Research Topics
Genomes and Genes
| Dlx5SummaryGene Symbol: Dlx5 Description: distal-less homeobox 5 Alias: AI385752, homeobox protein DLX-5 Species: mouse Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Defective neuronogenesis in the absence of Dlx5Marzia Perera
Laboratorio di Biologia dello Sviluppo, Istituto Nazionale per la Ricerca sul Cancro IST, 16132 Genova, Italy
Mol Cell Neurosci 25:153-61. 2004..Single or compound inactivation of Dlx1, Dlx2, or Dlx5 in the mouse causes defects of neuronal migration and differentiation...
Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signalingGinam Cho
Children s Hospital of Philadelphia, ARC 516h, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
Mol Cell Biol 28:1565-72. 2008..These data indicate that Sizn1 is a positive modulator of BMP signaling and provide further insight into how BMP signaling can be modulated in neuronal progenitor subsets to influence cell-type-specific gene expression and development...- Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expressionThorsten Stühmer
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
Development 129:245-52. 2002..This approach showed that ectopic expression of Dlx2 and Dlx5 induced the expression of glutamic acid decarboxylases (GADs), the enzymes that synthesize GABA... - Abnormal urethra formation in mouse models of split-hand/split-foot malformation type 1 and type 4Kentaro Suzuki
Center for Animal Resources and Development, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Eur J Hum Genet 16:36-44. 2008..type 1 (SHFM1) is linked to genomic deletions or rearrangements, which includes the distal-less-related homeogenes DLX5 and DLX6 as well as DSS1... - Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner earVictoria E Abraira
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Development 135:4091-9. 2008..Thus, the Lrig3/Ntn1 feedback loop dictates when and where basement membrane breakdown occurs during canal development, revealing a new mechanism of complex tissue morphogenesis... - Partially overlapping expression of Gata2 and Gata3 during inner ear developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
Dev Dyn 231:775-81. 2004..5 and Gata3 expression was unchanged. In contrast, a delay and strong reduction of Gata2 expression was detected in Gata3-/- otic epithelium... - TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone developmentTomoyo Sasaki
Center for Craniofacial Molecular Biology School of Dentistry University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Development 133:371-81. 2006.... - Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila HmxWeidong Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Dev Cell 7:439-53. 2004.... - Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactionsUlla Pirvola
Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
Dev Biol 273:350-60. 2004..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis... - Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neuronsCeline Zimmer
Developmental Biology Institute of Marseille, NMDA, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France
Cereb Cortex 14:1408-20. 2004..This suggests that laminar determination of upper cortical layer neurons occurs during the earliest stages of corticogenesis... - Endothelin-1 regulates the dorsoventral branchial arch patterning in miceHidenori Ozeki
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Mech Dev 121:387-95. 2004..Correspondingly, the expression of Dlx5 and Dlx6, Distalless-related homeobox genes determining the ventral identity of the anterior branchial arches, and .. - Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitationQing Ping Zhou
Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
Nucleic Acids Res 32:884-92. 2004..double knockout mice die at birth with multiple defects including abnormal forebrain development and decreased Dlx5 and Dlx6 expression... - Dlx5 regulates chondrocyte differentiation at multiple stagesAndrew J Bendall
Center for Advanced Biotechnology and Medicine, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Int J Dev Biol 47:335-44. 2003..Here, we describe the expression of Dlx5 in the cartilaginous core of limb skeletal elements in chicken and mouse embryos... - BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expressionMi Hye Lee
Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, 700 422 Korea
J Biol Chem 278:34387-94. 2003..We found that Dlx5 is specifically expressed in osteogenic cells, and is specifically induced by BMP-2 or -4 signaling but not by .. - Fgfr1 regulates patterning of the pharyngeal regionNina Trokovic
Institute of Biotechnology, Viikki Biocenter, 00014 University of Helsinki, Finland
Genes Dev 17:141-53. 2003..Our results indicate that Fgfr1 patterns the pharyngeal region to create a permissive environment for neural crest cell migration... - Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndromeShin ichi Horike
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mail Stop 84 171, University of California, Berkeley, California 94720, USA
Nat Genet 37:31-40. 2005..Several sequences mapped to an imprinted gene cluster on chromosome 6, including Dlx5 and Dlx6, whose transcription was roughly two times greater in brains of Mecp2-null mice compared with those of .. - Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of ShhMartin M Riccomagno
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 19:1612-23. 2005..signaling is active in dorsal regions of the otic vesicle, where it functions to regulate the expression of genes (Dlx5/6 and Gbx2) necessary for vestibular morphogenesis... 
Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch developmentTakahiro Sato
Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Development 135:755-65. 2008..the Edn1/Ednra signaling is thought to regulate the dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation...- Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone developmentJun Han
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
Mech Dev 124:729-45. 2007..This early function of the Msx genes is likely independent of the Bmp signaling pathway... - Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limbHsian Jean Chin
Department of Genetics and Developmental Biology, University of Connecticut Health Center, School of Medicine, Farmington, Connecticut 06030, USA
Dev Growth Differ 49:515-21. 2007The homeodomain transcription factor Dlx5 has been implicated in the regulation of chondrocyte and osteoblast differentiation during endochondral ossification in the developing limb... - Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zoneMarie Catherine Tiveron
Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
J Neurosci 26:13273-8. 2006..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis... - Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cellsHuansheng Xu
Institute of Biosciences and Technologies, Texas A and M University System, 2121 W Holcombe, Room 820C, TX, USA
Dev Biol 302:670-82. 2007..We conclude that the main functions of Tbx1 in the inner ear are to control, cell-autonomously, contribution, size and fate of a large population of otic epithelial cells, and, cell non-autonomously, cochlear morphogenesis... - Dlx5- and Dlx6-mediated chondrogenesis: Differential domain requirements for a conserved functionShu Hsuan Claire Hsu
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ont, Canada N1G 2W1
Mech Dev 123:819-30. 2006..b>Dlx5 and Dlx6 are functionally redundant regulators of chondrocyte hypertrophy... - Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatusRaymond F Robledo
The Jackson Laboratory, Bar Harbor, Maine
Genesis 44:425-37. 2006..and is observed in patients with split hand/split foot malformation, a malformation which is phenocopied by Dlx5/6 null mice... - Gata3 is required for early morphogenesis and Fgf10 expression during otic developmentKersti Lilleväli
Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
Mech Dev 123:415-29. 2006..Inactivation of Gata3 leads also to a loss of Fgf10 expression in otic epithelium and auditory ganglion demonstrating that Gata3 is an important regulator of Fgf-signalling during otic development... - The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivatorJianchi Feng
Program in Neurobiology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
Genes Dev 20:1470-84. 2006.... - Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crestMamoru Ishii
Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
Development 132:4937-50. 2005..This increase in apoptosis may contribute to the mispatterning of the cranial ganglia and the hypoplasia of the first arch... - Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsyInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
Nat Neurosci 8:1059-68. 2005..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss... - Jaw transformation with gain of symmetry after Dlx5/Dlx6 inactivation: mirror of the past?Annemiek Beverdam
Laboratory of Molecular Morphogenesis, National Institute for Cancer Research, Genova, Italy
Genesis 34:221-7. 2002..Here we show that simultaneous inactivation of the murine homeobox genes Dlx5 and Dlx6 results in the transformation of the lower jaw into an upper jaw and in symmetry of the snout... - Specification of the mammalian cochlea is dependent on Sonic hedgehogMartin M Riccomagno
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 16:2365-78. 2002..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh... - Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5D Acampora
International Institute of Genetic and Biophysics, CNR, Via Marconi 10, Italy
Development 126:3795-809. 1999The Dlx5 gene encodes a Distal-less-related DNA-binding homeobox protein first expressed during early embryonic development in anterior regions of the mouse embryo... - Dlx5 regulates regional development of the branchial arches and sensory capsulesM J Depew
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, Oral Biology and Biomedical Sciences, University of California at San Fran
Development 126:3831-46. 1999We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene... - Mutations of the homeobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neuronsS A Anderson
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143, USA
Neuron 19:27-37. 1997..Several lines of evidence suggest that mutations in Dlx-1 and Dlx-2 produce abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons... - Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second archesM Qiu
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
