Gene Symbol: Dnmt3l
Description: DNA (cytosine-5-)-methyltransferase 3-like
Alias: D6Ertd14e, ecat7, DNA (cytosine-5)-methyltransferase 3-like
Species: mouse
Products:     Dnmt3l

Top Publications

  1. Ooi S, Qiu C, Bernstein E, Li K, Jia D, Yang Z, et al. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature. 2007;448:714-7 pubmed
    ..The establishment of patterns of DNA methylation during gametogenesis depends in part on DNMT3L, an enzymatically inactive regulatory factor that is related in sequence to the DNA methyltransferases DNMT3A and ..
  2. Niles K, Chan D, La Salle S, Oakes C, Trasler J. Critical period of nonpromoter DNA methylation acquisition during prenatal male germ cell development. PLoS ONE. 2011;6:e24156 pubmed publisher
    ..and postnatal germ cells isolated from wildtype mice and mice deficient in the DNA methyltransferase cofactor DNMT3L. Erasure of the parental DNA methylation pattern occurred by 13...
  3. Henckel A, Nakabayashi K, Sanz L, Feil R, Hata K, Arnaud P. Histone methylation is mechanistically linked to DNA methylation at imprinting control regions in mammals. Hum Mol Genet. 2009;18:3375-83 pubmed publisher
    ..important question, we analyzed histone modifications at ICRs in mid-gestation embryos that were obtained from Dnmt3L(-/-) females, in which DNA methylation imprints at ICRs are not established during oogenesis...
  4. Kuramochi Miyagawa S, Watanabe T, Gotoh K, Totoki Y, Toyoda A, Ikawa M, et al. DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. Genes Dev. 2008;22:908-17 pubmed publisher
    ..Our data strongly suggest that MILI and MIWI2 play essential roles in establishing de novo DNA methylation of retrotransposons in fetal male germ cells. ..
  5. Aapola U, Lyle R, Krohn K, Antonarakis S, Peterson P. Isolation and initial characterization of the mouse Dnmt3l gene. Cytogenet Cell Genet. 2001;92:122-6 pubmed
    We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cytosine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarity to members of the DNMT3/Dnmt3 family...
  6. Hata K, Okano M, Lei H, Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002;129:1983-93 pubmed
    ..In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is ..
  7. Jelinic P, Stehle J, Shaw P. The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. PLoS Biol. 2006;4:e355 pubmed
    ..These results suggest that CTCFL and PRMT7 may play a role in male germline imprinted gene methylation. ..
  8. Aravin A, Sachidanandam R, Bourc his D, Schaefer C, Pezic D, Toth K, et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell. 2008;31:785-99 pubmed publisher
    ..The Piwi pathway lies upstream of known mediators of DNA methylation, since piRNAs are still produced in dnmt3L mutants, which fail to methylate transposons...
  9. Aapola U, Scott H, Ollila J, Vihinen M, Heino M, Shintani A, et al. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. Genomics. 2000;65:293-8 pubmed
    We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the AIRE and the KIAA0653 genes and spans approximately 16 kb of genomic sequence...

More Information


  1. Bowles J, Feng C, Spiller C, Davidson T, Jackson A, Koopman P. FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell. 2010;19:440-9 pubmed publisher
  2. Hata K, Kusumi M, Yokomine T, Li E, Sasaki H. Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Mol Reprod Dev. 2006;73:116-22 pubmed
    The DNA methyltransferase-like protein Dnmt3L is necessary for the establishment of genomic imprints in oogenesis and for normal spermatogenesis (Bourc'his et al., 2001; Hata et al., 2002)...
  3. Suzuki A, Saba R, Miyoshi K, Morita Y, Saga Y. Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. PLoS ONE. 2012;7:e33558 pubmed publisher
  4. La Salle S, Mertineit C, Taketo T, Moens P, Bestor T, Trasler J. Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells. Dev Biol. 2004;268:403-15 pubmed
    ..We compared the temporal expression patterns of the DNA methyltransferases, DNMT1, DNMT3a, DNMT3b, and DNMT3l in the male and female germ lines...
  5. Kato Y, Kaneda M, Hata K, Kumaki K, Hisano M, Kohara Y, et al. Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum Mol Genet. 2007;16:2272-80 pubmed
    ..Furthermore, we have examined the roles of the de novo methyltransferases (Dnmt3a and Dnmt3b) and related protein (Dnmt3L) in this process...
