Gene Symbol: Dstn
Description: destrin
Alias: 2610043P17Rik, ADF, AU042046, Dsn, corn1, sid23p, destrin, actin-depolymerizing factor, corneal disease 1, sid 23
Species: mouse
Products:     Dstn

Top Publications

  1. Wang I, Kao C, Liu C, Saika S, Nishina P, Sundberg J, et al. Characterization of Corn1 mice: Alteration of epithelial and stromal cell gene expression. Mol Vis. 2001;7:20-6 pubmed
    b>Corn1 is an autosomal recessive mutation characterized by corneal epithelial hyperplasia and stromal neovascularization...
  2. Verdoni A, Schuster K, Cole B, Ikeda A, Kao W, Ikeda S. A pathogenic relationship between a regulator of the actin cytoskeleton and serum response factor. Genetics. 2010;186:147-57 pubmed publisher
    ..mice are homozygous for a spontaneous null allele of the destrin (Dstn) gene, which is also known as actin depolymerizing factor (ADF)...
  3. Ambati B, Nozaki M, Singh N, Takeda A, Jani P, Suthar T, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993-7 pubmed
    ..The spontaneously vascularized corneas of corn1 and Pax6+/- mice and Pax6+/- patients with aniridia are deficient in sflt-1, and recombinant sflt-1 administration ..
  4. Herde M, Friauf E, Rust M. Developmental expression of the actin depolymerizing factor ADF in the mouse inner ear and spiral ganglia. J Comp Neurol. 2010;518:1724-41 pubmed publisher
    ..Here we examined the expression and subcellular location of the actin filament depolymerizing factor (ADF) in the cochlea and vestibular organs...
  5. Smith R, Hawes N, Kuhlmann S, Heckenlively J, Chang B, Roderick T, et al. Corn1: a mouse model for corneal surface disease and neovascularization. Invest Ophthalmol Vis Sci. 1996;37:397-404 pubmed
    ..Anatomic changes were demonstrated in corn1 and control A...
  6. Verdoni A, Smith R, Ikeda A, Ikeda S. Defects in actin dynamics lead to an autoinflammatory condition through the upregulation of CXCL5. PLoS ONE. 2008;3:e2701 pubmed publisher
    ..A spontaneous mouse mutant, corneal disease 1(corn1), is deficient for DSTN, which causes epithelial hyperproliferation and neovascularization in the ..
  7. Vartiainen M, Mustonen T, Mattila P, Ojala P, Thesleff I, Partanen J, et al. The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol Biol Cell. 2002;13:183-94 pubmed
    Actin-depolymerizing factor (ADF)/cofilins are essential regulators of actin filament turnover. Several ADF/cofilin isoforms are found in multicellular organisms, but their biological differences have remained unclear...
  8. Ikeda S, Cunningham L, Boggess D, Hawes N, Hobson C, Sundberg J, et al. Aberrant actin cytoskeleton leads to accelerated proliferation of corneal epithelial cells in mice deficient for destrin (actin depolymerizing factor). Hum Mol Genet. 2003;12:1029-37 pubmed
    ..Here, we report that the phenotypes in both mutants are caused by mutations within the destrin gene (also known as actin-depolymerizing factor)...
  9. Gurniak C, Perlas E, Witke W. The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005;278:231-41 pubmed
    ..Our data suggest that in mammalian development, regulation of the actin cytoskeleton by the F-actin depolymerizing factor n-cofilin is critical for epithelial-mesenchymal type of cell shape changes as well as cell ..

More Information


  1. Bellenchi G, Gurniak C, Perlas E, Middei S, Ammassari Teule M, Witke W. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 2007;21:2347-57 pubmed
    ..Here we show that the F-actin depolymerizing factor n-cofilin controls cell migration and cell cycle progression in the cerebral cortex...
  2. Verdoni A, Aoyama N, Ikeda A, Ikeda S. Effect of destrin mutations on the gene expression profile in vivo. Physiol Genomics. 2008;34:9-21 pubmed publisher
    ..A spontaneous mouse mutant, corneal disease 1 (corn1), is deficient for a regulator of actin dynamics, destrin (DSTN, also known as ADF), which causes ..
