Dusp1

Summary

Gene Symbol: Dusp1
Description: dual specificity phosphatase 1
Alias: 3CH134, MKP1, Ptpn16, U19515, erp, mkp-1, dual specificity protein phosphatase 1, MAP kinase phosphatase 1, mitogen-activated protein kinase phosphatase-1, protein tyrosine phosphatase, non-receptor type 16, protein-tyrosine phosphatase 3CH134, protein-tyrosine phosphatase ERP
Species: mouse
Products:     Dusp1

Top Publications

  1. Hu J, Chen T, Zhuang Z, Kong L, Yu M, Liu Y, et al. Feedback control of MKP-1 expression by p38. Cell Signal. 2007;19:393-400 pubmed
    ..These results indicate a critical role of p38-MK2-dependent induction of MKP-1 in innate immune responses. ..
  2. Dorfman K, Carrasco D, Gruda M, Ryan C, Lira S, Bravo R. Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts. Oncogene. 1996;13:925-31 pubmed
    Externally regulated phosphatase (ERP or MKP-1) is a dual specificity phosphatase that has been implicated in the dephosphorylation of mitogen activated protein kinases (MAP kinases)...
  3. Hammer M, Mages J, Dietrich H, Servatius A, Howells N, Cato A, et al. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J Exp Med. 2006;203:15-20 pubmed
    ..Here, we identify the MAPK phosphatase dual specificity phosphatase 1 (DUSP1) as an essential endogenous regulator of the inflammatory response to lipopolysaccharide (LPS)...
  4. Roth R, Le A, Zhang L, Kahn M, Samuel V, Shulman G, et al. MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice. J Clin Invest. 2009;119:3817-29 pubmed publisher
    ..Collectively, these data demonstrate an essential role for MKP-1 as a regulator of the myofiber composition of skeletal muscle and suggest a potential role for MKP-1 in metabolic syndrome. ..
  5. Kondoh K, Sunadome K, Nishida E. Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis. J Biol Chem. 2007;282:3058-65 pubmed
    ..These results reveal a novel cross-talk between the Notch pathway and the p38 MAPK pathway that is mediated by Notch induction of MKP-1. ..
  6. Salojin K, Owusu I, Millerchip K, Potter M, Platt K, Oravecz T. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol. 2006;176:1899-907 pubmed
  7. Sánchez Tilló E, Comalada M, Xaus J, Farrera C, Valledor A, Caelles C, et al. JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J Biol Chem. 2007;282:12566-73 pubmed
    ..activating responses are balanced by the kinetics of ERK phosphorylation, the inactivation of which correlates with Mkp1 induction...
  8. Zhao Q, Wang X, Nelin L, Yao Y, Matta R, Manson M, et al. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J Exp Med. 2006;203:131-40 pubmed
    ..Our studies demonstrate that MKP-1 is a pivotal feedback control regulator of the innate immune responses and plays a critical role in suppressing endotoxin shock. ..
  9. Calvert T, Chicoine L, Liu Y, Nelin L. Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin. Am J Physiol Heart Circ Physiol. 2008;294:H1621-9 pubmed publisher
    ..We speculate that defects in the Mkp-1 gene may increase susceptibility for the development of septic shock. ..

More Information

Publications84

  1. Lee K, Lee C, Kim Y, Han S, Shim Y, Yoo C. Preheating accelerates mitogen-activated protein (MAP) kinase inactivation post-heat shock via a heat shock protein 70-mediated increase in phosphorylated MAP kinase phosphatase-1. J Biol Chem. 2005;280:13179-86 pubmed
    ..These results indicate that preheating accelerated MAP kinase inactivation after a second HS and that this is related to a HSP70-mediated increase in p-MKP-1. ..
  2. Carrasco D, Bravo R. Expression of the nontransmembrane tyrosine phosphatase gene erp during mouse organogenesis. Cell Growth Differ. 1993;4:849-59 pubmed
    We have studied the expression of the nontransmembrane tyrosine phosphatase gene erp during mouse development using in situ hybridization analysis...
