Dnm2

Summary

Gene Symbol: Dnm2
Description: dynamin 2
Alias: Dyn2, Udnm, b2b2159Clo, dynamin-2
Species: mouse
Products:     Dnm2

Top Publications

  1. Lee M, Skoura A, Park E, Landskroner Eiger S, Jozsef L, Luciano A, et al. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development. 2014;141:1465-72 pubmed publisher
    Here we show that dynamin 2 (Dnm2) is essential for angiogenesis in vitro and in vivo...
  2. McNiven M, Kim L, Krueger E, Orth J, Cao H, Wong T. Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J Cell Biol. 2000;151:187-98 pubmed
    ..In quiescent cells, dynamin 2 (Dyn 2) associates predominantly with clathrin-coated vesicles at the plasma membrane and the Golgi apparatus...
  3. Park R, Shen H, Liu L, Liu X, Ferguson S, De Camilli P. Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. J Cell Sci. 2013;126:5305-12 pubmed publisher
    ..Dynamin 1 and 3 are predominantly expressed in brain, whereas dynamin 2 is ubiquitously expressed...
  4. Wang Z, Humphrey C, Frilot N, Wang G, Nie Z, Moniri N, et al. Dynamin2- and endothelial nitric oxide synthase-regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli. J Cell Biol. 2011;192:101-10 pubmed publisher
    ..coli invasion. These findings suggest that UPEC escape urinary flushing and immune cell surveillance by means of eNOS-dependent dynamin2 S-nitrosylation and invasion of host cells to cause recurrent UTIs. ..
  5. Tosoni D, Puri C, Confalonieri S, Salcini A, De Camilli P, Tacchetti C, et al. TTP specifically regulates the internalization of the transferrin receptor. Cell. 2005;123:875-88 pubmed
    ..Thus, TTP might represent one of the long sought for molecules that allow cargo-specific control of clathrin endocytosis...
  6. Liu Y, Surka M, Schroeter T, Lukiyanchuk V, Schmid S. Isoform and splice-variant specific functions of dynamin-2 revealed by analysis of conditional knock-out cells. Mol Biol Cell. 2008;19:5347-59 pubmed publisher
    ..The mammalian genome encodes three isoforms, Dyn1, Dyn2, and Dyn3, and several splice variants of each, leading to the suggestion that distinct isoforms and/or distinct ..
  7. Wang Q, Liu J, Wang Z, Zhang Y, Duan X, Cui X, et al. Dynamin 2 regulates actin-mediated spindle migration in mouse oocytes. Biol Cell. 2014;106:193-202 pubmed publisher
    ..This is dependent on the regulation of actin and actin-related molecules. Dynamin 2, a large guanosine triphosphatases (GTPase) known to regulate clathrin-mediated endocytosis, is involved in ..
  8. Durieux A, Vassilopoulos S, Laine J, Fraysse B, Brinas L, Prudhon B, et al. A centronuclear myopathy--dynamin 2 mutation impairs autophagy in mice. Traffic. 2012;13:869-79 pubmed publisher
    b>Dynamin 2 (Dnm2) is involved in endocytosis and intracellular membrane trafficking through its function in vesicle formation from distinct membrane compartments...
  9. Durieux A, Vignaud A, Prudhon B, Viou M, Beuvin M, Vassilopoulos S, et al. A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice. Hum Mol Genet. 2010;19:4820-36 pubmed publisher
    Autosomal dominant centronuclear myopathy (AD-CNM) is due to mutations in the gene encoding dynamin 2 (DNM2) involved in endocytosis and intracellular membrane trafficking...

More Information

Publications71

  1. Ferguson S, Ferguson S, Raimondi A, Paradise S, Shen H, Mesaki K, et al. Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits. Dev Cell. 2009;17:811-22 pubmed publisher
    ..Our data also demonstrate that the relationship between dynamin and actin is intimately connected to dynamin's endocytic role and that dynamin terminates a powerful actin- and BAR protein-dependent tubulating activity...
