Gene Symbol: Dpp4
Description: dipeptidylpeptidase 4
Alias: Cd26, Dpp-4, THAM, dipeptidyl peptidase 4, DPP IV, T-cell activation antigen CD26, dipeptidyl peptidase IV, thymocyte-activating molecule
Species: mouse
Products:     Dpp4

Top Publications

  1. Shah Z, Kampfrath T, Deiuliis J, Zhong J, Pineda C, Ying Z, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis. Circulation. 2011;124:2338-49 pubmed publisher
    ..DPP-4i exerts antiatherosclerotic effects and reduces inflammation via inhibition of monocyte activation/chemotaxis. These findings have important implications for the use of this class of drugs in atherosclerosis. ..
  2. Conarello S, Li Z, Ronan J, Roy R, Zhu L, Jiang G, et al. Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. Proc Natl Acad Sci U S A. 2003;100:6825-30 pubmed
    b>Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone, glucagon-like peptide 1 (GLP-1), and other incretin ..
  3. Zaruba M, Theiss H, Vallaster M, Mehl U, Brunner S, David R, et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell. 2009;4:313-23 pubmed publisher
    ..Since SDF-1alpha is cleaved and inactivated by CD26/dipeptidylpeptidase IV (DPP-IV), we established a therapeutic concept--applicable to ischemic disorders in general--..
  4. Marguet D, Baggio L, Kobayashi T, Bernard A, Pierres M, Nielsen P, et al. Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26. Proc Natl Acad Sci U S A. 2000;97:6874-9 pubmed
    A subset of prolyl oligopeptidases, including dipeptidyl-peptidase IV (DPP IV or CD26, EC ), specifically cleave off N-terminal dipeptides from substrates having proline or alanine in amino acid position 2...
  5. Preller V, Gerber A, Togni M, Wrenger S, Schraven B, Rocken C, et al. CD26/DP IV in T cell activation and autoimmunity. Adv Exp Med Biol. 2006;575:187-93 pubmed
  6. Delacour D, Koch A, Ackermann W, Eude Le Parco I, Elsässer H, Poirier F, et al. Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo. J Cell Sci. 2008;121:458-65 pubmed publisher
    ..Taken together, our results demonstrate that, in addition to a pivotal role in apical trafficking, galectin-3 also participates in epithelial morphogenesis in mouse enterocytes. ..
  7. Geier M, Tenikoff D, Yazbeck R, McCaughan G, Abbott C, Howarth G. Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV. J Cell Physiol. 2005;204:687-92 pubmed
    ..However, its bioactivity is limited by dipeptidyl peptidase IV (DPIV)-mediated degradation...
  8. Tinoco A, Kim Y, Tagore D, Wiwczar J, Lane W, Danial N, et al. A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones. Biochemistry. 2011;50:2213-22 pubmed publisher
    ..Moreover, integrating this peptidomics approach with bioassays (i.e., GSIS) provides a general strategy to reveal proteolytic pathways that may regulate the activity of peptide hormones. ..
  9. Driskell R, Lichtenberger B, Hoste E, Kretzschmar K, Simons B, Charalambous M, et al. Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature. 2013;504:277-281 pubmed publisher
    ..They also form a platform for discovering fibroblast lineages in other tissues and for examining fibroblast changes in ageing and disease. ..

More Information


  1. Sueyoshi R, Woods Ignatoski K, Okawada M, Hartmann B, Holst J, Teitelbaum D. Stimulation of intestinal growth and function with DPP4 inhibition in a mouse short bowel syndrome model. Am J Physiol Gastrointest Liver Physiol. 2014;307:G410-9 pubmed publisher
    ..been shown to be effective in patients with short bowel syndrome (SBS), but it is rapidly inactivated by dipeptidyl peptidase IV (DPP4)...
  2. Takasuga S, Horie Y, Sasaki J, Sun Wada G, Kawamura N, Iizuka R, et al. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013;110:1726-31 pubmed publisher
  3. Aoyama M, Kawase H, Bando Y, Monji A, Murohara T. Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis. Circ Heart Fail. 2016;9:e002081 pubmed publisher
    Ample evidence demonstrates cardiovascular protection by incretin-based therapy using dipeptidyl peptidase 4 inhibitor (DPP4i) and glucagon-like peptide-1 (GLP-1) under either diabetic or nondiabetic condition...