  6. Mahadevaiah S, Bourc his D, de Rooij D, Bestor T, Turner J, Burgoyne P. Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol. 2008;182:263-76 pubmed publisher
    ..In contrast, three mutants (Dnmt3l, Msh5, and Dmc1) with high levels of asynapsis and numerous persistent unrepaired DSBs have a severely impaired ..
  7. Jia D, Jurkowska R, Zhang X, Jeltsch A, Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature. 2007;449:248-51 pubmed
    ..DNA methyltransferase 3a (Dnmt3a) and its regulatory factor, DNA methyltransferase 3-like protein (Dnmt3L), are both required for the de novo DNA methylation of imprinted genes in mammalian germ cells...
  8. Lucifero D, La Salle S, Bourc his D, Martel J, Bestor T, Trasler J. Coordinate regulation of DNA methyltransferase expression during oogenesis. BMC Dev Biol. 2007;7:36 pubmed
    ..Here we report the expression dynamics of Dnmt3a and Dnmt3b, as well as a regulator of DNA methylation, Dnmt3L, in isolated female germ cells...
  9. Hu Y, Hirasawa R, Hu J, Hata K, Li C, Jin Y, et al. Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development. Hum Mol Genet. 2008;17:2654-64 pubmed publisher
    ..The activity of both enzymes increases in the presence of Dnmt3L, a Dnmt3a/3b-like protein. However, it is unclear how the function of Dnmt3L is regulated...
  10. Ciccone D, Su H, Hevi S, Gay F, Lei H, Bajko J, et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature. 2009;461:415-8 pubmed publisher
    ..in male and female germ cells during gametogenesis, and the de novo DNA methyltransferase DNMT3A and its cofactor DNMT3L are required in this process...
  11. Gowher H, Liebert K, Hermann A, Xu G, Jeltsch A. Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L. J Biol Chem. 2005;280:13341-8 pubmed
    b>Dnmt3L has been identified as a stimulator of the catalytic activity of de novo DNA methyltransferases. It is essential in the development of germ cells in mammals...
  12. Bourc his D, Xu G, Lin C, Bollman B, Bestor T. Dnmt3L and the establishment of maternal genomic imprints. Science. 2001;294:2536-9 pubmed
    ..The Dnmt3L gene is expressed during gametogenesis at stages where genomic imprints are established...
  13. Arnaud P, Hata K, Kaneda M, Li E, Sasaki H, Feil R, et al. Stochastic imprinting in the progeny of Dnmt3L-/- females. Hum Mol Genet. 2006;15:589-98 pubmed
    ..data in mice indicate that Dnmt3a, an enzyme with de novo DNA methyltransferase activity, and the related protein Dnmt3L are required for methylation of imprinted loci in germ cells...
  14. Lees Murdock D, Shovlin T, Gardiner T, De Felici M, Walsh C. DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev Dyn. 2005;232:992-1002 pubmed
    ..DNMT) 3A and DNMT3B are both active de novo DNA methyltransferases required for development, whereas DNMT3L, which has no demonstrable methyltransferase activity, is required for methylation of imprinted genes in the ..
  15. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, et al. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009;17:775-87 pubmed publisher
  16. Deplus R, Brenner C, Burgers W, Putmans P, Kouzarides T, De Launoit Y, et al. Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res. 2002;30:3831-8 pubmed
    The Dnmt3L protein belongs to the Dnmt3 family of DNA methyltransferases by virtue of its sequence homology in the plant homeodomain (PHD)-like motif...
  17. La Salle S, Oakes C, Neaga O, Bourc his D, Bestor T, Trasler J. Loss of spermatogonia and wide-spread DNA methylation defects in newborn male mice deficient in DNMT3L. BMC Dev Biol. 2007;7:104 pubmed
    ..Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA ..
  18. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-42 pubmed
    ..nanog-deficient ES cells lost pluripotency and differentiated into extraembryonic endoderm lineage. These data demonstrate that Nanog is a critical factor underlying pluripotency in both ICM and ES cells. ..
  19. Lucifero D, Mann M, Bartolomei M, Trasler J. Gene-specific timing and epigenetic memory in oocyte imprinting. Hum Mol Genet. 2004;13:839-49 pubmed
    ..acquisition was probably related to oocyte diameter and coincided with the accumulation of Dnmt3a, Dnmt3b and Dnmt3L transcripts...
  20. Bourc his D, Bestor T. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature. 2004;431:96-9 pubmed
    ..Here we show that DNA methyltransferase 3-like (Dnmt3L (ref...
