Gene Symbol: Dnm3os
Description: dynamin 3, opposite strand
Alias: 6030416H16Rik, Hag2, Npn1, P/L01
Loebel D, Tsoi B, Wong N, Tam P. A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. 2005;85:782-9 pubmed
A 6-kb antisense transcript (Dnm3os) contained within an intron of the mouse Dnm3 gene has been identified in a screen for genes that may be regulated by the basic helix-loop-helix transcription factor Twist during mouse development...
Sun Y, Hegamyer G, Colburn N. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res. 1994;54:1139-44 pubmed
Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed
Watanabe T, Sato T, Amano T, Kawamura Y, Kawamura N, Kawaguchi H, et al
. Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn. 2008;237:3738-48 pubmed publisher
b>Dnm3os, a gene that is transcribed into a non-coding RNA (ncRNA), contains three micro RNAs (miRNAs), miR-199a, miR-199a*, and miR-214, whose functions remain unknown in mammals...
Thiagarajan R, Cloonan N, Gardiner B, Mercer T, Kolle G, Nourbakhsh E, et al
. Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling. BMC Genomics. 2011;12:441 pubmed publisher
Gong S, Zheng C, Doughty M, Losos K, Didkovsky N, Schambra U, et al
. A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature. 2003;425:917-25 pubmed
..The atlas, library of BAC vectors and BAC transgenic mice generated in this screen provide a rich resource that allows a broad array of investigations not previously available to the neuroscience community. ..
Liu J, Luo X, Xiong A, Zhang Z, Yue S, Zhu M, et al
. MicroRNA-214 promotes myogenic differentiation by facilitating exit from mitosis via down-regulation of proto-oncogene N-ras. J Biol Chem. 2010;285:26599-607 pubmed publisher
..Thus, our data uncovered a novel microRNA-mediated mechanism that controls myogenic differentiation. ..
el Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, et al
. The hypoxia-inducible microRNA cluster miR-199aâˆ¼214 targets myocardial PPARÎ´ and impairs mitochondrial fatty acid oxidation. Cell Metab. 2013;18:341-54 pubmed publisher
..We demonstrate that under hemodynamic stress, cardiac hypoxia activates DNM3os, a noncoding transcript that harbors the microRNA cluster miR-199aâˆ¼214, which shares PPARÎ´ as common ..
Rowton M, Ramos P, Anderson D, Rhee J, Cunliffe H, Rawls A. Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013;242:1332-44 pubmed publisher
..These data demonstrate that PARAXIS initiates and stabilizes somite epithelialization by integrating signals from multiple pathways to control the reorganization of the ECM, cytoskeleton, and adhesion junctions during MET. ..