  2. Cowling B, Toussaint A, Amoasii L, Koebel P, Ferry A, Davignon L, et al. Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness. Am J Pathol. 2011;178:2224-35 pubmed publisher
    b>Dynamin 2 (DNM2) is a large GTPase implicated in many cellular functions, including cytoskeleton regulation and endocytosis...
  3. Klocke R, Augustin A, Ronsiek M, Stief A, van Der Putten H, Jockusch H. Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 1997;41:290-2 pubmed
    ..Two distinct gene-specific cDNAs were used to analyze the segregation of dynamin genes Dnm1 and Dnm2 in a mouse interspecies backcross...
  4. Shin N, Choi H, Neff L, Wu Y, Saito H, Ferguson S, et al. Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts. J Cell Biol. 2014;207:73-89 pubmed publisher
  5. Joshi H, Subramanian I, Schnettler E, Ghosh G, Rupaimoole R, Evans C, et al. Dynamin 2 along with microRNA-199a reciprocally regulate hypoxia-inducible factors and ovarian cancer metastasis. Proc Natl Acad Sci U S A. 2014;111:5331-6 pubmed publisher
    ..b>Dynamin 2 (DNM2), a GTPase, is a critical mediator of endocytosis. Hypoxia decreased the levels of DNM2...
  6. Salinas S, Zussy C, Loustalot F, Henaff D, Menendez G, Morton P, et al. Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting. J Biol Chem. 2014;289:680-95 pubmed publisher
    ..Moreover, ligands that disrupted the homodimeric CAR interactions in its D1 domains triggered an internalization cascade involving sequences in its intracellular tail. ..
  7. Brown F, Collett M, Tremblay C, Rank G, De Camilli P, Booth C, et al. Loss of Dynamin 2 GTPase function results in microcytic anaemia. Br J Haematol. 2017;178:616-628 pubmed publisher
    ..we identified a pedigree with a novel microcytic hypochromia caused by a V235G missense mutation in Dynamin 2 (Dnm2)...
  8. Li B, Ding S, Feng N, Mooney N, Ooi Y, Ren L, et al. Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. Proc Natl Acad Sci U S A. 2017;114:E3642-E3651 pubmed publisher
    ..Our study unveiled an unexpected role of DBN1 in restricting the entry of RV and other viruses into host cells and more broadly to function as a crucial negative regulator of diverse dynamin-dependent endocytic pathways. ..
  9. Yaqoob U, Jagavelu K, Shergill U, de Assuncao T, Cao S, Shah V. FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway. PLoS ONE. 2014;9:e98130 pubmed publisher
    ..These studies extend our understanding of the relationships between RTK binding, internalization, endosomal targeting, and angiogenic signaling. ..
  10. Grabs D, Bergmann M. Differential appearance of dynamin in constitutive and regulated exo-endocytosis: a single-cell multiplex RT-PCR study. Cell Tissue Res. 2005;322:237-44 pubmed
    ..Moreover, the data exclude that dynamin 1 takes part in constitutive recycling before synapse formation, but dynamin 2 is present at this stage. Thus, dynamin 2 may be the constitutive counterpart of dynamin 1 in growing neurons...
  11. Tremblay C, Brown F, Collett M, Saw J, Chiu S, Sonderegger S, et al. Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia. 2016;30:1993-2001 pubmed publisher
    Mutations in the DYNAMIN2 (DNM2) gene are frequently detected in human acute T-cell lymphoblastic leukemia (T-ALL), although the mechanisms linking these mutations to disease pathogenesis remain unknown...
  12. Redgrove K, Bernstein I, Pye V, Mihalas B, Sutherland J, Nixon B, et al. Dynamin 2 is essential for mammalian spermatogenesis. Sci Rep. 2016;6:35084 pubmed publisher
    ..In the context of reproduction, dynamin 1 (DNM1) and dynamin 2 (DNM2) have recently been shown to act as key mediators of sperm acrosome formation and function...
  13. Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005;6:261-70 pubmed
    ..Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell ..
  14. Chappie J, Acharya S, Liu Y, Leonard M, Pucadyil T, Schmid S. An intramolecular signaling element that modulates dynamin function in vitro and in vivo. Mol Biol Cell. 2009;20:3561-71 pubmed publisher
    ..These data suggest that the components of the GTPase-GED interface act as an intramolecular signaling module, which we term the bundle signaling element, that can modulate dynamin function in vitro and in vivo. ..