  4. Nakano H, Moran T, Nakano K, Gerrish K, Bortner C, Cook D. Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. J Immunol. 2015;194:3808-19 pubmed publisher
    ..preDC-derived conventional DCs (cDCs), including CD103(+) and CD11b(hi) cDCs, express dipeptidyl peptidase-4/CD26. Flow cytometric analysis of multiple organs, including the kidney, liver, lung, lymph nodes, small intestine, and ..
  5. Mulvihill E, Varin E, Ussher J, Campbell J, Bang K, Abdullah T, et al. Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice. Diabetes. 2016;65:742-54 pubmed publisher
    Dipeptidyl peptidase-4 (DPP4) inhibitors used for the treatment of type 2 diabetes are cardioprotective in preclinical studies; however, some cardiovascular outcome studies revealed increased hospitalization rates for heart failure (HF) ..
  6. Liu L, Liu J, Yu X. Dipeptidyl peptidase-4 inhibitor MK-626 restores insulin secretion through enhancing autophagy in high fat diet-induced mice. Biochem Biophys Res Commun. 2016;470:516-520 pubmed publisher
    ..Furthermore, the beneficial effects of MK-626 were inhibited by GLP-1 receptor antagonist exendin 9-39. The present study reveals the activation of autophagy to mediate the anti-diabetic effect of GLP-1. ..
  7. Engel M, Hoffmann T, Wagner L, Wermann M, Heiser U, Kiefersauer R, et al. The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A. 2003;100:5063-8 pubmed
    The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique multifunctional protein, acting as receptor, binding and proteolytic molecule. We have determined the sequence and 1...
  8. Bernard A, Mattei M, Pierres M, Marguet D. Structure of the mouse dipeptidyl peptidase IV (CD26) gene. Biochemistry. 1994;33:15204-14 pubmed
    b>Dipeptidyl peptidase IV (DPP IV, EC is an ectopeptidase whose expression is modulated during thymocyte differentiation and T cell activation. We describe here the organization of the mouse DPP IV gene...
  9. Schürmann C, Linke A, Engelmann Pilger K, Steinmetz C, Mark M, Pfeilschifter J, et al. The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice. J Pharmacol Exp Ther. 2012;342:71-80 pubmed publisher
    ..Our data suggest a potentially beneficial role of DPP-4 inhibition in diabetes-affected wound healing. ..
  10. Broxmeyer H, Capitano M, Campbell T, Hangoc G, Cooper S. Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26. Stem Cells Dev. 2016;25:575-85 pubmed publisher
    b>Dipeptidyl peptidase 4 (DPP4)/CD26 truncates certain proteins, and this posttranslational modification can influence their activity...
  11. Kanno Y, Sakai A, Miyashita M, Tsuchida K, Matsuo O. Plasminogen deficiency is associated with improved glucose tolerance, and lower DPP-4 activity. Diabetes Res Clin Pract. 2016;120:190-3 pubmed publisher
    ..Additionally, Plg deficiency was associated with lower dipeptidyl peptidase-4 (DPP-4) activity, and enhanced glucagons-like peptide-1 (GLP-1) expression. Plg may regulate the DPP-4 activity and the glucose metabolism. ..
  12. Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, et al. TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26. J Immunol. 2007;178:4632-40 pubmed
    The T cell marker CD26/dipeptidyl peptidase (DP) IV is associated with an effector phenotype and markedly elevated in the human CNS disorder multiple sclerosis...
  13. Tanaka Y, Kume S, Chin Kanasaki M, Araki H, Araki S, Ugi S, et al. Renoprotective effect of DPP-4 inhibitors against free fatty acid-bound albumin-induced renal proximal tubular cell injury. Biochem Biophys Res Commun. 2016;470:539-545 pubmed publisher
  14. Takasawa W, Ohnuma K, Hatano R, Endo Y, Dang N, Morimoto C. Inhibition of dipeptidyl peptidase 4 regulates microvascular endothelial growth induced by inflammatory cytokines. Biochem Biophys Res Commun. 2010;401:7-12 pubmed publisher
    ..Recently, CD26/dipeptidyl peptidase 4 (DPP-4) inhibition has been used as a novel oral therapeutic approach for patients with type 2 diabetes...