  21. Shovlin T, Bourc his D, La Salle S, O Doherty A, Trasler J, Bestor T, et al. Sex-specific promoters regulate Dnmt3L expression in mouse germ cells. Hum Reprod. 2007;22:457-67 pubmed
    b>Dnmt3L, a member of the DNA methyltransferase 3 family, lacks enzymatic activity but is required for de-novo methylation of imprinted genes in oocytes and for transposon repression in male germ cells...
  22. Sakai Y, Suetake I, Shinozaki F, Yamashina S, Tajima S. Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos. Gene Expr Patterns. 2004;5:231-7 pubmed
    ..b>Dnmt3L, which is necessary for spermatogenesis, was co-expressed in gonocytes at identical stages to Dnmt3a2...
  23. Aravin A, van der Heijden G, Castañeda J, Vagin V, Hannon G, Bortvin A. Cytoplasmic compartmentalization of the fetal piRNA pathway in mice. PLoS Genet. 2009;5:e1000764 pubmed publisher
    ..Cumulatively, our data reveal elaborate cytoplasmic compartmentalization of the fetal piRNA pathway that relies on MAEL function. ..
  24. Webster K, O Bryan M, Fletcher S, Crewther P, Aapola U, Craig J, et al. Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A. 2005;102:4068-73 pubmed
    ..b>Dnmt3L, a DNA methyltransferase regulator, is expressed during gametogenesis, and its deletion results in sterility...
  25. Jurkowska R, Anspach N, Urbanke C, Jia D, Reinhardt R, Nellen W, et al. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res. 2008;36:6656-63 pubmed publisher
    The C-terminal domains of Dnmt3a and Dnmt3L form elongated heterotetramers (3L-3a-3a-3L). Analytical ultracentrifugation confirmed the Dnmt3a-C/3L-C complex exists as a 2:2 heterotetramer in solution...
  26. Shah M, Vasanthakumar A, Barnes N, Figueroa M, Kamp A, Hendrick C, et al. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 2010;70:5840-50 pubmed publisher
    ..These data represent the first in vivo modeling of cancer-associated DNA methylation changes and suggest that truncated DNMT3B isoforms contribute to the redistribution of DNA methylation characterizing virtually every human tumor. ..
  27. Krentz A, Murphy M, Zhang T, Sarver A, Jain S, Griswold M, et al. Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013;377:67-78 pubmed publisher
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease. ..
  28. Lee S, Lee Y, Bae J, Choi J, Tayama C, Hata K, et al. HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators. Proc Natl Acad Sci U S A. 2014;111:9555-60 pubmed publisher
    ..Normally, these CGIs were highly methylated (mCGIs) by the DNMT3L complex and marked with epigenetic signatures associated with active expression, such as H3K36me3...
  29. Kato Y, Katsuki T, Kokubo H, Masuda A, Saga Y. Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells. Nat Commun. 2016;7:11272 pubmed publisher
    ..We propose a dual system of NANOS2-mediated suppression of Dazl expression as a pivotal molecular mechanism promoting sexual differentiation of XY germ cells. ..
  30. Inoue K, Ichiyanagi K, Fukuda K, Glinka M, Sasaki H. Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice. PLoS Genet. 2017;13:e1006926 pubmed publisher
    ..studies of DNA methylation and polyA(+) RNAs (transcriptome) in developing male germ cells from Pld6/Mitopld and Dnmt3l knockout mice, which are defective in piRNA biogenesis and de novo DNA methylation, respectively...
  31. Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed
    ..is thought to be composed of three DNA methyltransferase enzymes (DNMT1, DNMT3A, and DNMT3B) and one cofactor (DNMT3L)...
  32. Monk D, Wagschal A, Arnaud P, Müller P, Parker Katiraee L, Bourc his D, et al. Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing. Genome Res. 2008;18:1270-81 pubmed publisher
    ..Examination of Dnmt3l(-/+) conceptuses shows that imprinted expression for all genes of the cluster depends upon the germline ..
  33. Niles K, Yeh J, Chan D, Landry M, Nagano M, Trasler J. Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline. Hum Reprod. 2013;28:519-30 pubmed publisher
    How does haploinsufficiency of the paternal-effect gene Dnmt3L affect DNA methylation establishment and stability in the male germline? Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-..
  34. Lee D, Singh P, Tsai S, Oates N, Spalla A, Spalla C, et al. CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia. PLoS Genet. 2010;6:e1001224 pubmed publisher
    ..CTCF-dependent allele-specific chromatin composition imposes a maternal allele-specific delay on de novo methylation imprint establishment at the H19/Igf2 ICR in prospermatogonia. ..