  15. Fan F, Ji C, Wu Y, Ferguson S, Tamarina N, Philipson L, et al. Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis. J Clin Invest. 2015;125:4026-41 pubmed publisher
    ..using temporally controlled gene ablation specifically in β cells in mice, we identified an essential role of dynamin 2 GTPase in preserving normal biphasic insulin secretion and blood glucose homeostasis...
  16. Cowling B, Chevremont T, Prokic I, Kretz C, Ferry A, Coirault C, et al. Reducing dynamin 2 expression rescues X-linked centronuclear myopathy. J Clin Invest. 2014;124:1350-63 pubmed publisher
    ..An autosomal dominant form of CNM results from mutations in the gene encoding dynamin 2 (DNM2), and loss-of-function mutations in the gene encoding myotubularin (MTM1) result in X-linked CNM (XLCNM, ..
  17. Shen H, Ferguson S, Dephoure N, Park R, Yang Y, Volpicelli Daley L, et al. Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin. Mol Biol Cell. 2011;22:493-502 pubmed publisher
    ..pits are frozen at a deeply invaginated state, that is, cells that lack dynamin (fibroblasts from dynamin 1, dynamin 2 double conditional knockout mice)...
  18. Shevchuk A, Novak P, Taylor M, Diakonov I, Ziyadeh Isleem A, Bitoun M, et al. An alternative mechanism of clathrin-coated pit closure revealed by ion conductance microscopy. J Cell Biol. 2012;197:499-508 pubmed publisher
    ..This technique now enables direct spatial and temporal correlation between functional molecule-specific fluorescence and structural information to follow key biological processes at cell surfaces. ..
  19. Rahaman S, Zhou G, Silverstein R. Vav protein guanine nucleotide exchange factor regulates CD36 protein-mediated macrophage foam cell formation via calcium and dynamin-dependent processes. J Biol Chem. 2011;286:36011-9 pubmed publisher
    ..Knockdown of expression by siRNA or inhibition of GTPase activity of dynamin 2, a Vav-interacting protein involved in endocytic vesicle fission, significantly blocked oxLDL uptake and ..
  20. Willinger T, Ferguson S, Pereira J, De Camilli P, Flavell R. Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. J Exp Med. 2014;211:685-700 pubmed publisher
    ..Here we identify dynamin 2, an essential component of endocytosis, as a novel regulator of T cell egress...
  21. Soda K, Balkin D, Ferguson S, Paradise S, Milosevic I, Giovedi S, et al. Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest. 2012;122:4401-11 pubmed publisher
    ..Here we used a conditional double-KO of dynamin 1 (Dnm1) and Dnm2 in mouse podocytes to confirm dynamin's role in podocyte foot process maintenance...
  22. Sousa L, Lax I, Shen H, Ferguson S, De Camilli P, Schlessinger J. Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane. Proc Natl Acad Sci U S A. 2012;109:4419-24 pubmed publisher
  23. Verma S, Leikina E, Melikov K, Chernomordik L. Late stages of the synchronized macrophage fusion in osteoclast formation depend on dynamin. Biochem J. 2014;464:293-300 pubmed publisher
    ..Thus dynamin that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes. ..
  24. Fan F, Funk L, Lou X. Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo. J Neurosci. 2016;36:6097-115 pubmed publisher
    ..Individual gene deletion of dynamin 1, a primary dynamin isoform in neurons, as well as dynamin 2 and 3, did not affect CH development...
  25. Liu Y, Neumann S, Ramachandran R, Ferguson S, Pucadyil T, Schmid S. Differential curvature sensing and generating activities of dynamin isoforms provide opportunities for tissue-specific regulation. Proc Natl Acad Sci U S A. 2011;108:E234-42 pubmed publisher
    Dynamin 1 (Dyn1) and Dyn2 are neuronal and ubiquitously expressed isoforms, respectively, of the multidomain GTPase required for clathrin-mediated endocytosis (CME)...
