Dlx5

Summary

Gene Symbol: Dlx5
Description: distal-less homeobox 5
Alias: AI385752, homeobox protein DLX-5
Species: mouse

Top Publications

  1. ncbi Defective neuronogenesis in the absence of Dlx5
    Marzia Perera
    Laboratorio di Biologia dello Sviluppo, Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Mol Cell Neurosci 25:153-61. 2004
  2. pmc Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling
    Ginam Cho
    Children s Hospital of Philadelphia, ARC 516h, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 28:1565-72. 2008
  3. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
  4. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
  5. ncbi BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression
    Mi Hye Lee
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, 700 422 Korea
    J Biol Chem 278:34387-94. 2003
  6. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
  7. ncbi Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function
    Y Masuda
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:5331-8. 2001
  8. pmc The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
    Jianchi Feng
    Program in Neurobiology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Genes Dev 20:1470-84. 2006
  9. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
  10. pmc Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
    Jun Han
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 136:4225-33. 2009

Scientific Experts

  • L Puelles
  • Valérie Dupé
  • Evan M Braunstein
  • Giorgio R Merlo
  • Francisco Barrionuevo
  • Daniel Choo
  • H Toresson
  • GRANT STEPHEN MASTICK
  • Won Gu Jang
  • R F Hevner
  • Zhiyong Zhao
  • Ulla Pirvola
  • Inma Cobos
  • Juhee Jeong
  • Giovanni Levi
  • Jun Han
  • John L R Rubenstein
  • Yang Chai
  • J L Rubenstein
  • Louis Bruno Ruest
  • Kersti Lilleväli
  • Stefano Mantero
  • Sara Paina
  • Jinfei Xu
  • Raymond F Robledo
  • Martin M Riccomagno
  • Thomas Lufkin
  • Nadia Lo Iacono
  • Pablo Bringas
  • Maria I Morasso
  • Marzia Perera
  • Jason E Long
  • David E Clouthier
  • Mamoru Ishii
  • Marie Catherine Tiveron
  • Doris K Wu
  • Takahiro Ohyama
  • Ottavia Barbieri
  • Andrew J Bendall
  • Muriel Rhinn
  • Vardina Bensoussan-Trigano
  • Yong Ri Jin
  • G Yu
  • Il Hyuk Chung
  • Michael J Depew
  • Laura Paleari
  • Li Chen
  • Rosalind S E Carney
  • Chan Ho Hwang
  • Allison M Bond
  • Joseph R Testa
  • Helen A Thomason
  • Richard L Maas
  • Kentaro Suzuki
  • Takahiro Sato
  • Arnau Ulsamer
  • Alea A Mills
  • Ginam Cho
  • Victoria E Abraira
  • Benoit Robert
  • Chathurani S Jayasena
  • Yinfei Tan
  • Luisa Guerrini
  • Giorgio Corte
  • Antonio Costanzo
  • Jhumku D Kohtz
  • Hsian Jean Chin
  • Andrea Kwakowsky
  • Ambra A Zaghetto
  • Isabelle Anselme
  • Nadezda Radoja
  • Huansheng Xu
  • Michael P Verzi
  • Kazuaki Yoshikawa
  • Takaaki Kuwajima
  • J K Liu
  • Shu Hsuan Claire Hsu
  • Olga Britanova
  • Yukiko Kurihara
  • Mohammad Q Hassan
  • Andrew K Groves
  • Hiroki Kurihara
  • Ji Yun Lee
  • Robert E Maxson
  • Yu Ping Yang
  • Tomoyo Sasaki
  • Gen Yamada
  • Jianchi Feng
  • David D Eisenstat
  • T Zerucha