  35. Bagheri Fam S, Bird A, Zhao L, Ryan J, Yong M, Wilhelm D, et al. Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2. Endocrinology. 2017;158:3832-3843 pubmed publisher
    ..Together with previous findings, our data suggest that testis determination involves FGFR2c-mediated repression of both the WNT4- and FOXL2-driven ovarian-determining pathways. ..
  36. Iglesias Platas I, Martin Trujillo A, Cirillo D, Court F, Guillaumet Adkins A, Camprubí C, et al. Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin. PLoS ONE. 2012;7:e38907 pubmed publisher
    ..Imprinted expression of these novel ncRNAs requires DNMT3L-mediated maternal DNA methylation, which is also indispensable for establishing the correct chromatin profile at ..
  37. Saba R, Wu Q, Saga Y. CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014;389:173-81 pubmed publisher
    ..Concomitantly, we found that the male genetic program represented by the expression of NANOS2 and DNMT3L was totally rescued in about half of dKO germ cells, indicating that meiotic entry causes the suppression of male ..
  38. Liao H, Mo C, Wu S, Cheng D, Yu C, Chang K, et al. Dnmt3l-knockout donor cells improve somatic cell nuclear transfer reprogramming efficiency. Reproduction. 2015;150:245-56 pubmed publisher
    ..In this study, we demonstrate that the use of Dnmt3l-knockout (Dnmt3l-KO) donor cells in combination with Trichostatin A treatment improved the developmental ..
  39. Liao H, Tai K, Chen W, Cheng L, Ho H, Lin S. Functions of DNA methyltransferase 3-like in germ cells and beyond. Biol Cell. 2012;104:571-87 pubmed publisher
    DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development...
  40. Sakashita A, Kobayashi H, Wakai T, Sotomaru Y, Hata K, Kono T. Dynamics of genomic 5-hydroxymethylcytosine during mouse oocyte growth. Genes Cells. 2014;19:629-36 pubmed publisher
    ..The 5hmC in the maternal genome was clearly detectable in DNA methyltransferase 3-like enzyme (Dnmt3L)-null oocytes and their fertilized zygotes, although Dnmt3L is essential for DNA methylation in oocytes...
  41. Western P, Ralli R, Wakeling S, Lo C, Van Den Bergen J, Miles D, et al. Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS ONE. 2011;6:e20736 pubmed publisher
    ..of p27(KIP1), p15(INK4B), activation of RB, the expression of male germ cell differentiation markers NANOS2, DNMT3L and MILI and repression of the pluripotency network...
  42. Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, et al. Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol. 2006;297:361-73 pubmed
    ..Although the DNA methyltransferase 3-like (Dnmt3L) protein lacks DNA methylase activity, it is thought to establish the maternal imprint in combination with the ..
  43. Schulz R, McCole R, Woodfine K, Wood A, Chahal M, Monk D, et al. Transcript- and tissue-specific imprinting of a tumour suppressor gene. Hum Mol Genet. 2009;18:118-27 pubmed publisher
    ..The imprinted expression of BLCAP and its interplay with NNAT at the transcriptional level may be relevant to human carcinogenesis. ..
  44. Chassot A, Gregoire E, Lavery R, Taketo M, de Rooij D, Adams I, et al. RSPO1/?-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS ONE. 2011;6:e25641 pubmed publisher
    ..Our results demonstrate that RSPO1/?-catenin signaling is involved in meiosis in fetal germ cells and contributes to the cellular decision of germ cells to differentiate into oocyte or sperm...
  45. Xie Z, Huang Y, Chen Z, Riggs A, Ding J, Gowher H, et al. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet. 2006;15:1375-85 pubmed
    ..novo methylation activity of the two related methyltransferases DNMT3A and DNMT3B by regulatory factors including DNMT3L which has a stimulatory effect...
  46. Nimura K, Ishida C, Koriyama H, Hata K, Yamanaka S, Li E, et al. Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Genes Cells. 2006;11:1225-37 pubmed
    ..DNA methyltransferase 3-like protein (Dnmt3L), a member of the Dnmt3 family of proteins, is required during the establishment of DNA methylation patterns in ..
  47. Hara S, Takano T, Fujikawa T, Yamada M, Wakai T, Kono T, et al. Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting. Hum Mol Genet. 2014;23:3853-64 pubmed publisher
    In mammals, genomic imprinting governed by DNA methyltransferase DNMT3A and its cofactor DNMT3L is essential for functional gametes...
