Dlx3

Summary

Gene Symbol: Dlx3
Description: distal-less homeobox 3
Alias: AV237891, Dlx-3, homeobox protein DLX-3, DII C
Species: mouse

Top Publications

  1. pmc Abnormal placental development and early embryonic lethality in EpCAM-null mice
    Keisuke Nagao
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8543. 2009
  2. ncbi Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
    Bin Fan
    Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Biol 303:222-30. 2007
  3. ncbi Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
    Kathryn Ivey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
    Dev Biol 255:230-7. 2003
  4. pmc Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Development 135:2083-91. 2008
  5. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
  6. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
  7. ncbi Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
  8. doi Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 377:428-48. 2013
  9. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
  10. pmc Placental failure in mice lacking the homeobox gene Dlx3
    M I Morasso
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:162-7. 1999

Scientific Experts

  • Zhiyong Zhao
  • M S Roberson
  • GRANT STEPHEN MASTICK
  • M I Morasso
  • K A Berghorn
  • Marc P Stemmler
  • D M Juriloff
  • H Toresson
  • Nathalie Coré
  • Olivier Duverger
  • Joonsung Hwang
  • André L P Tavares
  • Jane B Lian
  • Claudia Compagnucci
  • David E Clouthier
  • Mohammad Q Hassan
  • S J Choi
  • Takahiro Sato
  • Michael J Depew
  • Ariane Berdal
  • Chihiro Yamagishi
  • Hiroki Kurihara
  • Keiko Uchida
  • Sung Ho Lee
  • Na Zhao
  • Giovanni Levi
  • Kenta Sumiyama
  • Guobin Yang
  • Dagmara A Dettlaff-Swiercz
  • Renée K Edlund
  • M Hughes
  • Judith Reichmann
  • Valerie Begay
  • Patricia A Clark
  • Juliane Isaac
  • Angela Zah
  • Junko Okano
  • Hong Wei Sun
  • Bong Kyu Kim
  • Yanping Zhang
  • Katherine Kuhn
  • Francie Barron
  • Hiroyuki Yamagishi
  • Sandra Blanco
  • Simon J Tunster
  • Rosemary Oh-McGinnis
  • Yong Ri Jin
  • Kathryn Ivey
  • Maxence Vieux-Rochas
  • Mark C Udey
  • J Q Feng
  • N Haruyama
  • I S Song
  • Thomas C Hart
  • Louis Bruno Ruest
  • Eglantine Heude
  • Michelle L Brinkmeier
  • Keisuke Nagao
  • Giorgio R Merlo
  • Yukiko Kurihara
  • Rieko Asai
  • David G Simmons
  • Yumiko Kawamura
  • Yasunobu Uchijima
  • Sun Jin Choi
  • Motoko Aoki
  • Ute Schaeper
  • Nadezda Radoja
  • Li Han
  • Bin Fan
  • Stefan Offermanns
  • Douglas R Mackay
  • Achim Leutz
  • Susan Mackem
  • Marie Catherine Tiveron
  • Dan Zou
  • Billie A Moore-Scott
  • K M Weiss
  • Gary S Stein
  • Amjad Javed
  • Andre J Van Wijnen
  • Janet L Stein
  • Sonia Ghoul-Mazgar
  • Deepak Srivastava
  • Kenneth J Woodside
  • Ryuichi Yamada
  • Junji Hirota
  • J T Wright
  • T C Hart
  • Kyo Nyeo Oh

Detail Information

Publications90

  1. pmc Abnormal placental development and early embryonic lethality in EpCAM-null mice
    Keisuke Nagao
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8543. 2009
    ..EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells...
  2. ncbi Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth
    Bin Fan
    Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Biol 303:222-30. 2007
    ..Our study demonstrates the important role of HAI-1 in maintaining the integrity of basement membrane most likely by regulating extracellular proteolytic activities during placental development...
  3. ncbi Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme
    Kathryn Ivey
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9104, USA
    Dev Biol 255:230-7. 2003
    ..Expression of genes encoding the ET-1-dependent transcription factors Dlx3, Dlx6, dHAND, and eHAND was specifically downregulated in the pharyngeal arches of Galpha(q)/Galpha(11)-deficient ..
