dsu

Summary

Gene Symbol: dsu
Description: melanoregulin
Alias: Gm974, Wdt2, dsu, melanoregulin, dilute suppressor protein, whn-dependent transcript 2
Species: mouse
Products:     dsu

Top Publications

  1. Moore K, Seperack P, Strobel M, Swing D, Copeland N, Jenkins N. Dilute suppressor dsu acts semidominantly to suppress the coat color phenotype of a deletion mutation, dl20J, of the murine dilute locus. Proc Natl Acad Sci U S A. 1988;85:8131-5 pubmed
    The murine dilute suppressor (dsu) gene is the only unlinked trans-acting suppressor identified in mammals...
  2. Moore K, Swing D, Rinchik E, Mucenski M, Buchberg A, Copeland N, et al. The murine dilute suppressor gene dsu suppresses the coat-color phenotype of three pigment mutations that alter melanocyte morphology, d, ash and ln. Genetics. 1988;119:933-41 pubmed
    The murine dilute suppressor gene, dsu, was identified because of its ability to suppress the dilute coat color of mice homozygous for the retrovirally induced allele (dv) of the dilute locus (d)...
  3. Sweet H. Dilute suppressor, a new suppressor gene in the house mouse. J Hered. 1983;74:305-6 pubmed
    Dilute suppressor, dsu, a new fully penetrant autosomal recessive mutation, acts by restoring melanocytes of homozygous dilute (d/d) mice to normal shape and almost normal number...
  4. O Sullivan T, Wu X, Rachel R, Huang J, Swing D, Matesic L, et al. dsu functions in a MYO5A-independent pathway to suppress the coat color of dilute mice. Proc Natl Acad Sci U S A. 2004;101:16831-6 pubmed
    ..Mutation of a fourth gene, dilute suppressor (dsu), suppresses this coat color dilution...
  5. Damek Poprawa M, Diemer T, Lopes V, Lillo C, Harper D, Marks M, et al. Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. J Biol Chem. 2009;284:10877-89 pubmed publisher
    b>Melanoregulin (MREG), the product of the Mreg(dsu) gene, is a small highly charged protein, hypothesized to play a role in organelle biogenesis due to its effect on pigmentation in dilute, ashen, and leaden mutant mice...
  6. Ohbayashi N, Maruta Y, Ishida M, Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012;125:1508-18 pubmed publisher
    b>Melanoregulin (Mreg), a product of the dilute suppressor gene, has been implicated in the regulation of melanosome transport in mammalian epidermal melanocytes, given that Mreg deficiency was found to restore peripheral melanosome ..
  7. Bleul C, Boehm T. Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product. Eur J Immunol. 2001;31:2497-503 pubmed
    ..The presented results support our prediction that this systematic approach by gene expression profiling yields regulators of thymopoiesis. ..
  8. Nadeau J. Modifier genes in mice and humans. Nat Rev Genet. 2001;2:165-74 pubmed
  9. Boesze Battaglia K, Song H, Sokolov M, Lillo C, Pankoski Walker L, Gretzula C, et al. The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator. Biochemistry. 2007;46:1256-72 pubmed
    ..In this study, we show that peripherin-2 forms a complex with melanoregulin (MREG), the product of the Mreg locus. Genetic studies suggest that MREG is involved in organelle biogenesis...

More Information

Publications19

  1. Moore K, Swing D, Copeland N, Jenkins N. The murine dilute suppressor gene encodes a cell autonomous suppressor. Genetics. 1994;138:491-7 pubmed
    The murine dilute suppressor gene (dsu) suppresses the coat-color phenotype of three pigment mutations, dilute (d), ashen (ash) and leaden (ln), that each produce adendritic melanocytes...
  2. Wu X, Masedunskas A, Weigert R, Copeland N, Jenkins N, Hammer J. Melanoregulin regulates a shedding mechanism that drives melanosome transfer from melanocytes to keratinocytes. Proc Natl Acad Sci U S A. 2012;109:E2101-9 pubmed publisher
    ..Dilute mice that simultaneously lack melanoregulin, the product of the dilute suppressor locus, exhibit a nearly complete restoration of coat color, but, ..
  3. Rachel R, Nagashima K, O Sullivan T, Frost L, Stefano F, Marigo V, et al. Melanoregulin, product of the dsu locus, links the BLOC-pathway and OA1 in organelle biogenesis. PLoS ONE. 2012;7:e42446 pubmed publisher
    ..We show that the product of the Mreg(dsu) locus, melanoregulin (MREG), interacts both with members of the HPS BLOC-2 complex and with Oa1 in regulating melanosome size...
  4. Frost L, Lopes V, Stefano F, Bragin A, Williams D, Mitchell C, et al. Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium. Vis Neurosci. 2013;30:55-64 pubmed publisher
    ..b>Melanoregulin (MREG)-mediated loss of phagocytic capacity has been linked to diminished intracellular Cat-D activity...
  5. Xie W, Jen H, Seymour M, Yeh S, Pereira F, Groves A, et al. An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment. J Neurosci. 2017;37:8583-8594 pubmed publisher
    ..This opens up the possibility that missense mutations in ATOH1 could increase human vulnerability to loss of hair cells because of aging or trauma. ..
  6. Moore K, Swing D, Copeland N, Jenkins N. Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations. Genetics. 1990;125:421-30 pubmed
    The murine dilute suppressor gene, dsu, was previously shown to suppress the dilute coat color phenotypes of mice homozygous for the dilute (d), leaden (ln), and ashen (ash) mutations...
  7. Wu X, Martina J, Hammer J. Melanoregulin is stably targeted to the melanosome membrane by palmitoylation. Biochem Biophys Res Commun. 2012;426:209-14 pubmed publisher
    ..e. dilute mice). We recently showed that melanoregulin, the product of the dsu locus, functions as a negative regulator of a shedding mechanism that drives the ..
  8. Chu T, Tyznik A, Roepke S, Berkley A, Woodward Davis A, Pattacini L, et al. Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep. 2013;3:701-8 pubmed publisher
    ..Together, these data suggest an innate role for memory CD8 T cells in the early immune response before the onset of a de novo generated, antigen-specific CD8 T cell response. ..
  9. Frost L, Lopes V, Bragin A, Reyes Reveles J, Brancato J, Cohen A, et al. The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium. Mol Neurobiol. 2015;52:1135-1151 pubmed publisher
    ..Previously, we identified melanoregulin (MREG) as an intracellular cargo-sorting protein required for the degradation of POS disks...
  10. Reyes Reveles J, Dhingra A, Alexander D, Bragin A, Philp N, Boesze Battaglia K. Phagocytosis-dependent ketogenesis in retinal pigment epithelium. J Biol Chem. 2017;292:8038-8047 pubmed publisher
    ..These studies suggest that FAO and ketogenesis are key to supporting the metabolism of the RPE and preventing the accumulation of lipids that lead to oxidative stress and mitochondrial dysfunction. ..