  48. Epsztejn Litman S, Feldman N, Abu Remaileh M, Shufaro Y, Gerson A, Ueda J, et al. De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol. 2008;15:1176-1183 pubmed publisher
  49. Arand J, Spieler D, Karius T, Branco M, Meilinger D, Meissner A, et al. In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet. 2012;8:e1002750 pubmed publisher
    ..non-CpG methylation is strongly linked to neighboring CpG methylation and requires the presence of Dnmt3L. The generation of a comprehensive data set of 146,000 CpG dyads was used to apply and develop parameter estimated ..
  50. Mann W, Haaf T. Single cell RT-PCR on mouse embryos: a general approach for developmental biology. Methods Mol Biol. 2010;630:3-12 pubmed publisher
    ..It is tempting to speculate that cells expressing the reprogramming machinery have a higher developmental potential. ..
  51. Menheniott T, Woodfine K, Schulz R, Wood A, Monk D, Giraud A, et al. Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10. Mol Cell Biol. 2008;28:386-96 pubmed
    ..In Dnmt3L mutant embryos that lack maternal germ line methylation imprints, we show that Ddc is overexpressed and Grb10 is ..
  52. Suzuki A, Niimi Y, Saga Y. Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells. Biol Open. 2014;3:1207-16 pubmed publisher
    ..This alternate interaction might account for the molecular basis of the functional redundancy and differences in NANOS2 and NANOS3 functions. ..
  53. Zamudio N, Scott H, Wolski K, Lo C, Law C, Leong D, et al. DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription. PLoS ONE. 2011;6:e18276 pubmed publisher
    Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrated it is an essential regulator of paternal imprinting and early male meiosis. Dnmt3L is also a paternal effect gene, i.e...
  54. Lee M, Jun D, Hwang C, Park S, Kang J, Park H, et al. Selection of neural differentiation-specific genes by comparing profiles of random differentiation. Stem Cells. 2006;24:1946-55 pubmed
  55. Smallwood S, Tomizawa S, Krueger F, Ruf N, Carli N, Segonds Pichon A, et al. Dynamic CpG island methylation landscape in oocytes and preimplantation embryos. Nat Genet. 2011;43:811-4 pubmed publisher
    ..We show that these CGIs depend on DNMT3A and DNMT3L but are not distinct at the sequence level, including in CpG periodicity...
  56. Aapola U, Mäenpää K, Kaipia A, Peterson P. Epigenetic modifications affect Dnmt3L expression. Biochem J. 2004;380:705-13 pubmed
    ..b>Dnmt3L (DNA cytosine-5-methyltransferase 3 like), a member of de novo methyltransferase Dnmt3 protein family, is a ..
  57. Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, et al. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012;26:2477-82 pubmed publisher
    ..These results indicate that CDKI gene-specific control of transcription by 7SK snRNP plays a pivotal role in the maintenance of PGC proliferation. ..
  58. Heo J, Lim J, Lee S, Jeong J, Kang H, Kim Y, et al. Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l. Cell Rep. 2017;18:1930-1945 pubmed publisher
    ..Sirt1, selectively prevents abnormal DNA methylation of some developmental genes in murine ESCs by antagonizing Dnmt3l. Transcriptome and DNA methylome analyses demonstrated that Sirt1-null (Sirt1-/-) ESCs repress ..
  59. Liang X, Cui X, Sun S, Jin Y, Heo Y, Namgoong S, et al. Superovulation induces defective methylation in line-1 retrotransposon elements in blastocyst. Reprod Biol Endocrinol. 2013;11:69 pubmed publisher
    ..Unexpectedly, expression of Dnmt3a, Dnmt3b, Dnmt3L as well as maintenance Dnmt1o in oocytes and zygotes was not disrupted...
  60. Guenatri M, Duffié R, Iranzo J, Fauque P, Bourc his D. Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013;140:562-72 pubmed publisher
    A stimulatory DNA methyltransferase co-factor, Dnmt3L, has evolved in mammals to assist the process of de novo methylation, as genetically demonstrated in the germline. The function of Dnmt3L in the early embryo remains unresolved...
  61. Liu L, Bailey S, Okuka M, Muñoz P, Li C, Zhou L, et al. Telomere lengthening early in development. Nat Cell Biol. 2007;9:1436-41 pubmed
  62. Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y. Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016;17:37-46 pubmed publisher
    ..We also present the first evidence that the zinc finger domain of Nanos acts as a protein-interacting domain for another RBP, providing a novel insight into Nanos-mediated germ cell development. ..
  63. Glass J, Fazzari M, Ferguson Smith A, Greally J. CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains. Mamm Genome. 2009;20:633-43 pubmed publisher
    The Dnmt3a and Dnmt3L genes are critical mediators of cytosine methylation during gametogenesis, with major actions noted at transposable elements and imprinted loci...