Dmp1

Summary

Gene Symbol: Dmp1
Description: dentin matrix protein 1
Alias: AG1, AV020965, DMP-1, Dmp, dentin matrix acidic phosphoprotein 1, serine rich acidic phosphoprotein
Species: mouse
Products:     Dmp1

Top Publications

  1. Lu Y, Xie Y, Zhang S, Dusevich V, Bonewald L, Feng J. DMP1-targeted Cre expression in odontoblasts and osteocytes. J Dent Res. 2007;86:320-5 pubmed
    ..Because dentin matrix protein 1 (DMP1), an extracellular matrix protein, is highly expressed in both types of cells, we next tested, using a transgenic ..
  2. Sun Y, Lu Y, Chen L, Gao T, D SOUZA R, Feng J, et al. DMP1 processing is essential to dentin and jaw formation. J Dent Res. 2011;90:619-24 pubmed publisher
    Dentin matrix protein 1 (DMP1), an acidic protein that is essential to the mineralization of bone and dentin, exists as proteolytically processed fragments in the mineralized tissues...
  3. Jiang B, Cao Z, Lu Y, Janik C, Lauziere S, Xie Y, et al. DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype. J Bone Miner Res. 2010;25:2155-64 pubmed publisher
    b>DMP1 mutations in autosomal recessive hypophosphatemic rickets (ARHR) patients and mice lacking Dmp1 display an overlapping pathophysiology, such as hypophosphatemia...
  4. Feng J, Huang H, Lu Y, Ye L, Xie Y, Tsutsui T, et al. The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res. 2003;82:776-80 pubmed
    Dentin Matrix Protein 1 (Dmp1) was originally identified from dentin. However, its expression and function in vivo are not clear...
  5. Ye L, Macdougall M, Zhang S, Xie Y, Zhang J, Li Z, et al. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004;279:19141-8 pubmed
    The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development. In vitro study suggests that this noncollagen acidic phosphoprotein plays a role in mineralization...
  6. Feng J, Ward L, Liu S, Lu Y, Xie Y, Yuan B, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006;38:1310-5 pubmed
    ..Dentin matrix protein 1 (encoded by DMP1) is highly expressed in osteocytes and, when deleted in mice, results in a hypomineralized bone phenotype...
  7. Lv K, Huang H, Lu Y, Qin C, Li Z, Feng J. Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus. Int J Biol Sci. 2010;6:537-45 pubmed
    ..Yet, the potential influence of osteoporosis on body balance is largely unknown. Dentin matrix protein 1 (DMP1) is highly expressed in bone and required for phosphate homeostasis and mineralization...
  8. Zhang K, Barragan Adjemian C, Ye L, Kotha S, Dallas M, Lu Y, et al. E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Mol Cell Biol. 2006;26:4539-52 pubmed
    ..These data suggest that osteocytes may be able to extend their cellular processes after embedment in mineralized matrix and have implications for osteocytic modification of their microenvironment. ..
  9. Maciejewska I, Qin D, Huang B, Sun Y, Mues G, Svoboda K, et al. Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells. Cells Tissues Organs. 2009;189:186-91 pubmed publisher
    Dentin matrix protein 1 (DMP1) has been shown to be critical for the formation of dentin and bone. However, the precise pathway by which DMP1 participates in dentinogenesis and osteogenesis remains to be clarified...

More Information

Publications82

  1. Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, et al. Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res. 2011;26:1047-56 pubmed publisher
    ..Here we used Dmp1 null mice, a hypophosphatemic rickets/osteomalacia model, combined with a metatarsal organ culture and an ..
  2. Martin A, Liu S, David V, Li H, Karydis A, Feng J, et al. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J. 2011;25:2551-62 pubmed publisher
    ..Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in equivalent intrinsic bone mineralization defects and increased Fgf23 expression in osteocytes...
  3. Liu S, Zhou J, Tang W, Menard R, Feng J, Quarles L. Pathogenic role of Fgf23 in Dmp1-null mice. Am J Physiol Endocrinol Metab. 2008;295:E254-61 pubmed publisher
    ..activity, and rickets/osteomalacia, is caused by inactivating mutations of dentin matrix protein 1 (DMP1)...