  4. pmc Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Development 135:2083-91. 2008
    ..These data indicate that the three differentiated trophoblast cell types in the labyrinth arise from distinct and autonomous precursors in the chorion that are patterned before morphogenesis begins...
  5. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
    ..Here, we demonstrate the central role of Dlx3 as a crucial transcriptional regulator of hair formation and regeneration...
  6. pmc An endothelin-1 switch specifies maxillomandibular identity
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:18806-11. 2008
    ..Also, we show that, within PA1, CNCCs are competent to form both mandibular and maxillary structures and that an Edn1 switch is responsible for the choice of either morphogenetic program...
  7. ncbi Specification of jaw subdivisions by Dlx genes
    Michael J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, 401 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Science 298:381-5. 2002
    ..We suggest that nested Dlx expression in the arches patterns their proximodistal axes. Evolutionary acquisition and subsequent refinement of jaws may have been dependent on modification of Dlx expression...
  8. doi Pattern and polarity in the development and evolution of the gnathostome jaw: both conservation and heterotopy in the branchial arches of the shark, Scyliorhinus canicula
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 377:428-48. 2013
    ....
  9. ncbi Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches
    M Qiu
    Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143 0984, USA
    Dev Biol 185:165-84. 1997
    ..Finally, the Dlx-2 and Dlx-1 and -2 mutants have ectopic skull components that resemble bones and cartilages found in phylogenetically more primitive vertebrates...
  10. pmc Placental failure in mice lacking the homeobox gene Dlx3
    M I Morasso
    Laboratory of Molecular Genetics, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:162-7. 1999
    b>Dlx3 is a homeodomain transcription factor and a member of the vertebrate Distal-less family. Targeted deletion of the mouse Dlx3 gene results in embryonic death between day 9...
  11. pmc Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch
    André L P Tavares
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Dev Biol 371:47-56. 2012
    ..Together, our results illustrate an integral role for ectoderm-derived Edn1 in early arch morphogenesis, particularly in the intermediate domain...
  12. doi Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
    Takahiro Sato
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 135:755-65. 2008
    ..This RMCE-mediated knock-in system can serve as a useful tool for studies on gene functions in craniofacial development...
  13. doi Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development
    Keiko Uchida
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan Health Center, Keio University, Kanagawa, Japan
    Dev Biol 418:89-97. 2016
    ..This is the first demonstration of the essential role of IP3/IP3Rs signaling in the development of the vasculature at the embryonic-maternal interface. ..
  14. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis...
  15. pmc Mutant DLX 3 disrupts odontoblast polarization and dentin formation
    S J Choi
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA
    Dev Biol 344:682-92. 2010
    ..A 4-bp deletion mutation in the Distal-Less 3 (DLX3) gene is etiologic for most cases of TDO...
  16. doi Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center
    Claudia Compagnucci
    Department of Craniofacial Development, King s College London, Guy s Hospital, London SE1 9RT, United Kingdom
    Genesis 49:307-25. 2011
    ..Pax6 therefore regulates craniofacial form, at stages when CNC has just arrived in the frontonasal region, through its control of surface cephalic ectodermal competence to form an essential craniofacial patterning center...
  17. pmc Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis
    Francie Barron
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    Development 138:2249-59. 2011
    ..Hand2 thus appears to establish a distal mandibular arch domain that is conducive for lower jaw development, including the initiation of tongue mesenchyme morphogenesis...
  18. doi DLX3 negatively regulates osteoclastic differentiation through microRNA-124
    Na Zhao
    Department of Prosthodontics, Peking University School and Hospital of Stomatology, PR China
    Exp Cell Res 341:166-76. 2016
    Homeodomain gene Distal-less-3 (DLX3) plays an essential role in the development of bones. Mutations of DLX3 are closely associated with Tricho-Dento-Osseous (TDO) syndrome featured with increased bone formation...
  19. pmc Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders
    André L P Tavares
    Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, CO 80108, United States
    Dev Biol 400:191-201. 2015
    ....
  20. pmc Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers
    Renée K Edlund
    Program in Developmental Biology, Baylor College of Medicine, BCM295, 1 Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 390:1-13. 2014
    ..Our results suggest that Foxi3 may play a role in the establishment of signaling centers in the branchial arches that are required for neural crest survival, patterning and the subsequent development of branchial arch derivatives. ..
