest a molecular mechanism for the neural tube defect seen in Lp mice...
  9. Ahmad Annuar A, Ciani L, Simeonidis I, Herreros J, Fredj N, Rosso S, et al. Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol. 2006;174:127-39 pubmed
    ..We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a phenotype in the cerebellum...
  10. Wang J, Mark S, Zhang X, Qian D, Yoo S, Radde Gallwitz K, et al. Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet. 2005;37:980-5 pubmed
  11. Terabayashi T, Funato Y, Fukuda M, Miki H. A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). J Biol Chem. 2009;284:26716-24 pubmed publisher
    ..We identify CVAK104 as a novel binding partner of Dishevelled (Dvl), a scaffold protein in the Wnt signaling pathway...
  12. Ciani L, Krylova O, Smalley M, Dale T, Salinas P. A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol. 2004;164:243-53 pubmed
    Dishevelled (DVL) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3beta (GSK-3beta)...
  13. Yang Y, Lijam N, Sussman D, Tsang M. Genomic organization of mouse Dishevelled genes. Gene. 1996;180:121-3 pubmed
    ..clones were isolated from a mouse 129 strain gamma FIXII genomic library and have identical exon/intron organization to Dvl1. All three Dishevelled genes span 15 exons and 14 introns and have a number of conserved splice junction sites.
  14. Etheridge S, Ray S, Li S, Hamblet N, Lijam N, Tsang M, et al. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 2008;4:e1000259 pubmed publisher
    ..Three mammalian Dvl genes have been identified and the developmental roles of Dvl1 and Dvl2 were previously determined...
  15. Elbert M, Cohen D, Müsch A. PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells. Mol Biol Cell. 2006;17:3345-55 pubmed
    ..2) Par1b attenuates the effect of Dishevelled (Dvl) expression, an inducer of wnt signaling that causes transformation of epithelial cells...
  16. Schulte G, Bryja V, Rawal N, Castelo Branco G, Sousa K, Arenas E. Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. J Neurochem. 2005;92:1550-3 pubmed
    ..Furthermore, we identify dishevelled as a key player in transducing both Wnt canonical and non-canonical signals in dopaminergic cells. ..
  17. Pan W, Choi S, Wang H, Qin Y, Volpicelli Daley L, Swan L, et al. Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science. 2008;321:1350-3 pubmed publisher
    ..In turn, PtdIns (4,5)P2 regulated phosphorylation of LRP6 at Thr1479 and Ser1490. Therefore, our study reveals a signaling mechanism for Wnt to regulate LRP6 phosphorylation. ..
  18. Liu W, Sato A, Khadka D, Bharti R, Diaz H, Runnels L, et al. Mechanism of activation of the Formin protein Daam1. Proc Natl Acad Sci U S A. 2008;105:210-5 pubmed
    ..we report that Daam1 is not significantly activated by Rho binding but rather by its interaction with Dishevelled (Dvl)...
  19. Ciani L, Boyle K, Dickins E, Sahores M, Anane D, Lopes D, et al. Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²?/Calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A. 2011;108:10732-7 pubmed publisher
    ..Wnt7a or postsynaptic expression of Dishevelled-1 (Dvl1), a core Wnt signaling component, increases the frequency and amplitude of miniature excitatory postsynaptic ..
  20. Lee J, Ishimoto A, Yanagawa S. Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J Biol Chem. 1999;274:21464-70 pubmed
    ..To demonstrate functional conservation of Dsh family proteins, two mouse homologs of Drosophila Dsh, Dvl-1 and Dvl-2, were biochemically characterized in mouse and Drosophila cell culture systems...
  21. González Sancho J, Brennan K, Castelo Soccio L, Brown A. Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol. 2004;24:4757-68 pubmed
    ..Dishevelled (Dvl) is a key component of Wnt/beta-catenin signaling and becomes phosphorylated upon activation of this pathway...
