Dmp1

Summary

Gene Symbol: Dmp1
Description: dentin matrix protein 1
Alias: AV020965, Dmp, AG1, DMP-1, dentin matrix acidic phosphoprotein 1, serine rich acidic phosphoprotein
Species: mouse

Top Publications

  1. ncbi DMP1-targeted Cre expression in odontoblasts and osteocytes
    Y Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 86:320-5. 2007
  2. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
  3. ncbi Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo
    Jelica Gluhak-Heinrich
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Bone Miner Res 18:807-17. 2003
  4. pmc Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus
    Kun Lv
    The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    Int J Biol Sci 6:537-45. 2010
  5. pmc The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment
    Yongbo Lu
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, TX 75246, USA
    J Bone Miner Res 26:331-40. 2011
  6. ncbi Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
  7. pmc Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis
    Yao Sun
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Texas 75246, USA
    J Biol Chem 285:31713-22. 2010
  8. pmc Protective roles of DMP1 in high phosphate homeostasis
    Afsaneh Rangiani
    Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas, United States of America
    PLoS ONE 7:e42329. 2012
  9. pmc Unique roles of phosphorus in endochondral bone formation and osteocyte maturation
    Rong Zhang
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi an, People s Republic of China
    J Bone Miner Res 26:1047-56. 2011
  10. ncbi TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts
    A Unterbrink
    Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MCS 7888, San Antonio, Texas 78229 3900, USA
    Connect Tissue Res 43:354-8. 2002

Scientific Experts

  • Jian Q Feng
  • Chunlin Qin
  • Shiguang Liu
  • Ling Ye
  • Ivo Kalajzic
  • A Veis
  • Yongbo Lu
  • Yao Sun
  • Yixia Xie
  • Lynda F Bonewald
  • Karthikeyan Narayanan
  • Afsaneh Rangiani
  • Baozhi Yuan
  • Aline Martin
  • RENA N D'SOUZA
  • Jianjun Hao
  • Anne George
  • Tian Gao
  • Zhengguo Cao
  • Amsaveni Ramachandran
  • Stephen E Harris
  • Y Lu
  • Sarah L Dallas
  • Monica Prasad Gibson
  • Ying Liu
  • Suzhen Wang
  • Olivier Duverger
  • Ai Kyono
  • Arwa Siyam
  • A Martin
  • Donna P Frazier
  • Qinglin Zhu
  • Xiaofang Wang
  • Y Sun
  • Rong Zhang
  • Marc K Drezner
  • Jelica Gluhak-Heinrich
  • Kun Lv
  • Yinfang Xu
  • Hideo Masuki
  • Baichun Jiang
  • Valentin David
  • Bingzhen Huang
  • Izabela Maciejewska
  • Shibin Yu
  • Tao Peng
  • Lynda Bonewald
  • Marc D McKee
  • William T Butler
  • M MacDougall
  • L F Bonewald
  • Gamze Kilic
  • Keqin Zhang
  • Shubin Zhang
  • V Dusevich
  • Shiva Kotha
  • Shuo Chen
  • Yunfeng Ling
  • H F Rios
  • Zu Bing Li
  • Wuchen Yang
  • Megan J Wilson
  • Barry M Steiglitz
  • Thomas Aberg
  • Makiko Terasawa
  • Partha Mukhopadhyay
  • Mary Macdougall
  • R N D'Souza
  • A Unterbrink
  • Amel Gritli-Linde
  • Jian Q Fen
  • Qilin Liu
  • L Bruno Ruest
  • Ariane Berdal
  • Anika Voisey Rodgers
  • Elizabeth A Fry
  • H Li
  • Angela Zah
  • V David
  • Sarah J Lagedrost
  • B Dai
  • K Inoue
  • Dejan Maglic
  • Nanthawan Avishai
  • ROY STEVENS
  • Fumitake Kai
  • Anne K Bartels
  • Kazushi Inoue
  • Juliane Isaac
  • L D Quarles

Detail Information

Publications62

  1. ncbi DMP1-targeted Cre expression in odontoblasts and osteocytes
    Y Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 86:320-5. 2007
    ..Because dentin matrix protein 1 (DMP1), an extracellular matrix protein, is highly expressed in both types of cells, we next tested, using a transgenic ..