  3. Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong L, Cuhlmann S, et al. Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. Circ Res. 2008;103:726-32 pubmed publisher
    ..We conclude that MKP-1 induction is required for the antiinflammatory effects of shear stress. Thus, our findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis. ..
  4. Tchen C, Martins J, Paktiawal N, Perelli R, Saklatvala J, Clark A. Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence. J Biol Chem. 2010;285:2642-52 pubmed publisher
    Anti-inflammatory effects of glucocorticoids (GCs) are partly mediated by up-regulation of DUSP1 (dual specificity phosphatase 1), which dephosphorylates and inactivates mitogen-activated protein kinases...
  5. Shi H, Boadu E, Mercan F, Le A, Flach R, Zhang L, et al. MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. FASEB J. 2010;24:2985-97 pubmed publisher
    ..Hence, MKP-1 plays a critical role in muscle stem cells and in the immune response to coordinate muscle repair and regeneration. ..
  6. Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose John S, Männel D, et al. Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology. 2010;131:395-404 pubmed publisher
    The mitogen-activated protein kinase phosphatase Dusp1 (also known as MKP-1) is essential for control of the inflammatory response to systemic challenge with the lipopolysaccharide of Gram-negative bacteria...
  7. Duric V, Banasr M, Licznerski P, Schmidt H, Stockmeier C, Simen A, et al. A negative regulator of MAP kinase causes depressive behavior. Nat Med. 2010;16:1328-32 pubmed publisher
    ..significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls...
  8. Shields K, Panzhinskiy E, Burns N, Zawada W, Das M. Mitogen-activated protein kinase phosphatase-1 is a key regulator of hypoxia-induced vascular endothelial growth factor expression and vessel density in lung. Am J Pathol. 2011;178:98-109 pubmed publisher
    ..Therefore, our data strongly suggest that MKP-1 might be the key regulator of vascular densities through the regulation of VEGF levels in hypoxic lung. ..
  9. Huang G, Wang Y, Shi L, Kanneganti T, Chi H. Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 2011;35:45-58 pubmed publisher
  10. Kim H, Ullevig S, ZAMORA D, Lee C, Asmis R. Redox regulation of MAPK phosphatase 1 controls monocyte migration and macrophage recruitment. Proc Natl Acad Sci U S A. 2012;109:E2803-12 pubmed publisher
  11. Zhao Q, Shepherd E, Manson M, Nelin L, Sorokin A, Liu Y. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem. 2005;280:8101-8 pubmed
    ..Our studies indicated that MKP-1 plays an important role in dampening the inflammatory responses of alveolar macrophages. We speculate that MKP-1 may represent a novel target for therapeutic intervention of inflammatory lung diseases. ..
  12. Wu J, Bennett A. Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem. 2005;280:16461-6 pubmed
    ..MKP-1-deficient MEFs were also sensitive to anisomycin-induced apoptosis. Collectively, these data demonstrate that MKP-1 promotes cell survival by attenuating stress-responsive MAPK-mediated apoptosis. ..
  13. Abraham S, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, et al. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J Exp Med. 2006;203:1883-9 pubmed
    ..They can also induce the expression of dual specificity phosphatase 1 (DUSP1; otherwise known as mitogen-activated protein kinase [MAPK] phosphatase 1), which dephosphorylates and inactivates ..
  14. Nimah M, Zhao B, Denenberg A, Bueno O, Molkentin J, Wong H, et al. Contribution of MKP-1 regulation of p38 to endotoxin tolerance. Shock. 2005;23:80-7 pubmed
    ..wild type) mice (24% vs. 72% reductions, respectively). These data demonstrate that the dual specific phosphatase MKP-1 is an important mediator of endotoxin tolerance via p38 regulation. ..
