Genomes and Genes
Gene Symbol: Duplin
Description: chromodomain helicase DNA binding protein 8
Alias: 5830451P18Rik, AU015341, Duplin, HELSNF1, mKIAA1564, chromodomain-helicase-DNA-binding protein 8, ATP-dependent helicase CHD8, CHD-8, axis duplication inhibitor, helicase with SNF2 domain 1
- Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama K. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 2004;24:8386-94 pubmedThe Wnt signaling pathway plays a pivotal role in vertebrate early development and morphogenesis. Duplin (axis duplication inhibitor) interacts with beta-catenin and prevents its binding to Tcf, thereby inhibiting downstream Wnt signaling...
- Ishihara K, Oshimura M, Nakao M. CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell. 2006;23:733-42 pubmed..These findings provide insight into the role of CTCF-CHD8 complex in insulation and epigenetic regulation at active insulator sites. ..
- Shingleton J, Hemann M. The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies. PLoS ONE. 2015;10:e0143275 pubmed publisher..Our results demonstrate that CHD8 has a context-dependent role in cell survival, and its inhibition may be an effective treatment for B lymphoid malignancies. ..
- Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, et al. CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol. 2009;11:172-82 pubmed publisher..These observations reveal a mode of p53 regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 function through recruitment of histone H1. ..