  4. Narayanan K, Ramachandran A, Hao J, He G, Park K, Cho M, et al. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem. 2003;278:17500-8 pubmed
    Dentin matrix protein 1 (DMP1) is a bone- and teeth-specific protein initially identified from mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts...
  5. Ye L, Mishina Y, Chen D, Huang H, Dallas S, Dallas M, et al. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem. 2005;280:6197-203 pubmed
    ..In the present studies, we present evidence for a critical role of DMP1 (dentin matrix protein 1) in postnatal chondrogenesis...
  6. Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee M, et al. Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Dev Biol. 2007;303:191-201 pubmed
    Dentin matrix protein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to defects in odontogenesis and mineralization...
  7. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas S, et al. The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res. 2011;26:331-40 pubmed publisher
    ..I collagen promoter was used to express this 57-kDa C-terminal fragment for comparison with full-length DMP-1 in Dmp1 null osteoblasts/osteocytes...
  8. Fen J, Zhang J, Dallas S, Lu Y, Chen S, Tan X, et al. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002;17:1822-31 pubmed
    Dentin matrix protein 1 (Dmp1), a phosphoprotein highly linked to dentin formation, has also been reported to be expressed in the skeleton. However, the role of Dmp1 in skeletal tissues remains unclear...
  9. Kyono A, Avishai N, Ouyang Z, Landreth G, Murakami S. FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation. J Bone Miner Metab. 2012;30:19-30 pubmed publisher
    ..Real-time PCR analysis indicated that FGF2 upregulates Ank, Enpp1, Mgp, Slc20a1, and Dmp1 in MLO-Y4 cells...
  10. Ye L, Zhang S, Ke H, Bonewald L, Feng J. Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets. J Dent Res. 2008;87:624-9 pubmed
    Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium...
  11. Siyam A, Wang S, Qin C, Mues G, STEVENS R, D Souza R, et al. Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochem Biophys Res Commun. 2012;424:641-6 pubmed publisher
    Dentin matrix protein 1 (DMP1) is highly expressed in odontoblasts and osteoblasts/osteocytes and plays an essential role in tooth and bone mineralization and phosphate homeostasis...
  12. Steiglitz B, Ayala M, Narayanan K, George A, Greenspan D. Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem. 2004;279:980-6 pubmed
    ..Dentin matrix protein-1 (DMP1), deposited into the ECM during assembly and involved in initiating mineralization of bones and teeth, is thought ..
  13. Ling Y, Rios H, Myers E, Lu Y, Feng J, Boskey A. DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res. 2005;20:2169-77 pubmed
    The role of DMP1 in mineralization was analyzed by comparing bone mineral and matrix properties in dmp1-null female mice to heterozygous and wildtype controls by FTIR imaging spectroscopy...
  14. Terasawa M, Shimokawa R, Terashima T, Ohya K, Takagi Y, Shimokawa H. Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues. J Bone Miner Metab. 2004;22:430-8 pubmed
    Dentin matrix protein 1 (DMP1) is an Arg-Gly-Asp-containing acidic phosphoprotein that was originally identified from a rat incisor cDNA library and was thought to be a dentin-specific protein...
  15. Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D SOUZA R, et al. Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem. 2010;285:31713-22 pubmed publisher
    Dentin matrix protein 1 (DMP1), an acidic protein important to the formation of bone and dentin, primarily exists as the processed NH(2)-terminal and COOH-terminal fragments in the extracellular matrix of the two tissues...
  16. Lu Y, Qin C, Xie Y, Bonewald L, Feng J. Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs. 2009;189:175-85 pubmed publisher
    b>Dmp1-null mice and patients with mutations in dentin matrix protein 1 (DMP1) resulting in autosomal recessive hypophosphatemic rickets display similar skeletal defects...
  17. Rangiani A, Cao Z, Sun Y, Lu Y, Gao T, Yuan B, et al. Protective roles of DMP1 in high phosphate homeostasis. PLoS ONE. 2012;7:e42329 pubmed publisher
    b>Dmp1 (dentin matrix protein1) null mice (Dmp1(-/-)) display hypophosphatemic rickets with a sharp increase in fibroblast growth factor 23 (FGF23)...
  18. Narayanan K, Ramachandran A, Hao J, George A. Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors. Connect Tissue Res. 2002;43:365-71 pubmed
    Dentin matrix protein 1 (DMP1) is an extracellular matrix phosphoprotein whose expression is precisely controlled temporally and spatially during the differentiation of the odontoblasts...