  15. Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, et al. Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6. J Leukoc Biol. 2010;88:579-87 pubmed publisher
    The MAPK phosphatase DUSP1 is an essential negative regulator of TLR-triggered innate immune activation...
  16. Shepherd E, Zhao Q, Welty S, Hansen T, Smith C, Liu Y. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J Biol Chem. 2004;279:54023-31 pubmed
    ..7 cells and further suggest a central role for this phosphatase in controlling the inflammatory responses of primary macrophages to Gram-positive bacterial infection. ..
  17. Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li J. Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation. J Biol Chem. 2008;283:21011-23 pubmed publisher
  18. Cao W, Bao C, Padalko E, Lowenstein C. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med. 2008;205:1491-503 pubmed publisher
    ..Our data suggest that acetylation of MKP-1 inhibits innate immune signaling. This pathway may be an important therapeutic target in the treatment of inflammatory diseases. ..
  19. Maier J, Brema S, Tuckermann J, Herzer U, Klein M, Stassen M, et al. Dual specificity phosphatase 1 knockout mice show enhanced susceptibility to anaphylaxis but are sensitive to glucocorticoids. Mol Endocrinol. 2007;21:2663-71 pubmed
    Dual specificity phosphatase DUSP1 (otherwise known as mitogen-activated phosphatase 1 or MKP-1) dephosphorylates MAPKs, particularly p38, and negatively regulates innate immunity...
  20. Ito A, Suganami T, Miyamoto Y, Yoshimasa Y, Takeya M, Kamei Y, et al. Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy. J Biol Chem. 2007;282:25445-52 pubmed
    ..This study provides evidence that the down-regulation of MKP-1 is critical for increased production of MCP-1 during the course of adipocyte hypertrophy. ..
  21. Doi M, Cho S, Yujnovsky I, Hirayama J, Cermakian N, Cato A, et al. Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons. J Biol Rhythms. 2007;22:127-39 pubmed
    b>MAP kinase phosphatase 1 (MKP1) is a negative regulator for the mitogen-activated protein kinase (MAPK)-mediated signal transduction, a key pathway that leads to the regulated expression of circadian clock genes...
  22. Wu J, Roth R, Anderson E, Hong E, Lee M, Choi C, et al. Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab. 2006;4:61-73 pubmed
    ..These results suggest that nuclear regulation of the MAPKs by MKP-1 is essential for the management of metabolic homeostasis in a manner that is spatially uncoupled from the cytosolic actions of the MAPKs. ..
  23. Chen P, Li J, Barnes J, Kokkonen G, Lee J, Liu Y. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J Immunol. 2002;169:6408-16 pubmed
    ..These findings highlight MKP-1 as a critical negative regulator of the macrophage inflammatory response, underscoring its premise as a potential target for developing novel anti-inflammatory drugs. ..
  24. Chi H, Barry S, Roth R, Wu J, Jones E, Bennett A, et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A. 2006;103:2274-9 pubmed
    ..These results highlight the complex mechanisms by which the MAPKs regulate innate immunity. ..
  25. Sun H, Charles C, Lau L, Tonks N. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 1993;75:487-93 pubmed
    ..Here we report that a growth factor-inducible gene, 3CH134, encodes a dual specificity phosphatase that dephosphorylates and inactivates p42MAPK both in vitro and in vivo...
  26. Zhang Y, Reynolds J, Chang S, Martin Orozco N, Chung Y, Nurieva R, et al. MKP-1 is necessary for T cell activation and function. J Biol Chem. 2009;284:30815-24 pubmed publisher
    ..MKP-1, also known as DUSP1, was previously shown to negatively regulate innate immunity by inhibiting pro-inflammatory cytokine production...
  27. Frazier W, Wang X, Wancket L, Li X, Meng X, Nelin L, et al. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice. J Immunol. 2009;183:7411-9 pubmed publisher
  28. Imaizumi S, Grijalva V, Priceman S, Wu L, Su F, Farias Eisner R, et al. Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels. Mol Genet Metab. 2010;101:66-75 pubmed publisher
    ..MKP-1 may serve as a potential therapeutic target for the treatment of atherosclerotic disease. ..
