Gene Symbol: Duplin
Description: chromodomain helicase DNA binding protein 8
Alias: 5830451P18Rik, AU015341, Duplin, HELSNF1, mKIAA1564, chromodomain-helicase-DNA-binding protein 8, ATP-dependent helicase CHD8, CHD-8, axis duplication inhibitor, helicase with SNF2 domain 1
Species: mouse
Products:     Duplin

Top Publications

  1. Nishiyama M, Skoultchi A, Nakayama K. Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-?-catenin signaling pathway. Mol Cell Biol. 2012;32:501-12 pubmed publisher
    ..Given that CHD8 is expressed predominantly during embryogenesis, it may thus contribute to setting a threshold for responsiveness to Wnt signaling that operates in a development-dependent manner. ..
  2. Notwell J, Heavner W, Darbandi S, Katzman S, McKenna W, Ortiz Londono C, et al. TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016;26:1013-22 pubmed publisher
    ..Our findings highlight a TBR1-regulated network of ASD genes in the developing neocortex that are relatively intolerant to LoF mutations, indicating that these genes may play critical roles in normal cortical development. ..
  3. Durak O, Gao F, Kaeser Woo Y, Rueda R, Martorell A, Nott A, et al. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci. 2016;19:1477-1488 pubmed publisher
    ..Together, these observations provide new insights into the neurodevelopmental role of Chd8. ..
  4. Platt R, Zhou Y, Slaymaker I, Shetty A, Weisbach N, Kim J, et al. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Cell Rep. 2017;19:335-350 pubmed publisher
    ..These results support a mechanism linking chromatin modification to striatal dysfunction and the molecular pathology of ASD. ..
  5. Gompers A, Su Feher L, Ellegood J, Copping N, Riyadh M, Stradleigh T, et al. Germline Chd8 haploinsufficiency alters brain development in mouse. Nat Neurosci. 2017;20:1062-1073 pubmed publisher
    ..This integrative analysis offers an initial picture of the consequences of Chd8 haploinsufficiency for brain development. ..
  6. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S, et al. A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation. J Biol Chem. 2000;275:32871-8 pubmed
    ..Here we report a novel protein, designated Duplin (for axis duplication inhibitor), which negatively regulates the function of beta-catenin in the nucleus...
  7. Kobayashi M, Kishida S, Fukui A, Michiue T, Miyamoto Y, Okamoto T, et al. Nuclear localization of Duplin, a beta-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. J Biol Chem. 2002;277:5816-22 pubmed
    b>Duplin binds to beta-catenin and inhibits the Wnt signaling pathway, thereby leading to repression of the beta-catenin-mediated transactivation and Xenopus axis formation...
  8. Rodenberg J, Hoggatt A, Chen M, Touw K, Jones R, Herring B. Regulation of serum response factor activity and smooth muscle cell apoptosis by chromodomain helicase DNA-binding protein 8. Am J Physiol Cell Physiol. 2010;299:C1058-67 pubmed publisher
    ..A novel SRF cofactor, chromodomain helicase DNA binding protein 8 (CHD8), was isolated from a yeast two-hybrid screen using SRF as bait...
  9. Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, et al. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature. 2016;537:675-679 pubmed publisher
    ..Our results are thus consistent with the notion that CHD8 haploinsufficiency is a highly penetrant risk factor for ASD, with disease pathogenesis probably resulting from a delay in neurodevelopment. ..

More Information


  1. Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama K. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 2004;24:8386-94 pubmed
    The Wnt signaling pathway plays a pivotal role in vertebrate early development and morphogenesis. Duplin (axis duplication inhibitor) interacts with beta-catenin and prevents its binding to Tcf, thereby inhibiting downstream Wnt signaling...
  2. Ishihara K, Oshimura M, Nakao M. CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell. 2006;23:733-42 pubmed
    ..These findings provide insight into the role of CTCF-CHD8 complex in insulation and epigenetic regulation at active insulator sites. ..
  3. Shingleton J, Hemann M. The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies. PLoS ONE. 2015;10:e0143275 pubmed publisher
    ..Our results demonstrate that CHD8 has a context-dependent role in cell survival, and its inhibition may be an effective treatment for B lymphoid malignancies. ..
  4. Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, et al. CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol. 2009;11:172-82 pubmed publisher
    ..These observations reveal a mode of p53 regulation mediated by CHD8, which may set a threshold for induction of apoptosis during early embryogenesis by counteracting p53 function through recruitment of histone H1. ..