  15. Tai W, Zhao G, Sun S, Guo Y, Wang Y, Tao X, et al. A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection. Virology. 2016;499:375-382 pubmed publisher
    ..It bound strongly to the receptor of MERS-CoV, dipeptidyl peptidase 4 (DPP4), and elicited robust RBD-specific neutralizing antibodies in mice, maintaining long-term ..
  16. Earnest J, Hantak M, Li K, McCray P, Perlman S, Gallagher T. The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases. PLoS Pathog. 2017;13:e1006546 pubmed publisher
    ..lines, we found that the tetraspanin CD9, but not the tetraspanin CD81, formed cell-surface complexes of dipeptidyl peptidase 4 (DPP4), the MERS-CoV receptor, and the type II transmembrane serine protease (TTSP) member TMPRSS2, a CoV-..
  17. Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, et al. GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development. 2007;134:189-98 pubmed
  18. Aroor A, Habibi J, Kandikattu H, Garro Kacher M, Barron B, Chen D, et al. Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol. 2017;16:61 pubmed publisher
    ..Together, these in vivo and in vitro results suggest that inhibition of DPP-4 activity by linagliptin reverses WD-induced DD, possibly by targeting TRAF3IP2 expression and its downstream inflammatory signaling. ..
  19. Mentzel S, Dijkman H, van Son J, Koene R, Assmann K. Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice. J Histochem Cytochem. 1996;44:445-61 pubmed
    The hydrolases aminopeptidase A and dipeptidyl peptidase IV, both present in the kidney on the brush borders of the proximal tubule epithelial cells and podocytes, are involved in the induction of experimental membranous ..
  20. Richard E, Alam S, Arredondo Vega F, Patel D, Hershfield M. Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. J Biol Chem. 2002;277:19720-6 pubmed
    ..and lymphoid cells of humans, but not mice, ADA also occurs bound to the membrane glycoprotein CD26/dipeptidyl peptidase IV. This "ecto-ADA" has been postulated to regulate extracellular Ado levels, and also the ..
  21. Akita K, Isoda K, Shimada K, Daida H. Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice. J Am Heart Assoc. 2015;4:e001469 pubmed publisher
    ..AGP appeared to suppress neointimal formation by inhibiting inflammation, independently of its effects on glucose or cholesterol metabolism in atherogenic LKO mice. ..
  22. Aroor A, Zuberek M, Duta C, Meuth A, Sowers J, Whaley Connell A, et al. Angiotensin II Stimulation of DPP4 Activity Regulates Megalin in the Proximal Tubules. Int J Mol Sci. 2016;17: pubmed publisher
    ..in the proximal tubule, is downregulated in obese mice, which was prevented by inhibition of dipeptidyl protease 4 (DPP4)...
  23. Shi S, Srivastava S, Kanasaki M, He J, Kitada M, Nagai T, et al. Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition. Kidney Int. 2015;88:479-89 pubmed publisher
    ..Hence, inhibiting DPP-4 may be a therapeutic target for treating kidney fibrosis in diabetes. ..
  24. Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T. The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology. 2004;127:1775-86 pubmed
    ..Our results suggest that Notch signaling has an important role in the differentiation of biliary epithelial cells and is essential for their tubular formation during IHBD development. ..
  25. Lee S, Yu S, Nakayama J, Khoo K, Stone E, Fukuda M, et al. Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation. J Biol Chem. 2010;285:37683-92 pubmed publisher
    ..These studies are the first to clearly identify functional mucin-type O-glycan structures modulating cell surface expression of SI and DPP-IV during the intestinal cell differentiation. ..
  26. Yoo E, Paganessi L, Alikhan W, Paganessi E, Hughes F, Fung H, et al. Loss of CD26 protease activity in recipient mice during hematopoietic stem cell transplantation results in improved transplant efficiency. Transfusion. 2013;53:878-87 pubmed publisher
    ..Our earlier findings suggested that suppression of CD26 (dipeptidyl peptidase IV) proteolytic activity in the donor cell population can be utilized as a method for increasing transplant ..
  27. Min H, Kim J, Lee M, Song H, Kang Y, Lee M, et al. Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction. Lab Invest. 2014;94:598-607 pubmed publisher
    b>Dipeptidyl peptidase IV (DPPIV) is an exopeptidase that modulates the function of several substrates, among which insulin-releasing incretin hormones are the most well known...