  19. Gaikwad J, Cavender A, D Souza R. Identification of tooth-specific downstream targets of Runx2. Gene. 2001;279:91-7 pubmed
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development. ..
  20. Fujio K, Nosaka T, Kojima T, Kawashima T, Yahata T, Copeland N, et al. Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain. Blood. 2000;95:2204-10 pubmed
    ..These results suggest that delta1 is a subunit of cytokine receptor that may be involved in multiple receptor systems and play a regulatory role in the immune system and hematopoiesis. ..
  21. Ichikawa S, Gerard O Riley R, Acton D, McQueen A, Strobel I, Witcher P, et al. A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice. Endocrinology. 2017;158:470-476 pubmed publisher
    Mutations in the dentin matrix protein 1 (DMP1) gene cause autosomal recessive hypophosphatemic rickets (ARHR)...
  22. Lu Y, Zhang S, Xie Y, Pi Y, Feng J. Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells Tissues Organs. 2005;181:241-7 pubmed
    Dentin matrix protein 1 (DMP1) is highly expressed in mineralized tooth and bone. Both in vitro and in vivo data show that DMP1 is critical for mineralization and tooth morphogenesis (growth and development)...
  23. Li Z, Li Z, Shang Z. [The preliminary study on the characteristics of mandible and condyle in dentin matrix protein-1 gene knockout mice]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2005;40:335-7 pubmed
    To study the characteristics of mandible and condyle in Dmp1 gene knockout mice, and to investigate the role of Dmp1 in the osteogenesis and mineralization of bone and cartilage...
  24. Toyosawa S, Sato A, O hUigin C, Tichy H, Klein J. Expression of the dentin matrix protein 1 gene in birds. J Mol Evol. 2000;50:31-8 pubmed
    ..genes in the birds, we tested a domestic fowl cDNA library for the expression of the dentin matrix protein 1 (DMP1) gene...
  25. Gluhak Heinrich J, Ye L, Bonewald L, Feng J, Macdougall M, Harris S, et al. Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. J Bone Miner Res. 2003;18:807-17 pubmed
    Dentin matrix protein 1 (DMP1) was originally postulated to be dentin specific. Further analysis showed that DMP1 is also expressed in mature cartilage and bone...
  26. Aberg T, Cavender A, Gaikwad J, Bronckers A, Wang X, Waltimo Siren J, et al. Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem. 2004;52:131-9 pubmed
    ..These data support the hypothesis that Runx2 is one of the key mesenchymal factors that influences tooth morphogenesis and the subsequent differentiation of ameloblasts and odontoblasts...
  27. Xiao Z, Riccardi D, Velazquez H, Chin A, Yates C, Carrick J, et al. A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia. Sci Signal. 2016;9:ra113 pubmed
    ..These chemical probes provide a platform to develop lead compounds to treat disorders caused by excess FGF-23. ..
  28. Sun Y, Gao Y, Zhao Z, Huang B, Yin J, Taylor G, et al. Involvement of P311 in the affective, but not in the sensory component of pain. Mol Pain. 2008;4:23 pubmed publisher
    ..Our study thus provides the first evidence suggesting that the affective and sensory pain may be regulated by distinct molecular mechanisms. ..
  29. Bouleftour W, Juignet L, Bouet G, Granito R, Vanden Bossche A, Laroche N, et al. The role of the SIBLING, Bone Sialoprotein in skeletal biology - Contribution of mouse experimental genetics. Matrix Biol. 2016;52-54:60-77 pubmed publisher
    ..Such interplay between the partly overlapping functions of SIBLING proteins, as well as the network of cross-regulations in which they are involved should now be the focus of further work. ..
  30. D Souza R, Cavender A, Sunavala G, Alvarez J, Ohshima T, Kulkarni A, et al. Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J Bone Miner Res. 1997;12:2040-9 pubmed
    ..Here we compared the in vivo temporospatial expression patterns of two dentin NCP genes, dentin matrix protein 1 (Dmp1), and dentin sialophosphoprotein (DSPP) in developing molars...