  22. Lijam N, Sussman D. Organization and promoter analysis of the mouse dishevelled-1 gene. Genome Res. 1995;5:116-24 pubmed
    We have characterized the genomic organization of a mouse homolog (Dvl-1) of Drosophila dishevelled, a segment polarity gene required for wingless signal transduction...
  23. Purro S, Ciani L, Hoyos Flight M, Stamatakou E, Siomou E, Salinas P. Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci. 2008;28:8644-54 pubmed publisher
    ..Analyses of Dishevelled-1 (Dvl1) mutant neurons demonstrate that Dvl1 is required for Wnt-mediated microtubule reorganization and axon remodeling...
  24. Lijam N, Paylor R, McDonald M, Crawley J, Deng C, Herrup K, et al. Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1. Cell. 1997;90:895-905 pubmed
    Mice completely deficient for Dvl1, one of three mouse homologs of the Drosophila segment polarity gene Dishevelled, were created by gene targeting. Dvl1-deficient mice are viable, fertile, and structurally normal...
  25. Sussman D, Klingensmith J, Salinas P, Adams P, Nusse R, Perrimon N. Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol. 1994;166:73-86 pubmed
    ..The 695-amino-acid protein encoded by the mouse dishevelled gene (Dvl-1) shares 50% identity (65% similarity) with dsh...
  26. Vladar E, Bayly R, Sangoram A, Scott M, Axelrod J. Microtubules enable the planar cell polarity of airway cilia. Curr Biol. 2012;22:2203-12 pubmed publisher
  27. Hamblet N, Lijam N, Ruiz Lozano P, Wang J, Yang Y, Luo Z, et al. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development. 2002;129:5827-38 pubmed
    ..These skeletal abnormalities were more pronounced in mice deficient for both Dvl1 and Dvl2...
  28. Sinha T, Wang B, Evans S, Wynshaw Boris A, Wang J. Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol. 2012;370:135-44 pubmed publisher
    ..Previous genetic studies in mice indicated that outflow tract (OFT) formation requires Dvl1 and 2, but it was unclear which pathway was involved and whether Dvl1/2-mediated signaling was required in the ..
  29. Tissir F, Goffinet A. Expression of planar cell polarity genes during development of the mouse CNS. Eur J Neurosci. 2006;23:597-607 pubmed
    ..they do in flies, we used mRNA in situ hybridization to compare the expression of Celsr3 and Fzd3 with that of dishevelled 1, 2 and 3 (Dvl1-3), van gogh-like 1 and 2 (Vangl1, 2), and prickle-like 1 and 2 (Prickle1, 2), during mouse CNS ..
  30. Suriben R, Kivimäe S, Fisher D, Moon R, Cheyette B. Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009;41:977-85 pubmed publisher
    ..We conclude that Dact1 contributes to morphogenesis at the primitive streak by regulating Vangl2 upstream of cell adhesion and the PCP pathway. ..
  31. Wong H, Bourdelas A, Krauss A, Lee H, Shao Y, Wu D, et al. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell. 2003;12:1251-60 pubmed
    The cytoplasmic protein Dishevelled (Dvl) and the associated membrane-bound receptor Frizzled (Fz) are essential in canonical and noncanonical Wnt signaling pathways...
  32. Yu Z, Liu N, Wang Y, Li X, Wang X. Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Neuroscience. 2012;200:99-105 pubmed publisher
    ..Our findings provide molecular targets for investigating protein interaction-based biological functions and neuroprotective mechanisms of Ngb. ..
  33. Bryja V, Cajanek L, Grahn A, Schulte G. Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiol (Oxf). 2007;190:55-61 pubmed
  34. Orelio C, Dzierzak E. Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Blood. 2003;101:2246-9 pubmed
    ..The identification of differentially expressed genes in the AGM region should yield further insights into the development of this tissue and into the emergence and regulation of HSCs...
  35. Goggolidou P, Hadjirin N, Bak A, Papakrivopoulou E, Hilton H, Norris D, et al. Atmin mediates kidney morphogenesis by modulating Wnt signaling. Hum Mol Genet. 2014;23:5303-16 pubmed publisher
    ..The identification of a novel modulator of Wnt signaling has important implications for understanding the pathobiology of renal disease. ..