Detail Information

Publications106 found, 100 shown here

  1. ncbi Defective neuronogenesis in the absence of Dlx5
    Marzia Perera
    Laboratorio di Biologia dello Sviluppo, Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
    Mol Cell Neurosci 25:153-61. 2004
    ..Single or compound inactivation of Dlx1, Dlx2, or Dlx5 in the mouse causes defects of neuronal migration and differentiation...
  2. pmc Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling
    Ginam Cho
    Children s Hospital of Philadelphia, ARC 516h, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 28:1565-72. 2008
    ..These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development...
  3. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  4. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  5. ncbi BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression
    Mi Hye Lee
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, 700 422 Korea
    J Biol Chem 278:34387-94. 2003
    ..We found that Dlx5 is specifically expressed in osteogenic cells, and is specifically induced by BMP-2 or -4 signaling but not by ..
  6. ncbi DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation
    D D Eisenstat
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
    J Comp Neurol 414:217-37. 1999
    ..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb...
  7. ncbi Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function
    Y Masuda
    Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:5331-8. 2001
    b>Dlx5, a member of the Dlx family of homeodomain proteins, plays a critical role in bone development and fracture healing...
  8. pmc The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
    Jianchi Feng
    Program in Neurobiology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Genes Dev 20:1470-84. 2006
    ....
  9. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
  10. pmc Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice
    Jun Han
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, CSA 103, Los Angeles, CA 90033, USA
    Development 136:4225-33. 2009
    ..questions and show that O-N patterning is associated with the expansion and fusion of the palatal shelves and that Dlx5 is required for the O-N patterning of palatal mesenchyme...
  11. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..In contrast, Rspo2 regulates expression of the Dlx5, Dlx6, and Hand2 genes in mesenchymal cells via inducing expression of their upstream activator, Endothelin1 (Edn1),..
  12. ncbi Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4
    Kentaro Suzuki
    Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Eur J Hum Genet 16:36-44. 2008
    ..type 1 (SHFM1) is linked to genomic deletions or rearrangements, which includes the distal-less-related homeogenes DLX5 and DLX6 as well as DSS1...
  13. ncbi Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?
    Annemiek Beverdam
    Laboratory of Molecular Morphogenesis, National Institute for Cancer Research, Genova, Italy
    Genesis 34:221-7. 2002
    ..Here we show that simultaneous inactivation of the murine homeobox genes Dlx5 and Dlx6 results in the transformation of the lower jaw into an upper jaw and in symmetry of the snout...
  14. pmc Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear
    Victoria E Abraira
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Development 135:4091-9. 2008
    ..Thus, the Lrig3/Ntn1 feedback loop dictates when and where basement membrane breakdown occurs during canal development, revealing a new mechanism of complex tissue morphogenesis...
  15. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  16. pmc Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Genes Dev 18:937-51. 2004
    ..Further, our analysis of Shh-Fox gene regulatory interactions leads us to propose that Fox genes mediate the action of Shh in facial development...
  17. ncbi The role of Dlx homeogenes in early development of the olfactory pathway
    Giorgio R Merlo
    Dulbecco Telethon Institute, CNR ITB Milano, Via F lli Cervi 93, 20090 Segrate, Milano, Italy
    J Mol Histol 38:347-58. 2007
    ..Little is known about the genetic control of intrinsic ORN properties. Inactivation of the distalless-related Dlx5 prevents connections between ORNs and FB...
  18. pmc Fgfr1 regulates patterning of the pharyngeal region
    Nina Trokovic
    Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
    Genes Dev 17:141-53. 2003
    ..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration...
  19. pmc Msx1 and Dlx5 function synergistically to regulate frontal bone development
    Il Hyuk Chung
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Genesis 48:645-55. 2010
    ..Loss of Msx1 in mice results in multiple developmental defects including craniofacial malformations. Although Dlx5 is widely expressed during embryonic development, targeted null mutation of Dlx5 mainly affects the development of ..
  20. doi Msx1 and Msx2 in limb mesenchyme modulate digit number and identity
    Vardina Bensoussan-Trigano
    Institut Pasteur, Génétique Moléculaire de la Morphogenèse, CNRS URA 2578, Paris, France
    Dev Dyn 240:1190-202. 2011
    ..With this strategy, we demonstrate that mesenchymal expression of Msx1 and Msx2 is required for proper Shh and Bmp4 signaling to specify digit number and identity...
  21. ncbi Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
    Shin ichi Horike
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 84 171, University of California, Berkeley, California 94720, USA
    Nat Genet 37:31-40. 2005
    ..Several sequences mapped to an imprinted gene cluster on chromosome 6, including Dlx5 and Dlx6, whose transcription was roughly two times greater in brains of Mecp2-null mice compared with those of ..
  22. ncbi Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
