Gene Symbol: Dnah1
Description: dynein, axonemal, heavy chain 1
Alias: B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7, dynein heavy chain 1, axonemal, axonemal beta dynein heavy chain 1, ciliary dynein heavy chain 1, dynein, axon, heavy chain 1, dynein, axonemal, heavy polypeptide 1
Species: mouse
Products:     Dnah1

Top Publications

  1. Ebsen M, Morgenroth K, Neesen J. Ultrastructural changes in the cilia of experimental mice. Bull Exp Biol Med. 2004;137:619-21 pubmed
    ..The number of inner dynein arms was lower, in some cilia secondary changes presenting as swelling of the outer part of the ciliary membrane or formation of complex cilia were seen. ..
  2. Neesen J, Kirschner R, Ochs M, Schmiedl A, Habermann B, Mueller C, et al. Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency. Hum Mol Genet. 2001;10:1117-28 pubmed
    ..To elucidate the role of the mouse dynein heavy chain 7 (MDHC7) gene, which encodes a component of the inner dynein arm, we have generated mice lacking this dynein heavy chain ..
  3. Loschi M, Leishman C, Berardone N, Boccaccio G. Dynein and kinesin regulate stress-granule and P-body dynamics. J Cell Sci. 2009;122:3973-82 pubmed publisher
    ..Finally, we found that regulation of SG dynamics by dynein and kinesin is conserved in Drosophila. ..
  4. Raaijmakers J, Tanenbaum M, Medema R. Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013;201:201-15 pubmed publisher
  5. Neesen J, Koehler M, Kirschner R, Steinlein C, Kreutzberger J, Engel W, et al. Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Gene. 1997;200:193-202 pubmed
    ..Two of these clones, gHDHC7 and gMDHC7, are homologous genes encoding axonemal inner arm dyneins. While the human clone is assigned to 3p21, the mouse gene maps to chromosome 14. ..
  6. Supp D, Potter S, Brueckner M. Molecular motors: the driving force behind mammalian left-right development. Trends Cell Biol. 2000;10:41-5 pubmed
    ..Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development. ..
  7. Ori McKenney K, Vallee R. Neuronal migration defects in the Loa dynein mutant mouse. Neural Dev. 2011;6:26 pubmed publisher
    ..They also provide the first evidence for a link between dynein processivity and somal movement, which is essential for proper development of the brain. ..