  3. Yeoh S, Pope B, Mannherz H, Weeds A. Determining the differences in actin binding by human ADF and cofilin. J Mol Biol. 2002;315:911-25 pubmed
    The actin-depolymerizing factor (ADF)/cofilin family of proteins play an essential role in actin dynamics and cytoskeletal re-organization...
  4. Cursiefen C, Ikeda S, Nishina P, Smith R, Ikeda A, Jackson D, et al. Spontaneous corneal hem- and lymphangiogenesis in mice with destrin-mutation depend on VEGFR3 signaling. Am J Pathol. 2005;166:1367-77 pubmed
    ..corn1 mice, which suffer from a deletion in the gene encoding the cytoskeletal protein destrin, develop hemangiogenesis as well as spontaneous outgrowth of LYVE-1+++/CD31+ lymphatic vessels into the cornea ..
  5. Bender M, Eckly A, Hartwig J, Elvers M, Pleines I, Gupta S, et al. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010;116:1767-75 pubmed publisher
    ..Here, we tailored a mouse model lacking all ADF/n-cofilin-mediated actin dynamics in megakaryocytes to specifically elucidate the role of actin filament turnover ..
  6. Mahaffey J, Grego Bessa J, Liem K, Anderson K. Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013;140:1262-71 pubmed publisher
    ..We propose that Vangl2 and cofilin cooperate to target Rab11(+) vesicles containing PCP proteins to the apical membrane during the initiation of planar cell polarity. ..
  7. Kawakami Schulz S, Verdoni A, Sattler S, Jessen E, Kao W, Ikeda A, et al. Serum response factor: positive and negative regulation of an epithelial gene expression network in the destrin mutant cornea. Physiol Genomics. 2014;46:277-89 pubmed publisher
    ..Dstn(corn1) mice, deficient for the actin depolymerizing factor destrin (DSTN), display an increase of serum response factor (SRF) that results in epithelial ..
  8. Wang J, Sun L, Si Y, Li B. Overexpression of actin-depolymerizing factor blocks oxidized low-density lipoprotein-induced mouse brain microvascular endothelial cell barrier dysfunction. Mol Cell Biochem. 2012;371:1-8 pubmed publisher
    The aim of present work was to elucidate the role of actin-depolymerizing factor (ADF), an important regulator of actin cytoskeleton, in the oxidized low-density lipoprotein (ox-LDL)-induced blood-brain barrier (BBB) disruption...
  9. Kirov J, Adkisson M, Nava A, Cipollone A, Willis B, Engelhard E, et al. Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation. PLoS ONE. 2015;10:e0134155 pubmed publisher
    ..The results support the conclusion that there is promoter silencing in a subset of mutants carrying the tm1a allele. The features of targeted genes which promote local silencing when targeted remain unknown. ..
  10. Zhang W, Zhao J, Chen L, Urbanowicz M, Nagasaki T. Abnormal epithelial homeostasis in the cornea of mice with a destrin deletion. Mol Vis. 2008;14:1929-39 pubmed
    Dstn(corn1) mice lack normal destrin expression and develop corneal abnormality shortly after birth such as epithelial hyperplasia and total vascularization. Thus, the mice serve as a model for ocular surface disorders...
  11. Brzóska H, d Esposito A, Kolatsi Joannou M, Patel V, Igarashi P, Lei Y, et al. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016;90:1274-1284 pubmed publisher
    ..Thus, PCP genes are important in mammalian kidney development and have an unexpected role in rostrocaudal patterning during organogenesis. ..
  12. Kawakami Schulz S, Verdoni A, Sattler S, Ikeda A, Ikeda S. Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background. Mol Vis. 2012;18:606-16 pubmed
    Mutations in destrin (Dstn) cause corneal abnormalities in mice. A null mutation, Dstn(corn1), results in corneal epithelial hyperproliferation, inflammation, and neovascularization in the A.BY background (A.BY Dstn(corn1))...
  13. Gurniak C, Chevessier F, Jokwitz M, Jönsson F, Perlas E, Richter H, et al. Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur J Cell Biol. 2014;93:252-66 pubmed publisher
    Mutations in the human actin depolymerizing factor cofilin2 result in an autosomal dominant form of nemaline myopathy...