  26. Vigano M, Lamartine J, Testoni B, Merico D, Alotto D, Castagnoli C, et al. New p63 targets in keratinocytes identified by a genome-wide approach. EMBO J. 2006;25:5105-16 pubmed
    ..We discovered several new specific targets whose functional categorization links p63 to cell growth and differentiation. ..
  27. Cao H, Chen J, Krueger E, McNiven M. SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol. 2010;30:781-92 pubmed publisher
    ..subsequently, phosphorylation of two important components of the endocytic machinery, namely, the large GTPase dynamin 2 (Dyn2) and its associated actin-binding protein, cortactin (Cort)...
  28. Singleton P, Pendyala S, Gorshkova I, Mambetsariev N, Moitra J, Garcia J, et al. Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium. J Biol Chem. 2009;284:34964-75 pubmed publisher
    ..hyperoxia treatment of human pulmonary artery endothelial cells induced recruitment of the vesicular regulator, dynamin 2, the non-receptor tyrosine kinase, c-Abl, and the NADPH oxidase subunit, p47(phox), to caveolin-enriched ..
  29. Cao H, Chen J, Awoniyi M, Henley J, McNiven M. Dynamin 2 mediates fluid-phase micropinocytosis in epithelial cells. J Cell Sci. 2007;120:4167-77 pubmed
    It is well-known that dynamin 2 (Dyn2) participates in clathrin- and caveolae-mediated endocytosis; however, the role of Dyn2 in coat-independent endocytic processes remains controversial...
  30. Quesnel Vallieres M, Dargaei Z, Irimia M, Gonatopoulos Pournatzis T, Ip J, Wu M, et al. Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders. Mol Cell. 2016;64:1023-1034 pubmed publisher
    ..Collectively, our results provide evidence that misregulation of an nSR100-dependent splicing network controlled by changes in neuronal activity is causally linked to a substantial fraction of autism cases. ..
  31. Weng L, Enomoto A, Miyoshi H, Takahashi K, Asai N, Morone N, et al. Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin. EMBO J. 2014;33:2098-112 pubmed publisher
    ..Girdin interacts with dynamin 2, a GTPase that excises endocytic vesicles from the plasma membrane, and functions as its GTPase-activating ..
  32. Wan K, Sambi B, Frame M, Tate R, Pyne N. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. J Biol Chem. 2001;276:37802-8 pubmed
    ..We conclude that PDEgamma is an entirely novel intermediate regulating mitogenic signaling from both receptor tyrosine kinase and G-protein-coupled receptors in human embryonic kidney 293 cells. ..
  33. Gao D, Yang J, Wu Y, Wang Q, Wang Q, Lai E, et al. Targeting Dynamin 2 as a Novel Pathway to Inhibit Cardiomyocyte Apoptosis Following Oxidative Stress. Cell Physiol Biochem. 2016;39:2121-2134 pubmed
    ..It remains unknown if Dynamin 2 inhibition results in similar protective effects...
  34. Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, et al. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011;72:587-601 pubmed publisher
  35. Zhao L, Shi X, Li L, Miller D. Dynamin 2 associates with complexins and is found in the acrosomal region of mammalian sperm. Mol Reprod Dev. 2007;74:750-7 pubmed
    ..We showed that both complexins I and II bound mouse sperm dynamin 2. Dynamin 2 is a 100 kDa GTPase essential to many aspects of endocytosis but its potential role in exocytosis is ..
  36. Otsuka A, Abe T, Watanabe M, Yagisawa H, Takei K, Yamada H. Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells. Biochem Biophys Res Commun. 2009;378:478-82 pubmed publisher
    b>Dynamin 2 has been reported to be implicated in phagocytosis. However, the mode of action of dynamin is poorly understood. In this study, we examined whether dynamin 2 participates in actin assembly during phagocytosis in Sertoli cells...