  29. Li S, Zhu F, Zykova T, Kim M, Cho Y, Bode A, et al. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway. J Biol Chem. 2011;286:29601-9 pubmed publisher
    ..we found that TOPK negatively regulated the activity of p38? by phosphorylating the p38?-specific phosphatase MKP1 and enhancing the stability of MKP1...
  30. Korhonen R, Huotari N, Hömmö T, Leppänen T, Moilanen E. The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism related to interferon regulatory factor 1. Mol Immunol. 2012;51:219-26 pubmed publisher
    ..MKP-1, through regulation of IRF1 and IL-12, therefore may be an important factor supporting the development of Th1 type of immune response and anti-microbial defense. ..
  31. Wancket L, Meng X, Rogers L, Liu Y. Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. Toxicol Pathol. 2012;40:1095-105 pubmed publisher
    ..The more severe phenotype exhibited by Mkp-1?/? mice indicates that Mkp-1 plays a protective role during acute acetaminophen overdose, potentially through regulation of JNK. ..
  32. Schaljo B, Kratochvill F, Gratz N, Sadzak I, Sauer I, Hammer M, et al. Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol. 2009;183:1197-206 pubmed publisher
    ..These findings establish that TTP is required for full responses of bone marrow-derived murine macrophages to IL-10. ..
  33. Caceres A, Perdiguero B, Gomez C, Cepeda M, Caelles C, Sorzano C, et al. Involvement of the cellular phosphatase DUSP1 in vaccinia virus infection. PLoS Pathog. 2013;9:e1003719 pubmed publisher
    ..Here, we have evaluated the role of the MAPK negative regulator dual specificity phosphatase 1 (DUSP1) in the infection of VACV...
  34. Datta N, Kolailat R, Fite A, Pettway G, Abou Samra A. Distinct roles for mitogen-activated protein kinase phosphatase-1 (MKP-1) and ERK-MAPK in PTH1R signaling during osteoblast proliferation and differentiation. Cell Signal. 2010;22:457-66 pubmed publisher
  35. Tomasi M, Ramani K, Lopitz Otsoa F, Rodriguez M, Li T, Ko K, et al. S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes. Hepatology. 2010;51:2152-61 pubmed publisher
    ..p44/42 MAPK (extracellular signal-regulated kinase [ERK]1/2) and the dual-specificity MAPK phosphatase MKP-1/DUSP1. ERK phosphorylates DUSP1, facilitating its proteasomal degradation, whereas DUSP1 inhibits ERK activity...
  36. Auger Messier M, Accornero F, Goonasekera S, Bueno O, Lorenz J, van Berlo J, et al. Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy. Circ Res. 2013;112:48-56 pubmed publisher
    ..To determine the role of DUSP1 and DUSP4 in regulating p38 MAPK function in the heart and the effect on disease...
  37. Datta N, Chukkapalli S, Vengalil N, Zhan E, Przyklenk K, LASLEY R. Parathyroid hormone-related peptide protects cardiomyocytes from oxidative stress-induced cell death: First evidence of a novel endocrine-cardiovascular interaction. Biochem Biophys Res Commun. 2015;468:202-7 pubmed publisher
    ..Moreover, myocytes derived from MKP1 KO mice were resistant to oxidative injury...
  38. Ferguson B, Nam H, Stephens J, Morrison R. Mitogen-Dependent Regulation of DUSP1 Governs ERK and p38 Signaling During Early 3T3-L1 Adipocyte Differentiation. J Cell Physiol. 2016;231:1562-74 pubmed publisher
    ..3T3-L1 preadipocytes as a model of adipocyte hyperplasia, we examined a role for dual-specificity phosphatase 1 (DUSP1) on the timely modulation of MAPK signaling during states of growth arrest, proliferation, and differentiation...