  2. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Dentin matrix protein 1 (encoded by DMP1) is highly expressed in osteocytes and, when deleted in mice, results in a hypomineralized bone phenotype...
  3. ncbi Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo
    Jelica Gluhak-Heinrich
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    J Bone Miner Res 18:807-17. 2003
    Dentin matrix protein 1 (DMP1) was originally postulated to be dentin specific. Further analysis showed that DMP1 is also expressed in mature cartilage and bone...
  4. pmc Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus
    Kun Lv
    The State Key Laboratory Breeding Base of Basic Science of Stomatology Hubei MOST and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    Int J Biol Sci 6:537-45. 2010
    ..Yet, the potential influence of osteoporosis on body balance is largely unknown. Dentin matrix protein 1 (DMP1) is highly expressed in bone and required for phosphate homeostasis and mineralization...
  5. pmc The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment
    Yongbo Lu
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, TX 75246, USA
    J Bone Miner Res 26:331-40. 2011
    ..I collagen promoter was used to express this 57-kDa C-terminal fragment for comparison with full-length DMP-1 in Dmp1 null osteoblasts/osteocytes...
  6. ncbi Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas, City, Kansas City, Missouri 64108, USA
    J Biol Chem 279:19141-8. 2004
    The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development. In vitro study suggests that this noncollagen acidic phosphoprotein plays a role in mineralization...
  7. pmc Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis
    Yao Sun
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Texas 75246, USA
    J Biol Chem 285:31713-22. 2010
    Dentin matrix protein 1 (DMP1), an acidic protein important to the formation of bone and dentin, primarily exists as the processed NH(2)-terminal and COOH-terminal fragments in the extracellular matrix of the two tissues...
  8. pmc Protective roles of DMP1 in high phosphate homeostasis
    Afsaneh Rangiani
    Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas, United States of America
    PLoS ONE 7:e42329. 2012
    b>Dmp1 (dentin matrix protein1) null mice (Dmp1(-/-)) display hypophosphatemic rickets with a sharp increase in fibroblast growth factor 23 (FGF23)...
  9. pmc Unique roles of phosphorus in endochondral bone formation and osteocyte maturation
    Rong Zhang
    Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi an, People s Republic of China
    J Bone Miner Res 26:1047-56. 2011
    ..Here we used Dmp1 null mice, a hypophosphatemic rickets/osteomalacia model, combined with a metatarsal organ culture and an ..
  10. ncbi TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts
    A Unterbrink
    Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MCS 7888, San Antonio, Texas 78229 3900, USA
    Connect Tissue Res 43:354-8. 2002
    ..the potential transcriptional regulation by TGF beta-1 of two dentin matrix proteins: dentin matrix protein 1 (DMP-1), and dentin sialophosphoprotein (DSPP)...
  11. pmc Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells
    Izabela Maciejewska
    Department of Biomedical Science, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex 75246, USA
    Cells Tissues Organs 189:186-91. 2009
    Dentin matrix protein 1 (DMP1) has been shown to be critical for the formation of dentin and bone. However, the precise pathway by which DMP1 participates in dentinogenesis and osteogenesis remains to be clarified...
  12. pmc E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation
    Keqin Zhang
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, 630 East 25th Street, Kansas City, MO 64108 2784, USA
    Mol Cell Biol 26:4539-52. 2006
    ..These data suggest that osteocytes may be able to extend their cellular processes after embedment in mineralized matrix and have implications for osteocytic modification of their microenvironment...
