Dnaic1

Summary

Gene Symbol: Dnaic1
Description: dynein, axonemal, intermediate chain 1
Alias: 1110066F04Rik, BB124644, Dnai1, b2b1526Clo, dynein intermediate chain 1, axonemal, axonemal dynein intermediate chain 1
Species: mouse
Products:     Dnaic1

Top Publications

  1. Ikegami K, Sato S, Nakamura K, Ostrowski L, Setou M. Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A. 2010;107:10490-5 pubmed publisher
    ..Our findings provide evidence that tubulin glutamylation is essential for ciliary function through the regulation of beating asymmetry, and provides insight into the molecular basis underlying the beating asymmetry. ..
  2. Kishi M, Kummer T, Eglen S, Sanes J. LL5beta: a regulator of postsynaptic differentiation identified in a screen for synaptically enriched transcripts at the neuromuscular junction. J Cell Biol. 2005;169:355-66 pubmed
    ..Thus, a strategy designed to identify novel synaptic components led to identification of a protein required for assembly of the postsynaptic apparatus. ..
  3. Zariwala M, Leigh M, Ceppa F, Kennedy M, Noone P, Carson J, et al. Mutations of DNAI1 in primary ciliary dyskinesia: evidence of founder effect in a common mutation. Am J Respir Crit Care Med. 2006;174:858-66 pubmed
    ..Disease-causing mutations have been reported in DNAI1 and DNAH5 encoding outer dynein arm (ODA) proteins of cilia...
  4. Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, et al. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009;64:173-87 pubmed publisher
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development. ..
  5. Jacquet B, Muthusamy N, Sommerville L, Xiao G, Liang H, Zhang Y, et al. Specification of a Foxj1-dependent lineage in the forebrain is required for embryonic-to-postnatal transition of neurogenesis in the olfactory bulb. J Neurosci. 2011;31:9368-82 pubmed publisher
    ..For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods. ..
  6. Damerla R, Chatterjee B, Li Y, Francis R, Fatakia S, Lo C. Ion Torrent sequencing for conducting genome-wide scans for mutation mapping analysis. Mamm Genome. 2014;25:120-8 pubmed publisher
    ..Further analysis of genes in the map interval identified a splicing mutation in Dnaic1(c.204+1G>A), an intermediate chain dynein, as the disease causing mutation in Bishu...
  7. Dong F, Shinohara K, Botilde Y, Nabeshima R, Asai Y, Fukumoto A, et al. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. J Cell Biol. 2014;204:203-13 pubmed publisher
    ..Our results suggest that Pih1d3 contributes to cytoplasmic preassembly of dynein complexes in spermatogenic cells by stabilizing and promoting complex formation by ODA and IDA proteins. ..
  8. Young S, Miyata H, Satouh Y, Kato H, Nozawa K, Isotani A, et al. CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Int J Mol Sci. 2015;16:24732-50 pubmed publisher
    ..Using the advanced technology of CRISPR/Cas9 we have targeted three dynein group members; Dnaic1, Wdr63 and Ccdc63 in mice. All three of these genes are expressed strongly in the testis...
  9. Gao F, Shi L, Hines T, Hebbar S, Neufeld K, Smith D. Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell. 2017;28:587-599 pubmed publisher
    ..Mutations in APC likely impair the ability to respond appropriately to insulin signaling. This is exciting because it has the potential to be a contributing factor in the development of colorectal cancer in patients with diabetes. ..

More Information

Publications14

  1. Ostrowski L, Yin W, Rogers T, Busalacchi K, Chua M, O Neal W, et al. Conditional deletion of dnaic1 in a murine model of primary ciliary dyskinesia causes chronic rhinosinusitis. Am J Respir Cell Mol Biol. 2010;43:55-63 pubmed publisher
    ..have generated a transgenic mouse line in which two conserved exons of the mouse intermediate dynein chain gene, Dnaic1, are flanked by loxP sites (Dnaic1(flox/flox))...
  2. Yu J, Lei K, Zhou M, Craft C, Xu G, Xu T, et al. KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011;20:1061-73 pubmed publisher
    ..These key retinal developmental signaling results will advance our understanding of the mechanism of nuclear migration in the mammalian retina. ..
  3. Francis R, Christopher A, Devine W, OSTROWSKI L, Lo C. Congenital heart disease and the specification of left-right asymmetry. Am J Physiol Heart Circ Physiol. 2012;302:H2102-11 pubmed publisher
    ..in cardiovascular development, we examined situs anomalies and CHD in mice with a loss of function allele of Dnaic1, a dynein protein required for motile cilia function and left-right patterning...
  4. Jacquet B, Salinas Mondragon R, Liang H, Therit B, Buie J, Dykstra M, et al. FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. Development. 2009;136:4021-31 pubmed publisher
    ..Our results suggest that time- and cell-specific expression of FoxJ1 in the brain acts on an array of target genes to regulate the differentiation of ependymal cells and a small subset of astrocytes in the adult stem cell niche. ..
  5. Li Y, Yagi H, Onuoha E, Damerla R, Francis R, Furutani Y, et al. DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genet. 2016;12:e1005821 pubmed publisher
    ..patient harboring heterozygous DNAH6 mutation was identified to also carry a rare heterozygous PCD-causing DNAI1 mutation, suggesting a DNAH6/DNAI1 trans-heterozygous interaction...