  39. Luo C, Yang X, Yao L, Jiang L, Liu W, Li X, et al. Mitogen-activated protein kinase phosphatase-1 expression in macrophages is controlled by lymphocytes during macrophage activation. Int J Mol Med. 2012;29:25-31 pubmed publisher
    ..MKP-1 plays an important role in the control of macrophage activation by the adaptive immune system. ..
  40. Musikacharoen T, Yoshikai Y, Matsuguchi T. Histone acetylation and activation of cAMP-response element-binding protein regulate transcriptional activation of MKP-M in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2003;278:9167-75 pubmed
    ..Altogether, our data indicated that the activation of mkp-M gene transcription in macrophages by LPS is associated with histone acetylation and chromatin remodeling. ..
  41. Chen Y, Chou H, Yang C, Chen H, Liu Y, Lin T, et al. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 2017;36:6509-6517 pubmed publisher
    ..These collective data indicate that VHR is a FAK phosphatase and participates in regulating the formation and disassembly of focal adhesions. ..
  42. Noguchi T, Metz R, Chen L, Mattei M, Carrasco D, Bravo R. Structure, mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth. Mol Cell Biol. 1993;13:5195-205 pubmed
    We have characterized a growth factor-inducible gene, erp, and demonstrated that it encodes a 367-amino-acid nontransmembrane tyrosine phosphatase protein with significant similarity to the vaccinia virus H1 protein...
  43. Perdiguero E, Kharraz Y, Serrano A, Munoz Canoves P. MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair. Cell Cycle. 2012;11:877-86 pubmed publisher
  44. Ardura J, Portal Nuñez S, Castelbón Calvo I, Martínez de Toda I, De la Fuente M, Esbrit P. Parathyroid Hormone-Related Protein Protects Osteoblastic Cells From Oxidative Stress by Activation of MKP1 Phosphatase. J Cell Physiol. 2017;232:785-796 pubmed publisher
    ..its bone counterpart, PTH-related protein (PTHrP), can regulate MAPK activation by modulating MAPK phosphatase-1 (MKP1). Thus, we hypothesized that PTHrP might protect osteoblasts from ROS-induced apoptosis by targeting MKP1...
  45. Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, Siddiqui Z, et al. Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med. 2017;23:472-482 pubmed publisher
    ..of the signaling proteins FBJ osteosarcoma oncogene (c-FOS, encoded by Fos) and dual-specificity phosphatase 1 (DUSP1)...
  46. Geetha N, Mihaly J, Stockenhuber A, Blasi F, Uhrin P, Binder B, et al. Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of LRP-1 leads to sustained ERK phosphorylation via down. J Biol Chem. 2011;286:25663-74 pubmed publisher
    ..accumulation of phospho-ERK was accounted for by enhanced proteasomal degradation of dual specificity phosphatases DUSP1 and DUSP6, which precluded dephosphorylation of cytosolic ERK...
  47. Srivastava N, Sudan R, Saha B. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J Immunol. 2011;186:5863-72 pubmed publisher
    ..The findings reveal a novel parasite-devised immune evasion strategy and an effective target to redirect CD40-regulated immune responses. ..
  48. Qian F, Deng J, Cheng N, Welch E, Zhang Y, Malik A, et al. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009;28:2896-907 pubmed publisher
    ..Using a modified mouse model of local Shwartzman reaction, we found that deletion of the MKP5 gene, but not the MKP1 gene, led to robust and accelerated vascular inflammatory responses to a single dose of LPS injection...
  49. Reddy S, Nguyen J, Grijalva V, Hough G, Hama S, Navab M, et al. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol. 2004;24:1676-81 pubmed
    ..We now report that MKP-1 protein is expressed in the atherosclerotic lesions of mice and inhibition of tyrosine phosphatase activity and MKP-1 protein reduce atherosclerotic lesions in mouse models. ..