  13. ncbi Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1
    Barry M Steiglitz
    Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 279:980-6. 2004
    ..Dentin matrix protein-1 (DMP1), deposited into the ECM during assembly and involved in initiating mineralization of bones and teeth, is thought ..
  14. pmc Pathogenic role of Fgf23 in Dmp1-null mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 295:E254-61. 2008
    ..activity, and rickets/osteomalacia, is caused by inactivating mutations of dentin matrix protein 1 (DMP1)...
  15. ncbi Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    I Kalajzic
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington 06030, USA
    Bone 35:74-82. 2004
    ..Furthermore, we have generated transgenic mice utilizing a mouse DMP1 cis-regulatory system to drive GFP as a marker for living osteocytes...
  16. ncbi Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store
    Karthikeyan Narayanan
    Department of Oral Biology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:17500-8. 2003
    Dentin matrix protein 1 (DMP1) is a bone- and teeth-specific protein initially identified from mineralized dentin. Here we report that DMP1 is primarily localized in the nuclear compartment of undifferentiated osteoblasts...
  17. ncbi Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo
    R N D'Souza
    Department of Basic Sciences, Dental Branch, University of Texas Houston Health Science Center 77030, USA
    J Bone Miner Res 12:2040-9. 1997
    ..Here we compared the in vivo temporospatial expression patterns of two dentin NCP genes, dentin matrix protein 1 (Dmp1), and dentin sialophosphoprotein (DSPP) in developing molars...
  18. ncbi Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain
    K Fujio
    Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Blood 95:2204-10. 2000
    ..These results suggest that delta1 is a subunit of cytokine receptor that may be involved in multiple receptor systems and play a regulatory role in the immune system and hematopoiesis...
  19. pmc Studies of the DMP1 57-kDa functional domain both in vivo and in vitro
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri at Kansas City, Kansas City, MO, USA
    Cells Tissues Organs 189:175-85. 2009
    b>Dmp1-null mice and patients with mutations in dentin matrix protein 1 (DMP1) resulting in autosomal recessive hypophosphatemic rickets display similar skeletal defects...
  20. pmc DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis
    Yunfeng Ling
    Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, New York, USA
    J Bone Miner Res 20:2169-77. 2005
    The role of DMP1 in mineralization was analyzed by comparing bone mineral and matrix properties in dmp1-null female mice to heterozygous and wildtype controls by FTIR imaging spectroscopy...
  21. ncbi Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues
    Makiko Terasawa
    Developmental Oral Health Science, Department of Orofacial Development and Function, Division of Oral Health Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Bone Miner Metab 22:430-8. 2004
    Dentin matrix protein 1 (DMP1) is an Arg-Gly-Asp-containing acidic phosphoprotein that was originally identified from a rat incisor cDNA library and was thought to be a dentin-specific protein...
  22. ncbi The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development
    J Q Feng
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    J Dent Res 82:776-80. 2003
    Dentin Matrix Protein 1 (Dmp1) was originally identified from dentin. However, its expression and function in vivo are not clear...
  23. pmc Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th Street, Kansas City, MO 64108, USA
    Dev Biol 303:191-201. 2007
    Dentin matrix protein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to defects in odontogenesis and mineralization...
  24. ncbi Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene
    Jian Q Fen
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 64108, USA
    J Bone Miner Res 17:1822-31. 2002
    Dentin matrix protein 1 (Dmp1), a phosphoprotein highly linked to dentin formation, has also been reported to be expressed in the skeleton. However, the role of Dmp1 in skeletal tissues remains unclear...
  25. pmc Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype
    Ling Ye
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, 650 E 25th St, Kansas City, MI 64108, USA
    J Biol Chem 280:6197-203. 2005
    ..In the present studies, we present evidence for a critical role of DMP1 (dentin matrix protein 1) in postnatal chondrogenesis...
