Gene Symbol: Dnm3
Description: dynamin 3
Alias: 9630020E24Rik, AW061159, B230343F03Rik, C530045C17, Dyna III, mKIAA0820, dynamin-3, dynamin III, t-dynamin, testicular dynamin
Species: mouse
Products:     Dnm3

Top Publications

  1. Reems J, Wang W, Tsubata K, Abdurrahman N, Sundell B, Tijssen M, et al. Dynamin 3 participates in the growth and development of megakaryocytes. Exp Hematol. 2008;36:1714-27 pubmed publisher
    ..001 with a fold change cutoff of three or more in expression level, dynamin 3 (DNM3) was identified to be differentially expressed during the course of MK development with a mean fold-change ..
  2. Raimondi A, Ferguson S, Lou X, Armbruster M, Paradise S, Giovedi S, et al. Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron. 2011;70:1100-14 pubmed publisher
    ..We show that dynamin 3, thought to play a predominantly postsynaptic role, has a major presynaptic function...
  3. Park R, Shen H, Liu L, Liu X, Ferguson S, De Camilli P. Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. J Cell Sci. 2013;126:5305-12 pubmed publisher
    ..As low-level expression of the dynamin 3 gene in these cells could not be excluded, we have now engineered dynamin 1, 2 and 3 triple KO (TKO) fibroblasts...
  4. Watanabe T, Sato T, Amano T, Kawamura Y, Kawamura N, Kawaguchi H, et al. Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn. 2008;237:3738-48 pubmed publisher
    ..Thus, Dnm3os has emerged as an miRNA-encoding gene that is indispensable for normal skeletal development and body growth in mammals. ..
  5. Fan F, Funk L, Lou X. Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo. J Neurosci. 2016;36:6097-115 pubmed publisher
    ..This study highlights the important role of dynamin-mediated endocytosis in the development of central synapses in the mammalian brain. ..
  6. Zhou W, De Iuliis G, Turner A, Reid A, Anderson A, McCluskey A, et al. Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis. Biol Reprod. 2017;96:159-173 pubmed publisher
    ..In support of this hypothesis, selective inhibition of dynamin altered the profile of proteins secreted from an immortalized caput epididymal cell line. ..
  7. Loebel D, Tsoi B, Wong N, Tam P. A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. 2005;85:782-9 pubmed
    A 6-kb antisense transcript (Dnm3os) contained within an intron of the mouse Dnm3 gene has been identified in a screen for genes that may be regulated by the basic helix-loop-helix transcription factor Twist during mouse development...
  8. Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger L, et al. Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Proc Natl Acad Sci U S A. 2012;109:E515-23 pubmed publisher
  9. Wu Y, O TOOLE E, Girard M, Ritter B, Messa M, Liu X, et al. A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. elife. 2014;3:e01621 pubmed publisher
    ..These findings support the existence of a pathway for SV reformation that bypasses the requirement for clathrin and dynamin 1/3 and that operates during intense synaptic activity. ..

More Information


  1. Gideons E, Lin P, Mahgoub M, Kavalali E, Monteggia L. Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling. elife. 2017;6: pubmed publisher
    ..Collectively, these findings demonstrate a requirement for BDNF in the antimanic action of lithium and identify enhanced dynamin-dependent endocytosis of AMPARs as a potential mechanism underlying the therapeutic effects of lithium. ..
  2. Noakes P, Chin D, Kim S, Liang S, Phillips W. Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. J Comp Neurol. 1999;410:531-40 pubmed
    ..day (P0), the short carboxy-terminal splicing form of dynamin I (dynamin I*b) was up-regulated, as was dynamin III, relative to dynamin II mRNA...
  3. Medrihan L, Rohlmann A, Fairless R, Andrae J, Döring M, Missler M, et al. Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009;587:5095-106 pubmed publisher
  4. Grossman G, Ebke L, Beight C, Jang G, Crabb J, Hagstrom S. Protein partners of dynamin-1 in the retina. Vis Neurosci. 2013;30:129-39 pubmed publisher
    ..This finding is confirmed by western blot analysis. Results further implicate dynamin-1 in vesicular protein transport processes relevant to synaptic and post-Golgi pathways and indicate a possible role in photoreceptor stability. ..
  5. Rowton M, Ramos P, Anderson D, Rhee J, Cunliffe H, Rawls A. Regulation of mesenchymal-to-epithelial transition by PARAXIS during somitogenesis. Dev Dyn. 2013;242:1332-44 pubmed publisher
    ..These data demonstrate that PARAXIS initiates and stabilizes somite epithelialization by integrating signals from multiple pathways to control the reorganization of the ECM, cytoskeleton, and adhesion junctions during MET. ..
  6. Meng J, Wang J, Lawrence G, Dolly J. Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons. FASEB J. 2013;27:3167-80 pubmed publisher
  7. Salinas S, Zussy C, Loustalot F, Henaff D, Menendez G, Morton P, et al. Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting. J Biol Chem. 2014;289:680-95 pubmed publisher
    ..Moreover, ligands that disrupted the homodimeric CAR interactions in its D1 domains triggered an internalization cascade involving sequences in its intracellular tail. ..