  50. Cao T, Yang D, Zhang X, Wang Y, Qiao Z, Gao L, et al. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling. Cell Biol Toxicol. 2017;33:457-466 pubmed publisher
    ..activity, as well as extracellular-regulated protein kinase 1/2 (ERK1/2) signaling and induced MAPK phosphatase 1 (MKP1) expression...
  51. Perdiguero E, Sousa Victor P, Ruiz Bonilla V, Jardi M, Caelles C, Serrano A, et al. p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J Cell Biol. 2011;195:307-22 pubmed publisher
    ..This novel regulatory mechanism involving the appropriate balance of p38, MKP-1, miR-21, and AKT activities may have implications in chronic inflammatory degenerative diseases. ..
  52. Vattakuzhi Y, Abraham S, Freidin A, Clark A, Horwood N. Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis. Arthritis Rheum. 2012;64:2201-10 pubmed publisher
    ..The purpose of this study was to examine the effect of Dusp1 deficiency on bone destruction...
  53. Lin N, Lin T, Yang W, Wang S, Wang K, Su Y, et al. Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci. 2012;8:761-77 pubmed publisher
    ..Inhibition of adipogenesis also occurred in ZFP36L1 and TTP knockdown cells. The findings indicate that the differential expression of TTP family members regulates immediate early gene expression and modulates adipogenesis. ..
  54. Gorostizaga A, Brion L, Maloberti P, Cornejo Maciel F, Podesta E, Paz C. Heat shock triggers MAPK activation and MKP-1 induction in Leydig testicular cells. Biochem Biophys Res Commun. 2005;327:23-8 pubmed
    ..In summary, this study indicates that the response to heat stress in Leydig cells includes the activation of MAPKs related to cell survival (ERK1/2) and death (JNK), and the induction of a MAPK activity inhibitory loop. ..
  55. Pinart M, Hussain F, Shirali S, Li F, Zhu J, Clark A, et al. Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury. Eur J Pharmacol. 2014;744:108-14 pubmed publisher
    ..Bronchial hyperresponsiveness, lung inflammation and emphySEMa after chronic exposure are CS-insensitive, and the contribution of MKP-1 to CS sensitivity in this model was negligible. ..
  56. Conradie M, Cato A, Ferris W, de Wet H, Horsch K, Hough S. MKP-1 knockout does not prevent glucocorticoid-induced bone disease in mice. Calcif Tissue Int. 2011;89:221-7 pubmed publisher
    ..However, identical results were obtained in MKP-1 knockout mice, suggesting that in these animals upregulation of MKP-1 by GCs cannot be regarded as the sole mediator of the GC effects on bone. ..
  57. Millien G, Spira A, Hinds A, Wang J, Williams M, Ramirez M. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006;6:35 pubmed
    ..Many genes identified were not previously associated with lung development and may participate in formation of alveolar sacs prenatally. ..
  58. Talwar H, Bauerfeld C, Bouhamdan M, Farshi P, Liu Y, Samavati L. MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression. Cell Signal. 2017;34:1-10 pubmed publisher
    ..These findings demonstrate a regulatory function for MKP-1 in modulating IL-1β expression through p38 activation, ROS production and HIF-1α expression. ..
  59. Wang J, Zhou J, Kho D, Reiners J, Wu G. Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy. Autophagy. 2016;12:1791-1803 pubmed
    ..Here we report that DUSP1/MKP-1, the founding member of the DUSP family, plays a critical role in regulating autophagy...
  60. Horsch K, de Wet H, Schuurmans M, Allie Reid F, Cato A, Cunningham J, et al. Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferation. Mol Endocrinol. 2007;21:2929-40 pubmed
    ..causal evidence that this effect of GC is mediated by induction of the dual-specificity MAPK phosphatase, MKP-1/DUSP1. Excessive MKP-1 production is both necessary and sufficient to account for the impaired osteoblastic response to ..