  21. pmc Estrogen Receptor α Regulates Dlx3-Mediated Osteoblast Differentiation
    Sung Ho Lee
    College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Korea
    Mol Cells 39:156-62. 2016
    ..b>Dlx3 is essential for the skeletal development and plays an important role in osteoblast differentiation...
  22. doi BMP-2 induction of Dlx3 expression is mediated by p38/Smad5 signaling pathway in osteoblastic MC3T3-E1 cells
    Guobin Yang
    The State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China
    J Cell Physiol 229:943-54. 2014
    b>Dlx3 is essential for osteoblast differentiation and bone formation, and its expression is regulated by bone morphogenetic protein-2 (BMP-2)...
  23. doi Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta
    M Hughes
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada
    Placenta 34:831-5. 2013
    ..Our findings suggest that LY6E is expressed in differentiated syncytiotrophoblast and may also be useful as an early marker, expressed in progenitors of this cell-type...
  24. pmc Matrix metalloproteinase 9 is a distal-less 3 target-gene in placental trophoblast cells
    Patricia A Clark
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Am J Physiol Cell Physiol 305:C173-81. 2013
    ..Microarray studies in mouse placenta suggested that MMP-9 transcript abundance was dependent on distal-less 3 (Dlx3), a placental-specific transcriptional regulator; however, it was not clear if this was a direct or indirect effect...
  25. pmc Cutaneous retinoic acid levels determine hair follicle development and downgrowth
    Junko Okano
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:39304-15. 2012
    ..Our results establish that proper RA distribution is essential for morphogenesis, development, and differentiation of hfs...
  26. pmc The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate
    Sandra Blanco
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 7:e1002403. 2011
    ..Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate...
  27. pmc Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12230-40. 2012
    During development, Dlx3 is expressed in ectodermal appendages such as hair and teeth...
  28. pmc The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice
    Judith Reichmann
    MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Universityof Edinburgh, Crewe Road, Edinburgh, UK
    Hum Mol Genet 22:1791-806. 2013
    ....
  29. pmc In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, NIH, Bethesda, Maryland
    J Cell Physiol 228:654-64. 2013
    Mutations in DLX3 in humans lead to defects in craniofacial and appendicular bones, yet the in vivo activities related to Dlx3 function during normal skeletal development have not been fully elucidated...
  30. pmc Hairless plays a role in formation of inner root sheath via regulation of Dlx3 gene
    Bong Kyu Kim
    Department of Medical Life Sciences, The Catholic University of Korea, Seoul, 137 701, Korea
    J Biol Chem 287:16681-8. 2012
    ..In this study, we documented abnormal formation of inner root sheath (IRS), suppressed expression of Dlx3, and IRS keratins in the Hr(Hp)/Hr(Hp) skin...
  31. pmc Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2
    Yanping Zhang
    Department of Biomedical Sciences, TAMHSC Baylor College of Dentistry, Dallas, Texas, USA
    Dev Dyn 241:924-40. 2012
    ..To determine the role of Twist1 during mandibular development, we used the Hand2-Cre transgene to conditionally inactivate the gene in the neural crest cells populating the mandibular pharyngeal arch...
  32. ncbi Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias
    Nadezda Radoja
    Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD 20892, USA
    Development 134:13-8. 2007
    ..b>Dlx3 and p63 act as part of the transcriptional regulatory pathways relevant in ectoderm derivatives, and autosomal ..
  33. pmc Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Dev Biol 293:499-512. 2006
    ..Together, these analyses establish an essential role for Eya1 and Six genes in patterning the third pouch into organ-specific primordia...
  34. ncbi BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 281:40515-26. 2006
    ..Here we show that BMP2 induces DLX3, a homeodomain protein that activates Runx2 gene transcription...
  35. ncbi Tshz1 is required for axial skeleton, soft palate and middle ear development in mice
    Nathalie Coré
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, F 13288 Marseille Cedex 09, France
    Dev Biol 308:407-20. 2007
    ..Finally, we demonstrate that Tshz1 is required for the development of the soft palate...
  36. pmc Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo
    Ute Schaeper
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 104:15376-81. 2007
    ..These data demonstrate that Gab1 induces different biological responses through the recruitment of distinct effectors and that different modes of recruitment for Gab1 are required in different organs...