  36. Walf Vorderwülbecke V, de Boer J, Horton S, van Amerongen R, Proost N, Berns A, et al. Frat2 mediates the oncogenic activation of Rac by MLL fusions. Blood. 2012;120:4819-28 pubmed publisher
    ..FRAT2 activates Rac through a signaling mechanism that requires glycogen synthase kinase 3 and DVL. Disruption of this pathway abrogates the leukemogenic activity of MLL fusions...
  37. Voronina V, Takemaru K, Treuting P, Love D, Grubb B, Hajjar A, et al. Inactivation of Chibby affects function of motile airway cilia. J Cell Biol. 2009;185:225-33 pubmed publisher
    ..As the phenotypes of Cby(-/-) mice bear striking similarities to primary ciliary dyskinesia, Cby(-/-) mice may prove to be a useful model for this condition. ..
  38. Lee I, Choi S, Yun J, Seo S, Choi S, Choi K, et al. Crystal structure of the PDZ domain of mouse Dishevelled 1 and its interaction with CXXC5. Biochem Biophys Res Commun. 2017;485:584-590 pubmed publisher
    ..Although solution structures of the Dvl1 PDZ domain have been reported, a high-resolution crystal structure would provide detailed sidechain information ..
  39. Ma P, Wang H, Guo R, Ma Q, Yu Z, Jiang Y, et al. Stage-dependent Dishevelled-1 expression during mouse spermatogenesis suggests a role in regulating spermatid morphological changes. Mol Reprod Dev. 2006;73:774-83 pubmed
    Dishevelled (Dsh in Drosophila or DVL in mice) is a member of the highly conserved Wg/Wnt signaling pathway, which regulates important processes such as cell proliferation, polarity, and specification of cell fate...
  40. Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, et al. Nucleoredoxin sustains Wnt/?-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010;20:1945-52 pubmed publisher
    Overexpression of Dishevelled (Dvl), an essential component of the Wnt signaling pathway, is frequently associated with tumors, and thus the Dvl protein level must be tightly controlled to sustain Wnt signaling without causing tumors...
  41. Yu P, Yang W, Han D, Wang X, Guo S, Li J, et al. Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016;99:195-201 pubmed publisher
  42. Beier D, Dushkin H, Sussman D. Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992;89:9102-6 pubmed
    ..We also tested the utility of this approach for characterizing genes that have not been previously mapped. Dvl, the mouse homolog of the putative Drosophila dishevelled gene, and Adfp, encoding an adipocyte differentiation-..
  43. Onishi K, Shafer B, Lo C, Tissir F, Goffinet A, Zou Y. Antagonistic functions of Dishevelleds regulate Frizzled3 endocytosis via filopodia tips in Wnt-mediated growth cone guidance. J Neurosci. 2013;33:19071-85 pubmed publisher
  44. Ishida Takagishi M, Enomoto A, Asai N, Ushida K, Watanabe T, Hashimoto T, et al. The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility. Nat Commun. 2012;3:859 pubmed publisher
    ..These findings indicate that Daple interacts with Dishevelled to direct the Dishevelled/protein kinase ? protein complex to activate Rac, which in turn mediates the non-canonical Wnt signalling pathway required for cell migration. ..
  45. van de Schans V, van den Borne S, Strzelecka A, Janssen B, Van Der Velden J, Langen R, et al. Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension. 2007;49:473-80 pubmed
    ..Stimulation of the Wnt/Frizzled pathway activates the disheveled (Dvl) protein...
  46. Ciani L, Marzo A, Boyle K, Stamatakou E, Lopes D, Anane D, et al. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1. Nat Commun. 2015;6:8302 pubmed publisher
    ..examine the mechanisms involved, we investigated the interaction of release machinery proteins with Dishevelled-1 (Dvl1), a scaffold protein that determines the cellular locale of Wnt action...
