Dmbt1

Summary

Gene Symbol: Dmbt1
Description: deleted in malignant brain tumors 1
Alias: CRP, CRP-[a], CRP-[b], Crpd, DBMT1, gp300, p80, deleted in malignant brain tumors 1 protein, apactin, crp-ductin, deleted in malignant brain tumors 1 pseudogene, ebnerin, glycoprotein 300, hensin, mucin-like glycoprotein, muclin, vomeroglandin
Species: mouse
Products:     Dmbt1

Top Publications

  1. Madsen J, Tornøe I, Nielsen O, Lausen M, Krebs I, Mollenhauer J, et al. CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol. 2003;33:2327-36 pubmed
    b>CRP-ductin is a protein expressed mainly by mucosal epithelial cells in the mouse...
  2. De Lisle R, Isom K. Expression of sulfated gp300 and changes in glycosylation during pancreatic development. J Histochem Cytochem. 1996;44:57-66 pubmed
    The pancreatic zymogen granule membrane protein gp300 is the major sulfated glycoprotein of the mouse acinar cell and has been proposed to be an important structural component of the zymogen granule membrane...
  3. Takito J, Yan L, Ma J, Hikita C, Vijayakumar S, Warburton D, et al. Hensin, the polarity reversal protein, is encoded by DMBT1, a gene frequently deleted in malignant gliomas. Am J Physiol. 1999;277:F277-89 pubmed
    ..have these domains include CRP-ductin, a cDNA expressed at high levels in mouse intestine (8 SRCR, 5 CUB, 1 ZP), ebnerin, a protein cloned from a rat taste bud library (4 SRCR, 3 CUB, 1 ZP), and DMBT1, a sequence in human chromosome ..
  4. Cheng H, Bjerknes M, Chen H. CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts. Anat Rec. 1996;244:327-43 pubmed
    A subtraction screen isolated CRP-ductin (CRP), a gene expressed in intestinal crypts. DNA sequencing, in situ hybridization, immunostaining, Western and Northern blotting were used to characterize murine CRP...
  5. De Lisle R, Norkina O, Roach E, Ziemer D. Expression of pro-Muclin in pancreatic AR42J cells induces functional regulated secretory granules. Am J Physiol Cell Physiol. 2005;289:C1169-78 pubmed
    ..Here, the sulfated mucin-type glycoprotein pro-Muclin was tested for its ability to induce RSG in the poorly differentiated rat pancreatic cell line AR42J...
  6. Garay J, Piazuelo M, Lopez Carrillo L, Leal Y, Majumdar S, Li L, et al. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies. Oncotarget. 2017;8:47076-47089 pubmed publisher
    ..Deleted in malignant brain tumors 1 (DMBT1) belongs to the group of secreted scavenger receptor cysteine-rich proteins and is considered to be involved in ..
  7. End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, et al. DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands. Eur J Immunol. 2009;39:833-42 pubmed publisher
    Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial-binding spectrum...
  8. Blackburn A, Hill L, Roberts A, Wang J, Aud D, Jung J, et al. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Am J Pathol. 2007;170:2030-41 pubmed
    ..7 to 61.1 weeks and increased risk twofold (P = 0.002). Dmbt1 (deleted in malignant brain tumors 1) was identified as a candidate modifier gene within the SuprMam1 interval ..
  9. Tandon C, De Lisle R, Boulatnikov I, Naik P. Interaction of carboxyl-terminal peptides of cytosolic-tail of apactin with PDZ domains of NHERF/EBP50 and PDZK-1/CAP70. Mol Cell Biochem. 2007;302:157-67 pubmed
    ..Previous work showed that the membrane phosphoprotein apactin (an 80-kDa type I membrane protein derived from pro-Muclin) is associated with the acinar cell apical actin ..

More Information

Publications20

  1. Takito J, Al Awqati Q. Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin. J Cell Biol. 2004;166:1093-102 pubmed
    ..Here, we show that mouse embryonic stem cells seeded on hensin or laminin, but not fibronectin or collagen type IV, formed hemispheric epithelial structures whose outermost ..
  2. Boulatnikov I, De Lisle R. Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides. J Biol Chem. 2004;279:40918-26 pubmed
    ..characterized the pH-dependent interactions of pancreatic acinar cell-regulated secretory proteins (zymogens) with Muclin, a putative Golgi cargo receptor...
  3. De Lisle R, Isom K, Ziemer D, Cotton C. Changes in the exocrine pancreas secondary to altered small intestinal function in the CF mouse. Am J Physiol Gastrointest Liver Physiol. 2001;281:G899-906 pubmed
    ..The CF mouse pancreas has approximately 50% of normal amylase levels and approximately 200% normal Muclin levels, the major sulfated glycoprotein of the pancreas...
  4. Matsushita F, Miyawaki A, Mikoshiba K. Vomeroglandin/CRP-Ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: identification and characterization of mouse vomeroglandin. Biochem Biophys Res Commun. 2000;268:275-81 pubmed
    b>Vomeroglandin, a subform of mouse CRP-ductin, is a protein strongly expressed in the glands of mouse vomeronasal system. Both the proteins contain several of scavenger receptor cysteine-rich and CUB domains and one ZP domain...
  5. Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, et al. DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease. Gastroenterology. 2007;133:1499-509 pubmed
    ..Deleted in malignant brain tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein with predominant expression in the intestine and has been ..
  6. De Lisle R, Xu W, Roe B, Ziemer D. Effects of Muclin (Dmbt1) deficiency on the gastrointestinal system. Am J Physiol Gastrointest Liver Physiol. 2008;294:G717-27 pubmed publisher
    ..The heavily sulfated membrane glycoprotein mucin-like glycoprotein (Muclin) is a Dmbt1 product that is strongly expressed in organs of the gastrointestinal (GI) system...
  7. De Lisle R, Petitt M, Huff J, Isom K, Agbas A. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. Gastroenterology. 1997;113:521-32 pubmed
    ..The aim of this study was to use a recently described sulfated mucin-like glycoprotein (MUCLIN: formerly called gp300) as a model glycoconjugate to study such changes in the gastrointestinal system in the ..
  8. Gao X, Eladari D, Leviel F, Tew B, Miró Julià C, Cheema F, et al. Deletion of hensin/DMBT1 blocks conversion of beta- to alpha-intercalated cells and induces distal renal tubular acidosis. Proc Natl Acad Sci U S A. 2010;107:21872-7 pubmed publisher
    ..to acid feeding, a process that depended on the secretion and deposition of an extracellular matrix protein termed hensin (DMBT1)...
  9. Müller H, Hu J, Popp R, Schmidt M, Muller Decker K, Mollenhauer J, et al. Deleted in malignant brain tumors 1 is present in the vascular extracellular matrix and promotes angiogenesis. Arterioscler Thromb Vasc Biol. 2012;32:442-8 pubmed publisher
    Deleted in malignant brain tumors 1 (DMBT1) belongs to the scavenger receptor cysteine-rich superfamily of proteins and is implicated in innate immunity, cell polarity, and differentiation...
  10. Diegelmann J, Olszak T, Goke B, Blumberg R, Brand S. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory p. J Biol Chem. 2012;287:286-98 pubmed publisher
    ..The IL-27-induced expression of the anti-bacterial gene deleted in malignant brain tumor 1 (DMBT1) is mediated by p38 and STAT3 signaling, whereas the activation of the anti-inflammatory and anti-bacterial gene ..
  11. De Lisle R. Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem. 1994;56:385-96 pubmed
    The major sulfated protein of the mouse pancreatic acinar cell, gp300, has been identified and characterized with monoclonal and polyclonal antibodies...