Gene Symbol: Dusp10
Description: dual specificity phosphatase 10
Alias: 2610306G15Rik, AI158871, MKP-5, MKP5, dual specificity protein phosphatase 10, MAP kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5
Species: mouse
Products:     Dusp10

Top Publications

  1. Zhang Y, Nguyen T, Tang P, Kennedy N, Jiao H, Zhang M, et al. Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5. J Biol Chem. 2015;290:14875-83 pubmed publisher
    ..In this study, we show that mice deficient in MAPK phosphatase 5 (MKP5) develop insulin resistance spontaneously at an early stage of life and glucose intolerance at a later age...
  2. Shi H, Verma M, Zhang L, Dong C, Flavell R, Bennett A. Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. J Clin Invest. 2013;123:2064-77 pubmed publisher
    ..Here we show that the dual-specificity protein phosphatase DUSP10/MKP-5 negatively regulates muscle stem cell function in mice...
  3. Masuda K, Shima H, Kikuchi K, Watanabe Y, Matsuda Y. Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. Cytogenet Cell Genet. 2000;90:71-4 pubmed
    ..On the other hand, the 2.7-kb transcript was specifically and highly expressed in testis. The MKP-5 genes (DUSP10/Dusp10) were localized to chr 1q41, Chr 1H5 and chr 13q26 in human, mouse and rat, respectively...
  4. Qian F, Deng J, Cheng N, Welch E, Zhang Y, Malik A, et al. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009;28:2896-907 pubmed publisher
    ..Using a modified mouse model of local Shwartzman reaction, we found that deletion of the MKP5 gene, but not the MKP1 gene, led to robust and accelerated vascular inflammatory responses to a single dose of LPS ..
  5. Luo L, Liu F, Wang X, Dai T, Dai Y, Dong C, et al. An essential function for MKP5 in the formation of oxidized low density lipid-induced foam cells. Cell Signal. 2012;24:1889-98 pubmed publisher
    ..However, the role of MKP5 in the formation of foam cells remains unknown...
  6. Hömmö T, Pesu M, Moilanen E, Korhonen R. Regulation of Inflammatory Cytokine Production by MKP-5 in Macrophages. Basic Clin Pharmacol Toxicol. 2015;117:96-104 pubmed publisher
  7. Zama T, Aoki R, Kamimoto T, Inoue K, Ikeda Y, Hagiwara M. A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. J Biol Chem. 2002;277:23909-18 pubmed
    ..Together, our findings indicate that SKRP1 interacts with its physiological substrate JNK through MKK7, thereby leading to the precise regulation of JNK activity in vivo. ..
  8. Vasudevan H, Mazot P, He F, Soriano P. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. elife. 2015;4: pubmed publisher
    ..Our results identify distinct responses to PDGF and FGF and provide insight into the mechanisms encoding RTK specificity. ..
  9. James S, Jiao H, Teh H, Takahashi H, Png C, Phoon M, et al. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015;: pubmed publisher
    ..Here, we show that virus infection induces the expression of MAPK phosphatase 5 (MKP5), a dual-specificity phosphatase (DUSP), in host cells...

More Information


  1. Png C, Weerasooriya M, Guo J, James S, Poh H, Osato M, et al. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. Oncogene. 2016;35:206-17 pubmed publisher
    Dual specificity phosphatase 10 (DUSP10), also known as MAP kinase phosphatase 5 (MKP5), negatively regulates the activation of MAP kinases...
  2. Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, et al. Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Proc Natl Acad Sci U S A. 2013;110:19884-9 pubmed publisher
    ..This study, therefore, reveals a hitherto unrecognized and important contribution of a beneficial innate signaling interference against bacterial infections. ..
  3. Papadopoulos P, Rosa Neto P, Rochford J, Hamel E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-? and cerebrovascular pathology. PLoS ONE. 2013;8:e68612 pubmed publisher
    ..They further suggest a potential benefit of pioglitazone in managing neuroinflammation, cerebral perfusion and glucose metabolism in AD patients devoid of cerebrovascular pathology. ..
  4. Zhang Y, Blattman J, Kennedy N, Duong J, Nguyen T, Wang Y, et al. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 2004;430:793-7 pubmed
    ..JNK activity was selectively increased in Mkp5 (also known as Dusp10)-deficient mouse cells...
  5. Lee H, Min K, Yi J, Shi H, Chang W, Jackson L, et al. A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis. J Biol Chem. 2017;292:3581-3590 pubmed publisher
    ..These data support the notion that MKP-5 serves as a negative regulator of MAPK-dependent signaling of critical skeletal muscle signaling pathways. ..
  6. Qian F, Deng J, Gantner B, Flavell R, Dong C, Christman J, et al. Map kinase phosphatase 5 protects against sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;302:L866-74 pubmed publisher
    ..MAPK phosphatase 5 (MKP5) is a member of the dual-specificity phosphatase family that dephosphorylates activated MAPKs...
  7. Choi H, Kim W, Kim E, Han B, Min J, Chi S, et al. Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase. PLoS ONE. 2013;8:e72340 pubmed publisher
    ..Here, we investigate the potential role of dual-specificity phosphatase 10 (DUSP10) in brown adipocyte differentiation using primary brown preadipocytes...
  8. Cheng Q, Zhang Q, Xu X, Yin L, Sun L, Lin X, et al. MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice. J Immunol. 2014;192:3686-96 pubmed publisher
    ..In this study, we investigated the impact of MAPK phosphotase 5 (MKP5) on protective immunity against a lethal Plasmodium yoelii 17XL blood-stage infection using MKP5 knockout C57BL/6 ..
  9. Taxman D, Holley Guthrie E, Huang M, Moore C, Bergstralh D, Allen I, et al. The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem. 2011;286:19605-16 pubmed publisher
    ..phosphorylation by pathogens and Toll-like receptor agonists via suppression of the dual-specificity phosphatase, DUSP10/MKP5. Chemokine induction, DUSP function, and MAPK phosphorylation were independent of caspase-1 and IL-1?...
  10. Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
    ..We show that a novel inhibitor for one of the identified genes, dual-specificity phosphatase DUSP10/MKP5, was also capable of inducing oligodendrocyte differentiation in primary oligodendrocyte precursors...