  31. Chen Z, Li W, Wang H, Wan C, Luo D, Deng S, et al. Klf10 regulates odontoblast differentiation and mineralization via promoting expression of dentin matrix protein 1 and dentin sialophosphoprotein genes. Cell Tissue Res. 2016;363:385-98 pubmed publisher
    ..Furthermore, the expression of Klf10, Dmp1, Dspp and Runx2 was significantly elevated during the process of mouse dental papilla mesenchymal differentiation ..
  32. Sun Y, Chen L, Ma S, Zhou J, Zhang H, Feng J, et al. Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis. Cells Tissues Organs. 2011;194:199-204 pubmed publisher
    Dentin matrix protein 1 (DMP1) is an acidic protein that plays critical roles in osteogenesis and dentinogenesis...
  33. Lin S, Zhang Q, Zhang H, Yan K, Ward L, Lu Y, et al. Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice. Int J Oral Sci. 2014;6:133-41 pubmed publisher
    Dentin matrix protein 1 (DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment...
  34. Sun Y, Weng Y, Zhang C, Liu Y, Kang C, Liu Z, et al. Glycosylation of Dentin Matrix Protein 1 is critical for osteogenesis. Sci Rep. 2015;5:17518 pubmed publisher
    Proteoglycans play important roles in regulating osteogenesis. Dentin matrix protein 1 (DMP1) is a highly expressed bone extracellular matrix protein that regulates both bone development and phosphate metabolism...
  35. Prasadam I, Zhou Y, Shi W, Crawford R, Xiao Y. Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis. Rheumatology (Oxford). 2014;53:2280-7 pubmed publisher
    The aim of this study was to test the possible involvement, relevance and significance of dentin matrix protein 1 (DMP1) in chondrocyte redifferentiation and OA...
  36. Li C, Xie X, Wang X, Sun Y, Liu P, Chen L, et al. Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands. J Mol Histol. 2013;44:231-9 pubmed publisher
    It has been demonstrated that dentin matrix protein 1 (DMP1) is an essential regulator in the formation of bone and tooth...
  37. Martin A, David V, Laurence J, Schwarz P, Lafer E, Hedge A, et al. Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology. 2008;149:1757-72 pubmed
    Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and DMP1 (dentin matrix protein 1) result in X-linked hypophosphatemic rickets (HYP) and autosomal-recessive hypophosphatemic-rickets (..
  38. Lieben L, Stockmans I, Moermans K, Carmeliet G. Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013;57:123-31 pubmed publisher
    ..In conclusion, these data indicate that high maternal 1,25(OH)2D levels are transferred across the placental barrier and adversely affect the total amount of calcium stored in fetal bones which is accompanied by neonatal death. ..
  39. Gritli Linde A, Bei M, Maas R, Zhang X, Linde A, McMahon A. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002;129:5323-37 pubmed
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells. ..
  40. Holm E, Aubin J, Hunter G, Beier F, Goldberg H. Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015;71:145-54 pubmed publisher
    ..These results suggest that BSP is an important and multifaceted protein that regulates both chondrocyte proliferation and apoptosis as well as transition from cartilage to bone during development of endochondral bone. ..
  41. Yang W, Lu Y, Kalajzic I, Guo D, Harris M, Gluhak Heinrich J, et al. Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J Biol Chem. 2005;280:20680-90 pubmed
    Dentin matrix protein 1 (DMP1) is highly expressed in osteocytes and is mechanically responsive...
  42. Martin A, David V, Li H, Dai B, Feng J, Quarles L. Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice. Mol Endocrinol. 2012;26:1883-95 pubmed publisher
    Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to ..
  43. Kang K, Hong J, Robling A. Postnatal ?-catenin deletion from Dmp1-expressing osteocytes/osteoblasts reduces structural adaptation to loading, but not periosteal load-induced bone formation. Bone. 2016;88:138-145 pubmed publisher
    ..cat floxed loss-of-function alleles (?cat(f/f)) were bred to the inducible osteocyte Cre transgenic (10)(kb)Dmp1-CreERt2...
  44. Dassule H, Lewis P, Bei M, Maas R, McMahon A. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000;127:4775-85 pubmed
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts. ..
  45. Liu Z, Kennedy O, Cardoso L, Basta Pljakic J, Partridge N, Schaffler M, et al. DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH. FASEB J. 2016;30:635-52 pubmed publisher
    ..We used dentin matrix protein (Dmp)-1-mediated Ghr knockout (DMP-GHRKO) mice to address the role of the GH/IGF axis in osteocytes...