  37. Bruzzaniti A, Neff L, Sandoval A, Du L, Horne W, Baron R. Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts. Mol Cell Biol. 2009;29:3644-56 pubmed publisher
  38. Ikeuchi Y, de la Torre Ubieta L, Matsuda T, Steen H, Okazawa H, Bonni A. The XLID protein PQBP1 and the GTPase Dynamin 2 define a signaling link that orchestrates ciliary morphogenesis in postmitotic neurons. Cell Rep. 2013;4:879-89 pubmed publisher
    ..We also find that PQBP1 interacts with Dynamin 2 and thereby inhibits its GTPase activity...
  39. Willinger T, Staron M, Ferguson S, De Camilli P, Flavell R. Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes. Proc Natl Acad Sci U S A. 2015;112:4423-8 pubmed publisher
    ..T-cell-specific deletion of dynamin 2, an essential component of endocytosis, resulted in reduced TCR signaling strength, impaired homeostatic ..
  40. Chin Y, Lee A, Kan H, Laiman J, Chuang M, Hsieh S, et al. Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation. Hum Mol Genet. 2015;24:5542-54 pubmed publisher
    ..The large GTPase dynamin-2 (Dyn2) is best known for catalyzing membrane fission during clathrin-mediated endocytosis (CME), which is critical for ..
  41. Yoo J, Jeong M, Cho H, Oh E, Han M. Dynamin II interacts with syndecan-4, a regulator of focal adhesion and stress-fiber formation. Biochem Biophys Res Commun. 2005;328:424-31 pubmed
    ..All of these results suggest that the interaction between dynamin II and syndecan-4 is important in mediating focal adhesion and stress-fiber formation. ..
  42. Schulze R, Weller S, Schroeder B, Krueger E, Chi S, Casey C, et al. Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes. J Cell Biol. 2013;203:315-26 pubmed publisher
    ..We hypothesized that the large GTPase dynamin 2 (Dyn2), well known for its involvement in membrane deformation and cellular protein trafficking, could ..
  43. Noakes P, Chin D, Kim S, Liang S, Phillips W. Expression and localisation of dynamin and syntaxin during neural development and neuromuscular synapse formation. J Comp Neurol. 1999;410:531-40 pubmed
    ..The delayed appearance of dynamin at the synapse, thus, heralds the neonatal development of robust synaptic transmission at the neuromuscular junction. ..
  44. Boissan M, Montagnac G, Shen Q, Griparic L, Guitton J, Romao M, et al. Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. Science. 2014;344:1510-5 pubmed publisher
    ..Thus, NDPKs interact with and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficiency. ..
  45. Reid A, Lord T, Stanger S, Roman S, McCluskey A, Robinson P, et al. Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. J Biol Chem. 2012;287:37659-72 pubmed publisher
    ..On the basis of our collective data, we propose that dynamin could regulate specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. ..
  46. Wang R, Ding Q, de Assuncao T, Mounajjed T, Maiers J, Dou C, et al. Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. Am J Pathol. 2017;187:134-145 pubmed publisher
    Dynamin-2 (Dyn2) is implicated in endocytosis of receptor tyrosine kinases, which contribute to hepatic stellate cell (HSC) activation and liver fibrosis...
  47. Volchuk A, Narine S, Foster L, Grabs D, De Camilli P, Klip A. Perturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes. Dynamin II participates in GLUT4 endocytosis. J Biol Chem. 1998;273:8169-76 pubmed
    ..We hypothesize that insulin may reduce GLUT4 endocytosis by regulating the function of dynamin II at the cell surface, as part of the mechanism to increase glucose uptake. ..
  48. Grossman G, Ebke L, Beight C, Jang G, Crabb J, Hagstrom S. Protein partners of dynamin-1 in the retina. Vis Neurosci. 2013;30:129-39 pubmed publisher
    ..This finding is confirmed by western blot analysis. Results further implicate dynamin-1 in vesicular protein transport processes relevant to synaptic and post-Golgi pathways and indicate a possible role in photoreceptor stability. ..
  49. Oh J, Choi B, Park J, Jeong S, Kim J, Kim J, et al. Expression of dynamin II in odontoblast during mouse tooth development. J Nanosci Nanotechnol. 2011;11:7096-9 pubmed
  50. Orth J, Krueger E, Cao H, McNiven M. The large GTPase dynamin regulates actin comet formation and movement in living cells. Proc Natl Acad Sci U S A. 2002;99:167-72 pubmed
    The large GTPase dynamin (Dyn2) has been demonstrated by us and others to interact with several different actin-binding proteins...