  37. pmc A 4 bp deletion mutation in DLX3 enhances osteoblastic differentiation and bone formation in vitro
    Sun Jin Choi
    Human Craniofacial Genetics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, USA
    Bone 42:162-71. 2008
    A 4 base-pair deletion mutation in the Distal-less 3 (DLX3) gene is etiologic for Tricho-Dento-Osseous syndrome (TDO). A cardinal feature of TDO is an increased thickness and density of bone...
  38. ncbi Analysis of the gene regulatory program induced by the homeobox transcription factor distal-less 3 in mouse placenta
    Li Han
    T3 004d Veterinary Research Tower, Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853
    Endocrinology 148:1246-54. 2007
    b>Dlx3, a homeodomain transcription factor, is essential for placental development in the mouse. The Dlx3(-/-) mouse embryo dies at embryonic d 9.5-10 putatively due to placental failure...
  39. pmc Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndrome
    Olivier Duverger
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 283:20198-208. 2008
    The homeodomain protein Distal-less-3 (Dlx3) plays a crucial role during embryonic development. This transcription factor is known to be essential for placental formation and to be involved in skin and skeletal organogenesis...
  40. pmc In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development
    S J Choi
    Human Craniofacial Genetics Section, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20854, USA
    Dev Biol 325:129-37. 2009
    Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c...
  41. pmc Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism
    Louis Bruno Ruest
    Department of Craniofacial Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Dev Biol 328:94-108. 2009
    ..These observations suggest that the advent of Ednra signaling in cranial NCCs may have been a crucial event in the evolution of the mammalian middle ear ossicles...
  42. doi Spatio-temporal dynamics of gene expression of the Edn1-Dlx5/6 pathway during development of the lower jaw
    Maxence Vieux-Rochas
    CNRS UMR, Museum national d histoire naturelle, Paris, France
    Genesis 48:262-373. 2010
    ..More in general, our findings emphasize the importance of quantitative gene expression in the fine control of morphogenetic events...
  43. doi A Cdh1HA knock-in allele rescues the Cdh1-/- phenotype but shows essential Cdh1 function during placentation
    Marc P Stemmler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Dev Dyn 239:2330-44. 2010
    ..Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport...
  44. pmc The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction
    Yong Ri Jin
    Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA
    Dev Biol 352:1-13. 2011
    ..Thus, our study identifies Rspo2 as a mesenchyme-derived factor that plays critical roles in regulating BA1 patterning and morphogenesis through ectodermal-mesenchymal interaction and a novel genetic factor for cleft palate...
  45. pmc Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction
    Rosemary Oh-McGinnis
    Department of Medical Genetics, Molecular Epigenetics Group, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada
    Dev Biol 351:277-86. 2011
    ....
  46. pmc Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation
    Joonsung Hwang
    Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:11566-71. 2011
    In an effort to understand the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, we generated and characterized a mouse model with epidermal ablation of Dlx3...
  47. pmc Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome
    Simon J Tunster
    Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK
    Dis Model Mech 4:814-21. 2011
    ....
  48. ncbi Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation
    H Toresson
    Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 126:1317-26. 1999
    ..These findings, therefore, strongly support the notion that local retinoid signalling within the lateral ganglionic eminence regulates striatal neuron differentiation...
  49. ncbi AP-2 gamma and the homeodomain protein distal-less 3 are required for placental-specific expression of the murine 3 beta-hydroxysteroid dehydrogenase VI gene, Hsd3b6
    Lihong Peng
    Division of Reproductive Biology, Department of Gynecology and Obstetrics, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 277:7945-54. 2002
    ..Further electrophoretic mobility shift assays identified AP-2 gamma and the homeodomain protein, Dlx 3, as the transcription factors that specifically bind to FPI and FPIII, respectively...
  50. ncbi R-spondin3 is required for mouse placental development
    Motoko Aoki
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, Japan
    Dev Biol 301:218-26. 2007
    ..These findings suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development...
  51. ncbi Expression of Dlx genes during the development of the murine dentition
    Z Zhao
    Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
    Dev Genes Evol 210:270-5. 2000
    ..The relationship of Dlx gene expression to their genomic organization suggests coordinate regulation of linked genes at early stages but regulatory differences at later stages...
