| Dusp5Gene Symbol: Dusp5 Description: dual specificity phosphatase 5 Alias: Gm337, dual specificity protein phosphatase 5 Species: mouse Clee S, Yandell B, Schueler K, Rabaglia M, Richards O, Raines S, et al. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet. 2006;38:688-93 pubmed ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus. .. Grasset M, Gobert Gosse S, Mouchiroud G, Bourette R. Macrophage differentiation of myeloid progenitor cells in response to M-CSF is regulated by the dual-specificity phosphatase DUSP5. J Leukoc Biol. 2010;87:127-35 pubmed publisher ..FD-Fms cells stimulated by M-CSF for 8 h in the presence or the absence of the MEK inhibitor U0126, we isolated DUSP5. DUSP5 expression is induced by M-CSF in various myeloid cells and acts as a specific negative-feedback regulator .. Finelli M, Murphy K, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013;3:1592-606 pubmed publisher ..Together, the BMP and neurotrophin pathways form a tightly regulated signaling network with a balanced ratio of Erk1/2 and pErk1/2 to direct the precise connections between sensory neurons and peripheral targets. .. Holmes D, Yeh J, Yan D, Xu M, Chan A. Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. EMBO J. 2015;34:218-35 pubmed publisher ..We demonstrate here that DUSP5 is expressed in eosinophils, is upregulated following IL-33 stimulation and regulates IL-33 signaling... Rushworth L, Kidger A, Delavaine L, Stewart G, van Schelven S, Davidson J, et al. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression. Proc Natl Acad Sci U S A. 2014;111:18267-72 pubmed publisher Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mitogen-activated protein (MAP) kinase phosphatase, specifically inactivates and anchors extracellular signal-regulated kinase (ERK)1/2 in the nucleus... Buffet C, Catelli M, Hecale Perlemoine K, Bricaire L, García C, Gallet Dierick A, et al. Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor. PLoS ONE. 2015;10:e0145484 pubmed publisher Serum stimulation of mammalian cells induces, via the MAPK pathway, the nuclear protein DUSP5 (dual-specificity phosphatase 5), which specifically interacts with and inactivates the ERK1/2 MAP kinases... Kutty R, Xin G, Schauder D, Cossette S, Bordas M, Cui W, et al. Dual Specificity Phosphatase 5 Is Essential for T Cell Survival. PLoS ONE. 2016;11:e0167246 pubmed publisher ..The final proteins in this pathway, ERK1/2, are regulated by dual specificity phosphatase 5 (DUSP5). DUSP5 is a nuclear, inducible phosphatase with high affinity and fidelity for ERK1/2... Kovanen P, Bernard J, Al Shami A, Liu C, Bollenbacher Reilley J, Young L, et al. T-cell development and function are modulated by dual specificity phosphatase DUSP5. J Biol Chem. 2008;283:17362-9 pubmed publisher ..Here we have evaluated the in vivo actions of DUSP5, an extracellular signal-regulated kinase 1/2 (ERK1/2)-specific phosphatase, by generating transgenic mice .. Muth K, Piefke S, Weider M, Sock E, Hermans Borgmeyer I, Wegner M, et al. The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia. 2016;64:2120-2132 pubmed publisher ..This argues that Dusp15 is not only a joint target of Sox10 and Myrf in oligodendrocytes but may also mediate some of their effects during oligodendrocyte differentiation and myelin formation. GLIA 2016;64:2120-2132. ..
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