  26. pmc DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype
    Baichun Jiang
    Institute of Medical Genetics, Shandong University School of Medicine, Jinan, People s Republic of China
    J Bone Miner Res 25:2155-64. 2010
    b>DMP1 mutations in autosomal recessive hypophosphatemic rickets (ARHR) patients and mice lacking Dmp1 display an overlapping pathophysiology, such as hypophosphatemia...
  27. ncbi Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo
    Wuchen Yang
    Department of Periodontics and Cellular and Structural Biology, University of Texas, San Antonio, Texas 78229, USA
    J Biol Chem 280:20680-90. 2005
    Dentin matrix protein 1 (DMP1) is highly expressed in osteocytes and is mechanically responsive...
  28. pmc Periodontal breakdown in the Dmp1 null mouse model of hypophosphatemic rickets
    L Ye
    Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    J Dent Res 87:624-9. 2008
    Dentin Matrix Protein 1 (DMP1) is highly expressed in alveolar bone and cementum, which are important components of the periodontium...
  29. pmc Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation
    Afsaneh Rangiani
    Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, TX 75246, USA
    Int J Oral Sci 4:189-95. 2012
    Deletion or mutation of dentin matrix protein 1 (DMP1) leads to hypophosphatemic rickets and defects within the dentin...
  30. pmc Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice
    A Martin
    University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Endocrinol 26:1883-95. 2012
    Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of the phosphaturic hormone fibroblast growth factor (FGF)-23, leading to ..
  31. pmc Nuclear localization of DMP1 proteins suggests a role in intracellular signaling
    Arwa Siyam
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, 3302 Gaston Ave, Dallas, TX 75246 2013, United States
    Biochem Biophys Res Commun 424:641-6. 2012
    Dentin matrix protein 1 (DMP1) is highly expressed in odontoblasts and osteoblasts/osteocytes and plays an essential role in tooth and bone mineralization and phosphate homeostasis...
  32. pmc Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12230-40. 2012
    ..This establishes a regulatory pathway where the transcription factor Dlx3 is essential in dentin formation by directly regulating a crucial matrix protein...
  33. pmc Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function
    Donna P Frazier
    Department of Pathology and Cancer Biology, and Graduate Program in Molecular Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 72:1740-50. 2012
    The transcription factor Dmp1 is a Ras/HER2-activated haplo-insufficient tumor suppressor that activates the Arf/p53 pathway of cell-cycle arrest...
  34. pmc The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis
    Monica Prasad Gibson
    Department of Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    J Biol Chem 288:7204-14. 2013
    Dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP) are essential for the formation of dentin. Previous in vitro studies have indicated that DMP1 might regulate the expression of DSPP during dentinogenesis...
  35. pmc FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation
    Ai Kyono
    Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road BRB 329, Cleveland, OH 44106, USA
    J Bone Miner Metab 30:19-30. 2012
    ..Real-time PCR analysis indicated that FGF2 upregulates Ank, Enpp1, Mgp, Slc20a1, and Dmp1 in MLO-Y4 cells...
  36. ncbi Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice
    Hideo Masuki
    Department of Developmental Biology of Hard Tissue, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    Biomed Res 31:307-18. 2010
    ..b>DMP1-positive osteocytes were evenly distributed throughout the wild-type epiphyses and cortical bone, as well as the ..
  37. pmc DMP1 processing is essential to dentin and jaw formation
    Y Sun
    Department of Biomedical Sciences, Texas A and M Health Science Center Baylor College of Dentistry, 3302 Gaston Ave, Dallas, TX 75246, USA
    J Dent Res 90:619-24. 2011
    Dentin matrix protein 1 (DMP1), an acidic protein that is essential to the mineralization of bone and dentin, exists as proteolytically processed fragments in the mineralized tissues...
  38. pmc Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling
    Aline Martin
    University of Tennessee Health Science Center, 956 Court Ave, Memphis TN 38163, USA
    FASEB J 25:2551-62. 2011
    ..Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in equivalent intrinsic bone mineralization defects and increased Fgf23 expression in osteocytes...
