DNA polymerase epsilon
Gene Symbol: DNA polymerase epsilon
Description: polymerase (DNA directed), epsilon
Alias: DNA polymerase epsilon catalytic subunit A, DNA polymerase II subunit A, DNA-directed DNA polymerase epsilon, pol-epsilon
Albertson T, Ogawa M, Bugni J, Hays L, Chen Y, Wang Y, et al
. DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. Proc Natl Acad Sci U S A. 2009;106:17101-4 pubmed publisher
..The relationship of these pathways in mammals and their functions in vivo are unknown. Here we show that mouse Pol epsilon and delta proofreading suppress discrete mutator and cancer phenotypes...
Vlatkovic N, Guerrera S, Li Y, Linn S, Haines D, Boyd M. MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase epsilon. Nucleic Acids Res. 2000;28:3581-6 pubmed
..We found that MDM2 can bind to the C-terminus of the catalytic subunit of DNA polymerase epsilon (DNA pol epsilon), to a region that is known to be essential in yeast...
Kamel D, Mackey Z, Sjoblom T, Walter C, McCarrey J, Uitto L, et al
. Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice. Biol Reprod. 1997;57:1367-74 pubmed
Previous studies on DNA polymerase epsilon indicate that this enzyme is involved in replication of chromosomal DNA...
Gotter A, Suppa C, Emanuel B. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. J Mol Biol. 2007;366:36-52 pubmed
Goldsby R, Singh M, Preston B. Mouse DNA polymerase epsilon gene (Pole) maps to chromosome 5. Mamm Genome. 1998;9:91-2 pubmed
Khalaj M, Abbasi A, Yamanishi H, Akiyama K, Wakitani S, Kikuchi S, et al
. A missense mutation in Rev7 disrupts formation of Pol?, impairing mouse development and repair of genotoxic agent-induced DNA lesions. J Biol Chem. 2014;289:3811-24 pubmed publisher
Oshige M, Yoshida H, Hirose F, Takata K, Inoue Y, Aoyagi N, et al
. Molecular cloning and expression during development of the Drosophila gene for the catalytic subunit of DNA polymerase epsilon. Gene. 2000;256:93-100 pubmed
We have cloned the genomic DNA and cDNA of Drosophila DNA polymerase epsilon (pol-epsilon) catalytic subunit (GenBank No. AB035512)...
Huang D, Knuuti R, Palosaari H, Pospiech H, Syvaoja J. cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit. Biochim Biophys Acta. 1999;1445:363-71 pubmed
The cDNA and the gene for the mouse DNA polymerase epsilon catalytic subunit were cloned. The deduced protein sequence shows remarkable evolutionary conservation in DNA polymerase epsilon family...