  28. Christopherson K, Cooper S, Broxmeyer H. Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells. Blood. 2003;101:4680-6 pubmed
    ..b>CD26 (dipeptidylpeptidase IV [DPPIV]) is a membrane-bound extracellular peptidase that cleaves dipeptides from the N-..
  29. Rosmaninho Salgado J, Marques A, Estrada M, Santana M, Cortez V, Grouzmann E, et al. Dipeptidyl-peptidase-IV by cleaving neuropeptide Y induces lipid accumulation and PPAR-? expression. Peptides. 2012;37:49-54 pubmed publisher
    ..These data indicate that DPPIV and NPY interact on lipid metabolism to promote adipose tissue depot. ..
  30. Christopherson K, Cooper S, Hangoc G, Broxmeyer H. CD26 is essential for normal G-CSF-induced progenitor cell mobilization as determined by CD26-/- mice. Exp Hematol. 2003;31:1126-34 pubmed
    ..Our previous studies suggested that that G-CSF-induced mobilization may involve the extracellular peptidase CD26 (DPPIV/dipeptidylpeptidase IV)...
  31. Ambrosi T, Scialdone A, Graja A, Gohlke S, Jank A, Bocian C, et al. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell. 2017;20:771-784.e6 pubmed publisher
    ..These studies delineate the molecular identity of the bone-resident adipocytic lineage, and they establish its involvement in age-dependent dysfunction of bone and hematopoietic regeneration. ..
  32. Rugg Gunn P, Cox B, Lanner F, Sharma P, Ignatchenko V, McDonald A, et al. Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012;22:887-901 pubmed publisher
    ..These results provide a comprehensive stem cell proteomic resource and enable new approaches to interrogate the mechanisms that regulate cell fate specification. ..
  33. Post S, Smits A, van den Broek A, Sluijter J, Hoefer I, Janssen B, et al. Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance. Cardiovasc Res. 2010;85:494-502 pubmed publisher
    ..factor-1alpha (SDF-1alpha) and the chemokine receptor CXCR4 are crucial for homing and negatively influenced by CD26. The aim of this study was to gain insight into the impaired homing of HHT1-MNCs...
  34. Delano D, Montesinos M, Desai A, Wilder T, Fernandez P, D EUSTACHIO P, et al. Genetically based resistance to the antiinflammatory effects of methotrexate in the air-pouch model of acute inflammation. Arthritis Rheum. 2005;52:2567-75 pubmed
    ..Genetic factors contribute to the antiinflammatory efficacy of MTX, and a single locus involved in MTX-induced adenosine up-regulation is likely responsible for the observed resistance to MTX in DBA/1J mice. ..
  35. Ogasawara W, Tanaka C, Suzuki M, Kobayashi G, Ogawa Y, Okada H, et al. Isoforms of dipeptidyl aminopeptidase IV from Pseudomonas sp. WO24: role of the signal sequence and overexpression in Escherichia coli. Protein Expr Purif. 2005;41:241-51 pubmed
    ..We developed purification steps for activting a large amount of 84-kDa isoform protein that will be useful for producing protein for crystallographic studies. ..
  36. Shin J, Fukuhara A, Onodera T, Yokoyama C, Otsuki M, Shimomura I. Regulation of Dipeptidyl Peptidase-4, its Substrate Chemokines, and Their Receptors in Adipose Tissue of ob/ob Mice. Horm Metab Res. 2017;49:380-387 pubmed publisher
    ..Actions of several substrate chemokines might be potentiated by downregulation of DPP-4, synergistically with upregulation of chemokines and their receptors in adipose tissues of obese mice. ..
  37. Peck K, Cockrell A, Yount B, Scobey T, Baric R, Heise M. Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection. J Virol. 2015;89:4696-9 pubmed publisher
    Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity...
  38. Weis V, Knowles B, Choi E, Goldstein A, Williams J, Manning E, et al. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016;2:131-157 pubmed
    ..However, the diarrheal pathology after MYO5B loss is due to deficits in transporter presentation at the apical membrane in duodenal enterocytes. ..
  39. Yan S, Gessner R, Dietel C, Schmiedek U, Fan H. Enhanced ovalbumin-induced airway inflammation in CD26-/- mice. Eur J Immunol. 2012;42:533-40 pubmed publisher
    In this study, we investigated the potential role of CD26 in ovalbumin (OVA)-induced airway inflammation using CD26 gene knockout mice...