  39. ncbi Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization
    Amel Gritli-Linde
    Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Development 129:5323-37. 2002
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells...
  40. pmc Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis
    Yao Sun
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Tex, USA
    Cells Tissues Organs 194:199-204. 2011
    Dentin matrix protein 1 (DMP1) is an acidic protein that plays critical roles in osteogenesis and dentinogenesis...
  41. ncbi Sonic hedgehog regulates growth and morphogenesis of the tooth
    H R Dassule
    Department of Molecular and Cellular Biology, The Biolabs, Divinity Avenue, Cambridge, MA 02138, USA
    Development 127:4775-85. 2000
    ..These studies demonstrate that Shh regulates growth and determines the shape of the tooth. However, Shh signaling is not essential for differentiation of ameloblasts or odontoblasts...
  42. ncbi Identification of tooth-specific downstream targets of Runx2
    J S Gaikwad
    Department of Orthodontics, Dental Branch, University of Texas at Houston Health Science Center, Houston, TX 77030, USA
    Gene 279:91-7. 2001
    ..In conclusion, we have successfully generated a library enriched in genes expressed in Runx2(+/+) molar tooth organs and performed preliminary studies to assess the role of Zfp in tooth development...
  43. pmc Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas
    K Inoue
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 15:2934-9. 2001
    Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age...
  44. pmc Transcription factor Sp3 is essential for post-natal survival and late tooth development
    P Bouwman
    Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2
    EMBO J 19:655-61. 2000
    ..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy...
  45. ncbi Expression of the dentin matrix protein 1 gene in birds
    S Toyosawa
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
    J Mol Evol 50:31-8. 2000
    ..genes in the birds, we tested a domestic fowl cDNA library for the expression of the dentin matrix protein 1 (DMP1) gene...
  46. ncbi Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues
    M MacDougall
    Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 78284 7888, USA
    J Bone Miner Res 13:422-31. 1998
    Dentin matrix protein 1 (Dmp1) is an acidic phosphoprotein first identified by cDNA cloning from a rat tooth library...
  47. ncbi The carboxyl-terminal domain of phosphophoryn contains unique extended triplet amino acid repeat sequences forming ordered carboxyl-phosphate interaction ridges that may be essential in the biomineralization process
    A George
    Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 271:32869-73. 1996
    ..PP gene, Dmp2, from our odontoblast cDNA library and localized it to mouse chromosome 5q21 within 2 centimorgans of Dmp1, another tooth-specific ECM protein...
  48. ncbi Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors
    Karthikeyan Narayanan
    Department of Oral Biology M C 690, University of Illinois at Chicago, Chicago, IL 60612, USA
    Connect Tissue Res 43:365-71. 2002
    Dentin matrix protein 1 (DMP1) is an extracellular matrix phosphoprotein whose expression is precisely controlled temporally and spatially during the differentiation of the odontoblasts...
  49. ncbi In situ localization and chromosomal mapping of the AG1 (Dmp1) gene
    A George
    Division of Oral Biology, Northwestern University, Chicago, Illinois
    J Histochem Cytochem 42:1527-31. 1994
    ..AG1 has been renamed Dmp1 (dentin matrix protein 1) in accordance with present chromosomal nomenclature...
  50. ncbi Phenotypic changes in dentition of Runx2 homozygote-null mutant mice
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    J Histochem Cytochem 52:131-9. 2004
    ..These data support the hypothesis that Runx2 is one of the key mesenchymal factors that influences tooth morphogenesis and the subsequent differentiation of ameloblasts and odontoblasts...
  51. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  52. pmc Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP
    Aline Martin
    Department of Internal Medicine, Division of Nephrology and Hypertension, The Kidney Institute, Kansas University Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Endocrinology 149:1757-72. 2008
    Mutations in PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and DMP1 (dentin matrix protein 1) result in X-linked hypophosphatemic rickets (HYP) and autosomal-recessive hypophosphatemic-rickets (..