  47. Lee H, Finkelstein D, Li X, Wu D, Shi D, Zheng J. Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein. J Biol Chem. 2010;285:41549-56 pubmed publisher
    ..Dishevelled (Dvl/Dsh) protein is one of key components in Wnt signaling and plays essential roles in regulating these pathways ..
  48. Alarcon V, Marikawa Y. Molecular study of mouse peri-implantation development using the in vitro culture of aggregated inner cell mass. Mol Reprod Dev. 2004;67:83-90 pubmed
    ..Taken together, we propose that the 5x ICM is a useful in vitro tool to study the mechanisms of peri-implantation development of the mouse embryo. Mol. Reprod. Dev. 67: 83-90, 2004. ..
  49. Lee H, Wang N, Shi D, Zheng J. Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew Chem Int Ed Engl. 2009;48:6448-52 pubmed publisher
  50. Ganner A, Lienkamp S, Schäfer T, Romaker D, Wegierski T, Park T, et al. Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A. 2009;106:17799-804 pubmed publisher
    ..In multiciliated Xenopus epidermal cells, recruitment of Dishevelled (Dvl) to the basal body and its localization to the center of the ciliary rootlet are required to correctly position the ..
  51. Huang T, Xie Z, Wang J, Li M, Jing N, Li L. Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J Biol Chem. 2011;286:37399-405 pubmed publisher
    ..nuclear factor of activated T cells (NFAT), a component of Ca(2+) signaling, interacts directly with Dishevelled (Dvl) in a Ca(2+)-dependent manner...
  52. Shafer B, Onishi K, Lo C, Colakoglu G, Zou Y. Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell. 2011;20:177-91 pubmed publisher
    ..Taken together, we propose that the antagonistic functions of Vangl2 and Dvl1 (over Frizzled3 hyperphosphorylation and endocytosis) allow sharpening of PCP signaling locally on the tips of the ..
  53. Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, et al. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol. 2001;21:330-42 pubmed
    In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex)...
  54. Ohata S, Nakatani J, Herranz Pérez V, Cheng J, Belinson H, Inubushi T, et al. Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus. Neuron. 2014;83:558-71 pubmed publisher
    ..Using the hGFAP-Cre;Dvl1(-/-);2(flox/flox);3(+/-) mouse, we show that compound genetic ablation of Dvls causes hydrocephalus...
  55. Liu Z, Tang Y, Qiu T, Cao X, Clemens T. A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem. 2006;281:17156-63 pubmed
    ..in 293T cells transfected with individual Smads and Wnt pathway components revealed a specific interaction between Dvl-1 and Smad1 that was dependent on the presence of Wnt3a or BMP-2...
  56. Huang X, McGann J, Liu B, Hannoush R, Lill J, Pham V, et al. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 2013;339:1441-5 pubmed publisher
    ..Wnt-dependent growth of xenografted human tumor cells was suppressed by RIPK4 knockdown, suggesting that RIPK4 overexpression may contribute to the growth of certain tumor types. ..
  57. Gibbs B, Damerla R, Vladar E, Chatterjee B, Wan Y, Liu X, et al. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016;5:323-35 pubmed publisher
    ..Together these findings show Pk1 plays an essential role in regulating cell polarity and directional cell migration during development. ..
  58. Zilber Y, Babayeva S, Seo J, Liu J, Mootin S, Torban E. The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium. Mol Biol Cell. 2013;24:555-65 pubmed publisher
    ..We show that loss of Fuzzy results in inhibition of PCP signaling and hyperactivation of the canonical WNT pathway. We propose a mechanism by which Fuzzy participates in ciliogenesis and affects both canonical WNT and PCP signaling. ..
  59. Kim W, Kim H, Katanaev V, Joon Lee S, Ishitani T, Cha B, et al. Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning. EMBO J. 2012;31:3384-97 pubmed publisher
    ..DP1 negatively regulates Wnt/?-catenin signalling by inhibiting Dvl-Axin interaction and by enhancing poly-ubiquitination of ?-catenin...