  40. Lee D, Lee E, Alam M, Jang J, Lee H, Oh H, et al. Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate. Metabolism. 2016;65:89-101 pubmed publisher
    ..Our findings suggest that sDPP-4 enhances inflammatory actions via TLR pathway, while DPP-4 inhibition with either an enzymatic or binding inhibitor has anti-inflammatory effects. ..
  41. Arwert E, Mentink R, Driskell R, Hoste E, Goldie S, Quist S, et al. Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation. Oncogene. 2012;31:992-1000 pubmed publisher
    ..We identified a single protein, CD26 (dipeptidyl peptidase-4). CD26 serum levels were not increased in InvEE mice...
  42. Powell D, Dacosta C, Gay J, Ding Z, Smith M, Greer J, et al. Improved glycemic control in mice lacking Sglt1 and Sglt2. Am J Physiol Endocrinol Metab. 2013;304:E117-30 pubmed publisher
  43. Nonogaki K, Kaji T. Pharmacological stimulation of serotonin 5-HT1B receptors enhances increases in plasma active glucagon-like peptide-1 levels induced by dipeptidyl peptidase-4 inhibition independently of feeding in mice. Diabetes Metab. 2015;41:425-8 pubmed publisher
    ..These findings suggest that pharmacological stimulation of 5-HT1B receptors enhances the increases in plasma active GLP-1 induced by DPP-4 inhibition independently of feeding and also improves glucose tolerance in mice. ..
  44. Zhu E, Hu L, Wu H, Piao L, Zhao G, Inoue A, et al. Dipeptidyl Peptidase-4 Regulates Hematopoietic Stem Cell Activation in Response to Chronic Stress. J Am Heart Assoc. 2017;6: pubmed publisher
    b>DPP4 (Dipeptidyl peptidase-4)-GLP-1 (glucagon-like peptide-1) and its receptor (GLP-1R) axis has been involved in several intracellular signaling pathways...
  45. Sakurada C, Sakurada S, Hayashi T, Katsuyama S, Tan No K, Sakurada T. Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study. Biochem Pharmacol. 2003;66:653-61 pubmed
    ..of endomorphin-2 and the accumulation of major metabolites were inhibited by specific inhibitors of dipeptidyl peptidase IV, such as diprotin A and B...
  46. Baumeier C, Saussenthaler S, Kammel A, Jähnert M, Schlüter L, Hesse D, et al. Hepatic DPP4 DNA Methylation Associates With Fatty Liver. Diabetes. 2017;66:25-35 pubmed publisher
    ..However, whether increased dipeptidyl peptidase 4 (DPP4) is involved in the pathogenesis or is rather a consequence of metabolic disease is not known...
  47. Busso N, Wagtmann N, Herling C, Chobaz Péclat V, Bischof Delaloye A, So A, et al. Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol. 2005;166:433-42 pubmed
    b>Dipeptidyl peptidase IV (DPPIV, CD26), a protease-cleaving N-terminal X-Pro dipeptide from selected proteins including some chemokines, is expressed both as a soluble form in plasma and on the cell surface of various immune and nonimmune ..
  48. Biton A, Bank U, Tager M, Ansorge S, Reinhold D, Lendeckel U, et al. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Adv Exp Med Biol. 2006;575:177-86 pubmed
  49. Ye Y, Bajaj M, Yang H, Perez Polo J, Birnbaum Y. SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor. Cardiovasc Drugs Ther. 2017;31:119-132 pubmed publisher
    ..The effects on remodeling were augmented when Saxa was added to Dapa. Yet, adding Saxa to Dapa did not result in a greater effect on myocardial fibrosis and collagen levels. ..
  50. Willard J, Barrow B, Zraika S. Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels. Diabetologia. 2017;60:701-708 pubmed publisher
    ..Thus, neprilysin inhibition may be a novel treatment strategy for type 2 diabetes. ..
  51. Vivier I, Marguet D, Naquet P, Bonicel J, Black D, Li C, et al. Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV). J Immunol. 1991;147:447-54 pubmed
    ..present study, we show that THAM is the mouse counterpart of the human T cell-activating ectoenzyme CD26 (dipeptidyl peptidase IV, DPP IV) and that highly purified THAM lacks neutral exoaminopeptidase activity...
  52. Lu H, Huang C, Shih C, Lin Y, Tsai C, Lin F, et al. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. J Vasc Surg. 2017;66:1217-1226.e1 pubmed publisher
    ..Dipeptidyl peptidase-4 (DPP-4, an adipokine known as CD26) influences cell signaling, cell-matrix interactions, and the regulation of the functional activity of incretins in ..
  53. Cordero O, Yang C, Bell E. On the role of CD26 in CD4 memory T cells. Immunobiology. 2007;212:85-94 pubmed
    We studied an in vivo mouse model to evaluate the relationships between CD26--a glycoprotein with dipeptidyl peptidase IV (DPP-IV) activity implicated in the regulation of immune functions--and T cells expressing the effector/memory ..
  54. Ruter J, Demuth H, Arck P, Hoffmann T, Klapp B, Hildebrandt M. Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions. Adv Exp Med Biol. 2003;524:155-63 pubmed
  55. Yan S, Marguet D, Dobers J, Reutter W, Fan H. Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen. Eur J Immunol. 2003;33:1519-27 pubmed
    To investigate the role of CD26 in the immune system, CD26 gene knockout mice with C57BL/6 background were used to study the immune response after stimulation with PWM. CD26(-/-) mice display an apparently normal phenotype...
  56. Christopherson K, Hangoc G, Mantel C, Broxmeyer H. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science. 2004;305:1000-3 pubmed
    ..The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins...
  57. Chen T, Smyth D, Abbott C. CD26. J Biol Regul Homeost Agents. 2004;18:47-54 pubmed
  58. Jungraithmayr W, De Meester I, Matheeussen V, Inci I, Augustyns K, Scharpe S, et al. Inhibition of CD26/DPP IV attenuates ischemia/reperfusion injury in orthotopic mouse lung transplants: the pivotal role of vasoactive intestinal peptide. Peptides. 2010;31:585-91 pubmed publisher
    The T cell activation Ag CD26/dipeptidylpeptidase IV (DPP IV) combines co-stimulatory and enzymatic properties. Catalytically, it functions as an exopeptidase, modulating biological activity of key chemokines and peptides...
  59. Sauvé M, Ban K, Momen M, Zhou Y, Henkelman R, Husain M, et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice. Diabetes. 2010;59:1063-73 pubmed publisher
    ..Cardiac structure and function was assessed by hemodynamic monitoring and echocardiography in DPP-4 knockout (Dpp4(-/-)) mice versus wild-type (Dpp4(+/+)) littermate controls and after left anterior descending (LAD) coronary ..
  60. Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, et al. Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. PLoS ONE. 2017;12:e0182422 pubmed publisher
    b>Dipeptidyl peptidase 4 inhibitors are used worldwide in the management of diabetes, but their role in the prevention or treatment of cardiovascular disorders has yet to be defined...
  61. Mulvihill E, Varin E, Gladanac B, Campbell J, Ussher J, Baggio L, et al. Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. Cell Metab. 2017;25:152-165 pubmed publisher
    Pharmacological inhibition of the dipeptidyl peptidase-4 (DPP4) enzyme potentiates incretin action and is widely used to treat type 2 diabetes...
  62. Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, et al. Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. Diabetologia. 2012;55:404-12 pubmed publisher
    ..Our results suggest that the ability of DPP-4 inhibition to suppress the progression to STZ-induced hyperglycaemia involves both alleviation of beta cell death and alpha cell proliferation. ..
  63. Christoforou N, Miller R, Hill C, Jie C, McCallion A, Gearhart J. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest. 2008;118:894-903 pubmed publisher
  64. Kohashi K, Hiromura M, Mori Y, Terasaki M, Watanabe T, Kushima H, et al. A Dipeptidyl Peptidase-4 Inhibitor but not Incretins Suppresses Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice. J Atheroscler Thromb. 2016;23:441-54 pubmed publisher
    ..DPP-4I, MK0626, but not native incretins has protective effects against AAA in Ang II-infused Apoe-/- mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall. ..
  65. Kubota A, Takano H, Wang H, Hasegawa H, Tadokoro H, Hirose M, et al. DPP-4 inhibition has beneficial effects on the heart after myocardial infarction. J Mol Cell Cardiol. 2016;91:72-80 pubmed publisher
    ..DPP-4 inhibition may have direct protective effects on the post-MI heart by inducing an antiapoptotic effect and inhibiting a decrease in vessel number through the SDF-1α/CXCR4-mediated STAT3 signaling pathway. ..