  61. Smallie T, Ross E, Ammit A, Cunliffe H, Tang T, Rosner D, et al. Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide. J Immunol. 2015;195:277-88 pubmed publisher
    ..It functions as an essential negative regulator of innate immune responses, hence disruption of the Dusp1 gene renders mice extremely sensitive to a wide variety of experimental inflammatory challenges...
  62. Vasudevan H, Mazot P, He F, Soriano P. Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. elife. 2015;4: pubmed publisher
    ..Our results identify distinct responses to PDGF and FGF and provide insight into the mechanisms encoding RTK specificity. ..
  63. Boerckel J, Chandrasekharan U, Waitkus M, Tillmaand E, Bartlett R, DiCorleto P. Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression. Arterioscler Thromb Vasc Biol. 2014;34:1020-31 pubmed publisher
    ..These observations reveal a novel function for MKP-1 and identify MKP-1 as a potential therapeutic target. ..
  64. Ha U, Lim J, Kim H, Wu W, Jin S, Xu H, et al. MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 2008;283:30624-31 pubmed publisher
    ..Moreover pneumolysin also selectively induced expression of MKP1 via a TLR4-dependent MyD88-TRAF6-ERK signaling pathway, which inhibited the PAK4-JNK signaling pathway, thereby ..
  65. Wang X, Zhao Q, Matta R, Meng X, Liu X, Liu C, et al. Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem. 2009;284:27123-34 pubmed publisher
    ..Our results suggest that MKP-1 may negatively regulate iNOS expression by controlling the expression of miR-155 and consequently the STAT pathway via SOCS-1. ..
  66. Vollmer T, Stockhausen A, Zhang J. Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1). J Biol Chem. 2012;287:35212-21 pubmed publisher
    ..Taken together, these results indicate that mapracorat exerts its anti-inflammatory effects, at least in part, by augmenting MKP-1 expression. ..
  67. Chen M, Chen H, Jen C. Exercise training upregulates macrophage MKP-1 and affects immune responses in mice. Med Sci Sports Exerc. 2010;42:2173-9 pubmed publisher
    ..Exercise training upregulated basal macrophage MKP-1 expression, accelerated LPS-evoked MKP-1 up-regulation, and affected LPS-evoked immune responses in mice. ..
  68. Günzl P, Bauer K, Hainzl E, Matt U, Dillinger B, Mahr B, et al. Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation. J Leukoc Biol. 2010;88:1259-69 pubmed publisher
    ..Simultaneously, we found increased levels of the MKP DUSP1, as well as the anti-inflammatory cytokine IL-10...
  69. Flach R, Qin H, Zhang L, Bennett A. Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27. J Biol Chem. 2011;286:22195-202 pubmed publisher
    ..Hence, MKP-1 plays an important role in MAPK-mediated control of hepatic lipid homeostasis. ..
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    ..These data suggest that Gln exerts a beneficial effect on endotoxic shock by inactivating p38 and JNK via a rapid induction of MKP-1 protein in an ERK-dependent way. ..
  72. Kinney C, Chandrasekharan U, Mavrakis L, DiCorleto P. VEGF and thrombin induce MKP-1 through distinct signaling pathways: role for MKP-1 in endothelial cell migration. Am J Physiol Cell Physiol. 2008;294:C241-50 pubmed
    ..Overall, these results demonstrate distinct MAPK signaling pathways for thrombin versus VEGF induction of MKP-1 in ECs and point to the importance of MKP-1 induction in VEGF-stimulated EC migration. ..
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    Dual specificity phosphatase 1 (DUSP1) dephosphorylates and, hence, regulates the activity of MAP kinases...
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    ..Together, these results indicate that miR-101 regulates the innate immune responses of macrophages to LPS through targeting MKP-1. ..
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    ..The release of AEA in injured CNS tissue might therefore represent a new mechanism of neuro-immune communication during CNS injury, which controls and limits immune response after primary CNS damage. ..