  60. Rodriguez Gil D, Hu W, Greer C. Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals. PLoS ONE. 2013;8:e56561 pubmed publisher
    ..Dishevelled (Dvl) is a key molecule downstream of Fz receptors...
  61. George A, Leahy H, Zhou J, Morin P. The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling. Neurobiol Dis. 2007;26:125-33 pubmed
    ..These data suggest that endosomal V-type ATPase activity and retromer trafficking proteins are functionally important in Wnt signal transduction. ..
  62. Beier D, Dushkin H, Telle T. Haplotype analysis of intra-specific backcross curly-tail mice confirms the localization of ct to chromosome 4. Mamm Genome. 1995;6:269-72 pubmed
    ..Finally, we examined Pax7 as a candidate gene for the ct mutation and found no evidence of protein sequence differences in ct compared with wild-type mice. ..
  63. Tsuji T, Ohta Y, Kanno Y, Hirose K, Ohashi K, Mizuno K. Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells. Mol Biol Cell. 2010;21:3590-600 pubmed publisher
    ..Dishevelled (Dvl) and its binding protein Daam1 mediate RhoA activation in this pathway...
  64. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, et al. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene. Hum Mol Genet. 1996;5:953-8 pubmed
    ..We have isolated and characterized cDNA clones from two different human dsh-homologous genes, designated as DVL-1 and DVL-3. DVL-1 and DVL-3 putative protein products show 64% amino acid identity...
  65. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein J, Cheyette B. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS ONE. 2013;8:e67679 pubmed publisher
    ..In sum, our results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1, in the formation of synapses on cortical interneuron dendrites. ..
  66. Fujimura L, Watanabe Takano H, Sato Y, Tokuhisa T, Hatano M. Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. Neurosci Lett. 2009;467:6-10 pubmed publisher
    ..Upon induction of the neurite-like process formation, the amount of Dvl1 protein decreased...
  67. GARCIA GARCIA M, Shibata M, Anderson K. Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008;135:3053-62 pubmed publisher
  68. Glasco D, Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, et al. The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol. 2012;369:211-22 pubmed publisher
    ..However, FBM neurons migrated normally in Dishevelled (Dvl) 1/2 double mutants, and in zebrafish embryos with disrupted Dvl signaling, suggesting that Dvl function is ..
  69. Lai W, Pakes S, Bennett M. Natural resistance to Mycoplasma pulmonis infection in mice: host resistance gene(s) map to chromosome 4. Nat Immun. 1996;15:241-8 pubmed
  70. Turm H, Maoz M, Katz V, Yin Y, Offermanns S, Bar Shavit R. Protease-activated receptor-1 (PAR1) acts via a novel Galpha13-dishevelled axis to stabilize beta-catenin levels. J Biol Chem. 2010;285:15137-48 pubmed publisher
    ..PAR1-Galpha(13) association is followed by the recruitment of DVL (Dishevelled), an upstream Wnt signaling protein via the DIX domain...
  71. Eicher E, Shown E. Molecular markers that define the distal ends of mouse autosomes 4, 13, and 19 and the sex chromosomes. Mamm Genome. 1993;4:226-9 pubmed
  72. Karasawa T, Yokokura H, Kitajewski J, Lombroso P. Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling. J Biol Chem. 2002;277:37479-86 pubmed
    ..Rfz9 overexpression induces the hyperphosphorylation and relocalization of mouse Dishevelled-1 (Dvl-1) from the cytoplasm to the cell membrane and the accumulation of cytosolic beta-catenin...
  73. Li L, Mao J, Sun L, Liu W, Wu D. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem. 2002;277:5977-81 pubmed
    ..We also showed that while both Axin and the DIX domain of Dishevelled (Dvl) could inhibit Dkk-2C2-induced activation of LEF-1, the DEP domain of Dvl, which inhibited Wnt-induced activation ..
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