  51. Koutsopoulos O, Kretz C, Weller C, Roux A, Mojzisova H, Böhm J, et al. Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome. Eur J Hum Genet. 2013;21:637-42 pubmed publisher
    Heterozygous mutations in dynamin 2 (DNM2) have been linked to dominant Charcot-Marie-Tooth neuropathy and centronuclear myopathy. We report the first homozygous mutation in the DNM2 protein p...
  52. Perry J, Wobus C. Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol. J Virol. 2010;84:6163-76 pubmed publisher
    ..Therefore, we conclude that the productive route of MNV-1 entry into murine macrophages is rapid and requires host cholesterol and dynamin II. ..
  53. Medrihan L, Rohlmann A, Fairless R, Andrae J, Döring M, Missler M, et al. Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol. 2009;587:5095-106 pubmed publisher
  54. Kusumi N, Watanabe M, Yamada H, Li S, Kashiwakura Y, Matsukawa T, et al. Implication of amphiphysin 1 and dynamin 2 in tubulobulbar complex formation and spermatid release. Cell Struct Funct. 2007;32:101-13 pubmed
    ..we here investigated the localization and physiological roles of endocytic proteins, amphiphysin 1 and dynamin 2, at TBCs...
  55. Singleton P, Salgia R, Moreno Vinasco L, Moitra J, Sammani S, Mirzapoiazova T, et al. CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin. J Biol Chem. 2007;282:30643-57 pubmed
    ..recruitment of c-Met, Tiam1 (a Rac1 exchange factor), cortactin (an actin cytoskeletal regulator), and dynamin 2 (a vesicular regulator) to CEM as well as HGF-induced trans-EC electrical resistance...
  56. Zhou W, De Iuliis G, Turner A, Reid A, Anderson A, McCluskey A, et al. Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis. Biol Reprod. 2017;96:159-173 pubmed publisher
    ..In contrast, dynamin 2 was expressed throughout the epididymis, but localized to the Golgi apparatus of the principal cells in the ..
  57. Bernatchez P, Acevedo L, Fernandez Hernando C, Murata T, Chalouni C, Kim J, et al. Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem. 2007;282:30745-53 pubmed
    ..These data are the first to report novel biological activities for myoferlin and reveal the role of membrane integrity to VEGF signaling. ..
  58. Bender M, Giannini S, Grozovsky R, Jönsson T, Christensen H, Pluthero F, et al. Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice. Blood. 2015;125:1014-24 pubmed publisher
    ..triphosphate) involved in endocytosis and vesicle transport, and mutations in the ubiquitous and housekeeping dynamin 2 (DNM2) have been associated with thrombocytopenia in humans...
  59. Fraysse B, Guicheney P, Bitoun M. Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy. Biol Open. 2016;5:1691-1696 pubmed publisher
    ..CNM results from mutations in the gene encoding dynamin 2 (DNM2), a large GTPase involved in endocytosis, intracellular membrane trafficking, and cytoskeleton regulation...
  60. Tinelli E, Pereira J, Suter U. Muscle-specific function of the centronuclear myopathy and Charcot-Marie-Tooth neuropathy-associated dynamin 2 is required for proper lipid metabolism, mitochondria, muscle fibers, neuromuscular junctions and peripheral nerves. Hum Mol Genet. 2013;22:4417-29 pubmed publisher
    The ubiquitously expressed large GTPase Dynamin 2 (DNM2) plays a critical role in the regulation of intracellular membrane trafficking through its crucial function in membrane fission, particularly in endocytosis...
  61. Meng J, Wang J, Lawrence G, Dolly J. Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons. FASEB J. 2013;27:3167-80 pubmed publisher
  62. Shin S, Vogt E, Jimenez Movilla M, Baibakov B, Dean J. Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017;8:1643 pubmed publisher
    ..Thus, the N-terminus of DPPA3 has a significant role in cytoplasmic vesicular trafficking in addition to its previously reported nuclear function. ..