  52. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..Pax6 up-regulation occurred only several hours postdifferentiation. The loss of Pax6 altered progenitor specification, and the Lhx1 neuronal marker was lost, indicating a role for Pax6 in the specification of forebrain neuron identity...
  53. ncbi Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family
    E Quint
    Loeb Health Research Institute at the Ottawa Hospital, Ontario, Canada
    J Exp Zool 288:235-41. 2000
    ..These pairs include Dlx1/Dlx2, Dlx7/Dlx3, and Dlx6/Dlx5 (the zebrafish orthologue of Dlx5 is named dlx4)...
  54. pmc Essential role of Gab1 for signaling by the c-Met receptor in vivo
    M Sachs
    Department of Growth and Differentiation, Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    J Cell Biol 150:1375-84. 2000
    ..This is genetic evidence that Gab1 is essential for c-Met signaling in vivo. Analogy exists to signal transmission by insulin receptors, which require IRS1 and IRS2 as specific docking proteins...
  55. ncbi Roles for Msx and Dlx homeoproteins in vertebrate development
    A J Bendall
    Center for Advanced Biotechnology and Medicine, Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Gene 247:17-31. 2000
    ..Moreover, their ability to oppose each other's transcriptional actions implies a mechanism underlying their complementary or antagonistic functions during development...
  56. pmc Placental failure in mice lacking the mammalian homolog of glial cells missing, GCMa
    J Schreiber
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    Mol Cell Biol 20:2466-74. 2000
    ..Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta...
  57. pmc Regulation of the Dlx3 homeobox gene upon differentiation of mouse keratinocytes
    G T Park
    Laboratory of Skin Biology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:26599-608. 1999
    The Distal-less Dlx3 homeodomain gene is expressed in terminally differentiated murine epidermal cells, and there is evidence to support an essential role as a transcriptional regulator of the terminal differentiation process in these ..
  58. ncbi Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence
    C Skogh
    Division of Neurobiology, Wallenberg Neuroscience Center, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Mol Cell Neurosci 17:811-20. 2001
    ..These results demonstrate that at least a subpopulation of neurogenic LGE precursors exhibit glial characteristics...
  59. ncbi Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome
    J A Price
    Department of Biochemistry, Wake Forest University School of Medicine, Bowman Gray Campus, Winston Salem, NC 27157, USA
    Hum Mol Genet 7:563-9. 1998
    ..the TDO locus to chromosome 17q21, a region that includes two members of the distal-less homeobox gene family, DLX3 and DLX7...
  60. pmc Regulation of epidermal differentiation by a Distal-less homeodomain gene
    M I Morasso
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 135:1879-87. 1996
    The Distal-less-related homeodomain gene Dlx3 is expressed in terminally differentiated murine epidermal cells...
  61. ncbi Genomic analysis of a new mammalian distal-less gene: Dlx7
    S Nakamura
    Department of Biology, Yale University, New Haven, Connecticut 06511, USA
    Genomics 38:314-24. 1996
    ..Both the human and the mouse Dlx7 are shown to be closely linked to Dlx3 in a convergently transcribed orientation...
  62. pmc The evolution of the vertebrate Dlx gene family
    D W Stock
    Department of Anthropology, Pennsylvania State University, University Park 16802, USA
    Proc Natl Acad Sci U S A 93:10858-63. 1996
    ..Determination of the linkage relationship of these additional zebrafish Dlx genes to Hox clusters should help resolve this issue...
  63. ncbi Distal-less and other homeobox genes in the development of the dentition
    K M Weiss
    Department of Anthropology, Penn State University, University Park 16802
    J Exp Zool 270:273-84. 1994
    ..The screening approach with degenerate primers is a successful way to identify new as well as previously known regulatory genes expressed in developing tooth embryos...
  64. ncbi Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development
    G W Robinson
    Laboratory of Mammalian Genes and Development, NICHD, National Institutes of Health, Bethesda, MD 20892
    Mech Dev 48:199-215. 1994
    ..The differential expression of Dlx genes in the branchial region suggests that they play key roles in craniofacial patterning and morphogenesis...
  65. ncbi Assignment of the human homolog of mouse Dlx3 to chromosome 17q21.3-q22 by analysis of somatic cell hybrids and fluorescence in situ hybridization
    S W Scherer
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Mamm Genome 6:310-1. 1995
  66. ncbi Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    H Sakano
    Nature 286:676-83. 1980
    ..The DNA sequencing studies suggest that the two types of recombination operate by different mechanisms...