  14. Narayanan P, Chatterton P, Ikeda A, Ikeda S, Corey D, Ervasti J, et al. Length regulation of mechanosensitive stereocilia depends on very slow actin dynamics and filament-severing proteins. Nat Commun. 2015;6:6855 pubmed publisher
    ..Finally, the proteins ADF and AIP1, which both mediate actin filament severing, contribute to stereocilia length maintenance...
  15. Wang D, Naydenov N, Feygin A, Baranwal S, Kuemmerle J, Ivanov A. Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation. Am J Pathol. 2016;186:844-58 pubmed publisher
    ..Members of the actin-depolymerizing factor (ADF) and cofilin protein family play key roles in actin dynamics by mediating filament severing and polymerization...
  16. Görlich A, Wolf M, Zimmermann A, Gurniak C, Al Banchaabouchi M, Sassoè Pognetto M, et al. N-cofilin can compensate for the loss of ADF in excitatory synapses. PLoS ONE. 2011;6:e26789 pubmed publisher
    ..of immunogold electron microscopy and immunocytochemistry, we here demonstrate the presence of ADF (actin depolymerizing factor), a close homolog of n-cofilin, in excitatory synapses, where it is particularly enriched in ..
  17. Nawaz S, Sánchez P, Schmitt S, Snaidero N, Mitkovski M, Velte C, et al. Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system. Dev Cell. 2015;34:139-151 pubmed publisher
    ..We identified the actin depolymerizing factor ADF/cofilin1, which mediates high F-actin turnover rates, as an essential factor in this process...
  18. Kuure S, Cebrian C, MACHINGO Q, Lu B, Chi X, Hyink D, et al. Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis. PLoS Genet. 2010;6:e1001176 pubmed publisher
    ..branching morphogenesis, we studied the functional requirements for the closely related ADFs cofilin1 (Cfl1) and destrin (Dstn) during mouse development...
  19. Luxenburg C, Heller E, Pasolli H, Chai S, Nikolova M, Stokes N, et al. Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity. Nat Cell Biol. 2015;17:592-604 pubmed publisher
    ..Here, we identify a key role for Wdr1 (also known as Aip1), an F-actin-binding protein that enhances cofilin/destrin-mediated F-actin disassembly...
  20. Zimmermann A, Jene T, Wolf M, Görlich A, Gurniak C, Sassoè Pognetto M, et al. Attention-Deficit/Hyperactivity Disorder-like Phenotype in a Mouse Model with Impaired Actin Dynamics. Biol Psychiatry. 2015;78:95-106 pubmed publisher
    Actin depolymerizing proteins of the actin depolymerizing factor (ADF)/cofilin family are essential for actin dynamics, which is critical for synaptic function...
  21. Hotulainen P, Paunola E, Vartiainen M, Lappalainen P. Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell. 2005;16:649-64 pubmed
    Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing actin filaments...
  22. Kawakami Schulz S, Sattler S, Doebley A, Ikeda A, Ikeda S. Genetic modification of corneal neovascularization in Dstn (corn1) mice. Mamm Genome. 2013;24:349-57 pubmed publisher
    Mutations in the gene for destrin (Dstn), an actin depolymerizing factor, lead to corneal abnormalities in mice. A null mutation in Dstn, termed Dstn (corn1) , isolated and maintained in the A.BY background (A...
  23. Hoekstra E, von Oerthel L, van der Linden A, Schellevis R, Scheppink G, Holstege F, et al. Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013;37:23-32 pubmed publisher
    ..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2. ..
  24. Kousaka K, Kiyonari H, Oshima N, Nagafuchi A, Shima Y, Chisaka O, et al. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Genesis. 2008;46:246-55 pubmed publisher
    ..Unexpectedly, ssh-3 was not essential for viability, fertility, or development of epithelial tissues; and ssh-3 did not genetically modify the corneal disorder of the corn1/ADF/destrin mutant.
  25. Huo Y, Xie X, Jiang B. Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice. Mol Med Rep. 2017;15:139-145 pubmed publisher
    ..expression profiling array GSE49688, which includes 3 samples each from the wild?type (WT), Dstncorn1 mutant (corn1) and corn1 mice following the conditional ablation of Srf from the corneal epithelium [namely rescued (res)] mouse ..