Gene Symbol: Dusp14
Description: dual specificity phosphatase 14
Alias: 1110014C10Rik, 2310042C07Rik, D11Ertd395e, MKP-L, Mkp6, dual specificity protein phosphatase 14, MAP kinase phosphatase 6, MAP kinase phsophatase 6, MKP-6, Mkp-1 like protein tyrosine phosphatase, mitogen-activated protein kinase phosphatase 6
Klinger S, Poussin C, Debril M, Dolci W, Halban P, Thorens B. Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. Diabetes. 2008;57:584-93 pubmed
..CREB) antagonists cAMP response element modulator (CREM)-alpha and ICERI; and the dual specificity phosphatase DUSP14, a negative regulator of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (..
Zeller E, Mock K, Horn M, Colnot S, Schwarz M, Braeuning A. Dual-specificity phosphatases are targets of the Wnt/?-catenin pathway and candidate mediators of ?-catenin/Ras signaling interactions. Biol Chem. 2012;393:1183-91 pubmed publisher
..Thus, ?-catenin is able to inhibit activation of the Egfr/Ras/MAPK signaling cascade, both at the receptor level and by interfering with MAPK activity via Dusps. ..
Marti F, Krause A, Post N, Lyddane C, Dupont B, Sadelain M, et al
. Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. J Immunol. 2001;166:197-206 pubmed
..technology, we cloned a novel CD28 cytoplasmic tail (CD28 CYT) interacting protein, MAP kinase phosphatase-6 (MKP6), which we demonstrate inactivates MAP kinases...
Romá Mateo C, Rios P, Tabernero L, Attwood T, Pulido R. A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. J Mol Biol. 2007;374:899-909 pubmed
..Our findings predict characteristic functional motifs for the diverse members of the DSP families of PTPs and provide insights into the functional properties of DSPs of unknown function. ..
Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, et al
. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014;192:1547-57 pubmed publisher
..Dual-specificity phosphatase 14 (DUSP14; also known as MKP6) is classified as a MAPK phosphatase. The in vivo functions of DUSP14 remain unclear...
Li C, Zhou Q, Yang L, Chen Y, Hou J, Guo K, et al
. Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Basic Res Cardiol. 2016;111:19 pubmed publisher
Dual-specificity phosphatase 14 (Dusp14), an important negative modulator of mitogen-activated protein kinase (MAPK) signaling pathways, has been implicated in inflammatory immune response, cancers, cell differentiation and proliferation...
Sánchez Tilló E, Comalada M, Xaus J, Farrera C, Valledor A, Caelles C, et al
. JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J Biol Chem. 2007;282:12566-73 pubmed
..This requirement is independent of Mkp1 expression, as shown in Mkp1 knock-out mice. Our results demonstrate a critical role for JNK1 in the regulation of Mkp1 induction and in LPS-dependent macrophage activation. ..
Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
..This work rigorously demonstrates the unique location of two highly similar DSPs on opposing sides of the mitochondrial inner membrane...