Dev Biol 185:165-84. 1997..Finally, the Dlx-2 and Dlx-1 and -2 mutants have ectopic skull components that resemble bones and cartilages found in phylogenetically more primitive vertebrates... - The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal developmentRaymond F Robledo
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Genes Dev 16:1089-101. 2002..In addition, human Dlx5 and Dlx6 homeobox genes have been identified as possible candidate genes for the autosomal dominant form of the .. - The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathwayGiorgio R Merlo
Dulbecco Telethon Institute DTI, Advanced Biotechnology Center, Largo R Benzi 10, 16132 Genoa, Italy
Dev Biol 248:157-69. 2002In the mouse embryo, Dlx5 is expressed in the otic placode and vesicle, and later in the semicircular canals of the inner ear... - Cloning and characterization of two members of the vertebrate Dlx gene familyA Simeone
International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
Proc Natl Acad Sci U S A 91:2250-4. 1994..We cloned and studied the expression of two members of this family, which we named Dlx5 and Dlx6, in human and mouse... - Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional functionY Masuda
Department of Geriatric Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka cho, Obu, Aichi 474 8522, Japan
J Biol Chem 276:5331-8. 2001b>Dlx5, a member of the Dlx family of homeodomain proteins, plays a critical role in bone development and fracture healing... - DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiationD D Eisenstat
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience and Developmental Biology, University of California at San Francisco, California 94143 0984, USA
J Comp Neurol 414:217-37. 1999..In the basal telencephalon, these DLX-positive cells differentiate into projection neurons of the striatum and pallidum as well as interneurons, some of which migrate to the cerebral cortex and the olfactory bulb... - Roles for Msx and Dlx homeoproteins in vertebrate developmentA J Bendall
Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Gene 247:17-31. 2000..Moreover, their ability to oppose each other's transcriptional actions implies a mechanism underlying their complementary or antagonistic functions during development... - A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrainT Zerucha
Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
J Neurosci 20:709-21. 2000Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns... - Specification of jaw subdivisions by Dlx genesMichael J Depew
Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
Science 298:381-5. 2002..mechanisms that specify the identity of skeletal elements within the arches, we examined mice lacking expression of Dlx5 and Dlx6, linked homeobox genes expressed distally but not proximally within the arches... - Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatumL Sussel
Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
Development 126:3359-70. 1999..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage... - Multiple functions of Dlx genesG R Merlo
Laboratory of Molecular Morphogenesis, National Cancer Institute IST, Genova, Italy
Int J Dev Biol 44:619-26. 2000..In addition, Dlx5 and Dlx6 are expressed in differentiating osteoblasts... - Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signalingZhengshi Lin
Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
Development 132:2309-18. 2005..fates such as the endolymphatic duct and semicircular canals by positively regulating genes such as Wnt2b and Dlx5. However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression... - Hmx2 homeobox gene control of murine vestibular morphogenesisW Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Development 128:5017-29. 2001..The developmental regulators Bmp4, Dlx5 and Pax2 all play a critical role in inner ear ontogeny, and the expression of each of these genes is affected in .. - Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivoSara Paina
Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
J Neurosci 31:2675-87. 2011..Dlx2 and Dlx5 interact with homeodomain binding sequences within the Wnt5a locus and activate its transcription... - Ebf1 controls early cell differentiation in the embryonic striatumS Garel
Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
Development 126:5285-94. 1999.... - AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cellsWon Gu Jang
Department of Pharmacology and Dental Therapeutics and BK21, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
Biochem Biophys Res Commun 404:1004-9. 2011..In addition, metformin induced the phosphorylation of Smad1/5/8 and expression of Dlx5 and Runx2, whereas compound C or dominant negative AMPK inhibited these effects... - Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamusLi Chen
Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
Development 136:1317-26. 2009..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei... - Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonismLouis Bruno Ruest