    ..mechanisms that specify the identity of skeletal elements within the arches, we examined mice lacking expression of Dlx5 and Dlx6, linked homeobox genes expressed distally but not proximally within the arches...
  23. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
    ..Finally, the Dlx-2 and Dlx-1 and -2 mutants have ectopic skull components that resemble bones and cartilages found in phylogenetically more primitive vertebrates...
  24. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis...
  25. ncbi Hmx2 homeobox gene control of murine vestibular morphogenesis
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Development 128:5017-29. 2001
    ..The developmental regulators Bmp4, Dlx5 and Pax2 all play a critical role in inner ear ontogeny, and the expression of each of these genes is affected in ..
  26. pmc Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch
    A Trumpp
    G W Hooper Foundation, Department of Microbiology, School of Medicine, University of California at San Francisco UCSF, San Francisco, California 94143 0552, USA
    Genes Dev 13:3136-48. 1999
    ..Because the mutant mice resemble humans with first arch syndromes that include agnathia, our results raise the possibility that some of these syndromes are caused by mutations that affect FGF8 signaling in BA1 ectoderm...
  27. ncbi Mash1 regulates neurogenesis in the ventral telencephalon
    S Casarosa
    IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
    Development 126:525-34. 1999
    ..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production...
  28. ncbi Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest
    Mamoru Ishii
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Development 132:4937-50. 2005
    ..This increase in apoptosis may contribute to the mispatterning of the cranial ganglia and the hypoplasia of the first arch...
  29. ncbi Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neurons
    Elena Colombo
    Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:631-9. 2004
    ..is enhanced during differentiation of the subpallial structures of the ganglionic eminences, overlapping with Dlx2, Dlx5, and Gad1 transcriptional domains...
  30. ncbi Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
    ..fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5. However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
  31. ncbi Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias
    Nadezda Radoja
    Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD 20892, USA
    Development 134:13-8. 2007
    ..Our results unravel aspects of the transcriptional cascade of events that contribute to ectoderm development and pathogenesis associated with p63 mutations...
  32. pmc Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism
    H Zhang
    Graduate Program in Microbiology and Molecular Genetics, UMDNJ Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 17:2920-32. 1997
    ..Finally, we show that the expression patterns of representative Msx and Dlx genes (Msx1, Msx2, Dlx2, and Dlx5) overlap in mouse embryogenesis during limb bud and craniofacial development, consistent with the potential for ..
  33. ncbi Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Development 129:245-52. 2002
    ..This approach showed that ectopic expression of Dlx2 and Dlx5 induced the expression of glutamic acid decarboxylases (GADs), the enzymes that synthesize GABA...
  34. doi Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo
    Sara Paina
    Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    J Neurosci 31:2675-87. 2011
    ..Dlx2 and Dlx5 interact with homeodomain binding sequences within the Wnt5a locus and activate its transcription...
  35. ncbi Multiple functions of Dlx genes
    G R Merlo
    Laboratory of Molecular Morphogenesis, National Cancer Institute IST, Genova, Italy
    Int J Dev Biol 44:619-26. 2000
    ..In addition, Dlx5 and Dlx6 are expressed in differentiating osteoblasts...
  36. doi Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects
    Nadia Lo Iacono
    Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
    Development 135:1377-88. 2008
    ..are known in humans; the most common (type-I) is linked to deletions of DSS1 and the distalless-related homeogenes DLX5 and DLX6...
  37. ncbi Gata3 is required for early morphogenesis and Fgf10 expression during otic development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
    Mech Dev 123:415-29. 2006
    ..Inactivation of Gata3 leads also to a loss of Fgf10 expression in otic epithelium and auditory ganglion demonstrating that Gata3 is an important regulator of Fgf-signalling during otic development...
  38. ncbi Dlx5 regulates regional development of the branchial arches and sensory capsules
    M J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, Oral Biology and Biomedical Sciences, University of California at San Fran
    Development 126:3831-46. 1999
    We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene...
  39. ncbi TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development
    Tomoyo Sasaki
    Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 133:371-81. 2006
    ....
  40. ncbi Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons
    Celine Zimmer
    Developmental Biology Institute of Marseille, NMDA, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France
    Cereb Cortex 14:1408-20. 2004
    ..This suggests that laminar determination of upper cortical layer neurons occurs during the earliest stages of corticogenesis...
  41. ncbi Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5
    D Acampora
    International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
    Development 126:3795-809. 1999
    The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo...
  42. ncbi Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons
    S A Anderson
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
    Neuron 19:27-37. 1997
    ..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons...
  43. pmc Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:1612-23. 2005
    ..signaling is active in dorsal regions of the otic vesicle, where it functions to regulate the expression of genes (Dlx5/6 and Gbx2) necessary for vestibular morphogenesis...
  44. ncbi Partially overlapping expression of Gata2 and Gata3 during inner ear development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:775-81. 2004
    ..5 and Gata3 expression was unchanged. In contrast, a delay and strong reduction of Gata2 expression was detected in Gata3-/- otic epithelium...
  45. ncbi The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway
    Giorgio R Merlo
    Dulbecco Telethon Institute DTI, Advanced Biotechnology Center, Largo R Benzi 10, 16132 Genoa, Italy
    Dev Biol 248:157-69. 2002
    In the mouse embryo, Dlx5 is expressed in the otic placode and vesicle, and later in the semicircular canals of the inner ear...
  46. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
    ..We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse...
  47. pmc The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development
    Raymond F Robledo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Genes Dev 16:1089-101. 2002
    ..In addition, human Dlx5 and Dlx6 homeobox genes have been identified as possible candidate genes for the autosomal dominant form of the ..
  48. pmc Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development
    Jun Han
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Mech Dev 124:729-45. 2007
    ..This early function of the Msx genes is likely independent of the Bmp signaling pathway...
  49. ncbi Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limb
    Hsian Jean Chin
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030, USA
    Dev Growth Differ 49:515-21. 2007
    The homeodomain transcription factor Dlx5 has been implicated in the regulation of chondrocyte and osteoblast differentiation during endochondral ossification in the developing limb...
  50. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
    ..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
  51. pmc Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells
    Huansheng Xu
    Institute of Biosciences and Technologies, Texas A and M University System, 2121 W Holcombe, Room 820C, TX, USA
    Dev Biol 302:670-82. 2007
    ..We conclude that the main functions of Tbx1 in the inner ear are to control, cell-autonomously, contribution, size and fate of a large population of otic epithelial cells, and, cell non-autonomously, cochlear morphogenesis...
  52. ncbi Dlx5 regulates chondrocyte differentiation at multiple stages
    Andrew J Bendall
    Center for Advanced Biotechnology and Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Int J Dev Biol 47:335-44. 2003
    ..Here, we describe the expression of Dlx5 in the cartilaginous core of limb skeletal elements in chicken and mouse embryos...
  53. ncbi Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved function
    Shu Hsuan Claire Hsu
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ont, Canada N1G 2W1
    Mech Dev 123:819-30. 2006
    ..b>Dlx5 and Dlx6 are functionally redundant regulators of chondrocyte hypertrophy...
  54. ncbi Roles for Msx and Dlx homeoproteins in vertebrate development
    A J Bendall
    Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Gene 247:17-31. 2000
    ..Moreover, their ability to oppose each other's transcriptional actions implies a mechanism underlying their complementary or antagonistic functions during development...
  55. pmc Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation
    Qing Ping Zhou
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Nucleic Acids Res 32:884-92. 2004
    ..double knockout mice die at birth with multiple defects including abnormal forebrain development and decreased Dlx5 and Dlx6 expression...
  56. doi Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 135:755-65. 2008
    ..the Edn1/Ednra signaling is thought to regulate the dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation...
  57. ncbi Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, Maine
    Genesis 44:425-37. 2006
    ..and is observed in patients with split hand/split foot malformation, a malformation which is phenocopied by Dlx5/6 null mice...
  58. pmc Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2
    Rosalind S E Carney
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Cereb Cortex 19:745-59. 2009
    ..Thus, in addition to their well-characterized cross-repressive roles in dorsal/ventral patterning our analyses reveal important novel functions of Gsh2 and Pax6 in the regulation of PSB progenitor pool specification and patterning...
  59. ncbi Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx
    Weidong Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 7:439-53. 2004
    ....
  60. ncbi Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
    ..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis...
  61. ncbi The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse
    Giovanni Levi
    Laboratoire de Physiologie Général et Comparée, CNRS, UMR 8572, Museum national d histoire naturelle, Paris, France
    Mol Cell Neurosci 22:530-43. 2003
    The distalless-related homeogene Dlx5 is expressed in the olfactory placodes and derived tissues and in the anterior-basal forebrain. We investigated the role of Dlx5 in olfactory development...
  62. ncbi Endothelin-1 regulates the dorsoventral branchial arch patterning in mice
    Hidenori Ozeki
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mech Dev 121:387-95. 2004
    ..Correspondingly, the expression of Dlx5 and Dlx6, Distalless-related homeobox genes determining the ventral identity of the anterior branchial arches, and ..
  63. ncbi Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins
    G Yu
