Gene Symbol: Dusp8
Description: dual specificity phosphatase 8
Alias: 5530400B01Rik, AI593498, Nttp1, dual specificity protein phosphatase 8, neuronal tyrosine threonine phosphatase 1
Paulsen M, Davies K, Bowden L, Villar A, Franck O, Fuermann M, et al
. Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Hum Mol Genet. 1998;7:1149-59 pubmed
..Our study opens the way for a systematic analysis of the cluster by genetic manipulation in the mouse which will lead to animal models of Beckwith-Wiedemann syndrome and childhood tumours. ..
Goldberg M, Wei M, Yuan L, Murty V, Tycko B. Biallelic expression of HRAS and MUCDHL in human and mouse. Hum Genet. 2003;112:334-42 pubmed
..The mouse orthologue of a third gene, DUSP8, located between H19 and MUCDHL, is also expressed biallelically...
Liu R, van Berlo J, York A, Vagnozzi R, Maillet M, Molkentin J. DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling. Circ Res. 2016;119:249-60 pubmed publisher
..To examine DUSP8 as a regulator of MAPK signaling in the heart and its impact on ventricular and cardiac myocyte growth dynamics...
Martell K, Seasholtz A, Kwak S, Clemens K, Dixon J. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. J Neurochem. 1995;65:1823-33 pubmed
..hVH-5 was induced in PC12 cells upon nerve growth factor and insulin treatment in a manner characteristic of an immediate-early gene, suggesting a possible role in the signal transduction cascade. ..
Theodosiou A, Rodrigues N, Nesbit M, Ambrose H, Paterson H, McLellan Arnold E, et al
. A member of the MAP kinase phosphatase gene family in mouse containing a complex trinucleotide repeat in the coding region. Hum Mol Genet. 1996;5:675-84 pubmed
..2 and 10q22. The presence of a CG-rich trinucleotide repeat in the coding region provides a target for mutation which might result in loss of function or altered properties of this phosphatase. ..
Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H. Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7. DNA Res. 1999;6:401-5 pubmed
Aoki N, Aoyama K, Nagata M, Matsuda T. A growing family of dual specificity phosphatases with low molecular masses. J Biochem. 2001;130:133-40 pubmed
..Taken together, it is conceivable that a distinct class of low molecular mass DSPs is present and plays a role in dephosphorylating unknown molecules other than MAP kinases. ..
Finelli M, Murphy K, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013;3:1592-606 pubmed publisher
..Together, the BMP and neurotrophin pathways form a tightly regulated signaling network with a balanced ratio of Erk1/2 and pErk1/2 to direct the precise connections between sensory neurons and peripheral targets. ..