Department of Craniofacial Biology, University of Colorado Denver, Aurora, CO 80045, USA
Dev Biol 328:94-108. 2009..These observations suggest that the advent of Ednra signaling in cranial NCCs may have been a crucial event in the evolution of the mammalian middle ear ossicles... - Mouse orthologue of ARX, a gene mutated in several X-linked forms of mental retardation and epilepsy, is a marker of adult neural stem cells and forebrain GABAergic neuronsElena Colombo
Stem Cell Research Institute, DIBIT, San Raffaele Science Park, Via Olgettina 58, 20132 Milan, Italy
Dev Dyn 231:631-9. 2004..is enhanced during differentiation of the subpallial structures of the ganglionic eminences, overlapping with Dlx2, Dlx5, and Gad1 transcriptional domains... - The transcription factor MEF2C is required for craniofacial developmentMichael P Verzi
Cardiovascular Research Institute and Department of Biochemistry and Biophysics, Mail Code 2240, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Cell 12:645-52. 2007..We show that MEF2C is required for expression of the Dlx5, Dlx6, and Hand2 transcription factor genes in the branchial arches, and we identify a branchial arch-specific .. - GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5Andrea Kwakowsky
Department of Gene Technology and Developmental Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
Dev Dyn 236:3532-44. 2007..This pattern correlates well with the expression of Dlx2 and Dlx5, known as upstream regulators of GAD... - Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatmentMuriel Rhinn
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
Proc Natl Acad Sci U S A 108:16687-92. 2011..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution... - Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouseM A Crackower
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Canada
Dev Biol 201:78-89. 1998..Moreover, the data suggest that the role of the AER maintenance factor is to promote cell proliferation in the ridge. Based on our findings, we propose a model for AER maintenance in the vertebrate limb... - Fgf3 and Fgf10 are required for mouse otic placode inductionTracy J Wright
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
Development 130:3379-90. 2003..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation... - Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteinsG Yu
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, 401 Parnassus Avenue, University of California at San Francisco, CA 94143 0984, USA
Brain Res Dev Brain Res 130:217-30. 2001..We provide evidence that GRIP1b can function as a transcriptional co-activator of DLX2 and DLX5. Glutamate receptors inhibit this co-activation... - A role for the mesenchymal T-box gene Brachyury in AER formation during limb developmentChunqiao Liu
Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
Development 130:1327-37. 2003.... - Pax6 regulates the identity of embryonic diencephalic neuronsG S Mastick
Department of Biology, University of Nevada, Reno, Nevada 89557, USA
Mol Cell Neurosci 17:190-207. 2001..Pax6 up-regulation occurred only several hours postdifferentiation. The loss of Pax6 altered progenitor specification, and the Lhx1 neuronal marker was lost, indicating a role for Pax6 in the specification of forebrain neuron identity... - Expression of mouse Foxi class genes in early craniofacial developmentTakahiro Ohyama
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
Dev Dyn 231:640-6. 2004.... - Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial developmentHiromi Yanagisawa
Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9148, USA
Development 130:1069-78. 2003.... - Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteinsTakaaki Kuwajima
Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
J Neurosci 26:5383-92. 2006..Immunohistochemical analysis revealed that necdin was coexpressed with Dlx2, Dlx5, or MAGE-D1 in a subpopulation of embryonic forebrain cells... - BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38Arnau Ulsamer
Departament de Ciències Fisiològiques II, Universitat de Barcelona, IDIBELL, L Hospitalet de Llobregat, E 08907, Spain
J Biol Chem 283:3816-26. 2008..Our results demonstrate that induction of Dlx5 by BMP-2 mediates Osterix transcriptional activation... - Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamusGracie L Andrews
Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
Mol Cell Neurosci 23:107-20. 2003..These data suggest that DLX genes act as forebrain-specific factors linking general neuron-inducing signals to region-specific neuron differentiation programs... - The evolution of the vertebrate Dlx gene familyD W Stock
Department of Anthropology, Pennsylvania State University, University Park 16802, USA
Proc Natl Acad Sci U S A 93:10858-63. 1996..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue... - A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic miceYinfei Tan
