Genomes and Genes
Gene Symbol: Dusp3
Description: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Alias: 2210015O03Rik, 5031436O03Rik, T-DSP11, VHR, dual specificity protein phosphatase 3, vaccinia H1-related phosphatase
- Singh P, Dejager L, Amand M, Theatre E, Vandereyken M, Zurashvili T, et al. DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock. J Immunol. 2015;194:4951-62 pubmed publisherb>DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological function...
- Chen Y, Chou H, Yang C, Chen H, Liu Y, Lin T, et al. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 2017;36:6509-6517 pubmed publisherVaccinia H1-related phosphatase (VHR/DUSP3) is a member of the dual-specificity phosphatase family. Deregulation of VHR is observed in various malignant diseases. We identified focal adhesion kinase (FAK) as a VHR-interacting molecule...
- Finelli M, Murphy K, Chen L, Zou H. Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013;3:1592-606 pubmed publisher..Together, the BMP and neurotrophin pathways form a tightly regulated signaling network with a balanced ratio of Erk1/2 and pErk1/2 to direct the precise connections between sensory neurons and peripheral targets. ..
- Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, et al. Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017;31:957-966 pubmed publisher..MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. This mechanistic insight points to pathways that might be targeted therapeutically in MPN. ..
- Romá Mateo C, Rios P, Tabernero L, Attwood T, Pulido R. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. J Mol Biol. 2007;374:899-909 pubmed..Our findings predict characteristic functional motifs for the diverse members of the DSP families of PTPs and provide insights into the functional properties of DSPs of unknown function. ..
- Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, et al. Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. PLoS ONE. 2017;12:e0185786 pubmed publisherVaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers...