Genomes and Genes
Gene Symbol: Draxin
Description: dorsal inhibitory axon guidance protein
Alias: 2610109H07Rik, neucrin, draxin, dorsal repulsive axon guidance protein
- Chinn G, Hirokawa K, Chuang T, Urbina C, Patel F, Fong J, et al. Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice. Cereb Cortex. 2015;25:2707-18 pubmed publisher..These studies define essential roles for Lhx2 in GW, hippocampal commissure, and corpus callosum formation, and suggest that defects in radial GW progenitors can give rise to ACC. ..
- Meli R, WeisovÃ¡ P, Propst F. Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3Î² (GSK-3Î²) and microtubule-associated protein 1B. PLoS ONE. 2015;10:e0119524 pubmed publisherb>Draxin is an important axon guidance cue necessary for the formation of forebrain commissures including the corpus callosum, but the molecular details of draxin signaling are unknown...
- Zhang S, Su Y, Shinmyo Y, Islam S, Naser I, Ahmed G, et al. Draxin, a repulsive axon guidance protein, is involved in hippocampal development. Neurosci Res. 2010;66:53-61 pubmed publisher..The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice ..
- Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, et al. Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. Nat Commun. 2015;6:10232 pubmed publisher..Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical ..