Gene Symbol: Dpep1
Description: dipeptidase 1 (renal)
Alias: AI327012, MBD, dipeptidase 1, MBD-1, membrane bound dipeptidase type II, membrane-bound dipeptidase 1, microsomal dipeptidase, renal dipeptidase
Species: mouse
Products:     Dpep1

Top Publications

  1. Satoh S, Keida Y, Konta Y, Maeda M, Matsumoto Y, Niwa M, et al. Purification and molecular cloning of mouse renal dipeptidase. Biochim Biophys Acta. 1993;1163:234-42 pubmed
    Mouse renal dipeptidase (mouseRDP, EC was purified from the membrane fraction of kidney...
  2. Habib G, Barrios R, Shi Z, Lieberman M. Four distinct membrane-bound dipeptidase RNAs are differentially expressed and show discordant regulation with gamma-glutamyl transpeptidase. J Biol Chem. 1996;271:16273-80 pubmed
    Membrane-bound dipeptidase (MBD) participates in the degradation of glutathione by cleaving the cysteinyl-glycine bond of cystinyl bisglycine (oxidized cysteinyl-glycine) following removal of a gamma-glutamyl group by gamma-glutamyl ..
  3. Habib G, Lieberman M. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Adv Exp Med Biol. 1999;469:295-300 pubmed
  4. Habib G, Shi Z, Cuevas A, Lieberman M. Identification of two additional members of the membrane-bound dipeptidase family. FASEB J. 2003;17:1313-5 pubmed
    ..cloned two mouse cDNAs encoding previously unidentified membrane-bound dipeptidases [membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3)] from membrane-bound dipeptidase-1 (MBD-1) deficient mice (Habib, G.M...
  5. Habib G, Shi Z, Cuevas A, Guo Q, Matzuk M, Lieberman M. Leukotriene D4 and cystinyl-bis-glycine metabolism in membrane-bound dipeptidase-deficient mice. Proc Natl Acad Sci U S A. 1998;95:4859-63 pubmed
    We have developed mice deficient in membrane-bound dipeptidase (MBD, EC, the enzyme believed to be responsible for the conversion of leukotriene D4 (LTD4) to leukotriene E4 (LTE4)...