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Cancer Res 68:1296-302. 2008..The proximal breakpoint maps to a region near a locus comprising the linked homeobox/transcription factor genes Dlx5 and Dlx6... - Sox9 is required for invagination of the otic placode in miceFrancisco Barrionuevo
Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
Dev Biol 317:213-24. 2008.... - Notch signaling augments the canonical Wnt pathway to specify the size of the otic placodeChathurani S Jayasena
Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
Development 135:2251-61. 2008.... - Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signalingHelen A Thomason
Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
Dev Biol 321:273-82. 2008..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting... - Deletion of the endothelin-A receptor gene within the developing mandibleLouis Bruno Ruest
Department of Molecular, Cellular and Craniofacial Biology and the Birth Defects Center, University of Louisville, Louisville, KY, 40292, USA
Cell Tissue Res 319:447-53. 2005..flanking a portion of the Ednra gene were bred with transgenic mice that express Cre recombinase under control of a Dlx5/6 enhancer element... - The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouseGiovanni Levi
Laboratoire de Physiologie Général et Comparée, CNRS, UMR 8572, Museum national d histoire naturelle, Paris, France
Mol Cell Neurosci 22:530-43. 2003The distalless-related homeogene Dlx5 is expressed in the olfactory placodes and derived tissues and in the anterior-basal forebrain. We investigated the role of Dlx5 in olfactory development... - Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial originRobert F Hevner
Department of Pathology, University of Washington, Harborview Medical Center, Box 359630, 325 Ninth Ave, Seattle, WA 98104 2499, USA
Brain Res Dev Brain Res 141:39-53. 2003..5. Our results suggest that the marginal zone contains two main types of neurons: Cajal-Retzius cells derived from the pallium, and migrating interneurons derived from the subpallium... - DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYCJinfei Xu
Cancer Signaling and Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 284:20593-601. 2009..Recently, DLX5 was reported to act as an oncogene in lymphomas and lung cancers, although the mechanism is not known... - Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitryAllison M Bond
Developmental Biology and Department of Pediatrics, Children s Memorial Hospital and Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Nat Neurosci 12:1020-7. 2009..how the long, polyadenylated Evf2 noncoding RNA regulates transcription of the homeodomain transcription factors DLX5 and DLX6 in the developing mouse forebrain... - Foxg1 is required for proper separation and formation of sensory cristae during inner ear developmentChan Ho Hwang
Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
Dev Dyn 238:2725-34. 2009..Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1(-/-) mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate... - Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein familiesMarjory L Givens
Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
J Biol Chem 280:19156-65. 2005..These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development... - Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1Zunyi Zhang
Department of Cell and Molecular Biology, Tulane University, 2000 Stern Hall, 6400 Freret St, New Orleans, LA 70118, USA zzhang
Mech Dev 120:1469-79. 2003..We show that the expression of Cbfa1 and Dlx5, two genes encode transcription factors that are critical for bone differentiation, overlaps with that of Msx1 and .. - Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiationJason E Long
Nina Ireland Laboratory of Developmental Neurobiology, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 27:3230-43. 2007.... - Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalonAndrea Faedo
Stem Cell Research Institute, DIBIT, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
Dev Dyn 231:614-20. 2004..5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5... - Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminenceC Skogh
Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
Mol Cell Neurosci 17:811-20. 2001..These results demonstrate that at least a subpopulation of neurogenic LGE precursors exhibit glial characteristics... - Roles of organizer factors and BMP antagonism in mammalian forebrain establishmentYu Ping Yang
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
Dev Biol 296:458-75. 2006..These results lead to a model in which BMP antagonism supplied by exogenous tissues promotes forebrain establishment and maintenance in the murine ectoderm... - The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neuronsTetsuji Mori
Department of Cell Science, Institute of Biomedical Sciences, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960 1295 Japan
