Dp1l1

Summary

Gene Symbol: Dp1l1
Description: receptor accessory protein 6
Alias: 0610011M24Rik, Dp1l1, receptor expression-enhancing protein 6, TB2 protein-like 1, deleted in polyposis 1-like 1, polyposis locus protein 1-like 1
Species: mouse
Products:     Dp1l1

Top Publications

  1. Saito H, Kubota M, Roberts R, Chi Q, Matsunami H. RTP family members induce functional expression of mammalian odorant receptors. Cell. 2004;119:679-91 pubmed
    ..We have used this approach to identify active odorant ligands for ORs, providing a platform for screening the chemical selectivity of the large OR family. ..
  2. Layman W, McEwen D, Beyer L, Lalani S, Fernbach S, Oh E, et al. Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. Hum Mol Genet. 2009;18:1909-23 pubmed publisher
    ..These studies provide evidence that mammalian olfactory dysfunction due to Chd7 haploinsufficiency is linked to primary defects in olfactory neural stem cell proliferation and may influence olfactory bulb development. ..
  3. Krolewski R, Packard A, Jang W, Wildner H, Schwob J. Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE. 2012;7:e51737 pubmed publisher
    ..Thus, persistent neurogenic failure distorts the differentiation of multiple other cell types in the olfactory epithelium. ..
  4. Björk S, Hurt C, Ho V, Angelotti T. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. PLoS ONE. 2013;8:e76366 pubmed publisher
    ..Therefore, some REEPs can be further described as ER membrane shaping adapter proteins. ..
  5. Hao H, Veleri S, Sun B, Kim D, Keeley P, Kim J, et al. Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL. Hum Mol Genet. 2014;23:4260-71 pubmed publisher
    ..Among the highly down-regulated genes in the Nrl(-/-) retina, we identified receptor expression enhancing protein 6 (Reep6), which encodes a member of a family of proteins involved in shaping of membrane tubules ..
  6. Agrawal S, Burgoyne T, Eblimit A, Bellingham J, Parfitt D, Lane A, et al. REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking. Hum Mol Genet. 2017;26:2667-2677 pubmed publisher
    ..We recently identified mutations in REEP6, which encodes the receptor expression enhancing protein 6, in several families with autosomal recessive RP...
  7. Sato H, Tomita H, Nakazawa T, Wakana S, Tamai M. Deleted in polyposis 1-like 1 gene (Dp1l1): a novel gene richly expressed in retinal ganglion cells. Invest Ophthalmol Vis Sci. 2005;46:791-6 pubmed
    To characterize a novel gene, deleted in polyposis 1-like 1 (Dp1l1), which is expressed in the retina...
  8. Moore Scott B, Opoka R, Lin S, Kordich J, Wells J. Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation. Dev Dyn. 2007;236:1997-2003 pubmed
    ..We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9...
  9. Pfister S, Jones V, Power M, Truisi G, Khoo P, Steiner K, et al. Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55:45-58 pubmed publisher
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal. ..

More Information

Publications11

  1. Arno G, Agrawal S, Eblimit A, Bellingham J, Xu M, Wang F, et al. Mutations in REEP6 Cause Autosomal-Recessive Retinitis Pigmentosa. Am J Hum Genet. 2016;99:1305-1315 pubmed publisher
    ..Therefore, our study implicates REEP6 in retinal homeostasis and highlights a pathway previously uncharacterized in retinal dystrophy. ..
  2. Veleri S, Nellissery J, Mishra B, Manjunath S, Brooks M, Dong L, et al. REEP6 mediates trafficking of a subset of Clathrin-coated vesicles and is critical for rod photoreceptor function and survival. Hum Mol Genet. 2017;26:2218-2230 pubmed publisher
    ..Our studies suggest a critical function of REEP6 in trafficking of cargo via a subset of Clathrin-coated vesicles to selected membrane sites in retinal rod photoreceptors. ..