Draxin

Summary

Gene Symbol: Draxin
Description: dorsal inhibitory axon guidance protein
Alias: 2610109H07Rik, neucrin, draxin, dorsal repulsive axon guidance protein
Species: mouse
Products:     Draxin

Top Publications

  1. Riyadh M, Shinmyo Y, Ohta K, Tanaka H. Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons. Biochem Biophys Res Commun. 2014;449:169-74 pubmed publisher
    ..Here, we report that draxin, a repulsive axon guidance protein, is involved in PCN development...
  2. Islam S, Shinmyo Y, Okafuji T, Su Y, Naser I, Ahmed G, et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science. 2009;323:388-93 pubmed publisher
    ..We identified a secreted protein, draxin, that shares no homology with known guidance cues...
  3. Ahmed G, Shinmyo Y, Ohta K, Islam S, Hossain M, Naser I, et al. Draxin inhibits axonal outgrowth through the netrin receptor DCC. J Neurosci. 2011;31:14018-23 pubmed publisher
    b>Draxin, a recently identified axon guidance protein, is essential for the formation of forebrain commissures, and can mediate repulsion of netrin-stimulated spinal commissural axons...
  4. Hau A, Grebbin B, Agoston Z, Anders Maurer M, Müller T, Groß A, et al. MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1. J Cell Biol. 2017;216:2715-2729 pubmed publisher
    ..These results for the first time link MEIS proteins to PARP-regulated chromatin dynamics and provide a mechanistic basis to explain the profound cellular changes elicited by these proteins. ..
  5. Zhang S, Su Y, Gao J, Zhang C, Tanaka H. A potential inhibitory function of draxin in regulating mouse trunk neural crest migration. In Vitro Cell Dev Biol Anim. 2017;53:43-53 pubmed publisher
    b>Draxin is a repulsive axon guidance protein that plays important roles in the formation of three commissures in the central nervous system and dorsal interneuron 3 (dI3) in the chick spinal cord...
  6. Miyake A, Takahashi Y, Miwa H, Shimada A, Konishi M, Itoh N. Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling. Biochem Biophys Res Commun. 2009;390:1051-5 pubmed publisher
    A gene encoding a novel secreted protein in mice and humans was identified, and named Neucrin. Mouse Neucrin consists of 343 amino acids with a cysteine-rich domain in its carboxyl terminal region...
  7. Ahmed G, Shinmyo Y, Naser I, Hossain M, Song X, Tanaka H. Olfactory bulb axonal outgrowth is inhibited by draxin. Biochem Biophys Res Commun. 2010;398:730-4 pubmed publisher
    ..Several classes of axon guidance molecules influence the pathfinding of the olfactory bulb axons. Draxin, a recently identified novel class of repulsive axon guidance protein, is essential for the formation of forebrain ..
  8. Hossain M, Ahmed G, Naser I, Shinmyo Y, Ito A, Riyadh M, et al. The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation. Dev Biol. 2013;374:58-70 pubmed publisher
    We have shown that draxin is a repulsive axon guidance molecule for a variety of neuron classes and that genetic deletion of draxin in mice results in the absence of all forebrain commissures...
  9. Dillman A, Hauser D, Gibbs J, Nalls M, McCoy M, Rudenko I, et al. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013;16:499-506 pubmed publisher
    ..We provide this data set and analysis as a resource for understanding gene expression in the embryonic and adult cerebral cortex. ..

More Information

Publications13

  1. Chinn G, Hirokawa K, Chuang T, Urbina C, Patel F, Fong J, et al. Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice. Cereb Cortex. 2015;25:2707-18 pubmed publisher
    ..These studies define essential roles for Lhx2 in GW, hippocampal commissure, and corpus callosum formation, and suggest that defects in radial GW progenitors can give rise to ACC. ..
  2. Meli R, Weisová P, Propst F. Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and microtubule-associated protein 1B. PLoS ONE. 2015;10:e0119524 pubmed publisher
    b>Draxin is an important axon guidance cue necessary for the formation of forebrain commissures including the corpus callosum, but the molecular details of draxin signaling are unknown...
  3. Zhang S, Su Y, Shinmyo Y, Islam S, Naser I, Ahmed G, et al. Draxin, a repulsive axon guidance protein, is involved in hippocampal development. Neurosci Res. 2010;66:53-61 pubmed publisher
    ..The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice ..
  4. Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, et al. Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex. Nat Commun. 2015;6:10232 pubmed publisher
    ..Herein we report that an axon guidance cue, draxin, is expressed in early-born neocortical neurons, including subplate neurons, and is necessary for thalamocortical ..