Gene Symbol: Dppa5a
Description: developmental pluripotency associated 5A
Alias: AA536857, Dppa5, Esg1, ecat2, developmental pluripotency-associated protein 5A, ES cell-associated transcript 2 protein, ESG-1, developmental pluripotency associated 5, embryonal stem cell specific gene 1, embryonal stem cell-specific gene 1 protein, mDppa5, protein pH 34
Species: mouse
Products:     Dppa5a

Top Publications

  1. Lee E, Yuan T, Danielian P, West J, Lees J. E2F4 cooperates with pRB in the development of extra-embryonic tissues. Dev Biol. 2009;332:104-15 pubmed publisher
    ..Taken together, our data show that pRB and E2F4 cooperate in placental development, but play largely non-overlapping roles in the development of many embryonic tissues...
  2. Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry D, Yanagimachi R, et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003;130:1673-80 pubmed
    ..These observations suggest that failure to reactivate the full spectrum of these Oct4-related genes may contribute to embryonic lethality in somatic-cell clones. ..
  3. Astigiano S, Barkai U, Abarzua P, Tan S, Harper M, Sherman M. Changes in gene expression following exposure of nulli-SCCl murine embryonal carcinoma cells to inducers of differentiation: characterization of a down-regulated mRNA. Differentiation. 1991;46:61-7 pubmed
    ..Primer extension experiments revealed that the insert contains the full 5' sequence. Comparison with known sequences failed to reveal significant homology with previously sequenced proteins...
  4. Bierbaum P, MacLean Hunter S, Ehlert F, Moroy T, Muller R. Cloning of embryonal stem cell-specific genes: characterization of the transcriptionally controlled gene esg-1. Cell Growth Differ. 1994;5:37-46 pubmed
  5. Tanaka T, Kunath T, Kimber W, Jaradat S, Stagg C, Usuda M, et al. Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res. 2002;12:1921-8 pubmed
    ..We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage...
  6. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-42 pubmed
    ..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells. ..
  7. Western P, Maldonado Saldivia J, van den Bergen J, Hajkova P, Saitou M, Barton S, et al. Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines. Stem Cells. 2005;23:1436-42 pubmed
    ..We have analyzed Esg1 expression in mouse and human cells and shown that in the mouse the gene is specifically expressed in ..
  8. Tanaka T, Lopez de Silanes I, Sharova L, Akutsu H, Yoshikawa T, Amano H, et al. Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets. Dev Growth Differ. 2006;48:381-90 pubmed
    ..in the maintenance of cellular pluripotency, we found that KH-domain protein Embryonal stem cell-specific gene 1 (Esg1) showed similar expression patterns to those of Oct3/4 (Pou5f1), whereas the forced repression of Oct3/4 in mouse ..
  9. Miharada K, Sigurdsson V, Karlsson S. Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress. Cell Rep. 2014;7:1381-1392 pubmed publisher
    Developmental pluripotency-associated 5 (Dppa5) is an RNA binding protein highly expressed in undifferentiated pluripotent stem cells...

More Information


  1. Krentz A, Murphy M, Zhang T, Sarver A, Jain S, Griswold M, et al. Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013;377:67-78 pubmed publisher
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease. ..
  2. Amano H, Itakura K, Maruyama M, Ichisaka T, Nakagawa M, Yamanaka S. Identification and targeted disruption of the mouse gene encoding ESG1 (PH34/ECAT2/DPPA5). BMC Dev Biol. 2006;6:11 pubmed
    ..Previous studies identified genomic clones containing the mouse ESG1 gene and five pseudogenes...
  3. Pierre A, Gautier M, Callebaut I, Bontoux M, Jeanpierre E, Pontarotti P, et al. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. Genomics. 2007;90:583-94 pubmed publisher
    ..Khdc1a and Khdc1b belong to a family of several members including the so-called developmental pluripotency A5 (Dppa5) genes, the cat/dog oocyte expressed protein (cat OOEP and dog OOEP) genes, and the ES cell-associated transcript ..
  4. Mitiku N, Baker J. Genomic analysis of gastrulation and organogenesis in the mouse. Dev Cell. 2007;13:897-907 pubmed
    ..Drosophila homologs of these genes are also coordinately downregulated following gastrulation, suggesting that the combined function of these genes has been conserved during metazoan evolution. ..
  5. Han D, Tapia N, Joo J, Greber B, Arauzo Bravo M, Bernemann C, et al. Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell. 2010;143:617-27 pubmed publisher
    ..Our findings suggest that the rare ability of EpiSCs to contribute to chimeras is due to the presence of the minor EpiSC fraction representing the early epiblast. ..
  6. Saito K, Abe H, Nakazawa M, Irokawa E, Watanabe M, Hosoi Y, et al. Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells. Biol Reprod. 2010;82:687-97 pubmed publisher
    ..Taken together, it was concluded that these transcripts encoding homeoproteins are capable of regulating the maintenance and/or differentiation of mouse ES cells and likely regulate that of preimplantation embryos. ..
  7. Kim S, Suh M, Yoon H, Lee J, Oh S, Moon S, et al. Identification of developmental pluripotency associated 5 expression in human pluripotent stem cells. Stem Cells. 2005;23:458-62 pubmed
    ..We confirmed that developmental pluripotency associated 5 (Dppa5), originally found in mouse embryonic stem cells (ESCs) and mouse embryonic carcinoma ..
  8. Suzuki A, Niimi Y, Saga Y. Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3:1207-16 pubmed publisher
    ..This alternate interaction might account for the molecular basis of the functional redundancy and differences in NANOS2 and NANOS3 functions. ..