  46. Gibson M, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, et al. The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. J Biol Chem. 2013;288:7204-14 pubmed publisher
    Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) are essential for the formation of dentin. Previous in vitro studies have indicated that DMP1 might regulate the expression of DSPP during dentinogenesis...
  47. Miyagawa K, Yamazaki M, Kawai M, Nishino J, Koshimizu T, Ohata Y, et al. Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. PLoS ONE. 2014;9:e93840 pubmed publisher
    Osteocytes express multiple genes involved in mineral metabolism including PHEX, FGF23, DMP1 and FAM20C...
  48. Wang L, Tran A, Nociti F, Thumbigere Math V, Foster B, Krieger C, et al. PTH and Vitamin D Repress DMP1 in Cementoblasts. J Dent Res. 2015;94:1408-16 pubmed publisher
    ..Previously, we showed that 1,25D regulates mineral homeostasis by repressing dentin matrix protein 1 (DMP1) via the vitamin D receptor pathway...
  49. Fujikawa K, Yokohama Tamaki T, Morita T, Baba O, Qin C, Shibata S. An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59:2553 pubmed publisher
    ..in situ hybridization study was to investigate mRNA expression of three bone/cartilage matrix components (perlecan, DMP1, and MEPE) in developing primary (tibial) and secondary (condylar) cartilage...
  50. Jani P, Gibson M, Liu C, Zhang H, Wang X, Lu Y, et al. Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol. 2016;52-54:95-112 pubmed publisher
    Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) belong to the Small Integrin-Binding Ligand N-linked Glycoprotein (SIBLING) family...
  51. George A, Gui J, Jenkins N, Gilbert D, Copeland N, Veis A. In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem. 1994;42:1527-31 pubmed
    ..AG1 has been renamed Dmp1 (dentin matrix protein 1) in accordance with present chromosomal nomenclature...
  52. Kilic G, Wang J, Sosa Pineda B. Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice. Dev Dyn. 2006;235:1659-67 pubmed
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses. ..
  53. Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, et al. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014;29:340-9 pubmed publisher
    ..These results uncover a broad expression profile of Osterix and raise the intriguing possibility that distinct waves of stromal cells, primitive and definitive, may organize the developing BM. ..
  54. Wang X, Wang J, Yuan B, Lu Y, Feng J, Qin C. Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice. Connect Tissue Res. 2014;55:299-303 pubmed publisher
    ..had bone and dentin defects, along with hypophosphatemia and significant downregulation of dentin matrix protein 1 (DMP1)...
  55. Wilson M, Liaw L, Koopman P. Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005;233:1488-95 pubmed
    ..encoding the related SIBLING glycoproteins osteopontin (OPN), bone sialoprotein (BSP), and dentin matrix protein (DMP) during the development of male and female gonads during mouse embryogenesis...
  56. Murata H, Sunohara M, Sato I. Expression of DMP1 in the developing mouse tongue embryo. Ann Anat. 2015;200:136-48 pubmed publisher
    Dentin matrix protein 1 (DMP-1) is an important factor in the mineralization of hard tissues. However, it has many other functions in addition to the regulation of mineralized tissues...
  57. Hase N, Ozeki N, Hiyama T, Yamaguchi H, Kawai R, Kondo A, et al. Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells. Biosci Trends. 2015;9:228-36 pubmed publisher
    ..Because odontoblasts produce dentin matrix protein-1 (DMP-1), we examined whether the degraded products of DMP-1 by MMP-3 contribute to enhanced proliferation in odontoblast-..
  58. Wacker M, Touchberry C, Silswal N, Brotto L, Elmore C, Bonewald L, et al. Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets. Front Physiol. 2016;7:173 pubmed publisher
    ..ARHR results from inactivating mutations in the DMP1 gene with the human phenotype being recapitulated in the Dmp1 null mouse model which displays elevated plasma ..
  59. Feng J, Scott G, Guo D, Jiang B, Harris M, Ward T, et al. Generation of a conditional null allele for Dmp1 in mouse. Genesis. 2008;46:87-91 pubmed publisher
    Dentin matrix protein1 (DMP1), highly conserved in humans and mice, is highly expressed in teeth, the skeleton, and to a lesser extent in nonskeletal tissues such as brain, kidney, and salivary gland...