  67. ncbi Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain
    G W Robinson
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    New Biol 3:1183-94. 1991
    ..Thus, the Distal-less genes may contribute missing positional cues not provided by the previously identified vertebrate homeobox genes...
  68. ncbi Requirement for Mab21l2 during development of murine retina and ventral body wall
    Ryuichi Yamada
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, 630 0101, Japan
    Dev Biol 274:295-307. 2004
    ..Our results reveal that Mab21l2 plays crucial roles in retina and in ventral body wall formation...
  69. ncbi Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse
    E M Eicher
    Biochem Genet 14:651-60. 1976
    ..The red blood cells of mice of the subspecies M.m. casteneus have significantly reduced levels of CAR-1 and CAR-2...
  70. ncbi Sonic hedgehog is essential for first pharyngeal arch development
    Chihiro Yamagishi
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Pediatr Res 59:349-54. 2006
    ..These results demonstrate that epithelial-mesenchymal signaling and transcriptional events coordinated by Shh, partly via Fgf8, is essential for cell survival and tissue outgrowth of the developing PA1...
  71. pmc The mouse Ovol2 gene is required for cranial neural tube development
    Douglas R Mackay
    Department of Biological Chemistry, College of Medicine, D250 Med Sci I, University of California, Irvine, CA 92697 1700, USA
    Dev Biol 291:38-52. 2006
    ..Collectively, our studies indicate that Ovol2 is a key regulator of neural development and reveal a previously unexplored role for Ovo genes in mammalian embryogenesis...
  72. ncbi Expression pattern of Dlx3 during cell differentiation in mineralized tissues
    Sonia Ghoul-Mazgar
    Laboratoire de Biologie Oro faciale et Pathologie INSERM U 714, 15 21 rue de l Ecole de Médecine 75270, Universités Paris 7 and Paris 6 IFR58, Paris Cedex 06, France
    Bone 37:799-809. 2005
    The present study was designed to compare the expression pattern of Dlx3 in four different mineralized tissues because of: 1-its role in skeleton patterning, 2-its expression in dental epithelium and mesenchyme during morphogenesis, 3-the ..
  73. ncbi Developmental expression of the homeobox protein Distal-less 3 and its relationship to progesterone production in mouse placenta
    K A Berghorn
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Endocrinol 186:315-23. 2005
    Distal-less 3 (Dlx3) is a homeobox factor that functions as a placental-specific transcriptional regulator. Dlx3 null mice (-/-) have compromised placental development and do not survive in utero past embryonic day (E) 9.5...
  74. ncbi Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs
    Billie A Moore-Scott
    Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Dev Biol 278:323-35. 2005
    ..Our data suggest that, as in the posterior gut endoderm, exclusion of Shh expression from developing primordia is required for the proper development of pharyngeal-derived organs...
  75. pmc Essential requirement of CCAAT/enhancer binding proteins in embryogenesis
    Valerie Begay
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
    Mol Cell Biol 24:9744-51. 2004
    ..Our data thus reveal novel essential, redundant, and dosage dependent functions of C/EBPs...
  76. pmc Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes
    Geon Tae Park
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 30:515-22. 2002
    Expression of the Dlx3 homeodomain gene is induced in terminally differentiated epidermal cells...
  77. pmc The LIM-homeodomain protein Lhx2 is required for complete development of mouse olfactory sensory neurons
    Junji Hirota
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:8751-5. 2004
    ..OSN development appears to be arrested between the terminal differentiation into neurons and the transition to immature neurons. Thus, Lhx2 is required for complete development of OSNs in mice...
  78. ncbi Expression of Dlx and Lhx family homeobox genes in fetal thymus and thymocytes
    Kenneth J Woodside
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 2B 210, 9000 Rockville Pike, Bethesda, MD 20892 2780, USA
    Gene Expr Patterns 4:315-20. 2004
    ....
  79. ncbi Dlx transcription factors regulate differentiation of dopaminergic neurons of the ventral thalamus
    Gracie L Andrews
    Biology and Biochemistry Departments, Cell and Molecular Biology Graduate Program, University of Nevada, Reno 89557, USA
    Mol Cell Neurosci 23:107-20. 2003
    ..These data suggest that DLX genes act as forebrain-specific factors linking general neuron-inducing signals to region-specific neuron differentiation programs...