Eur J Neurosci 19:3129-41. 2004..Neurotransmitter phenotypes other than cholinergic in the basal forebrain appeared intact. From these results, we suggested that L3/Lhx8 has a pivotal and specific role in the development and/or maintenance of BFCNs... - Mash1 regulates neurogenesis in the ventral telencephalonS Casarosa
IGBMC, CNRS INSERM Universite Louis Pasteur, BP 163, CU de Strasbourg, France
Development 126:525-34. 1999..Therefore, Mash1 is an important regulator of neurogenesis in the ventral telencephalon, where it is required both to specify neuronal precursors and to control the timing of their production... - BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional networkMohammad Q Hassan
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Biol Chem 281:40515-26. 2006..show regulation of the Runx2 gene by several homeodomain proteins: MSX2 and CDP/cut repress whereas DLX3 and DLX5 activate endogenous Runx2 expression and promoter activity in non-osseous cells and osteoblasts... - The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neuronsJunji Hirota
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 101:8751-5. 2004..OSN development appears to be arrested between the terminal differentiation into neurons and the transition to immature neurons. Thus, Lhx2 is required for complete development of OSNs in mice... - Methylation of the mouse DIx5 and Osx gene promoters regulates cell type-specific gene expressionJi Yun Lee
Department of Anatomy, School of Medicine, Kyungpook National University, Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, Daegu 700 422, Korea
Mol Cells 22:182-8. 2006b>Dlx5 and Osx are master regulatory proteins essential for initiating the cascade leading to osteoblast differentiation in mammals, but the mechanism of osteoblast-specific expression is not fully understood... - Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiationJ K Liu
Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
Dev Dyn 210:498-512. 1997..Antisense Dlx-1 and -6 have their highest expression in the SVZ. These results suggest that each of these Dlx genes may have a distinct role in different steps of differentiation in the basal ganglia... - Defects in brain patterning and head morphogenesis in the mouse mutant Fused toesIsabelle Anselme
Biologie du Développement, CNRS UMR7622, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75252 Paris Cedex 05, France
Dev Biol 304:208-20. 2007..Given the diversity, localisation and nature of the defects, we propose that some of them are caused by the elimination of the IrxB cluster, while others result from the loss of one or several of the Fts, Ftm and Fto genes... - Organization of the mouse dorsal thalamus based on topology, calretinin immnunostaining, and gene expressionGertrudis González
Department of Morphological Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain
Brain Res Bull 57:439-42. 2002..More studies will be needed to analyze if the compartments proposed in this study represent true histogenetic units, and to find homologous developmental fields in all vertebrates... - Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeletonC Tribioli
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Mech Dev 65:145-62. 1997.... - Six1 controls patterning of the mouse otic vesicleHidenori Ozaki
Division of Biology, Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
Development 131:551-62. 2004..which were expressed ventrally in the wild-type otic vesicles, were abolished, while the expression domains of Dlx5, Hmx3, Dach1 and Dach2, which were expressed dorsally in the wild-type otic vesicles, expanded ventrally... - Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw developmentOlga Britanova
Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, Goettingen, Germany
Am J Hum Genet 79:668-78. 2006.... - Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connectionsAmbra A Zaghetto
Dulbecco Telethon Institute Consiglio Nazionale delle Ricerche Institute for Biomedical Technologies Milano, 20090 Segrate, Italy
J Neurosci 27:9757-68. 2007..Likewise, in Dlx5-/- embryos, in which the primary connections fail to form, Wnt-beta catenin response on the surface of the FB is ..
Research Grants
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2009..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel I Choo; Fiscal Year: 2010..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- Longitudinal axon guidance by long range cues in the embryonic brainGRANT STEPHEN MASTICK; Fiscal Year: 2010....
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2007..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- Regulation of Laminar Fate in Cerebral CortexRobert Hevner; Fiscal Year: 2006..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
- Molecular Development of the Endolymphatic Duct and SacDaniel Choo; Fiscal Year: 2005..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
- PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAINGRANT MASTICK; Fiscal Year: 2004..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
- Longitudinal axon guidance by long range cues in the embryonic brainGRANT STEPHEN MASTICK; Fiscal Year: 2011....