  60. Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg M, Mina M, et al. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone. 2004;35:74-82 pubmed
    ..Furthermore, we have generated transgenic mice utilizing a mouse DMP1 cis-regulatory system to drive GFP as a marker for living osteocytes...
  61. Masuki H, Li M, Hasegawa T, Suzuki R, Ying G, Zhusheng L, et al. Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice. Biomed Res. 2010;31:307-18 pubmed
    ..b>DMP1-positive osteocytes were evenly distributed throughout the wild-type epiphyses and cortical bone, as well as the ..
  62. Nociti F, Foster B, Tran A, Dunn D, Presland R, Wang L, et al. Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes. J Dent Res. 2014;93:148-54 pubmed publisher
    ..For example, mutations in dentin matrix protein 1 (DMP-1) result in increased FGF23 and hypophosphatemic rickets...
  63. Bouwman P, Gollner H, Elsasser H, Eckhoff G, Karis A, Grosveld F, et al. Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000;19:655-61 pubmed
    ..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy...
  64. Lin H, Liu H, Sun Q, Yuan G, Zhang L, Chen Z. KLF4 promoted odontoblastic differentiation of mouse dental papilla cells via regulation of DMP1. J Cell Physiol. 2013;228:2076-85 pubmed publisher
    ..Overexpression of Klf4 significantly up-regulated odontoblast-related genes, such as Dmp1, Dspp, and Alp, and promoted the accumulation of mineral nodules...
  65. Liang T, Meng T, Wang S, Qin C, Lu Y. The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum. J Cell Physiol. 2016;231:1468-75 pubmed publisher
    Dentin matrix protein 1 (DMP1) is found abundantly in the extracellular matrices of bone and dentin...
  66. Mukhopadhyay P, Greene R, Zacharias W, Weinrich M, Singh S, Young W, et al. Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004;70:912-26 pubmed
    ..This gene expression profiling study identifies a number of potentially unique developmental participants and serves as a valuable aid in deciphering the complex molecular mechanisms crucial for mammalian orofacial development. ..
  67. MacDougall M, Gu T, Luan X, Simmons D, Chen J. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. J Bone Miner Res. 1998;13:422-31 pubmed
    Dentin matrix protein 1 (Dmp1) is an acidic phosphoprotein first identified by cDNA cloning from a rat tooth library...
  68. Padovano J, Ramachandran A, Bahmanyar S, Ravindran S, George A. Bone-specific overexpression of DMP1 influences osteogenic gene expression during endochondral and intramembranous ossification. Connect Tissue Res. 2014;55 Suppl 1:121-4 pubmed publisher
    Dentin matrix protein 1 (DMP1) is a key regulator of biomineralization within the extracellular matrix (ECM) of bone and plays a role in regulating osteogenic gene expression...
  69. Inoue K, Zindy F, Randle D, Rehg J, Sherr C. Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev. 2001;15:2934-9 pubmed
    Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age...
  70. Navarro N, Maga A. Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?. G3 (Bethesda). 2016;6:1153-63 pubmed publisher
    ..Most of the main variation is, nonetheless, preferentially embedded in the natural 2D plane of the hemi-mandible, reinforcing the results of earlier influential investigations. ..
  71. George A, Bannon L, Sabsay B, Dillon J, Malone J, Veis A, et al. The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process. J Biol Chem. 1996;271:32869-73 pubmed
    ..PP gene, Dmp2, from our odontoblast cDNA library and localized it to mouse chromosome 5q21 within 2 centimorgans of Dmp1, another tooth-specific ECM protein...
  72. Hao J, Ramachandran A, George A. Temporal and spatial localization of the dentin matrix proteins during dentin biomineralization. J Histochem Cytochem. 2009;57:227-37 pubmed publisher
    ..Three major NCPs present in the dentin matrix are dentin matrix protein 1 (DMP1), dentin phosphophorin (DPP), and dentin sialoprotein (DSP)...
  73. Frazier D, Kendig R, Kai F, Maglic D, Sugiyama T, Morgan R, et al. Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function. Cancer Res. 2012;72:1740-50 pubmed publisher
    The transcription factor Dmp1 is a Ras/HER2-activated haplo-insufficient tumor suppressor that activates the Arf/p53 pathway of cell-cycle arrest...