  53. pmc Generation of a conditional null allele for Dmp1 in mouse
    Jian Q Feng
    Department of Biomedical Sciences, Baylor College of Dentistry, Texas A and M Health Science Center, Dallas, Texas 75246, USA
    Genesis 46:87-91. 2008
    Dentin matrix protein1 (DMP1), highly conserved in humans and mice, is highly expressed in teeth, the skeleton, and to a lesser extent in nonskeletal tissues such as brain, kidney, and salivary gland...
  54. ncbi Differential regulation of dentin matrix protein 1 expression during odontogenesis
    Yongbo Lu
    Department of Oral Biology, School of Dentistry, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Cells Tissues Organs 181:241-7. 2005
    Dentin matrix protein 1 (DMP1) is highly expressed in mineralized tooth and bone. Both in vitro and in vivo data show that DMP1 is critical for mineralization and tooth morphogenesis (growth and development)...
  55. ncbi DMP1 is essential for osteocyte formation and function
    H F Rios
    University of Missouri at Kansas City, Kansas City, MO, USA
    J Musculoskelet Neuronal Interact 5:325-7. 2005
  56. ncbi [The preliminary study on the characteristics of mandible and condyle in dentin matrix protein-1 gene knockout mice]
    Zu Bing Li
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University, Wuhan 430079, China
    Zhonghua Kou Qiang Yi Xue Za Zhi 40:335-7. 2005
    To study the characteristics of mandible and condyle in Dmp1 gene knockout mice, and to investigate the role of Dmp1 in the osteogenesis and mineralization of bone and cartilage.
  57. pmc Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues
    Tao Peng
    Department of Biomedical Science, Baylor College of Dentistry, Texas A and M University System Health Science Center, Dallas, Tex 75246, USA
    Cells Tissues Organs 189:192-7. 2009
    Dentin matrix protein 1 (DMP1) is present in the extracellular matrix (ECM) of dentin and bone as processed NH(2)- and COOH-terminal fragments, resulting from proteolytic cleavage at the NH(2) termini of 4 aspartic acid residues during ..
  58. ncbi Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development
    Megan J Wilson
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Dev Dyn 233:1488-95. 2005
    ..encoding the related SIBLING glycoproteins osteopontin (OPN), bone sialoprotein (BSP), and dentin matrix protein (DMP) during the development of male and female gonads during mouse embryogenesis...
  59. pmc Temporal and spatial localization of the dentin matrix proteins during dentin biomineralization
    Jianjun Hao
    Brodie Tooth Development Genetics and Regenerative Medicine Research Laboratory, Department of Oral Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Histochem Cytochem 57:227-37. 2009
    ..Three major NCPs present in the dentin matrix are dentin matrix protein 1 (DMP1), dentin phosphophorin (DPP), and dentin sialoprotein (DSP)...
  60. ncbi Developmental gene expression profiling of mammalian, fetal orofacial tissue
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky, KY 40292, USA
    Birth Defects Res A Clin Mol Teratol 70:912-26. 2004
    ..DNA microarray technology presents an efficient means of acquiring novel and valuable information regarding the expression, regulation, and function of a panoply of genes involved in mammalian orofacial development...
  61. ncbi Transcriptional regulation of dentin matrix protein 1 by JunB and p300 during osteoblast differentiation
    Karthikeyan Narayanan
    Department of Oral Biology, College of Dentistry, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 279:44294-302. 2004
    Dentin matrix protein 1 (DMP1) is an acidic noncollagenous protein localized specifically in the mineralized matrix of bone and dentin. Expression analyses demonstrate that DMP1 is differentially regulated in osteoblasts and odontoblasts...