  66. Bak E, Park H, Lee C, Lee T, Woo G, Na Y, et al. Effects of novel chalcone derivatives on ?-glucosidase, dipeptidyl peptidase-4, and adipocyte differentiation in vitro. BMB Rep. 2011;44:410-4 pubmed publisher
    ..Therefore, Chana 1 showed inhibitory effects on ?-glucosidase and DPP-4 as well as a stimulatory effect on adipocyte differentiation, suggesting that Chana 1 may be a potential beneficial agent for the treatment of type 2 diabetes. ..
  67. Herlihy S, Pilling D, Maharjan A, Gomer R. Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent. J Immunol. 2013;190:6468-77 pubmed publisher
    ..We found that a predicted structure of AprA has similarity to human dipeptidyl peptidase IV (DPPIV)...
  68. David F, Bernard A, Pierres M, Marguet D. Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases. J Biol Chem. 1993;268:17247-52 pubmed
    Dipeptidyl-peptidase IV (DPP IV, CD26, EC 3.4.14...
  69. El Yacoubi M, Vaugeois J, Marguet D, Sauze N, Guieu R, Costentin J, et al. Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity. Behav Brain Res. 2006;171:279-85 pubmed
    b>CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing...
  70. Schievenbusch S, Sauer E, Curth H, Schulte S, Demir M, Toex U, et al. Neighbor of Punc E 11: expression pattern of the new hepatic stem/progenitor cell marker during murine liver development. Stem Cells Dev. 2012;21:2656-66 pubmed publisher
    ..In conclusion, Nope should be most useful in future research to define the differentiation stage of hepatic-specified cells of various sources and is a promising candidate to identify and isolate hepatic stem cells from the adult liver. ..
  71. Mizutani S, Gomi H, Hirayama I, Izumi T. Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse. Mamm Genome. 2006;17:375-84 pubmed
    ..The present work physically delineates the major locus for adiposity in the TSOD mouse. ..
  72. Hirukawa H, Kaneto H, Shimoda M, Kimura T, Okauchi S, Obata A, et al. Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression. Mol Cell Endocrinol. 2015;413:49-60 pubmed publisher
    ..Taken together, combination of Pio and Alo exerts protective effects on β-cells in diabetic db/db mice, at least in part, through the augmentation of IRS-2 expression. ..
  73. Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, et al. A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci. 2017;86:212-221 pubmed publisher
    ..However, the pathogenesis of pruritus in PSO remains unclear. Dipeptidyl peptidase IV (DPPIV) enzyme activity is involved in the regulation of peptide hormones, chemokines and ..
  74. Choi S, Park S, Oh C, Leem J, Park K, Lee I. Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation. Vascul Pharmacol. 2015;73:11-9 pubmed publisher
    ..Taken together, our data indicate that gemigliptin exerts a preventative effect on the proliferation and migration of VSMCs via Nrf2. ..
  75. Wang X, Holz L, Chowdhury S, Cordoba S, Evans K, Gall M, et al. The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. Immunol Cell Biol. 2017;95:443-453 pubmed publisher
    ..b>Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a cell surface glycoprotein and serine protease...
  76. Zhong J, Rao X, Deiuliis J, Braunstein Z, Narula V, Hazey J, et al. A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation. Diabetes. 2013;62:149-57 pubmed publisher
    ..b>DPP4 has a number of nonenzymatic functions that involve its interaction with adenosine deaminase (ADA) and other ..
  77. Fatima S, Ruter J, Niess J, Klapp B, Arck P, Hildebrandt M. CD26-/DPP IV-positive lymphocytes in murine acute experimental colitis. Adv Exp Med Biol. 2003;524:345-50 pubmed
  78. Pascal K, Coleman C, Mujica A, Kamat V, Badithe A, Fairhurst J, et al. Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2015;112:8738-43 pubmed publisher
    ..The VelocImmune and VelociGene technologies are powerful platforms that can be used to rapidly respond to emerging epidemics. ..
  79. Marguet D, Bernard A, Vivier I, Darmoul D, Naquet P, Pierres M. cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992;267:2200-8 pubmed
    ..indicating that this molecule is the mouse homologue of the human T cell-activating ectoenzyme CD26 (dipeptidyl peptidase IV, DPP IV). We describe here the cloning and the characterization of THAM cDNA. Two clones (3.3 and 2...