  80. pmc Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements
    Kenta Sumiyama
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 100:4030-4. 2003
    The mammalian Distal-less (Dlx) clusters (Dlx1-2, Dlx5-6, and Dlx3-7) have a nested expression pattern in developing visceral (branchial) arches...
  81. ncbi A role for the mesenchymal T-box gene Brachyury in AER formation during limb development
    Chunqiao Liu
    Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA
    Development 130:1327-37. 2003
    ....
  82. ncbi Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization
    Amel Gritli-Linde
    Department of Oral Biochemistry, Sahlgrenska Academy at Goteborg University, Sweden
    Development 129:5323-37. 2002
    ..Furthermore, we provide evidence that Shh signaling between ameloblasts and the overlying stratum intermedium may involve subcellular localization of Patched 2 and Gli1 mRNAs, both of which are targets of Shh signaling in these cells...
  83. pmc Genomic structure and functional control of the Dlx3-7 bigene cluster
    Kenta Sumiyama
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 99:780-5. 2002
    ..In this study, we examine the regulation of the Dlx3-7 cluster of the mouse. We obtained and sequenced human and mouse P1 clones covering the entire Dlx3-7 cluster...
  84. pmc Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    Mohammad Q Hassan
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655 0106, USA
    Mol Cell Biol 24:9248-61. 2004
    ..that Msx2 and Dlx5 homeodomain (HD) proteins support skeletal development, but null mutation of the closely related Dlx3 gene results in early embryonic lethality...
  85. ncbi The bicoid-related homeoprotein Ptx1 defines the most anterior domain of the embryo and differentiates posterior from anterior lateral mesoderm
    C Lanctot
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, Quebec, Canada
    Development 124:2807-17. 1997
    ....
  86. pmc Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches
    Michelle L Brinkmeier
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI, 48109 5618, USA
    Genomics 93:449-60. 2009
    ..These genes are exciting candidates for regulators of pituitary development and function...
  87. ncbi Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice
    Dagmara A Dettlaff-Swiercz
    Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Dev Biol 282:174-82. 2005
    ..In contrast, ET-3/ET(B)-mediated development of neural crest-derived melanocytes and enteric neurons appears to involve G-proteins different from G(q)/G(11)/G(12)/G(13)...
  88. ncbi Dlx and other homeobox genes in the morphological development of the dentition
    K M Weiss
    Graduate Program in Genetics, Penn State University, University Park, Pennsylvania 16802, USA
    Connect Tissue Res 32:35-40. 1995
    ..The Msx and Dlx genes are the best current candidates for a combinatorial mechanism that controls the differentiation of structures within and between teeth, and perhaps also the evolution of those structures...
  89. ncbi Unravelling the complex genetics of cleft lip in the mouse model
    D M Juriloff
    Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, B C, V6T 1Z3, Canada
    Mamm Genome 12:426-35. 2001
    ..A screen of 54 YACs for 46 genes and SSLP loci located Wnt15, Wnt3, Crhr, Mtapt, Itgb3, Dlx3, and Dlx7 within the clf1 candidate region...
  90. ncbi Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice
    D E Clouthier
    Howard Hughes Medical Institute, Department of Molecular Genetics, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas, 75235, USA
    Dev Biol 217:10-24. 2000
    ..In particular, this developmental pathway appears distinct from the pathway that includes UFD1L, implicated as a causative gene in CATCH 22 patients, and suggests parallel complementary pathways mediating craniofacial development...

Research Grants4

  1. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  2. Combinatorial Signals & Gene Expression in Trophoblasts
    Mark Roberson; Fiscal Year: 2006
    ..Further, trophoblast differentiation depends upon gene programs induced by Dlx3. The overall goal is a comprehensive understanding of mechanisms governing CG synthesis and analysis of factors ..
  3. Two-photon excited fluorescence imaging of placental vasculature in vivo
    Mark Roberson; Fiscal Year: 2008
    ..The central hypothesis addressed in this R21 application is that Dlx3 plays a critical role in the developmental determination of the trophoblast population within the placental ..
  4. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....