  62. pmc Expression, functional, and structural analysis of proteins critical for otoconia development
    Yinfang Xu
    Vestibular Neurogenetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Dev Dyn 239:2659-73. 2010
    ..Analysis and modeling of Oc90 and Sc1 protein structures show common features that may be critical requirements for the otoconial matrix backbone protein. Such information will serve as the foundation for future regenerative purposes...

Research Grants24

  1. ROLES OF BMP4 & ITS REGULATION DURING TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2003
    ..Research into this relatively unexplored area will contribute to our understanding of the basic Msx1- Bmp4 signal pathway, mechanisms of tooth formation, and possible cause of autosomal dominant forms of familial tooth agenesis. ..
  2. DMP1 Mutations: Defects in Odontogenesis
    Jian Feng; Fiscal Year: 2009
    ..In a search for genes required for normal tooth morphogenesis we have studied Dentin matrix protein1 (DMP1), a non- collagenous matrix protein highly expressed in pulp/odontoblast cells, using in vivo loss- and gain-of-..
  3. Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis
    Chunlin Qin; Fiscal Year: 2010
    The research proposed in this competing grant renewal focuses on dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), two non-collagenous extracellular matrix (ECM) proteins that belong to the SIBLING family...
  4. Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis
    Chunlin Qin; Fiscal Year: 2009
    ..this competitive revision application as well as the parent grant application focuses on dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), two non-collagenous extracellular matrix (ECM) proteins that belong to the ..
  5. DMP1 Mutations: Defects in Odontogenesis
    Jian Feng; Fiscal Year: 2009
    ..In a search for genes required for normal tooth morphogenesis we have studied Dentin matrix protein1 (DMP1), a non- collagenous matrix protein highly expressed in pulp/odontoblast cells, using in vivo loss- and gain-of-..
  6. STUDIES OF PROTEINS INVOLVED IN DENTINOGENESIS
    Chunlin Qin; Fiscal Year: 2009
    ..Specifically, we are focusing upon the biological functions of dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP)...
  7. DMP1 Mutations: Defects in Odontogenesis
    Jian Q Feng; Fiscal Year: 2010
    ..In a search for genes required for normal tooth morphogenesis we have studied Dentin matrix protein1 (DMP1), a non- collagenous matrix protein highly expressed in pulp/odontoblast cells, using in vivo loss- and gain-of-..
  8. Strategy to assess the function of osteocyte restricted genes
    Ivo Kalajzic; Fiscal Year: 2007
    ..To separate osteocytes from osteoblasts, DMP1-tpz transgenic mice (osteocyte specific marker) will be crossed with pOBCol2...
  9. ROLES OF BMP4 AND ITS REGULATION IN TOOTH DEVELOPMENT
    Jian Feng; Fiscal Year: 2004
    ..Molecular techniques include RT-PCR, in situ hybridization, DNA sequence determination, SSCP (single strand conformational polymorphism), and heteroduplex analysis. ..
  10. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2006
    ..supports the latter hypothesis, as we have shown that mice lacking the bone ECM protein, Dentin matrix protein-1 (DMP-1) exhibit a dramatic osteomalacia/rickets phenotype with impaired mineralization...
  11. Roles of Dmp1 in dentinogenesis
    Ling Ye; Fiscal Year: 2007
    ..In a search for genes required for normal dentin morphogenesis we have studied Dentin matrix protein 1 (DMP1) using an in vivo loss-of-function approach...
  12. A Critical Role of DMP-1 in Mineralization
    Jian Feng; Fiscal Year: 2007
    ..supports the latter hypothesis, as we have shown that mice lacking the bone ECM protein, Dentin matrix protein-1 (DMP-1) exhibit a dramatic osteomalacia/rickets phenotype with impaired mineralization...
  13. Studies of the Roles of DMP1 and DSPP in Osteogenesis and Dentinogenesis
    Chunlin Qin; Fiscal Year: 2010
    The research proposed in this competing grant renewal focuses on dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), two non-collagenous extracellular matrix (ECM) proteins that belong to the SIBLING family...