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
    Brain Res Dev Brain Res 130:217-30. 2001
    ..We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation...
  64. ncbi Fgf3 and Fgf10 are required for mouse otic placode induction
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 130:3379-90. 2003
    ..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation...
  65. ncbi Ebf1 controls early cell differentiation in the embryonic striatum
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 126:5285-94. 1999
    ....
  66. pmc Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus
    Li Chen
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 136:1317-26. 2009
    ..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei...
  67. pmc Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism
    Louis Bruno Ruest
    Department of Craniofacial Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Dev Biol 328:94-108. 2009
    ..These observations suggest that the advent of Ednra signaling in cranial NCCs may have been a crucial event in the evolution of the mammalian middle ear ossicles...
  68. pmc The transcription factor MEF2C is required for craniofacial development
    Michael P Verzi
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, Mail Code 2240, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Cell 12:645-52. 2007
    ..We show that MEF2C is required for expression of the Dlx5, Dlx6, and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-specific ..
  69. pmc Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
    Proc Natl Acad Sci U S A 108:16687-92. 2011
    ..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution...
  70. ncbi A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
    Chunqiao Liu
    Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Development 130:1327-37. 2003
    ....
  71. ncbi GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5
    Andrea Kwakowsky
    Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Dev Dyn 236:3532-44. 2007
    ..This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD...
  72. ncbi Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development
    Hiromi Yanagisawa
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9148, USA
    Development 130:1069-78. 2003
    ....
  73. ncbi Expression of mouse Foxi class genes in early craniofacial development
    Takahiro Ohyama
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Dev Dyn 231:640-6. 2004
    ....
  74. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..Pax6 up-regulation occurred only several hours postdifferentiation. The loss of Pax6 altered progenitor specification, and the Lhx1 neuronal marker was lost, indicating a role for Pax6 in the specification of forebrain neuron identity...
  75. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
    ..Immunohistochemical analysis revealed that necdin was coexpressed with Dlx2, Dlx5, or MAGE-D1 in a subpopulation of embryonic forebrain cells...
  76. doi AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
    Won Gu Jang
    Department of Pharmacology and Dental Therapeutics and BK21, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    Biochem Biophys Res Commun 404:1004-9. 2011
    ..In addition, metformin induced the phosphorylation of Smad1/5/8 and expression of Dlx5 and Runx2, whereas compound C or dominant negative AMPK inhibited these effects...
  77. ncbi Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse
    M A Crackower
    Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada
    Dev Biol 201:78-89. 1998
    ..Moreover, the data suggest that the role of the AER maintenance factor is to promote cell proliferation in the ridge. Based on our findings, we propose a model for AER maintenance in the vertebrate limb...
  78. ncbi Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon
    Andrea Faedo
    Stem Cell Research Institute, DIBIT, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:614-20. 2004
    ..5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5...
  79. pmc Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode
    Chathurani S Jayasena
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Development 135:2251-61. 2008
    ....
  80. doi Sox9 is required for invagination of the otic placode in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 317:213-24. 2008
    ....
  81. doi Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
    Helen A Thomason
    Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
    Dev Biol 321:273-82. 2008
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
  82. pmc DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC
    Jinfei Xu
    Cancer Signaling and Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 284:20593-601. 2009
    ..Recently, DLX5 was reported to act as an oncogene in lymphomas and lung cancers, although the mechanism is not known...
  83. pmc Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry
    Allison M Bond
    Developmental Biology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nat Neurosci 12:1020-7. 2009
    ..how the long, polyadenylated Evf2 noncoding RNA regulates transcription of the homeodomain transcription factors DLX5 and DLX6 in the developing mouse forebrain...
  84. doi Foxg1 is required for proper separation and formation of sensory cristae during inner ear development
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Dev Dyn 238:2725-34. 2009
    ..Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1(-/-) mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate...
  85. ncbi The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons
    Tetsuji Mori
    Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
    Eur J Neurosci 19:3129-41. 2004
    ..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs...
  86. ncbi Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation
    J K Liu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Dyn 210:498-512. 1997
    ..Antisense Dlx-1 and -6 have their highest expression in the SVZ. These results suggest that each of these Dlx genes may have a distinct role in different steps of differentiation in the basal ganglia...
  87. ncbi Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton
    C Tribioli
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Mech Dev 65:145-62. 1997
    ....
  88. pmc The evolution of the vertebrate Dlx gene family
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Proc Natl Acad Sci U S A 93:10858-63. 1996
    ..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue...
  89. ncbi Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence
    C Skogh
    Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Mol Cell Neurosci 17:811-20. 2001
    ..These results demonstrate that at least a subpopulation of neurogenic LGE precursors exhibit glial characteristics...
  90. pmc Deletion of the endothelin-A receptor gene within the developing mandible
    Louis Bruno Ruest
    Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY, 40292, USA
    Cell Tissue Res 319:447-53. 2005
    ..flanking a portion of the Ednra gene were bred with transgenic mice that express Cre recombinase under control of a Dlx5/6 enhancer element...
  91. pmc Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families
    Marjory L Givens
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    J Biol Chem 280:19156-65. 2005
    ..These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development...
  92. pmc The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons
    Junji Hirota
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:8751-5. 2004
    ..OSN development appears to be arrested between the terminal differentiation into neurons and the transition to immature neurons. Thus, Lhx2 is required for complete development of OSNs in mice...
  93. ncbi Roles of organizer factors and BMP antagonism in mammalian forebrain establishment
    Yu Ping Yang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
    Dev Biol 296:458-75. 2006
    ..These results lead to a model in which BMP antagonism supplied by exogenous tissues promotes forebrain establishment and maintenance in the murine ectoderm...
  94. ncbi Six1 controls patterning of the mouse otic vesicle
    Hidenori Ozaki
    Division of Biology, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Development 131:551-62. 2004
    ..which were expressed ventrally in the wild-type otic vesicles, were abolished, while the expression domains of Dlx5, Hmx3, Dach1 and Dach2, which were expressed dorsally in the wild-type otic vesicles, expanded ventrally...
  95. ncbi Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1
    Zunyi Zhang
    Department of Cell and Molecular Biology, Tulane University, 2000 Stern Hall, 6400 Freret St, New Orleans, LA 70118, USA zzhang
    Mech Dev 120:1469-79. 2003
    ..We show that the expression of Cbfa1 and Dlx5, two genes encode transcription factors that are critical for bone differentiation, overlaps with that of Msx1 and ..
  96. ncbi BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 281:40515-26. 2006
    ..show regulation of the Runx2 gene by several homeodomain proteins: MSX2 and CDP/cut repress whereas DLX3 and DLX5 activate endogenous Runx2 expression and promoter activity in non-osseous cells and osteoblasts...
  97. ncbi Methylation of the mouse DIx5 and Osx gene promoters regulates cell type-specific gene expression
    Ji Yun Lee
    Department of Anatomy, School of Medicine, Kyungpook National University, Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700 422, Korea
    Mol Cells 22:182-8. 2006
    b>Dlx5 and Osx are master regulatory proteins essential for initiating the cascade leading to osteoblast differentiation in mammals, but the mechanism of osteoblast-specific expression is not fully understood...
  98. ncbi Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
    Gracie L Andrews
    Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
    Mol Cell Neurosci 23:107-20. 2003
    ..These data suggest that DLX genes act as forebrain-specific factors linking general neuron-inducing signals to region-specific neuron differentiation programs...
  99. ncbi Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes
    Isabelle Anselme
    Biologie du Développement, CNRS UMR7622, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
    Dev Biol 304:208-20. 2007
    ..Given the diversity, localisation and nature of the defects, we propose that some of them are caused by the elimination of the IrxB cluster, while others result from the loss of one or several of the Fts, Ftm and Fto genes...
  100. ncbi Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation
    Jason E Long
    Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:3230-43. 2007
    ....
  101. ncbi Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
    Brain Res Dev Brain Res 141:39-53. 2003
    ..5. Our results suggest that the marginal zone contains two main types of neurons: Cajal-Retzius cells derived from the pallium, and migrating interneurons derived from the subpallium...

Research Grants19

  1. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel Choo; Fiscal Year: 2009
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
  2. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel I Choo; Fiscal Year: 2010
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
  3. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2010
    ....
  4. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel Choo; Fiscal Year: 2007
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
  5. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  6. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  7. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  8. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....