Gene Symbol: Dusp9
Description: dual specificity phosphatase 9
Alias: Dusp4, Mpk4, Pyst3, dual specificity protein phosphatase 9, dual-specificity MAP kinase phosphatase 4
Species: mouse
Products:     Dusp9

Top Publications

  1. Dickinson R, Williams D, Slack D, Williamson J, Seternes O, Keyse S. Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase. Biochem J. 2002;364:145-55 pubmed
    ..Here, we report the isolation and characterization of the murine Pyst3 gene, which encodes a cytosolic dual-specificity MKP...
  2. Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, et al. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem. 2003;278:30187-92 pubmed
    ..Our data suggest that MKP-4 negatively regulates insulin signaling and, consequently, may contribute to the pathogenesis of insulin resistance. ..
  3. Christie G, Williams D, MacIsaac F, Dickinson R, Rosewell I, Keyse S. The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005;25:8323-33 pubmed
    To elucidate the physiological role(s) of DUSP9 (dual-specificity phosphatase 9), also known as MKP-4 (mitogen-activated protein kinase [MAPK] phosphatase 4), the gene was deleted in mice...
  4. Emanuelli B, Eberle D, Suzuki R, Kahn C. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc Natl Acad Sci U S A. 2008;105:3545-50 pubmed publisher
  5. Lin S, Ikegami M, Xu Y, Bosserhoff A, Malkinson A, Shannon J. Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol. 2008;316:441-55 pubmed publisher
    ..These results suggest that the silencing of Mia1 that occurs in late gestation may be required for maturation of the surfactant system. ..
  6. Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, et al. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell. 2012;10:171-82 pubmed publisher
    ..activity, BMP4 can steadily attenuate ERK activity by upregulating ERK-specific dual-specificity phosphatase 9 (DUSP9)...
  7. Choi J, Clement K, Huebner A, Webster J, Rose C, Brumbaugh J, et al. DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 2017;20:706-719.e7 pubmed publisher
    ..We show that the X-linked MAPK phosphatase DUSP9 is upregulated in female compared to male ESCs, and its heterozygous loss in female ESCs leads to male-like ..
  8. LU J, Qian J, Izvolsky K, Cardoso W. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004;273:418-35 pubmed
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation. ..
  9. Liu Y, Lagowski J, Sundholm A, Sundberg A, Kulesz Martin M. Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4. Cancer Res. 2007;67:10711-9 pubmed
    ..Thus, microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP and implies a novel therapeutic strategy through combined MAPK inhibitions that mimic the function of MKP4. ..

More Information


  1. Urness L, Li C, Wang X, Mansour S. Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development. Dev Dyn. 2008;237:163-9 pubmed
    ..otic development, we surveyed the expression domains of the three ERK-specific DUSP transcripts, Dusp6, Dusp7, and Dusp9, in the embryonic mouse ear...
  2. Dickinson R, Delavaine L, Cejudo Marín R, Stewart G, Staples C, Didmon M, et al. Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways. J Biol Chem. 2011;286:38018-26 pubmed publisher
    MAP kinase phosphatase 4 (DUSP9/MKP-4) plays an essential role during placental development and is one of a subfamily of three closely related cytoplasmic dual-specificity MAPK phosphatases, which includes the ERK-specific enzymes DUSP6/..
  3. Finelli M, Murphy K, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013;3:1592-606 pubmed publisher
    ..Together, the BMP and neurotrophin pathways form a tightly regulated signaling network with a balanced ratio of Erk1/2 and pErk1/2 to direct the precise connections between sensory neurons and peripheral targets. ..
  4. Niedzielska M, Raffi F, Tel J, Muench S, Jozefowski K, Alati N, et al. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-β Production. J Immunol. 2015;195:1753-62 pubmed publisher
    ..In this study, we identified the MAPK phosphatase Dusp9/MKP-4 by transcriptome analysis as selectively expressed in pDCs, but not cDCs...